Abstract
A theoretical model is developed to predict the elastic properties of very soft tissues such as glands, tumors and brain. Tissues are represented as regular arrays of polyhedral (cubic or tetrakaidecahedral) cells, surrounded by extracellular spaces of uniform width. Cells are assumed to be incompressible, with very low resistance to shear deformation. Tissue shear rigidity is assumed to result mainly from the extracellular matrix, which is treated as a compressible elastic mesh of interconnected fibers. Small‐strain elastic properties of tissue are predicted using a finite‐element method and an analytical method. The model can be used to estimate the compressibility of a very soft tissue based on its Young's modulus and extracellular volume fraction.