Abstract
The Rosalind Franklin Society (RFS), in partnership with Mary Ann Liebert, Inc., publishers, enthusiastically congratulate our distinguished recipient of the 2022 annual
Judy Strickland, et al., “Application of Defined Approaches to Assess Skin Sensitization Potency of Isothiazolinone Compounds,” Applied In Vitro Toxicology 8, no. 4 (December 2022): 117–128, http://doi.org/10.1089/aivt.2022.0014.
Abstract
Isothiazolinones are widely used as antimicrobial preservatives in cosmetics and in consumer and industrial products to control bacteria, fungi, and algae. While they are effective biocides, they have the potential to produce skin irritation and sensitization, which poses a human health hazard. In this project, we evaluated non-animal defined approaches for skin sensitization that can provide point-of-departure estimates for use in quantitative risk assessment for isothiazolinones. The skin sensitization potential of six isothiazolinones was evaluated using three internationally harmonized non-animal test methods. Results from these test methods were then applied to two versions of the Shiseido Artificial Neural Network defined approach. Sensitization hazard or potency predictions were compared to those of the in vivo murine local lymph node assay (LLNA). The non-animal methods produced skin sensitization hazard and potency classifications concordant with those of the LLNA. Potency values generated by the defined approaches had less variability than those from the LLNA, and confidence limits from the defined approaches overlapped those of the LLNA for most substances. The application of in silico models to non-animal skin sensitization data is a promising data integration procedure for defined approaches to support hazard and potency classification and quantitative risk assessment.
Biosketch
Dr. Judy Strickland is a principal predictive toxicologist at Inotiv, Inc., with 22 years of experience in evaluating alternative test methods that reduce, refine, or replace animals in regulatory toxicity test methods. Dr. Strickland has both coordinated and evaluated national and international validation studies to assess the performance of non-animal methods for assessing chemical toxicity. Her efforts in evaluating non-animal methods for the assessment of chemical skin sensitizers contributed to the first internationally harmonized guideline for non-animal approaches that can replace animal tests to identify skin sensitizers and classify their potency. This work continues in an effort to broaden the number and type of test methods and approaches accepted, including those can be used to establish safe exposure levels of chemical sensitizers. She serves on the Organization for Economic Cooperation and Development expert group on skin sensitization and the expert group on defined approaches for skin sensitization. Dr. Strickland received a PhD in pharmacology from East Carolina University and is a diplomate of the American Board of Toxicology.