Abstract
P161
Objectives: Primary hyperparathyroidism during pregnancy is a rare condition associated with a high complication rate in both mother and fetus. Our objective was to review diagnostic testing and treatment options for this disorder and to present 2 cases of pregnant females with primary hyperparathyroidism treated effectively with surgery.
Methods: A literature review was conducted, and 2 case reports of pregnant females with primary hyperparathyroidism were included.
Results: Under 200 cases of primary hyperparathyroidism during pregnancy were reported in the literature. Complications of untreated hypercalcemia in mother and fetus were well documented, and both medical and surgical treatment options were discussed. Surgical intervention was thought to be the only definitive treatment.
Conclusion: Primary hyperparathyroidism during pregnancy can cause serious medical complications in both mother and fetus. This rarely reported disorder, with less than 200 cases found in a recent literature review, can be treated conservatively with medical therapy. Surgical intervention, however, represents the only definitive treatment. This article outlines the pathophysiology, symptomatology, diagnostic testing, and medical management options of primary hyperparathyroidism in the pregnant patient. Recommended imaging and localizing studies, and timing for surgical intervention, are also discussed. Two case studies are then included to demonstrate the effectiveness of surgery as the definitive treatment option for this disorder.