The effect of repetitive administration of pilocarpine nitrate on the salivary volume and salivary IgA concentration was studied in the NIH white hamster. One and one-half to three-fold increases in salivary volume, coupled with decreases of 1/3 to 2/3 in IgA concentration, occurred as the frequency of administration of pilocarpine increased.
References
1.
Schneyer, C.A. and Hall, H.D.: Autonomic Pathways Involved in a Sympathetic-Like Action of Pilocarpine on Salivary Composition, Proc Soc Exp Biol Med121:96-100, 1966.
2.
Schneyer, C.A. ; Sucanthapree, C.; and Schneyer, L.H.: Neural Regulation of Calcium and Amylase of Rat Parotid Saliva, Proc Soc Exp Biod Med156:132-135, 1977.
3.
Zengo, A.N.; Mandel, I.D.; Solomon, A.; and Block, P.: Chemistry of Rat Saliva Following Isoproterenol Administration, J Oral Therap Pharmacol4:359-363, 1968.
4.
Brandtzaeg, P.: Human Secretory Immunoglobulin. VII. Concentrations of Parotid IgA and Other Secretory Proteins in Relation to the Rate of Flow and Duration of Secretory Stimulus, Arch Oral Biol16:1295-1310, 1971.
5.
Mandel, I.D. and Khurana, H.S.: The Relation of Human Salivary A Globulin and Albumin to Flow Rate, Arch Oral Biol14:1433-1435, 1969.
6.
Tourville, D.R. ; Adler, R.H.; Bienenstock , J.; and Tomasi, T.: The Human Secretory Immunoglobulin System: Immunochemical Localization of A, Secretory Piece and Lactoferrin in Normal Human Tissues, J Exp Med129:411, 1969.
7.
Smith, D.J.; Taubman, M.A.; and Ebersole, J.L.: Local and Systemic Antibody Response to Oral Administration of Glucosyltransferase Antigen Complex, Infect Immun28 :441-450, 1980.
8.
Lowry, O.H.; Rosebrough, N.J.; Farr, A.L.; and Randell, R.J.: Protein Measurement with the Folin Phenol Reagent, J Biol Chem193:265-275, 1951.
9.
Mandel, I.D. ; Zengo, A.; Katz , R.; and Wotman, S.: Effect of Adrenergic Agents on Salivary Composition , J Dent Res54:B27-B33, 1975.
10.
Bixler, D.; Webster, R.C.; and Mühler, J.C.: The Effect of Pilocarpine on the Submaxillary Gland of the Rat, J Dent Res37:649-653, 1958.
Gahnberg, L. and Krasse, B.: Salivary Immunoglobulin A Antibodies Reacting with Antigens from Oral Streptococci: Longitudinal Study in Humans , Infect Immun33:697-703, 1981.
