Effect of Enteral Feeding Bag Composition and Freezing and Thawing upon Vitamin Stability in an Enteral Feeding Solution

Abstract

The effect of enteral feeding bag composition and freezing and thawing upon the stability of riboflavin and vitamins A and E in an enteral feeding solution was tested. Feeding bags composed of either polyvinyl chloride or polyethylene were filled with an enteral feeding solution. The samples were frozen for 3 months, thawed in warm water, and allowed to stand in room temperature for 12 hr. Samples for vitamin analysis were obtained prior to freezing, upon thawing, and at 12 hr after thawing. No significant differences in vitamin stability due to bag composition or time were seen. These results support the viability of the concept of mixing large batches of enteral feeding solution, and freezing aliquots in individual feeding bags for later use. (Journal of Parenteral and Enteral Nutrition 10:245-246; 1986)

Get full access to this article

View all access options for this article.

References

Chiou WL , Moorhatch P. : Interactions between vitamin A and plastic intravenous fluid bags. (Letter) . J Am Med Assoc 223: 328, 1973

Moorhatch P. , Chiou WL : Interaction between drugs and plastic intravenous fluid bags. I. Sorption studies on seventeen drugs. Am J Hosp Pharm 30: 72-78, 1975

Hartline JV , Sachman D. : Vitamin A delivery in total parenteral nutrition solutions. Pediatrics 58: 448-451, 1976

Nedich RL : Vitamin A absorption from plastic IV bags (Letter). J Am Med Assoc 224: 1531-32, 1973

Howard L. , Chu R. , Feman S. , et al: Vitamin A deficiency from long-term parenteral nutrition. Ann Int Med 93: 576-577, 1980

Bryant CA , Neufeld JN : Differences in vitamin A content of enteral feeding solutions following exposure to a polyvinyl chloride enteral feeding system. JPEN 6: 403-405, 1983

Fagerman KE , Flaska L. , McCamish MA , et al: Mechanized production of enteral diet: A comparison with manual methods of preparation. Hosp Pharm 17: 374-79, 1982

Fagerman KE , Dean RE : Bulk production and freezing of elemental enteral feedings. Nutr Support Serv 3: 8-11, 1983

Bieri JG , Tolliver TJ , Catignani GL : Simultaneous determination of alpha-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography. Am J Clin Nutr 32: 2143-2149, 1979.

10.

Mansourian R. , Barclay D. , Dirren H. : HPLC analysis of thiamin and riboflavin in urine. Int J Vit Nutr Res 52: 288, 1982

11.

Steele RGD , Torrie JH : Principles and Procedures of Statistics , 2nd ed. McGraw Hill Book Co , New York, 1980