The association of maternal hepatitis B surface antigen carriers (HBsAg) and chromosomal abnormalities in their newborns has been previously sug gested. This is a report on two female infants with abnormalities of chromosome 18 and trisomy 3q syndrome who were born to HBsAg carriers. These cases indicate that a possible relationship exists between the HBsAg carrier state in the mother and chromosome abnormalities in her offspring. It is suggested that the parents of all newborns with a structural chromosomal abnormality be tested for HBsAg.
References
1.
Koff RS, Isselbacher KJ: Changing concepts in epidemiology of viral hepatitis. N Engl J Med278:25, 1371, 1968
2.
Stoller A., Collman RD: Incidence of infective hepatitis followed by Down's syndrome nine months later . Lancet2:1221, 1965
3.
Rubenstein CT , Verma RS, Dosik H.: Centromeric banding (C) of sequentially Q-and-R banded human chromosomes. Hum Genet40:279, 1978
4.
Verma RS, Lubs HA: A simple R banding technic. Am J Hum Genet27:10, 1975
5.
Verma RS, Lubs HA: Additional observations on the preparation of R banded human chromosomes with acridine orange. Can J Genet Cytol18:45, 1976
6.
Verma RS, Dosik H.: An improved method for photographing fluorescent human chromosomes . J Microscopy108:339, 1976
7.
Allerdice PWBrowne N., Murphy DP: Chromosome 3 duplication q21 → qter deletion p25 → pter syndrome in children of carriers of a pericentric inversion inv (3) (p25q21). Am J Hum Genet27:699, 1975
8.
Stark CR, Mantel N.: Lack of seasonal or temporal spatial clustering of Down's syndrome births in Michigan. Am J Epidemiol86:199, 1967
9.
Kogon A., Kronmal RJ, Peterson DR: The relationship between infectious hepatitis and Down's syndrome . Am Public Health58:305, 1968
10.
Lack I.: Incidence of epidemicity of Down's syndrome. Lancet2:457, 1966.
11.
Robinson A. , Puck TT: Sex chromation in newborns: presentive evidence for external factors in human non disjunction. Science148:83, 1965
12.
Alpert LI, Strauss L., Hirschhorn E.: Neonatal hepatitis and biliary atresia associated with trisomy 17-18 syndrome . N Engl J Med280:16, 1969
13.
Stengel-Rutkowski S., Murken JD, Pilar V., Dutrillaux B., Rodewald A., Goebel R., Bassermann R.: New chromosomal dysmorphic syndromes. III Partial trisomy 3q. Eur J Pediatr130:111, 1979
14.
DeGrouchy J. , Turleau C.: Clinical Atlas of Human Chromosomes. New York, Wiley, 1977
