Abstract
James Carroll has resumed his popular summary of the photobiomodulation literature, after a prolonged hiatus. We hope that it will now become a regular addition to Photobiomodulation, Photomedicine, and Laser Surgery.
Di Marino M, Conigliaro P, Aiello F, et al. Combined low-level light therapy and intense pulsed light therapy for the treatment of dry eye in patients with Sjögren's syndrome. J Ophthalmol 2021;2021:2023246.
Nonoguchi NM, Adachi M, Nogami A, et al. Stellate Ganglion phototherapy using low-level laser: a novel rescue therapy for patients with refractory ventricular arrhythmias. JACC Clin Electrophysiol 2021;S2405-500X(21)00440-0.
Duarte de Oliveira FJ, Brasil GMLC, Araújo Soares GP, Fernandes Paiva DF, de Assis de Souza Júnior F. Use of low-level laser therapy to reduce postoperative pain, edema, and trismus following third molar surgery: a systematic review and meta-analysis. J Craniomaxillofac Surg 2021;S1010-5182(21)00158-X.
Schneider C, Dungel P, Priglinger E, Danzer M, Schädl B, Nürnberger S. The impact of photobiomodulation on the chondrogenic potential of adipose-derived stromal/stem cells. J Photochem Photobiol B 2021;221:112243.
Zielińska P, Soroko M, Howell K, Godlewska M, Hildebrand W, Dudek K. Comparison of the effect of high-intensity laser therapy (HILT) on skin surface temperature and vein diameter in pigmented and non-pigmented skin in healthy racehorses. Animals (Basel) 2021;11:1965.
de Matos BTL, Buchaim DV, Pomini KT, et al. Photobiomodulation therapy as a possible new approach in COVID-19: a systematic review. Life (Basel) 2021;11:580.
Kocherova I, Bryja A, Błochowiak K, et al. Photobiomodulation with red and near-infrared light improves viability and modulates expression of mesenchymal and apoptotic-related markers in human gingival fibroblasts. Materials (Basel) 2021;14:3427.
Hanna R, Dalvi S, Bensadoun RJ, Benedicenti S. Role of photobiomodulation therapy in modulating oxidative stress in temporomandibular disorders. A systematic review and meta-analysis of human randomised controlled trials. Antioxidants (Basel) 2021;10:1028.
Khorsandi K, Kianmehr Z, Ghelichkhani E. Combination effect of red light irradiation and Traychspermum ammi essential oil on colorectal cancer cells (SW480). Lasers Med Sci 2021; Jun PMID: 34191208.
Monteiro L, Vasconcelos C, Pacheco JJ, Salazar F. Photobiomodulation laser therapy in a Lenvatinib-related osteonecrosis of the jaw: a case report. J Clin Exp Dent 2021;13:E626–E629. DOI:
Zaki Z, Ravanbod R, Schmitz M, Abbasi K. Comparison of low level and high power laser combined with kinesiology taping on shoulder function and musculoskeletal sonography parameters in subacromial impingement syndrome: a randomized placebo-controlled trial. Physiother Theory Pract 2021:1–12.
Khan I, Rahman SU, Tang E, et al. Accelerated burn wound healing with photobiomodulation therapy involves activation of endogenous latent TGF-β1. Sci Rep 2021;11:13371.
Murugan M, Regan R, Arumugam A. Effectiveness of low-level laser therapy compared with other conventional therapies on wound healing and pain reduction in patients with median sternotomy: a systematic review protocol. JBI Evid Synth 2021; Jun DOI: 10.11124/JBIES-20-00428.
Zheng J, Yang K. Clinical research: low-level laser therapy in accelerating orthodontic tooth movement. BMC Oral Health 2021;21:324.
Stefenon L, Boasquevisque M, Garcez AS, et al. Autophagy upregulation may explain inhibition of oral carcinoma in situ by photobiomodulation in vitro. J Photochem Photobiol B 2021;221:112245.
Chen Z, Huang S, Liu M. The review of the light parameters and mechanisms of Photobiomodulation on melanoma cells. Photodermatol Photoimmunol Photomed 2021; Jun PMID: 34181781.Review.
Azuma RHE, Merlo JK, Jacinto JL, et al. Photobiomodulation therapy at 808 nm does not improve biceps brachii performance to exhaustion and delayed-onset muscle soreness in young adult women: a randomized, controlled, crossover trial. Front Physiol 2021;12:664582.
Ekici Ö, Dündar Ü, Büyükbosna M. Effectiveness of high-intensity laser therapy in patients with myogenic temporomandibular joint disorder: a double-blind, placebo-controlled study. J Stomatol Oral Maxillofac Surg 2021;S2468-7855(21)00135-X.
Guimarães LS, Silva E, Hespanhol FG, Fontes K, Antunes L, Antunes LS. Effect of photobiomodulation on postoperative symptoms in teeth with asymptomatic apical periodontitis treated with foraminal enlargement: a randomized clinical trial. Int Endod J 2021.
Naudin T, Thorel D, Tétart F, Muraine M, Gueudry J. [Combined intense pulsed light and low-level light therapy in the treatment of Meibomian gland dysfunction]. J Fr Ophtalmol 2021; June: ISSN 0181-5512. Available at:
Zigmundo GCO, Schmidt TR, Silveira FM, et al. Analysis of referrals to the stomatology service in a Southern Brazilian hospital: a retrospective study. Braz Oral Res 2021;35:e072.
Eroglu B, Genova E, Zhang Q, et al. Photobiomodulation has rejuvenating effects on aged bone marrow mesenchymal stem cells. Sci Rep 2021;11:13067.
Martin LF, Moutal A, Cheng K, et al. Green light antinociceptive and reversal of thermal and mechanical hypersensitivity effects rely on endogenous opioid system stimulation. J Pain 2021; Jun 19. PMID: 34157406.
Koltak C, Yurt Y. Comparison of the effects of low level laser and insoles on pain, functioning, and muscle strength in subjects with stage 2 posterior tibial tendon dysfunction: a randomized study. J Back Musculoskelet Rehabil 2021; Jun. DOI: 10.3233/BMR-200199.
Robijns J, Lodewijckx J, Claes S, et al. Response to the Letter to the editor by Donnelly et al. regarding the article Photobiomodulation therapy for the prevention of acute radiation dermatitis in head and neck cancer patients (DERMISHEAD trial). Radiother Oncol 2021;S0167-8140(21)06581-6.
Wu X, Shen Q, Zhang Z, Zhang D, Gu Y, Xing D. Photoactivation of TGFβ/SMAD signaling pathway ameliorates adult hippocampal neurogenesis in Alzheimer's disease model. Stem Cell Res Ther 2021;12:345.
Quirk B, Whelan HT. Effect of red-to-near infrared light and a nitric oxide donor on the oxygen consumption of isolated cytochrome c oxidase. Photobiomodul Photomed Laser Surg 2021;39:463–470.
Miranda-Silva W, Fonseca FP, Gomes AA, Mafra ABB, Rocha V, Fregnani ER. Oral mucositis in pediatric cancer patients undergoing allogenic hematopoietic stem cell transplantation preventively treated with professional dental care and photobiomodulation: incidence and risk factors. Int J Paediatr Dent 2021; Jun 11. DOI: 10.1111/ipd.1285. [Epub ahead of print].
Michelogiannakis D, Jabr L, Barmak AB, Rossouw PE, Kotsailidi EA, Javed F. Influence of low-level-laser therapy on the stability of orthodontic mini-screw implants. A systematic review and meta-analysis. Eur J Orthod 2021; April. DOI: 10.1093/ejo/cjab016. Project: Clinical outcomes of orthodontic therapy.
Etemadi A, Sadatmansouri S, Sodeif F, Jalalishirazi F, Chiniforush N. Photobiomodulation effect of different diode wavelengths on the proliferation of human gingival fibroblast cells. Photochem Photobiol 2021; Jun. PMID: 34107547. DOI: 10.1111/php.13463.
Alves GÂDS, Gondim YRDR, Lima JAS, et al. Effects of photobiomodulation associated with orofacial myofactional therapy on temporomandibular joint dysfunction. Codas 2021;33:E20200193.
Gavish L, Spitzer E, Friedman I, et al. Photobiomodulation as an adjunctive treatment to physiotherapy for reduction of anterior knee pain in combat soldiers: a prospective, double-blind, randomized, pragmatic, sham-controlled trial. Lasers Surg Med 2021; Jun. Available at:
Almog M, Nissan M, Koifman I, Wollman Y, Rochkind S. On-site laser photobiomodulation treatment of crushed muscle due to prolonged pressure in rats. Lasers Surg Med 2021; Jun.
Bullock-Saxton J, Lehn A, Laakso EL. Exploring the effect of combined transcranial and intra-oral photobiomodulation therapy over a four-week period on physical and cognitive outcome measures for people with Parkinson's disease: a randomized double-blind placebo-controlled pilot study. J Alzheimers Dis 2021; Jun. DOI: 10.3233/JAD-210170 vol. Pre-press, no. Pre-press, pp. 1–14.
Spera V, Sitnikova T, Ward MJ, et al. Pilot study on dose-dependent effects of transcranial photobiomodulation on brain electrical oscillations: a potential therapeutic target in Alzheimer's disease. J Alzheimers Dis 2021; Jun. DOI: 10.3233/JAD-210058 vol. Pre-press, no. Pre-press, pp. 1–18.
Kinalski MA, Agostini BA, Bergoli CD, Dos Santos MBF. Influence of low-level laser therapy on implant stability in implants placed in healed sites: a randomized controlled trial. Int J Implant Dent 2021;7:49.
Ma M, Zhong Y, Jiang X. An injectable photothermally active antibacterial composite hydroxypropyl chitin hydrogel for promoting the wound healing process through photobiomodulation. J Mater Chem B 2021;9:4567–4576.
Jin XL, Zhang YN, Sun CR, Zou ZH. Protective effect of low-level laser irradiation on lipopolysaccharide-mediated inflammatory injury of human periodontal ligament fibroblasts. Hua Xi Kou Qiang Yi Xue Za Zhi 2021;39:260–266.
Yin Q, Chang H, Shen Q, Xing D. Photobiomodulation therapy promotes the ATP-binding cassette transporter A1-dependent cholesterol efflux in macrophage to ameliorate atherosclerosis. J Cell Mol Med 2021;25:5238–5249.
Domínguez A, Velásquez SA. Acceleration of dental movement by photobiomodulation: how does it happen? Photobiomodul Photomed Laser Surg 2021;39:379–380.
Guimarães LS, Costa LDCM, Araujo AC, et al. Photobiomodulation therapy is not better than placebo in patients with chronic nonspecific low back pain: a randomised placebo-controlled trial. Pain 2021;162:1612–1620.
Maher CG. Photobiomodulation therapy for chronic low back pain: time to move on. Pain 2021;162:1589–1590.
Zheng Q, Zhang J, Zuo X, et al. Photobiomodulation promotes neuronal axon regeneration after oxidative stress and induces a change in polarization from M1 to M2 in macrophages via stimulation of CCL2 in neurons: relevance to spinal cord injury. J Mol Neurosci 2021;71:1290–1300.
Kauark-Fontes E, Rodrigues-Oliveira L, Epstein JB, et al. Cost-effectiveness of photobiomodulation therapy for the prevention and management of cancer treatment toxicities: a systematic review. Support Care Cancer 2021;29:2875–2884.
Yang M, Yang Z, Wang P, Sun Z. Current application and future directions of photobiomodulation in central nervous diseases. Neural Regen Res 2021;16:1177–1185.
barra AMC, Biasotto-Gonzalez DA, Kohatsu EYI, de Oliveira SSI, Bussadori SK, Tanganeli JPC. Photobiomodulation on trigeminal neuralgia: systematic review. Lasers Med Sci 2021;36:715–722.
Martins AFL, Morais MO, de Sousa-Neto SS, et al. Photobiomodulation reduces the impact of radiotherapy on oral health-related quality of life due to mucositis-related symptoms in head and neck cancer patients. Lasers Med Sci 2021;36:903–912.
Rajendran NK, Houreld NN, Abrahamse H. Photobiomodulation reduces oxidative stress in diabetic wounded fibroblast cells by inhibiting the FOXO1 signaling pathway. J Cell Commun Signal 2021;15:195–206.
Park JH, Byun HJ, Kim HJ, et al. Effect of photobiomodulation therapy on radiodermatitis in a mouse model: an experimental animal study. Lasers Med Sci 2021;36:843–853.
Neves LMG, Tim CR, Floriano EM, et al. Lycium barbarum polysaccharide fraction associated with photobiomodulation protects from epithelium thickness and collagen fragmentation in a model of cutaneous photodamage. Lasers Med Sci 2021;36:863–870.
Martinelli A, Andreo L, Alves AN, et al. Photobiomodulation modulates the expression of inflammatory cytokines during the compensatory hypertrophy process in skeletal muscle. Lasers Med Sci 2021;36:791–802.
Pinheiro ALB, Soares LGP, da Silva ACP, et al. The use of photobiomodulation therapy or LED and mineral trioxide aggregate improves the repair of complete tibial fractures treated with wire osteosynthesis in rodents. Lasers Med Sci 2021;36:735–742.