The purpose of this study was to determine if there was a diurnal variation in the DNA synthesis pattern of epithelial basal cells in the dorsum of the mouse tongue between infancy and preadult ages. The pattern of DNA synthesis in the basal cells of mouse tongue in 24-hour periods for different age groups was studied by isotope labeling and radioautography. A strong diurnal variation was found in the pattern of DNA synthesis with the degree of variation dependent on the age of the experimental groups.
References
1.
Goepp, R.A., and Fitch, F.W.: Pathological Study of Oral Radiation Death in Mice, Radiat Res16:833-845, 1962.
2.
Goepp, R.A., and Fitch, F.W.: Radiation Effects on Oral Epithelium in Mice, J Dent Res48:641-645, 1969.
3.
Goepp, R.A.: Personal communication.
4.
Pizzarello, D.J., Witcofski, R.G.; and Lyons, E.A.: Variation in Survival Time After Whole-Body Radiation at Two Times of Day, Science139:349, 1962.
5.
Rugh, R. ; Castro, V.; Balter, S.; Ken-Elly, E.V.; Marsden, D.S.; Warmund, J.; and Wollin, M.: X-rays: Are There Cyclic Variations in Radiosensitivity? Science142: 53-56, 1963.
6.
Whitmore, G.F. : Some Radiation Effects on Mammalian Cells in Tissue Culture, Natl Acad Sci-Natl Res Council Publ888 :49-69, 1961.
7.
Lindrop, P.J. , and Rotblad, J.: The Age Factor in Radiation Sensitivity in Mice, Br J Radiol35:23-31, 1962.
8.
Von Smallman, L., and Grimes, P.: Effect of Age on Cell Division, 3H-Thymidine Incorporation, and Diurnal Rhythm in the Lens Epithelium of Rats , Invest Ophthamol5:560, 1966.
9.
Wakonig-Vaartaja, R.: The Effect of Urethane on Mitotic Cells of Mice of Different Ages and Strains, Aust J Biol Med Sci42:165-172, 1964.
10.
Brown, J.M. , and Berry, R.J.: The Relationship Between Diurnal Variation of the Number of Cells in Mitosis and the Number of Cells Synthesizing DNA in the Epithelium of the Hamster Cheek Pouch, Cell Tissue Kinet1 :23-33, 1968.
11.
Pilgrim, C. ; Erb, W.; and Maurer, W.: Diurnal Fluctuations in the Numbers of DNA Synthesizing Nuclei in Various Mouse Tissue, Nature199:863, 1963.
12.
Ellen M.Fagereng Tvermyr : Circadian Rhythms in Epidermal Mitotic Activity, Diurnal Variations of the Mitotic Index, the Mitotic Rate and the Mitotic Duration, Virchows Arch Abt B Zellpath2:318-325, 1969.
13.
Henry, J.L. ; Meyer, J.; Weinmann , J.P.; and Schour, I.: Pattern of Mitotic Activity in Oral Epithelium of Rabbits, Arch Pathol54:281-297, 1952.
14.
Scheving, L.E. , and Chiakulas, J.J.: Twenty-Four Hour Periodicity in the Uptake of Tritiated Thymidine and Its Relation to Mitotic Rate in Urodele Larval Epidermis, Exp Cell Res39:161-169, 1965.
15.
Kiely, M.L. , and Wilde, J.L.: Circadian Mitotic Rhythms in the Cervical Tissues of the Rat Maxillary Incisor, J Dent Res53: 1432-1438, 1974.
16.
Mühlemann, H.R.; Marthaler, T.M.; and Rateitschak , K.H.: Mitosenperiodik in der Nebennierenrinde, Schilddrüse, in Duodenal und Mundhohlenepithel der Ratte , Acta Anat (Basel) 28:331-341, 1956.
17.
Halberg, F.; Zander, H.A.; Houglum, M.W.; and Mühlemann, H.R.: Daily Variations in Tissue Mitoses, Blood Eosinophils and Rectal Temperatures of Rats, Am J Physiol177:361-366, 1954.
18.
Trott, J.R., and Gorenstein, S.L. : Mitotic Rates in the Oral and Gingival Epithelium of the Rat, Arch Oral Biol8:425-434, 1963.
19.
Irons, W.B., and Schaffer, W.M.: Circadian Rhythms in the Oral and Gingival Epithelium of the Rat, Periodontics4:316-321, 1966.
20.
Glass, R.T. , and Goepp, R.A.: Spatial Relationship of Basal Cells in the Mouse Tongue After Radiation Injury, Rad Res58: 219-229, 1974.
21.
Glass, R.T. , and Goepp, R.A.: Movement of Labeled Basal Cells in the Mouse Tongue After Radiation Injury, Rad Res58 :230-238, 1974.
22.
Kopriwa, B.M. , and Leblond, C.P. : Improvements in the Coating Technique of Radioautography, J Histochem Cytochem10: 269-284, 1962.
