This paper forms a short review of some of our previously published work. We assessed the cytotoxic and genotoxic effects of sodium fluoride (NaF) on the Chinese hamster V79 cell line and the human EUE cell line at neutral and acid pH (as found in the stomach). The effects of NaF on cell proliferation, DNA synthesis, protein synthesis and mutagenesis were assessed. The results found showed no mutagenic effects after exposure to NaF, despite some cytogenic effects, suggesting that NaF probably does not represent any serious mutagenic or carcinogenic threat to humans.
SlameñováD., GábelováA., & RuppováK. (1992). Cytotoxicity and genotoxicity testing of sodium fluoride on Chinese hamster V79 cells and human EUE cells.Mutation Research279, 109–115.
2.
SlameñováD., RuppováK., GábelováA., & WsólováL. (1996). Evaluation of mutagenic and cytotoxic effects of sodium fluoride on mammalian cells influenced by an acid environment.Cell Biology and Toxicology12, 11–17.
3.
SlameñováD., & RuppováK. (1980). The effects of sodium azide on mammalian cells cultivated in vitro.Mutation Research71, 253–261.
4.
AbbondanoloA., BonattiS., ColellaC., CortiG., MatteucciF., MazacarroA., and ReinaldiG. (1976). A comparative study of different experimental protocols for mutagenesis assay with 8-azaguanine resistant system in cultured Chinese hamster cells.Mutation Research37, 293–306.
5.
ChasinL.A. (1973). The effect of ploidy on chemical mutagenesis in cultured Chinese hamster cells.Journal of Cellular Physiology82, 299–308.
6.
LiY., DunipaceA.J., and StookeyG.K. (1988). Genotoxic effects of fluoride: a controversial issue.Mutation Research195, 127–136.
7.
ZeigerE., ShelbyM.D., and WittK. (1993). Genetic toxicity of fluoride.Environmental and Molecular Mutagenesis21, 309–318.
