Abstract

Dear Sir We carefully read the review article by La Mantia et al. (1); however, we believe that some facts regarding the Tolosa–Hunt syndrome (THS) diagnosis must be taken into account, based on the criteria of the International Classification of Headache Disorders, second edition (ICHD-II) (2).
In the first paragraph, the authors clearly show misunderstanding of the current diagnostic criteria for THS by claiming that the presence of granuloma by magnetic resonance imaging (MRI) or biopsy is essential for diagnosing THS. According to Criterion B (code 13.16: paresis of one or more of the third, fourth and/or sixth cranial nerves
We agree with La Mantia et al. that the clinical features suggesting THS are not specific for that syndrome, but are common to several conditions and that their presence alone does not guarantee the correct diagnosis. For this reason, we would like to point out that, in order to diagnose THS, it is necessary to rule out other causes of painful ophthalmoplegia through appropriate investigation, according to Criterion E (code 13.16, ICHD-II) (2).
