I was very fortunate to be a part of the AFMR's leadership at a time when clinical and translational research was growing in prominence at academic centers and across the overall biomedical research landscape. It was wonderful to be involved in AFMR's legislative advocacy efforts (e.g., passage of the Clinical Research Enhancement Act (https://www.govtrack.us/congress/bills/106/hr2498#summary/libraryofcongress), supporting grants for trainee-to-faculty transitions (e.g., http://grants.nih.gov/grants/guide/pa-files/PA-06133.html; http://www.bwfund.org/grant-programs/biomedical-sciences/career-awards-medical-scientists). It was particularly rewarding to participate in leading development efforts for training and support of clinical and translational research and researchers – through activities such as the educational sessions at the National Clinical Research meetings (e.g., http://www.afmr.org/archives/2002/Clinical-Research.cgi), offering translational symposia and workshops at the EB meetings (http://afmr.org/EB/archive/), and being involved in developing resources for medical researchers’ as they develop their careers (e.g., CTSciNet (http://sciencecareers.sciencemag.org/career_magazine/ctscinet), AFMR Career Connection (http://www.clinicalresearchcareers.org/). The broad, vibrant membership of AFMR and its focus on mentoring researchers and their works, which span the basic-clinical-practice research spectrum, continually positions AFMR to make positive impacts early and often for medical research—in its applications and its participants. Congratulations to AFMR on this 75th anniversary. I look forward to its continued good works in fulfilling its mission.