Abstract
Although the chimpanzee displays an immunological response to an HIV-1 challenge, it is a deficient animal model in AIDS research since it never develops the progressive symptoms of the disease. The continued use of the chimpanzee is also precluded because of its endangered status in the wild, the high cost per animal, and its failure to exhibit a CD4 decline (apoptosis) while infected. However, it is likely that the chimpanzee model will continue to be used in investigations relating to the epidemiology and mucosal transmission of the human AIDS virus.
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