Hydroxylamine is a natural product of cellular metabolism that possesses vasodilating properties similar to those of endothelium-derived relaxing factor (EDRF). In the rodent pulmonary circulation preconstricted with the endo peroxide analog U-46619, hydroxylamine relaxed the vasculature in a concen tration-dependent manner. Blockade of the hydroxylamine vasodilator response by methylene blue indicated that the mechanism of vasorelaxation is similar to that of EDRF. In this preparation, hydroxylamine is a more potent vasodilator than nitroglycerin.
References
1.
Furchgott RF : The role of endothelium in the responses of vascular smooth muscle to drugs . Ann Rev Pharmacol Toxicol24:175-197, 1984.
2.
Myers PR, Minor Jr RL, Guerra, R. Jr, et al: Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide. Nature345:61-163, 1990.
3.
Palmer Rmj, Ferrige AG, Moncada S.: Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature327:524-526, 1987.
4.
Gross P.: Biological activity of hydroxylamine, a review. Crit Rev Toxicol14:87-97, 1985.
5.
Thomas G., Ramwell PW: Vascular relaxation mediated by hydroxylamines and oximes: Their conversion to nitrites and mechanism of endothelium dependent vascular relaxation. Biochem Biophys Res Commun164: 889-893, 1989.
6.
Schmidt Hhw, Zernikow B., Baeblich S., et al: Basal and stimulated formation and release of L-arginine-derived nitrogen oxides from cultured endothelial cells. J Pharmacol Exp Ther254:591-594, 1990.
7.
DeMaster EG, Raij L., Archer SL, et al: Hydroxylamine is a vasorelaxant and a possible intermediate in the oxidative conversion of L-arginine to nitric oxide. Biochem Biophys Res Commun163:527-533, 1989.
8.
Santoian EC, Angerio AD, Schneidkraut MJ, et al: Role of calcium in U-46619 and PGF2a pulmonary vasoconstriction in rat lungs. Am J Physiol257: H2001-H2004, 1989.
9.
Rabinovitch M.: Structure and function of the pulmonary vascular bed: An update. Cardiol Clin7:895-914, 1989.
10.
Gryglewski RJ, Moncada S., Palmer Rmj: Bioassay of prostacyclin and endothelium-derived relaxing factor (EDRF) from porcine aortic endothelial cells. Br J Pharmacol87:685-694, 1986.
11.
Fukuto JM, Wallace GC, Hszieh R., et al: Chemical oxidation of N-hydroxyguanidine compounds: Release of nitric oxide, nitroxyl and possible relationship to the mechanism of biological nitric oxide generation. Biochem Pharmacol43:607-613, 1992.
