Abstract
Acetazolamide
CBF quantification analysis, equal-volume-split ECD SPECT method, 1020
Adenosine
in hypoxia-induced pial artery dilation, role of nitric oxide, cyclic nucleotides, and ATP-sensitive potassium channels, 100
Adhesion molecules
laminin, and leukocyte inhibition in focal cerebral ischemia, 605
Adrenomedullin
and regional CBF, in ischemic brain, 19
A1252G mutation
in α1-antichymotrypsin, in dementia patients, 233
Aging factors
brain, dopamine receptor quantification, 316, 331
brain stem circulation during hypotension, 680
and pH regulation in hippocampus, anoxia effects, 560
Aglycemia
and depression of glutamatergic excitation in striatum, 1121
Alpha-methyl-tryptophan
kinetics, serotonin synthesis rate, 659
Alzheimer's disease
neuronal thread protein gene expression, in brain infarction, 623
scopolamine-induced hypofrontality, physostigmine reversal of, 220
Amino acids
exchange between neurons and glia, fluoroacetate inhibition of, 1230
Aminoadipate
and glutamate release from brain, in oxygen and glucose deprivation, 567
1-Aminocyclopentane carboxylic acid
brain tumor imaging, 1239 α-Amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)
antagonist NBQX, protection of dentate hilus of hippocampus, after cerebral ischemia, 147
α-Aminoisobutyric acid
brain tumor imaging, 1239
Ammonia
and potassium regulation, methionine sulfoximine effects, 44
Amphetamine
and raclopride binding, 437
Anesthetics
isoflurane and propofol, and MK-801-induced neurotoxicity, 168
Angiogenesis
in cerebral hypoxia, regional differences, 801
Animal studies
baboon, dopamine D2 receptor, (F-18)N-methyl benperidol as PET tracer, 833
cat, endothelin-B receptors, in cerebral resistance arterioles, after ischemia, 1157
cat, focal cerebral ischemia, cortical depolarization, and calcium homeostasis and nitric oxide production, 1170
cat, halothane reduction of infarct volume, effect on CBF and spreading depression, 857
cat, PET in transient middle cerebral artery occlusion, postischemic reperfusion, 388
cow, brain capillaries, endothelial cell-pericyte interactions, 464
cow, nitric oxide synthase activation by vasoactive intestinal peptide, in cerebral arteries, 977
dog, basilar artery, vasodilator effects of intracisternal interleukin-1β, 1337
dog, cerebral arteries, nitric oxide and cationic polypeptide effects, 470
dog, cerebral vessels, phosphodiesterase type IV characterization, 210
dog, near infrared spectroscopy in reflectance mode, invalid CBF measurement, 695
dog, nitroxidergic nerve stimulation, hypoxia effect in cerebral arteries, 807
dog, phospholipase C protein expression, and neurodegeneration after global incomplete ischemia, 527
gerbil, brain, up-regulation of Nedd2 gene for ICE/Ced-3-like cysteine protease, 507
gerbil, forebrain ischemia, neuroprotection by benzodiazepine receptor agonist PNU-101017, 875
gerbil, ischemic brain, FK506 effect on binding of cAMP-dependent protein kinase, 412
monkey, amphetamine effect on raclopride binding, 437
monkey, raclopride kinetics, combined PET-microdialysis, 932
mouse, apolipoprotein E deficiency, and focal cerebral ischemia, 753
mouse, brain, NGFI-B, c-fos, and c-jun, expression after carbon monoxide intoxication, 771
mouse, brain infarction, and inhibition of tumor necrosis factor, 229
mouse, brain ischemia, poly(ADP-ribose) polymerase activation of, 1143
mouse, brain ischemia, tumor necrosis factor induction in hippocampus, 491
mouse, brain ischemia, tumor necrosis factor pretreatment, 483
mouse, fluoroacetate in neuron-glial amino acid exchange, 1230
mouse, model of embolic focal cerebral ischemia, 1081
mouse, nitric oxide synthase null, nitroarginine binding in ischemia or excitotoxicity, 515
mouse, transgenic, superoxide dismutase overexpression, kainate neurotoxicity, 241
mouse, transgenic, with mutant ICE inhibitory protein, attentuation of focal cerebral ischemia, 370
pig, calcium-activated potassium channels, in cerebral arterioles, resistance to ischemia, 1152
pig, cerebral perivascular nerves, citrulline conversion to arginine, 884
pig, hypoxia-induced pial artery dilation, adenosine role, effects of nitric oxide, cyclic nucleotides, and ATP-sensitive potassium channels, 100
rabbit, brain trauma, leukocyte dynamics, 1210
rabbit, cerebral arteries, myofilament calcium sensitivity, 236
rabbit, nitric oxide in CBF response to hypoxemia and hemodilution, 1319
rabbit, perfusion with rt-PA and hirulog, model of embolic stroke, 401
rat, bacterial meningitis model, heparin effects on pial leukocytesand inflammatory changes, 1221
rat, bcl-2 expression by herpes simplex virus vectors, neuroprotection after stroke, 740
rat, BDNF gene expression, suppression by hyperglycemia and hypercapnia in brain ischemia, 1303
rat, brain, biological reducing activity in closed head injury, 273
rat, brain, dopamine receptors, regulation of DOPA decarboxylase, 1254
rat, brain, during forepaw stimulation, oxidative glucose metabolism, 1040
rat, brain, GABAergic regulation of microvascular tone, 992
rat, brain, glucoprivic effects on CBF, 54
rat, brain, glut1 glucose transporter distribution, immunoautoradiography, 204
rat, brain, hypoxia-induced angiogenesis, regional differences, 801
rat, brain, ischemia, adrenomedullin effect on regional CBF, 19
rat, brain, ischemia, apoptosis repressor genes Bcl-2 and Bcl-x-long expression, 2
rat, brain, ischemia, and arginine-induced regional CBF, 1074
rat, brain, ischemia, DNA fragmentation before internucleosomal leavage, 376
rat, brain, ischemia, glucose PET in Harderian glands, 116
rat, brain, ischemia, infarct size reduction by BDNF, 500
rat, brain, ischemia, interleukin-1β converting enzyme gene and bcl-2 gene, expression, 11
rat, brain, ischemia, laminin inhibition of leukocytes, 605
rat, brain, ischemia, mitochondrial respiratory chain enzymes, 1166
rat, brain, ischemia, NBQX protection of dentate hilus in hippocampus, 147
rat, brain, ischemia, neuroprotection by striatal interleukin-1 receptor antagonist, 597
rat, brain, ischemia, preconditioning effects on neuronal damage, 175
rat, brain, ischemia, reduction by nonselective cation channels, 534
rat, brain, ischemia, reperfusion damage, 1048
rat, brain, ischemia, SB 206284A effects, 421
rat, brain, ischemia, tau protein in oligodendrocytes, role of free radicals, 612
rat, brain, ischemia, and water diffusion, 183
rat, brain, ischemia, zinc finger immediate early genes, 636
rat, brain, isoflurane and propofol effect on MK-801 neurotoxicity, 168
rat, brain, neonatal, heme oxygenase-I induction by hypoxia-ischemia, 647
rat, brain, neonatal, monocyte chemoattractant protein-1 expression in hypoxia-ischemia, 759
rat, brain, nimodipine uptake, during cortical spreading depression, 586
rat, brain, potassium dysregulation during hyperammonemia, methionine sulfoximine effects, 44
rat, brain, tissue plasminogen activator, nicotine effects, 136
rat, brain, trauma, CBF and carbon dioxide reactivity, perfusion MRI using arterial spin-labeling, 865
rat, brain, trauma, glucose blood levels, 50
rat, brain, tumor imaging, with 1-aminocyclopentane carboxylic acid and α-aminoisobutyric acid, 1239
rat, brain stem circulation during hypotension, aging effects, 680
rat, brain stem circulation during hypotension, nitric oxide role, 1089
rat, cardiac arrest, functional activation of CBF, 1202
rat, CBF response to hypoglycemia, caffeine and glibenclamide effects, 1309
rat, cerebral cortex, astrocytes and vascular interactions of noradrenaline terminals, 894
rat, cerebral glucose metabolism and blood flow relationships in ischemia, 1266, 1281
rat, cerebral infarct volume, triphenyltetrazolium chloride staining, 1132
rat, developing cortex and corpus callosum, ischemia effects on extracellular space diffusion, potassium, and pH, 191
rat, flow-metabolism uncoupling, during stimulation of nucleus basalis of Meynert, 686
rat, focal cerebral ischemia, cyclin D1/cdk4 immunoreactivity in neurons and oligodendrocytes, 846
rat, focal cerebral ischemia, growth inhibitory factor mRNA expression, 745
rat, focal cerebral ischemia, hyperglycemia effects on nimodipine uptake, 1057
rat, focal cerebral ischemia, neuroprotective role of poly(ADP-ribose) synthetase, 1137
rat, focal cerebral ischemia, oxygenation during infarct depolarization, 950
rat, global forebrain ischemia, interleukin-1β and receptor expression, 1107
rat, hippocampus, DNA fragmentation in delayed neuronal death, 967
rat, hippocampus, metabotropic glutamate receptor-mediated nitric oxide production, 153
rat, hippocampus, synaptic transmission in CA1 neurons, during ischemia, 955
rat, input function in dynamic susceptibility contrast MRI, L-NAME effect, 791
rat, kainate-induced seizures, nitric oxide role in CBF, 94
rat, laminar analysis of CBF, laser-Doppler flowmetry, 1326
rat, neuronal death after forebrain ischemia, effect of platelet-derived growth factor-BB, 1097
rat, perfusion deficit, and cerebral ischemia/reperfusion injury in hyperglycemia, 553
rat, pneumococcal meningitis, 7-nitroindazole inhibition of pial arteriolar vasodilation, 985
rat, prepiriform cortex, and neuronal cell death in global ischemia, 356
rat, regional CBF after middle cerebral artery occlusion, 1066
rat, rotenoid binding to mitochondrial complex I, 265
rat, strain and vendor differences in collateral anastomoses, 571
rat, thalamus, hypothermia protection of ultra-early-type ischemic neuronal injury, 543
rat, thromboembolic stroke, nitric oxide synthase role in platelet accumulation and hemodynamic depression, 1182
rat, thrombotic focal cerebral ischemia, 123
sheep, brain, nitric oxide synthase and regional CBF, 109
Anoxia
aging effects on pH regulation in hippocampus, 560
α1 - Antichymotrypsin
A1252G mutation, in dementia patients, 233
Antioxidants
oxidative stress in closed head injury, 1007
Anxiety
and cerebral glucose utilization, reduction in second test session, 704
Apolipoprotein E
and focal cerebral ischemia, 753
Apoptosis
DNA fragmentation before internucleosomal cleavage, in ischemic brain, 376
gene expression induced by cerebral ischemia, 815
repressor genes Bcl-2 and Bcl-x-long expression, in ischemic brain, 2
zinc finger immediate early genes, in ischemic brain, 636
Arginine
and basal CBF, 309
citrulline conversion to, via argininosuccinate path, in cerebral perivascular nerves, 884
regional CBF induced by, ischemia effect, 1074
Arginosuccinate lyase
citrulline conversion, in cerebral perivascular nerves, 884
Arteriovenous malformations
theoretical model of cerebral hemodynamics, 905
Astrocytes
and vascular interactions of noradrenaline terminals, in cerebral cortex, 894
Astrogliosis
from excitotoxic injury in hippocampal cultures, 26
heat shock protein Hsp27, potassium-induced spreading depression, 781
ATP
in CBF response to hypoglycemia, caffeine and glibenclamideeffects, 1309
Autoradiography
brain tumors, imaging with 1-aminocyclopentane carboxylic acid and α-aminoisobutyric acid, 1239
flow-metabolism uncoupling, during stimulation of nucleus basalis of Meynert, 686
glut1 transporter distribution in brain, 204
nimodipine uptake, in cortical spreading depression, 586
nimodipine uptake in focal cerebral ischemia, in hyperglycemia, 1057
nitric oxide synthase, and cerebrovascular-metabolic responses to somatosensory stimulation, 1197
nitroarginine binding after ischemia or excitotoxicity, in nitric oxide synthase null mouse, 515
three-dimensional, cerebral glucose metabolism and blood flow relationships in ischemia, 1266
Autoregulation
arginine effects on basal CBF, 309
brain stem circulation during hypotension, aging effects, 680
brain stem circulation during hypotension, nitric oxide role, 1089
frequency dependence of cerebrovascular impedance, in preterm neonates, 1127
theoretical model of cerebral hemodynamics, 905
Bacterial meningitis
heparin effects on pial leukocytes and inflammatory changes, 1221
Bcl-2 gene
and Bcl-x-long gene, apoptosis repressor, expression in ischemic brain, 2
expression in brain ischemia, 11, 815
herpes simplex virus vectors, neuroprotection after stroke, 740
Benzodiazepine receptors
agonist PNU-101017, neuroprotection in forebrain ischemia, 875
quantification using partial-saturation injection, 343
Binding
cAMP-dependent protein kinase, FK506 effect in ischemic brain, 412
diprenorphine, in Huntington's disease, comparison of region of interest analysis and statistical parametric mapping, 943
dynamic radioligand displacement activation studies, 80
nitroarginine, after ischemia or excitotoxicity, in nitric oxide synthase null mouse, 515
raclopride, amphetamine effects, 437
rotenoid, to mitochondrial complex I, neurotoxin effects, 265
Bipolar illness
dopamine receptor quantification, in aging brain, 331
Blood flow, cerebral (CBF)
after cardiac arrest, 1202
arginine-induced, ischemia effect, 1074
in arteriovenous malformations, 905
basal, arginine effects, 309
brain stem, during hypotension, aging effects, 680
brain stem circulation during hypotension, nitric oxide role, 1089
in brain trauma, perfusion MRI using arterial spin-labeling, 865
coupling with oxygen metabolism during neural stimulation, 64
flow-metabolism uncoupling, during stimulation of nucleus basalis of Meynert, 686
glucose deprivation, and deoxyglucose effects, 54
and glucose metabolism, relationships in ischemia, 1266, 1281
hypoglycemia effect, blockade by caffeine and glibenclamide, 1309
during hypoxemia and hemodilution, nitric oxide role, 1319
infarct volume reduction by halothane, 857
input function in dynamic susceptibility contrast MRI, L-NAME effect, 791
laminar analysis by laser-Doppler flowmetry, 1326
near infrared spectroscopy in reflectance mode, 695
in newborn infants, HMPAO as tracer, 448
and nitric oxide, in kainate-induced seizures, 94
quantification analysis, equal-volume-split ECD SPECT method, 1020
regional, adrenomedullin effect, 19
regional, during finger movements, comparison of MRI and PET, 670
regional, after middle cerebral artery occlusion, 1066
regional, nitric oxide synthase activity, 109
velocity monitoring, functional hemispheric asymmetry, 577
Blood-brain barrier
drug delivery to brain, 713
endothelial cell—pericyte interactions, 464
and interleukin-8 in CSF in brain injury, 280
leukocyte dynamics after brain trauma, 1210
Brain
aging, dopamine receptor quantification, 316, 331
angiogenesis in hypoxia, regional differences, 801
arteries, hypoxia effect on nitroxidergic nerve stimulation, 807
arteries, myofilament calcium sensitivity, 236
arteries, nitric oxide and cationic polypeptide effects, 470
arteries, nitric oxide synthase activation by vasoactive intestinal peptide, 977
arteries, phosphodiesterase type IV characterization, 210
arterioles, endothelin-B receptors after focal cerebral ischemia, 1157
astrocytes and vascular interactions of noradrenaline terminals, 894
capillaries, endothelial cell—pericyte interactions, 464
closed head injury, biological reducing activity, cyclic voltammetry, 273
developing cortex and corpus callosum, ischemia effects on extracellular space diffusion, potassium, and pH, 191
dopamine receptors, regulation of DOPA decarboxylase, 1254
drug delivery, 713
focal ischemia, and apolipoprotein E deficiency, 753
focal ischemia, embolic, mouse model, 1081
focal ischemia, growth inhibitory factor mRNA expression, 745
focal ischemia, in transgenic mice with mutant ICE inhibitory protein, 370
focal ischemia, mitochondrial respiratory chain enzymes, 1166
focal ischemia, neuroprotective role of poly(ADP-ribose) synthetase, 1137
focal ischemia, tau protein in oligodendrocytes, role of free radicals, 612
focal ischemia, thrombotic, rat model, 123
glucose utilization, reduction in second test session, 704
glut1 glucose transporter distribution, immunoautoradiography, 204
glutamate release, aminoadipate effects in oxygen and glucose deprivation, 567
hemodynamics, study of arteriovenous malformations, 905
hypercapnia suppression of low-frequency fluctuations, echo-planar MRI, 301
infarction, and inhibition of tumor necrosis factor, 229
infarction, neuronal thread protein gene expression, 623
infarction, volume analysis, triphenyltetrazolium chloride staining, 1132
injury, interleukin-8 in CSF, blood-brain barrier function and nerve growth factor production, 280
interleukin-1β converting enzyme gene and bcl-2 gene, expression after ischemia, 11
ischemia, adrenomedullin effect on regional CBF, 19
ischemia, apoptosis repressor gene Bcl-2 and Bcl-x-long expression, 2
ischemia, autoradiographic image analysis of local glucose metabolism and blood flow relationships, 1266
ischemia, BDNF gene expression, suppression by hyperglycemia and hypercapnia, 1303
ischemia, FK506 effect on binding of cAMP-dependent protein kinase, 412
ischemia, forebrain, interleukin-1β and receptor expression, 1107
ischemia, gene expression induced by, 815
ischemia, glucose PET in Harderian glands, 116
ischemia, ionotropic glutamate receptor subunits in hippocampal glial cells, 290
ischemia, laminin inhibition of leukocytes, 605
ischemia, localization of phosphorylated eukaryotic initiation factor 2α, 1291
ischemia, NBQX protection of dentate hilus in hippocampus, 147
ischemia, neurological deficits and histopathology, correlation with CBF and glucose metabolism, 1281
ischemia, neuroprotection by striatal interleukin-1 receptor antagonist, 597
ischemia, poly(ADP-ribose) polymerase activation of, 1143
ischemia, preconditioning effects on neuronal damage, 175
ischemia, SB 206284A effects, 421
ischemia, tumor necrosis factor induction in hippocampus, 491
ischemia, tumor necrosis factor pretreatment, 483
ischemia, up-regulation of Nedd2 gene for ICE/Ced-3-like cysteine protease, 507
ischemia, zinc finger immediate early genes, 636
ischemia/reperfusion injury, perfusion deficit in hyperglycemia, 553
isoflurane and propofol effect on MK-801 neurotoxicity, 168
microvascular tone, GABAergic regulation of, 992
neonatal, heme oxygenase-I induction by hypoxia-ischemia, 647
nimodipine uptake, during cortical spreading depression, 586
nitric oxide synthase and regional CBF, 109
oxidative glucose metabolism, during forepaw stimulation, 1040
oxygenation, during infarct depolarization, near infrared spectroscopy in focal cerebral ischemia, 950
perivascular nerves, citrulline conversion to arginine, 884
potassium dysregulation during hyperammonemia, methionine sulfoximine effects, 44
prepiriform cortex, and neuronal cell death in global ischemia, 356
reperfusion damage after transient focal ischemia, 1048
temperature, and neuroprotection by NMDA receptor glycine antagonists, 161
temperature, noninvasive measurements by proton magnetic resonance spectroscopy, 363
tissue plasminogen activator, nicotine effects, 136
trauma, CBF and carbon dioxide reactivity, perfusion MRI using arterial spin-labeling, 865
trauma, glucose blood levels, 50
trauma, leukocyte dynamics, 1210
tumors, imaging with 1-aminocyclopentane carboxylic acid and α-aminoisobutyric acid, 1239
water clearance, vibrotactile stimulation, 73
Brain stem
circulation during hypotension, aging effects, 680
circulation during hypotension, nitric oxide role, 1089
Brain-derived neurotrophic factor (BDNF)
gene expression in brain ischemia, suppression by hyperglycemia and hypercapnia, 1303
infarct size reduction, 500
Caffeine
and CBF response to hypoglycemia, 1309
Calcineurin
inhibitor FK506, and binding of cAMP-dependent protein kinase in ischemic brain, 412
Calcium
homeostasis, cortical depolarization in focal cerebral ischemia, 11170
in myofilaments, resting load and modulation in cerebral arteries, 236
SB 206284A effects, in brain ischemia, 421
Capases
gene expression in brain ischemia, 815
Capillaries, brain
endothelial cell—pericyte interactions, 464
nicotine effects on tissue plasminogen activator, 136
Carbon dioxide
reactivity, in brain trauma, perfusion MRI using arterial spin-labeling, 865
Carbon monoxide intoxication
NGFI-B, c-fos, and c-jun expression in brain, 771
Cardiac arrest
functional activation of CBF, 1202
Cardiopulmonary resuscitation
CBF activation after cardiac arrest, 1202
neurological recovery, role of blood glucose, 430
Cation
nonselective channels, reduction of focal ischemia injury, 534
Cerebrospinal fluid (CSF)
interleukin-8, after brain injury, blood-brain barrier function and nerve growth factor production, 280
c-fos and c-jun expression
after carbon monoxide intoxication, 771
in kainic acid neurotoxicity, superoxide dismutase in transgenic mice, 241
Citrulline
conversion to arginine via argininosuccinate path, in cerebral perivascular nerves, 884
Clinical studies
arginine effect on basal CBF, 309
brain temperature, noninvasive measurements by proton magnetic resonance spectroscopy, 363
CBF quantification, equal-volume-split ECD SPECT method, 1020
CBF velocity monitoring, functional hemispheric asymmetry, 577
cerebral glucose utilization, reduction in second test session, 704
cerebral water clearance, vibrotactile stimulation, 73
dementia, A1252G mutation in α1-antichymotrypsin, 233
diprenorphine binding, in Huntington's disease, comparison of region of interest analysis and statistical parametric mapping, 943
frequency dependence of cerebrovascular impedance, in preterm neonates, 1127
glucose blood levels, and neurological recovery after cardiopulmonary resuscitation, 430
hypercapnia suppression of low-frequency fluctuations in motor cortex, echo-planar MRI, 301
interleukin-8 in CSF in brain injury, role of blood-brain barrier and nerve growth factor, 280
newborn infants, HMPAO as tracer of CBF, 448
physostigmine reversal of scopolamine-induced hypofrontality, 220
regional CBF during finger movements, comparison of MRI and PET, 670
three-dimensional PET, noninvasive activation studies, 732
Collateral circulation
rat strain and vendor differences, 571
Critical closing pressure
frequency dependence of cerebrovascular impedance, in preterm neonates, 1127
Cyclic nucleotides
and adenosine in hypoxic pial artery dilation, 100
Cyclin D1/cdk4
immunoreactivity, in neurons and oligodendrocytes, after focal cerebral ischemia, 846
Cysteine protease
ICE/Ced-3-like, up-regulation of Nedd2 gene, 507
Cytoskeleton
endothelial cell—pericyte interactions, in brain capillaries, 464
Dementia
A1252G mutation in α1-antichymotrypsin, 233
Deoxyglucose
glucoprivic effects on CBF, 54
Depolarization
cortical, calcium homeostasis and nitric oxide production, 1170
spreading depression, and infarct volume reduction by halothane, 857
Development
brain, nitric oxide synthase and regional CBF, 109
Diffusion
extracellular, in ischemic cortex and corpus callosum, 191
Dihydrotetrabenazine (DTBZ)
and PET, equilibrium analysis of vesicular monoamine transporter, 919
Diprenorphine
binding, in Huntington's disease, comparison of region of interest analysis and statistical parametric mapping, 943
DNA fragmentation
after delayed neuronal death, in ischemic CA1 neurons, 967
gene expression in brain ischemia, 815
before internucleosomal cleavage, in cerebral ischemia, 376
kainic acid neurotoxicity, overexpression of superoxide dismutase, 241
DOPA decarboxylase
regulation by brain dopamine receptors, 1254
Dopamine
D2 receptor, (F-18)N-methyl benperidol as PET tracer, 833
receptors, in brain, regulation of DOPA decarboxylase, 1254
receptors, quantification in aging human brain, 316, 331
Drugs
delivery to brain, 713
Editorial
Welcome Changes to the Journal, 1
Eicosanoids
interleukin-1β effects on basilar artery, 1337
Electrical stimulation
of nucleus basalis of Meynert, flow-metabolism uncoupling, 686
Electrophysiology
aglycemia-induced depression of glutamatergic excitation, in striatum, 1121
CBF activation after cardiac arrest, 1202
Embolism
focal cerebral ischemia, mouse model, 1081
Endothelin-B
receptors, in cerebral resistance arterioles, after ischemia, 1157
Endothelium
and pericyte interactions, in brain capillaries, 464
Enzymes
cysteine protease, ICE/Ced-3-like, up-regulation of Nedd2 gene, 507
DOPA decarboxylase, regulation by brain dopamine receptors, 1254
heme oxygenase-I, in neonatal brain, induction by hypoxia-ischemia, 647
interleukin-1β converting enzyme, expression in ischemic brain, 11
interleukin-1β converting enzyme, inhibitory protein, and focal cerebral ischemia in transgenic mouse, 370
nitric oxide synthase, activation by vasoactive intestinal peptide, in cerebral arteries, 977
nitric oxide synthase, and cerebrovascular-metabolic responses to somatosensory stimulation, 1197
nitric oxide synthase, and platelet accumulation and hemodynamic depression in thromboembolic stroke, 1182
nitric oxide synthase, and regional CBF, 109
phosphodiesterase type IV, characterization and function in cerebral vessels, 210
phospholipase C, protein expression, and neurodegeneration after global incomplete ischemia, 527
poly(ADP-ribose) polymerase, activation of brain ischemia, 1143
poly(ADP-ribose) synthetase, neuroprotective role in cerebral ischemia, 1137
protein kinase, cAMP-dependent, FK506 effect on binding in ischemic brain, 412
respiratory chain, mitochondria, after focal ischemia, 1166
superoxide dismutase, in transgenic mice, kainate-induced neurotoxicity, DNA fragmentation and c-fos, c-jun, and hsp expression, 241
Equilibrium analysis
vesicular monoamine transporter, use of DTBZ and PET, 919
Errata, 596, 1263
Excitotoxicity
astrogliosis in hippocampal cultures, 26
NMDA-induced, nitroarginine binding in nitric oxide synthase null mouse, 515
temperature-dependent neurotoxicity, fluorescence multiwell plate scanner, 455
Extracellular space
diffusion, potassium, and pH, in ischemic cortex and corpus callosum, 191
Fiber separation
laminar analysis of CBF, laser-Doppler flowmetry, 1326
Finger movements
and regional CBF, comparison of MRI and PET, 670
FK506
calcineurin inhibitor, and binding of cAMP-dependent protein kinase in ischemic brain, 412
Flumazenil
dynamic radioligand displacement activation studies, 80
Fluorescence
multiwell plate scanner, temperature-dependent neurotoxicity in cultured neurons, 455
Fluoroacetate
in neuron-glial amino acid exchange, 1230
Free radicals
and tau protein in oligodendrocytes after focal ischemia, 612
GABA (γ-aminobutyric acid)
and cerebral microvascular tone, 992
Gene expression
bcl-2, by herpes simplex virus vectors, neuroprotection after stroke, 740
Bcl-2 and Bcl-x-long, apoptosis repressor, in ischemic brain, 2
BDNF, in brain ischemia, suppression by hyperglycemia and hypercapnia, 1303
cerebral ischemia induction of, 815
growth inhibitory factor, after focal cerebral ischemia, 745
Nedd2, encoding for ICE/Ced-3-like cysteine protease, 507
neuronal thread protein, in cerebral infarction, 623
NGFI-B, c-fos, and c-jun, in brain, after carbon monoxide intoxication, 771
zinc finger immediate early genes, in ischemic brain, 636
Glia
and neuron interactions, amino acid exchange, fluoroacetate inhibition of, 1230
Glial fibrillary acidic protein (GFAP)
in hippocampal organotypic cultures, reactive astrocytosis from excitotoxic injury, 26
Glibenclamide
and CBF response to hypoglycemia, 1309
Glucose
aglycemia-induced depression of glutamatergic excitation, in striatum, 1121
blood levels, and brain trauma, 50
blood levels, and neurological recovery after cardiopulmonary resuscitation, 430
cerebral metabolism, and blood flow relationships in ischemia, 1266, 1281
cerebral utilization, reduction in second test session, 704
and deoxyglucose, effects on CBF, 54
glut1 transporter distribution, immunoautoradiography, 204
oxidative metabolism, in forepaw stimulation, 1040
quantitative PET, in ischemic brain, Harderian glands, 116
Glut1
glucose transporter, distribution in brain, immunoautoradiography, 204
Glutamate
brain, aminoadipate effects in oxygen and glucose deprivation, 567
receptor, ionotropic subunits, in hippocampal glial cells, after forebrain ischemia, 290
receptor, metabotropic, and nitric oxide in hippocampus, 153
Glutamine synthetase
inhibitor methionine sulfoximine, and potassium dysregulation during hyperammonemia, 44
Glycine
NMDA receptor antagonists, neuroprotection and brain temperature, 161
Glycoproteins
in drug delivery to brain, 713
Growth inhibitory factor
mRNA, after focal cerebral ischemia, 745
Halothane
infarct volume reduction, effect on CBF or spreading depression-like depolarization, 857
Harderian glands
glucose PET in brain ischemia, 116
Heat shock protein
expression in brain ischemia, 815
Hsp27, in astrocytes, potassium-induced spreading depression, 781
in kainic acid neurotoxicity, superoxide dismutase in transgenic mice, 241
Heme oxygenase-I
in neonatal brain, induction by hypoxia-ischemia, 647
Hemisphere
functional asymmetry, CBF velocity monitoring, 577
Hemodynamics
CBF activation after cardiac arrest, 1202
cerebral, study of arteriovenous malformations, 905
leukocytes, after brain trauma, 1210
in thromboembolic stroke, nitric oxide synthase role, 1182
Heparin
in bacterial meningitis model, effects on pial leukocytes and inflammatory changes, 1221
Herpes simplex virus
vectors, Bcl-2 expression, neuroprotection in stroke, 740
Hippocampus
aging effects on pH regulation, and anoxia, 560
dentate hilus, NBQX protection in cerebral ischemia, 147
glial cells, ionotropic glutamate receptor subunits after forebrain ischemia, 290
ischemia, DNA fragmentation in CA1 neurons, 967
ischemia, synaptic transmission in CA1 neurons, 955
nitric oxide, effect of metabotropic glutamate receptor, 153
organotypic cultures, reactive astrocytosis from excitotoxic injury, 26
preconditioning effects on neuronal damage, 175
tumor necrosis factor induction, after forebrain ischemia, 491
Hirulog
perfusion in model of embolic stroke, 401
Histopathology
pixel-based correlation, cerebral blood flow and glucose metabolism in ischemia, 1281
HMPAO (hexamethylpropylene amine oxime)
as tracer of CBF in newborn infants, 448
Huntington's disease
diprenorphine binding, comparison of region of interest analysis and statistical parametric mapping, 943
Hybridization, in situ
interleukin-1β and receptor expression, in global forebrain ischemia, 1107
neuronal thread protein gene expression, in brain infarction, 623
zinc finger immediate early genes, in brain ischemia, 636
Hypercapnia
and BDNF gene expression in brain ischemia, 1303
and low-frequency fluctuations in motor cortex, echo-planar MRI, 301
Hyperglycemia
after spreading depression, effect on depolarization and repolarization, 591
and BDNF gene expression in brain ischemia, 1303
and nimodipine uptake in focal cerebral ischemia, 1057
perfusion deficit, and cerebral ischemia/reperfusion injury, 553
Hypoglycemia
and CBF, caffeine and glibenclamide effects, 1309
Hypotension
brain stem circulation, aging effects, 680
brain stem circulation during, nitric oxide role, 1089
Hypoxia
cerebral angiogenesis, regional differences, 801
and hemodilution, CBF during, nitric oxide role, 1319
and ischemia, heme oxygenase-I expression, in neonatal brain, 647
and ischemia, monocyte chemoattractant protein-1 expression in neonatal brain, 759
and nitroxidergic nerve stimulation, in cerebral arteries, 807
pial artery dilation, adenosine role, effects of nitric oxide, cyclic nucleotides, and ATP-sensitive potassium channels, 100
tolerance, and oxidative phosphorylation, chemical preconditioning, 257
Immediate early genes
c-fos, c-jun, and NGFI-B, expression after carbon monoxide intoxication, 771
expression in brain ischemia, 815
Immunoautoradiography
glut1 transporter distribution in brain, 204
Immunohistochemistry
interleukin-1β and receptor expression, in global forebrain ischemia, 1107
phosphorylated eukaryotic initiation factor 2α, in brain ischemia, 1291
reactive astrocytosis from excitotoxic injury, in hippocampal organotypic cultures, 26
Impedance, cerebrovascular
frequency dependence, in preterm neonates, 1127
Infarction
brain, and inhibition of tumor necrosis factor, 229
brain, neuronal thread protein gene expression, 623
cerebral, neurological deficits and histopathology, correlation with CBF and glucose metabolism, 1281
cerebral volume, triphenyltetrazolium chloride staining, 1132
depolarization, cerebral blood oxygenation, near infrared spectroscopy, 950
size reduction by BDNF, 500
volume reduction by halothane, effect on CBF or spreading depression-like depolarization, 857
Inflammation
leukocyte dynamics after brain trauma, 1210
pial, in bacterial meningitis, heparin effects, 1221
Initiation factor 2α
phosphorylated eukaryotic, in brain ischemia, 1291
Interleukin-1
receptor antagonist, striatal, neuroprotection after cerebral ischemia, 597
Interleukin-1β
and receptor expression, in global forebrain ischemia, 1107
vasodilator effects on basilar artery, 1337
Interleukin-1β converting enzyme (ICE)
gene expression in ischemic brain, 11
inhibitory protein, and focal cerebral ischemia in transgenic mouse, 370
Interleukin-8
in CSF after brain injury, blood-brain barrier function and nerve growth factor production, 280
Ischemia
brain, adrenomedullin effect on regional CBF, 19
brain, apoptosis repressor genes Bcl-2 and Bcl-x-long expression, 2
brain, autoradiographic image analysis of local glucose metabolism and blood flow relationships, 1266
brain, BDNF gene expression, suppression by hyperglycemia and hypercapnia, 1303
brain, DNA fragmentation before internucleosomal cleavage, 376
brain, FK506 effect on binding of cAMP-dependent protein kinase, 412
brain, gene expression induced by, 815
brain, infarct size reduction by BDNF, 500
brain, interleukin-1β converting enzyme and bcl-2 gene expression, 11
brain, laminin inhibition of leukocytes, 605
brain, localization of phosphorylated eukaryotic initiation factor 2α, 1291
brain, NBQX protection of dentate hilus in hippocampus, 147
brain, neurological deficits and histopathology, correlation with CBF and glucose metabolism, 1281
brain, neuroprotection by striatal interleukin-1 receptor antagonist, 597
brain, poly(ADP-ribose) polymerase activation of, 1143
brain, preconditioning effects on neuronal damage, 175
brain, regional CBF, 1066
brain, SB 206284A effects, 421
brain, tumor necrosis factor induction in hippocampus, 491
brain, tumor necrosis factor pretreatment, 483
brain, zinc finger immediate early genes, 636
cerebral arterioles, calcium-activated potassium channels, 1152
collateral anastomoses, rat strain and vendor differences, 571
developing cortex and corpus callosum, effects on extracellular space diffusion, potassium, and pH, 191
focal, brain reperfusion damage, 1048
focal, nitroarginine binding in nitric oxide synthase null mouse, 515
focal, reduction by nonselective cation channels, 534
focal cerebral, and apolipoprotein E deficiency, 753
focal cerebral, and arginine-induced regional CBF, 1074
focal cerebral, cortical depolarization, and calcium homeostasis and nitric oxide production, 1170
focal cerebral, cyclin D1/cdk4 immunoreactivity in neurons and oligodendrocytes, 846
focal cerebral, embolic, mouse model, 1081
focal cerebral, endothelin-B receptors in cerebral resistance arterioles, 1157
focal cerebral, growth inhibitory factor mRNA expression, 745
focal cerebral, hyperglycemia effects on nimodipine uptake, 1057
focal cerebral, in transgenic mice with mutant ICE inhibitory protein, 370
focal cerebral, mitrochondrial respiratory chain enzymes, 1166
focal cerebral, neuroprotective role of poly(ADP-ribose) synthetase, 1137
focal cerebral, oxygenation during infarct depolarization, 950
focal cerebral, tau protein in oligodendrocytes, role of free radicals, 612
focal cerebral, thrombotic, rat model, 123
focal cerebral, water diffusion and cerebral perfusion, 183
forebrain, interleukin-1β and receptor expression, 1107
forebrain, ionotropic glutamate receptor subunits in hippocampal glial cells, 290
forebrain, neuroprotection by benzodiazepine receptor agonist PNU-101017, 875
forebrain, platelet-derived growth factor-BB effect on neuronal death, 109r7
global, neuronal cell death modulation by prepiriform cortex, 356
global incomplete, neurodegeneration and phospholipase C protein expression, 527
hippocampus, DNA fragmentation in CA1 neurons, 967
hippocampus, synaptic transmission in CA1 neurons, 955
and hypoxia, heme oxygenase-I expression, in neonatal brain, 647
and hypoxia, monocyte chemoattractant protein-1 expression in neonatal brain, 759
and reperfusion injury, in hyperglycemia, perfusion deficit, 553
thalamus, ultra-early-type injury, protection by hypothermia, 543
transient, PET studies, postischemic reperfusion, 388
Isoflurane
and MK-801-induced neurotoxicity, 168
Kainic acid
seizures induced by, nitric oxide role in CBF, 94
Kinetics
DOPA decarboxylase, regulation by brain dopamine receptors, 1254
(F-18)N-methyl benperidol, PET tracer for dopaminergic D2 receptors, 833
HMPAO as tracer of CBF in infants, 448
alpha-methyl-tryptophan, serotonin synthesis rate, 659
raclopride modeling, combined PET-microdialysis, 932
Laminin
and leukocyte inhibition in focal cerebral ischemia, 605
Laser scanning confocal microscopy
embolic focal cerebral ischemia, mouse model, 1081
Laser-Doppler flowmetry
laminar analysis of CBF, 1326
Letter to the Editor
Effects of Extracranial Radioactivity on Measurement of Cerebral Glucose Metabolism by Rat-PET with [18F]-2-fluoro-2-deoxy-D-glucose, 1261
Leukocytes
dynamics after brain trauma, 1210
in focal cerebral ischemia, inhibition by laminin, 605
pial, in bacterial meningitis, heparin effects, 1221
Lipids
in drug delivery to brain, 713
Low-frequency fluctuations
hypercapnia suppression of, in motor cortex, echo-planar MRI, 301
Magnesium
and glucose blood levels, in brain trauma, 50
Magnetic resonance imaging (MRI)
coupling of CBF and oxygen metabolism during neural stimulation, 64
diffusion-weighted, perfusion with rt-PA and hirulog, model of embolic stroke, 401
dynamic susceptibility contrast, L-NAME effect on input function, 791
echo-planar, hypercapnia suppression of low-frequency fluctuations in motor cortex, 301
finger movements, and regional CBF, 670
focal cerebral ischemia, thrombotic, rat model, 123
functional imaging, oxidative glucose metabolism, during forepaw stimulation, 1040
glucose blood levels, in brain trauma, 50
ischemia reduction by nonselective cation channels, 534
perfusion, with arterial spin-labeling, CBF and carbon dioxide reactivity in brain trauma, 865
serial diffusion mapping, hyperglycemia effect on depolarization and repolarization, after peri-infarct spreading depression, 591
volume-localized proton spectroscopy, brain temperature measurement, 363
water diffusion and cerebral perfusion, 183
Mapping
single-subject oxygen-water PET activation, 1033
Mathematical analysis
alpha-methyl-tryptophan kinetics, serotonin synthesis rate, 659
cerebral hemodynamics, study of arteriovenous malformations, 905
coupling between CBF and oxygen metabolism during neural stimulation, 64
dopamine receptor quantification, in aging brain, 316, 331
dynamic radioligand displacement, activation studies, 80
near infrared spectroscopy in reflectance mode, invalid CBF measurement, 695
raclopride binding, amphetamine effects, 437
raclopride modeling, combined PET-microdialysis, 932
regional CBF during finger movements, comparison of MRI and PET, 670
three-dimensional PET, noninvasive activation studies, 732
In Memoriam
Niels A Lassen, 1005
Methionine sulfoximine
and potassium dysregulation during hyperammonemia, 44
(F-18)N-Methyl benperidol
PET tracer for dopaminergic D2 receptors, 833
N-Methyl-D-aspartate (NMDA)
receptor glycine antagonists, neuroprotection and brain temperature, 161
Microcirculation, cerebral
arterioles, calcium-activated potassium channels, resistance to ischemia, 1152
GABAergic regulation, 992
leukocyte dynamics after trauma, 1210
Microdialysis
and PET, kinetic modeling of raclopride, 932
Middle cerebral artery occlusion. See Ischemia.
Mitochondria
complex I, rotenoid binding, neurotoxin effects, 265
respiratory chain enzymes, after focal ischemia, 1166
Monoamine
vesicular transporter, equilibrium analysis using DTBZ and PET, 919
Monocyte chemoattractant protein-1
expression in hypoxia-ischemia, in neonatal brain, 759
Myofilaments
calcium sensitivity, resting load and modulation in cerebral arteries, 236
NADPH diaphorase
and citrulline conversion to arginine, in cerebral perivascular nerves, 884
L-NAME (nitro-L-arginine methyl ester)
and input function in dynamic susceptibility contrast MRI, 791
NBQX
AMPA antagonist, protection of dentate hilus of hippocampus, after cerebral ischemia, 147
Near infrared spectroscopy
in reflectance mode, invalid CBF measurement, 695
Nedd2 gene
for ICE/Ced-3-like cysteine protease, up-regulation in ischemic brain, 507
Nerve growth factor
and interleukin-8 in CSF in brain injury, 280
Nerves
cerebral perivascular, citrulline conversion to arginine, 884
Neurodegeneration
in ischemia, and phospholipase C protein expression, 527
Neurological recovery
after cardiopulmonary resuscitation, role of blood glucose, 430
Neuronal cell death
after forebrain ischemia, effect of platelet-derived growth factor-BB, 1097
DNA fragmentation, in ischemic CA1 neurons, 967
in global ischemia, modulation by prepiriform cortex, 356
Neuronal thread protein
gene modulation with cerebral infarction, 623
Neurons
cyclin D1/cdk4 immunoreactivity, in focal cerebral ischemia, 846
and glia interactions, amino acid exchange, fluoroacetate inhibition of, 1230
Neuroprotection
by benzodiazepine receptor agonist PNU-101017, in forebrain ischemia, 875
by herpes simplex virus vectors expressing bcl-2, after stroke, 740
hypoxia tolerance, and oxidative phosphorylation, chemical preconditioning, 257
by NBQX, of dentate hilus of hippocampus, after cerebral ischemia, 147
NMDA receptor glycine antagonists, and brain temperature, 161
oxidative stress in closed head injury, antioxidant capacity, 1007
platelet-derived growth factor-BB effect on neuronal death, after forebrain ischemia, 1097
poly(ADP-ribose) synthetase role in cerebral ischemia, 1137
preconditioning in ischemic neuronal damage, 175
SB 206284A effects, in brain ischemia, 421
by striatal interleukin-1 receptor antagonist, after cerebral ischemia, 597
tumor necrosis factor pretreatment, 483
ultra-early-type ischemic injury, hypothermia protection in thalamus, 543
Neurotoxicity
kainate-induced, DNA fragmentation and c-fos, c-jun, and hsp expression, superoxide dismutase in transgenic mice, 241
MK-801-induced, isoflurane and propofol effects, 168
and rotenoid binding to mitochondrial complex I, 265
temperature-dependent effects, in cultured neurons, fluorescence multiwell plate scanner, 455
Neurotrophins
in drug delivery to brain, 713
Nicotine
and brain microvascular tissue plasminogen activator, 136
Nimodipine
brain uptake, during cortical spreading depression, 586
in focal cerebral ischemia, hyperglycemia effects, 1057
Nitric oxide
and adenosine in hypoxic pial artery dilation, 100
in arginine-induced regional CBF, ischemia effects, 1074
and brain stem circulation during hypotension, 1089
and cationic polypeptides, effects in cerebral arteries, 470
and CBF in kainate-induced seizures, 94
in CBF response to hypoxemia and hemodilution, 1319
and cortical depolarization in focal cerebral ischemia, 11170
in hippocampus, effect of metabotropic glutamate receptor, 153
in interleukin-1β effects on basilar artery, 1337
nerve stimulation, hypoxia effect in cerebral arteries, 807
Nitric oxide synthase
activation by vasoactive intestinal peptide, in cerebral arteries, 977
and citrulline conversion to arginine, in cerebral perivascular nerves, 884
inhibition, and cerebrovascular-metabolic responses to somatosensory stimulation, 1197
inhibition, and platelet accumulation and hemodynamic depression in thromboembolic stroke, 1182
nitroarginine binding after ischemia or excitotoxicity, 515
and regional CBF, 109
Nitroarginine
binding, after ischemia or excitotoxicity, in nitric oxide synthase null mouse, 515
7-Nitroindazole
and pial arteriolar vasodilation, in pneumococcal meningitis, 985
Noradrenaline
terminals, astrocytes and vascular interactions, in cerebral cortex, 894
Nucleus basalis of Meynert
flow-metabolism uncoupling during stimulation of, 686
Oligodendrocytes
cyclin D1/cdk4 immunoreactivity, in focal cerebral ischemia, 846
tau protein, after focal ischemia, role of free radicals, 612
Oxidative stress
in closed head injury, brain antioxidant capacity, 1007
gene expression in brain ischemia, 815
Oxygen
CBF during hypoxemia and hemodilution, nitric oxide role, 1319
and glucose deprivation, aminoadipate effects on glutamate release from brain, 567
reactive species, in closed head injury, cyclic voltammetry, 273
transport, coupling with CBF during neural stimulation, 64
and water PET activation, randomization test, 10133
Oxygenation
cerebral blood, during infarct depolarization, near infrared spectroscopy in focal cerebral ischemia, 950
glucose metabolism, in forepaw stimulation, 1040
Parametric imaging
benzodiazepine receptors, quantification using partial-saturation injection, 343
Pegylation
drug delivery to brain, 713
Perfusion
deficit, and cerebral ischemia/reperfusion injury, in hyperglycemia, 553
with re-PA and hirulog, model of embolic stroke, 401
residual, PET studies in transient MCAO, 388
Pericytes
and endothelial cell interactions, in brain capillaries, 464
Permutation test
single-subject oxygen-water PET activation, 1033
pH
and extracellular diffusion, in ischemic cortex and corpus callosum, 191
regulation in hippocampus, anoxia effects, aging factors, 560
Pharmacokinetics
drug delivery to brain, 713
Phosphodiesterase
type IV, characterization and function in cerebral vessels, 210
type IV, in cerebral vessels, effects of inhibitors, 210
Phospholipase C
protein expression, and neurodegeneration after global incomplete ischemia, 527
Phosphorylation
eukaryotic initiation factor 2α, in brain ischemia, 1291
oxidative, preconditioning in hypoxia tolerance, 257
Physostigmine
and scopolamine-induced hypofrontality, 220
Pial vessels
arteriolar vasodilation, 7-nitroindazole inhibition of, in pneumococcal meningitis, 985
in bacterial meningitis, heparin effects on leukocytes and inflammation, 1221
hypoxia-induced dilation, adenosine role, effects of nitric oxide, cyclic nucleotides, and ATP-sensitive potassium channels, 100
Platelet-derived growth factor-BB
and neuronal death after forebrain ischemia, 1097
Platelets
in thromboembolic stroke, nitric oxide synthase role, 1182
Pneumococcal meningitis
7-nitroindazole inhibition of pial arteriolar vasodilation, 985
PNU-101017
benzodiazepine receptor agonist, neuroprotection in forebrain ischemia, 875
Poly(ADP-ribose) polymerase
activation of brain ischemia, 1143
Poly(ADP-ribose) synthetase
neuroprotective role in cerebral ischemia, 1137
Polypeptides
cationic, and nitric oxide effects in cerebral arteries, 470
Positron emission tomography (PET)
alpha-methyl-tryptophan kinetics, serotonin synthesis rate, 659
benzodiazepine receptors, quantification using partial-saturation injection, 343
cerebral glucose utilization, reduction in second test session, 704
cerebral water clearance, vibrotactile stimulation, 73
dopamine receptor quantification, in aging brain, 316, 331
and DTBZ, equilibrium analysis of vesicular monoamine transporter, 919
dynamic radioligand displacement activation studies, 80
finger movements, and regional CBF, 670
(F-18)N-methyl benperidol, tracer for dopaminergic D2 receptors, 833
and microdialysis, kinetic modeling of raclopride, 932
quantitative, glucose metabolism in ischemic brain, Harderian glands, 116
raclopride binding, amphetamine effects, 437
region of interest analysis vs. statistical parametric mapping, diprenorphine binding in Huntington's disease, 943
single-subject oxygen-water activation, 1033
three-dimensional, noninvasive activation studies, 732
in transient middle cerebral artery occlusion, postischemic reperfusion, 388
Potassium
ATP-sensitive channels, and adenosine in hypoxic pial artery dilation, 100
calcium-activated channels, in cerebral arterioles, resistance to ischemia, 1152
extracellular, during hyperammonemia, methionine sulfoximine effects, 44
and extracellular diffusion, in ischemic cortex and corpus callosum, 191
spreading depression induced by, Hsp27 in astrocytes, 781
Preconditioning
hypoxia tolerance, and oxidative phosphorylation, 257
protection in ischemic neuronal damage, 175
Propofol
and MK-801-induced neurotoxicity, 168
Protein kinase
cAMP-dependent, FK506 effect on binding in ischemic brain, 412
Psychosis
dopamine receptor quantification, in aging brain, 331
Raclopride
binding, amphetamine effects, 437
kinetic modeling, combined PET-microdialysis, 932
Radioligand
dynamic displacement, activation studies, 80
Receptors
benzodiazepine, quantification using partial-saturation injection, 343
dopamine, in brain, regulation of DOPA decarboxylase, 1254
dopamine, quantification in aging human brain, 316, 331
dopamine D2, (F-18)N-methyl benperidol as PET tracer, 833
endothelin-B, in cerebral resistance arterioles, after ischemia, 1157
glutamate, ionotropic subunits, in hippocampal glial cells, after forebrain ischemia, 290
glutamate, metabotropic, and nitric oxide in hippocampus, 153
interleukin-1β, expression in global forebrain ischemia, 1107
Reperfusion
brain damage after transient focal ischemia, 1048
initiation factor 2α, phosphorylated eukaryotic, localization of, 1291
postischemic, PET studies in transient MCAO, 388
regional CBF after brain ischemia, 1066
Rotenoid
binding to mitochondrial complex I, neurotoxin effects, 265
SB 206284A
calcium antagonism, in cerebral ischemia, 421
Schizophrenia
dopamine receptor quantification, in aging brain, 316, 331
Scopolamine
memory deficit, physostigmine reversal of, 220
Seizures
kainate-induced, nitric oxide role in CBF, 94
Serotonin
synthesis rate, alpha-methyl-tryptophan kinetics, 659
Signal transduction
phospholipase C protein expression, and neurodegeneration after global incomplete ischemia, 527
Signal-to-noise ratio
three-dimensional PET, noninvasive activation studies, 732
Single photon emission computerized tomography (SPECT)
equal-volume-split ECD, CBF quantification, 1020
HMPAO as tracer of CBF in infants, 448
Somatosensory stimulation
cerebrovascular-metabolic responses to, nitric oxide synthase inhibition, 1197
Spectroscopy
near infrared, cerebral blood oxygenation during infarct depolarization, in focal cerebral ischemia, 950
near infrared, in reflectance mode, invalid CBF measurement, 695
Speech activation
single-subject oxygen-water PET, 1033
Spreading depression
cortical, nimodipine uptake, 586
depolarization, and infarct volume reduction by halothane, 857
laminar analysis by laser-Doppler flowmetry, 1326
peri-infarct, hyperglycemia effect on depolarization and repolarization, 591
potassium induction of, Hsp27 in astrocytes, 781
Statistical parametric mapping
diprenorphine binding in Huntington's disease, 943
Striatum
aglycemia-induced depression of glutamatergic excitation, 1121
interleukin-1 receptor antagonist, neuroprotection after cerebral ischemia, 597
rotenoid binding in mitochondrial complex I, neurotoxin effects, 265
Stroke
cerebral infarct volume, triphenyltetrazolium chloride staining, 1132
DNA fragmentation before internucleosomal cleavage, in ischemic brain, 376
embolic, perfusion with rt-PA and hirulog, 401
embolic focal cerebral ischemia, mouse model, 1081
neuronal thread protein gene expression, in brain infarction, 623
neuroprotection by herpes simplex virus vectors expressing bcl-2, 740
reperfusion injury after brain focal ischemia, 1048
thromboembolic, nitric oxide synthase role, 1182
Superoxide dismutase
in transgenic mice, kainate-induced neurotoxicity, DNA fragmentation and c-fos, c-jun, and hsp expression, 241
Synaptic transmission
aglycemia-induced depression of glutamatergic excitation, in striatum, 1121
in CA1 neurons of ischemic hippocampus, 955
Tau protein
in oligodendrocytes, after focal ischemia, role of free radicals, 612
Temperature
brain, and neuroprotection by NMDA receptor glycine antagonists, 161
brain, noninvasive measurements by proton magnetic resonance spectroscopy, 363
hypothermia protection of ultra-early-type ischemic neuronal injury, in thalamus, 543
and neurotoxicity, in cultured neurons, fluorescence multiwell plate scanner, 455
Thalamus
hypothermia protection of ultra-early-type ischemic neuronal injury, 543
Thromboembolism
nitric oxide synthase role in platelet accumulation and hemodynamic depression, 1182
Thrombolysis
perfusion with rt-PA and hirulog, model of embolic stroke, 401
postischemic reperfusion, PET studies in transient MCAO, 388
Thrombosis
focal cerebral ischemia, rat model, 123
Tissue culture
cortical neurons, temperature-dependent neurotoxicity, fluorescence multiwell plate scanner, 455
Tissue plasminogen activator
brain microvascular pool, nicotine effects, 136
perfusion in model of embolic stroke, 401
Transport
drug delivery to brain, 713
Trauma
brain, CBF and carbon dioxide reactivity, perfusion MRI using arterial spin-labeling, 865
brain, glucose blood levels, 50
brain, interleukin-8 in CSF, blood-brain barrier function and nerve growth factor production, 280
brain, leukocyte dynamics, 1210
closed head injury, biological reducing activity, cyclic voltammetry, 273
closed head injury, brain antioxidant capacity in oxidative stress, 1007
Triphenyltetrazolium chloride
delayed staining, cerebral infarct volume, 1132
Tumor necrosis factor
and brain infarction, 229
in hippocampus, after forebrain ischemia, 491
ischemic tolerance by pretreatment, 483
Ultrasonography
transcranial Doppler, CBF velocity monitoring, functional hemispheric asymmetry, 577
Up-regulation
of Nedd2 gene for ICE/Ced-3-like cysteine protease, in ischemic brain, 507
Vasoactive intestinal peptide (VIP)
in drug delivery to brain, 713
nitric oxide synthase activation by, in cerebral arteries, 977
Vasodilation
interleukin-1β effects on basilar artery, 1337
Videomicroscopy
leukocyte dynamics after brain trauma, 1210
Voltammetry, cyclic
biological reducing activity in closed head injury, 273
Water
cerebral clearance, vibrotactile stimulation, 73
diffusion and cerebral perfusion, 183
Zinc finger
immediate early genes, in ischemic brain, 636