Asian Indians and Insulin Resistance Syndrome: Global Perspective

Insulin resistance syndrome (IRS) is a crucial factor in causation of type 2 diabetes mellitus (T2DM) in Asian Indians. Approximately one-fifth of the migrant Asian Indians have evidence of metabolic syndrome. Furthermore, insulin resistance as estimated by homeostatic model assessment (HOMA-IR) was reported to be present in one-fifth of children and young adult Asian Indians with normal body mass index (BMI) and ∼45–67% of those having high BMI. The cause(s) of such high prevalence of IRS in Asian Indians is not clear; however, inherent genetic predisposition, physical inactivity, excess regional body fat, and factors associated with migration may play an important role. It is important that lifestyle factor modification to prevent IRS and T2DM in Asian Indians should start in early childhood.