Testing Interventions for Health-Enhancing Physical Activity (R01): PAR-14-315

Funding Opportunity Purpose

The purpose of this Funding Opportunity Announcement (FOA) is to fund highly innovative and promising research that tests multi-level intervention programs of 1 to 2 years in length that are designed to increase health-enhancing physical activity: 1) in persons or groups that can benefit from such activity; and 2) that could be made scalable and sustainable for broad use across the nation. This FOA provides support for up to 5 years for research planning, intervention delivery, and follow-up activities

Complete details available at: http://grants.nih.gov/grants/guide/pa-files/PAR-14-315.html.

Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) encourages applications for Phased Innovation (R21/R33) grant awards to support highly innovative research aimed at developing multi-level interventions that will increase health-enhancing physical activity: 1) in persons or groups who can benefit from such activity; and 2) that can be made scalable and sustainable for broad use across the nation. This FOA provides support for up to two years (R21 phase) for research planning activities and feasibility studies, followed by a possible transition to expanded research support (R33 phase). Transition to the R33 depends on the completion of applicant-defined milestones, as well as program priorities and the availability of funds.

Complete details available at: http://grants.nih.gov/grants/guide/pa-files/PAR-14-321.html.

Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) invites Research Project Grant (R01) applications from institutions/organizations which propose to characterize or identify factors in early childhood (birth-24 months) that may increase or mitigate risk for obesity and/or excessive weight gain and/or to fill methodological research gaps relevant to the understanding of risk for development of obesity in children. Studies must propose research in children from birth to 24 months, although any proposed follow-up assessments, if applicable, may continue past this period. Studies may also assess factors relevant to families and/or caregivers of children from birth to 24 months. Applications should seek to fill unique research needs and involve expertise across disciplines as appropriate for the proposed research question.

Complete details available at: http://grants.nih.gov/grants/guide/pa-files/PAR-14-323.html.

Funding Opportunity Purpose

The goal of this funding opportunity announcement is to support interdisciplinary research that will lead to a greater understanding of the mechanisms by which vascular factors contribute to the complex etiology of Alzheimer's disease.

Complete details available at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-15-010.html.

Funding Opportunity Purpose

The goal of this funding opportunity announcement is to enable the identification of the longitudinal progression of Alzheimer's disease in adults with Down Syndrome using clinical, cognitive, imaging, genetic and biochemical biomarkers.

Complete details available at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-15-011.html.

Funding Opportunity Purpose

This FOA encourages research applications from institutions/organizations proposing innovative studies focused on major obstacles to developing therapeutic approaches for complications of Type 1 Diabetes.

Complete details available at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-14-017.html.

Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) requests applications for the development of medium- to high-throughput “omics” technologies that can be used to explore human pancreatic tissues with single cell- or near single cell- resolution. Successful applicants will join the Consortium on Beta cell Death and Survival (CBDS), whose mission is to identify the mechanisms of beta cell stress and destruction central to the development of Type 1 Diabetes (T1D) in humans, with the long-term goal of protecting the residual beta cell mass in T1D patients as early as possible in the disease process, and preventing the progression towards autoimmunity. CBDS is part of the Human Islet Research Network (HIRN).

Complete details available at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-14-021.html.

Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) will support applications that address the mechanisms by which novel, unexplored targets and pathways, or known targets, mediate the sustained weight loss, diabetes resolution and improvements in other obesity-related metabolic diseases reported following bariatric surgery in humans. Studies directly addressing novel mechanisms using targeted approaches are of interest and responsive to this FOA particularly those which utilize up-to-date sophisticated methodologies. Studies simply identifying differences in responses before and after surgery that do not address mechanism will not be considered responsive. Only studies involving human subjects will be considered.

Complete details available at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-14-025.html.

Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) announces an opportunity for eligible investigators receiving research funding from The National Institutes of Health (NIH) to request administrative supplement support. The “parent” awards and the proposed administrative supplements must be in areas of cancer, allergy, immunology, and/or infectious diseases (including HIV/AIDS and its co-morbidities). The overall goal of this supplement program is to enhance ongoing research efforts through collaborations with Brazilian scientists in these scientific areas under the new U.S.-Brazil Collaborative Biomedical Research Program.

Complete details available at: http://grants.nih.gov/grants/guide/pa-files/PA-14-328.html.

Funding Opportunity Purpose

This funding opportunity announcement (FOA) is being issued by the NIH Adherence Network through the Office of Behavioral and Social Sciences Research (OBSSR), with participation from multiple NIH Institutes and Centers. This FOA seeks Research Project Grant (R01) applications that propose interventions to significantly improve medication adherence in individuals. Applications may target medication adherence in the context of treatment for a single illness or chronic condition (e.g., hypertension), to stave off a disease recurrence (e.g., cancer) or for multiple comorbid conditions (e.g., hypertension, diabetes, alcohol use disorders and HIV/AIDS). A well-articulated theoretical or conceptual framework is key for applications encouraged under this announcement. Primary outcomes of the research can include a patient self-report of medication adherence, but must also at least one non-self-report measure of medication adherence (e.g., pharmacy refill records, electronic monitoring, etc.). In addition, applications are encouraged to include a relevant health outcome or biomarker (e.g., blood pressure, viral load in HIV-infected individuals, cholesterol levels, HbA1c) that is expected to be affected by changes in the targeted adherence behavior. For diseases without identified biomarkers, inclusion of a clinical assessment (e.g., a medicine blood level, diagnostic interview or an independent clinician rating of the symptoms and behaviors) may be considered.

Complete details available at: http://grants.nih.gov/grants/guide/pa-files/PA-14-334.html.

Funding Opportunity Purpose

This funding opportunity announcement (FOA) is being issued by the NIH Adherence Network through the Office of Behavioral and Social Sciences Research (OBSSR), with participation from multiple NIH Institutes. This FOA encourages Exploratory/Developmental Research Project Grant (R21) applications for research and development of interventions to significantly improve medication adherence in individuals. Applications may target medication adherence in the context of treatment for a single illness or chronic condition (e.g., hypertension), to stave off a disease recurrence (e.g., cancer) or for multiple comorbid conditions (e.g., hypertension, diabetes, alcohol use disorders and HIV/AIDS). A well-articulated theoretical or conceptual framework is key for applications encouraged under this announcement. Applicants should demonstrate the feasibility of collecting multi-modal data on the targets of the intervention including: a patient self-report of medication adherence, at least one non-self-report measure of medication adherence (e.g., pharmacy refill records, electronic monitoring, etc.), and a relevant health outcome or biomarker (e.g., blood pressure, viral load in HIV-infected individuals, cholesterol levels, HbA1c) that is expected to be affected by changes in the targeted adherence behavior. For diseases without identified biomarkers, inclusion of a clinical assessment (e.g., a medicine blood level, diagnostic interview or an independent clinician rating of the symptoms and behaviors) may be considered. Applications for R21 awards should describe projects distinct from those supported through the traditional R01 mechanism. For example, long-term projects, or projects designed to increase knowledge in a well-established area, will not be considered for R21 awards. Applications submitted under this mechanism should be exploratory and novel. These studies should break new ground or extend previous discoveries toward new directions or applications.

Complete details available at: http://grants.nih.gov/grants/guide/pa-files/PA-14-335.html.

Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) encourages exploratory/developmental research grant applications, proposing the development of innovative, collaborative research projects on brain and other nervous system function and disorders throughout life, relevant to low- and middle-income countries (LMICs). Scientists in the United States (U.S.) or upper middle income countries (UMICs) are eligible to partner with scientists in LMIC institutions. Income categories used are as defined by the World Bank at http://data.worldbank.org/about/country-classifications/country-and-lending-groups.

These grants are expected to inform the development of more comprehensive research programs that contribute to the long-term goals of building sustainable research capacity in LMICs to address nervous system development, function and impairment throughout life and to lead to diagnostics, prevention, treatment and implementation strategies. The proposed work may also contribute to developing a base for research networking and evidence-based policy beyond the specific research project.

Complete details available at: http://grants.nih.gov/grants/guide/pa-files/PAR-14-331.html.

Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) encourages grant applications for the conduct of innovative, collaborative research projects between U.S. and low- and middle-income country (LMIC) scientists, on brain and other nervous system function and disorders throughout life, relevant to LMICs. Scientists in upper middle income countries (UMICs) are eligible to partner directly with scientists at other LMIC institutions. Income categories are defined by the World Bank at http://data.worldbank.org/about/country-classifications/country-and-lending-groups. The collaborative research programs are expected to contribute to the long-term goals of building sustainable research capacity in LMICs to address nervous system development, function and impairment throughout life and to lead to diagnostics, prevention, treatment and implementation strategies. The proposed work will also contribute to developing a base for research networking and evidence-based policy beyond the specific research project.

Complete details available at: http://grants.nih.gov/grants/guide/pa-files/PAR-14-332.html.

Funding Opportunity Purpose

The purpose of this funding opportunity announcement (FOA) is to invite applications to participate in the Clinical and Translational Science Award (CTSA) program which supports high quality translational and clinical research locally, regionally, and nationally, and fosters innovation in methods, training, and career development.

Complete details available at: http://grants.nih.gov/grants/guide/rfa-files/RFA-TR-14-009.html.

Funding Opportunity Purpose

This initiative invites applications for support of analyses of existing data (or data whose collection will be completed by one year from the date of this FOA) from older populations with high prevalence of mobility disability, low muscle mass, and low muscle strength (weakness). Interventions targeted at low muscle mass and/or weakness may prevent or reduce mobility disability in some older persons. To assess the efficacy of such interventions against mobility disability, there is a need to test them in persons in whom muscle mass and/or strength are (or will be) sufficiently low to be likely contributors to disability. Thus there is a need for evidence-based diagnostic cut-points to define target populations for treatments.

Applications submitted in response to this FOA should support development and evaluation of diagnostic cut-points based on analyses of relations of mobility disability to muscle mass and strength. These analyses should extend and expand upon analyses to date on this topic, which have identified and proposed cut-points for low muscle mass and weakness. Studies supported through this FOA should clarify relations between muscle mass and strength, impaired physical function, and mobility disability, and their implications for setting diagnostic cut-points, through analyses of data from populations with substantially more individuals with mobility disability than were included in previous analyses.

Applicants are encouraged to consider combining datasets from multiple populations that contain information on all of the following: at least one objective measure of muscle mass at the same anatomic site(s) common to all included studies, at least one direct measure of muscle strength common to included data sets, gait speed, and self-reported mobility status in populations of older adults. Analyses of relations to other measures of strength, muscle power, and physical performance (e.g., Short Physical Performance Battery), and mobility disability are encouraged.

Complete details available at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-15-013.html.

Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) will support research to measure psychosocial and behavioral variables in individuals undergoing bariatric surgery to understand how they predict success and risk and examine mechanisms of behavior change. The goals of this funding opportunity announcement are to: 1) improve the ability to identify who is at risk for sub-optimal weight loss, weight regain, and short- or long-term adverse metabolic/physiologic or behavioral outcomes based on pre-and/or post-operative behavioral characteristics and 2) inform the development of new treatment approaches to be used pre and/or post surgery to minimize risks and improve outcomes or allow for more tailored patient and procedure selection.

Complete details available at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-14-026.html.

Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) invites applications for P50 Research Center Grants for Specialized Programs of Research Excellence (SPOREs). The program will fund P50 SPORE grants to support state-of-the-art investigator-initiated translational research that will contribute to improved prevention, early detection, diagnosis, and treatment of an organ-specific cancer (or a related group of cancers). For the purpose of this funding announcement, cancers derived from the same organ system (i.e., group of organs that perform common function) are considered related. Examples of such organ systems include gastro-intestinal, endocrine, circulatory, and other biological systems. Other programmatically appropriate groups of cancers may include those centered around a common biological mechanism critical for promoting tumorigenesis and/or cancer progression in organ sites that belong to different organ systems. For example, a SPORE may focus on cancers caused by the same infectious agent, or sustained and promoted by dysregulation of a common signaling pathway. SPOREs are expected not only to conduct a wide spectrum of research activities, but also to contribute significantly to the development of specialized shared resources core facilities, improved research model systems, and collaborative research projects with other institutions. The research supported through this program must be translational in nature and must always be focused upon knowledge of human biology stemming from research using cellular, molecular, structural, biochemical, and/or genetic experimental approaches with the goal of a translational human endpoint within the project period of the grant. In addition, SPOREs must include both a Developmental Research Program for pilot studies and a Career Enhancement Program to foster careers in translational research related to the focus of the SPORE.

Complete details available at: http://grants.nih.gov/grants/guide/pa-files/PAR-14-353.html.