Platelets and cardiopulmonary bypass

Abstract

References

Ciaverella D , Snyder EL. Effects of cardiopulmonary bypass on platelet function. In: Dutcher JP ed. Modern transfusion therapy. Boca Raton, FL: CRC Press , 1990: 3-23.

Bachmann F , McKenna R , Cole ER , Najafi H. The hemostatic mechanism after open-heart surgery. I. Studies on plasma coagulation factors and fibrinolysis in 512 patients after extracorporeal circulation . J Thorac Cardiovasc Surg 1975; 70: 76-85 .

Bick RL. Hemostasis defects associated with cardiac surgery, prosthetic devices, and other extracorporeal circuits . Semin Thromb Hemost 1985; 11: 249-280 .

Harker LA , Malpass TW , Branson HE , Hessel EA II , Slichter SJ. Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: acquired transient platelet dysfunction associated with selective alpha-granule release . Blood 1980; 56: 824-834 .

Thompson AR , Harker LA. Concepts of haemostasis and thrombosis. In: Thompson AR , Harker LA eds. Manual of haemostasis and thrombosis, 3rd edn. Philadelphia, PA: FA Davis , 1983: 9-19.

Born GVR. Aggregation of blood platelets by adenosine diphosphate and its reversal . Nature 1962; 194: 927-927 .

Schmidt PJ , Peden JC , Brecher G , Baranovski A. Thrombocytopenia and bleeding tendency after extracorporeal circulation . N Engl J Med 1961; 265: 1181-1185 .

De Jong JC , Sibinga CT , Wildevuur CR. Platelet behaviour in extracorporeal circulation (ECC). In: Kenedi RM et al. eds. Artificial organs. Baltimore, MD, University Park Press ; 1976: 27-36.

Addonizio VP. Platelet function in cardiopulmonary bypass and artificial organs . Hematol Oncol Clin North Am 1990; 4: 145-155 .

10.

Jung G , Razafindranaibe F , Elkouby A , Durasnel P , Panes F , Monassier JP. Modifications of platelet shape change and ATP release during cardiopulmonary bypass . Haemostasis 1995; 25: 149-157 .

11.

Friedenberg WR , Myers WO , Plotka ED et al. Platelet dysfunction associated with cardiopulmonary bypass . Ann Thorac Surg 1978; 25: 298-305 .

12.

Umlas J. In vivo platelet function following cardiopulmonary bypass . Transfusion 1975; 15: 596-599 .

13.

Wenger RK , Lukasiewicz H , Mikuta BS , Niewiarowski S , Edmunds LH, Jr. Loss of platelet fibrinogen receptors during clinical cardiopulmonary bypass . J Thorac Cardiovasc Surg 1989; 97: 235-239 .

14.

Kestin AS , Valeri CR , Khuri SF et al. The platelet function defect of cardiopulmonary bypass [see comments] . Blood 1993; 82: 107-117 .

15.

Rinder CS , Mathew JP , Rinder HM , Bonan J , Ault KA , Smith BR. Modulation of platelet surface adhesion receptors during cardiopulmonary bypass . Anesthesiology 1991; 75: 563-570 .

16.

Kondo C , Tanaka K , Takagi K et al. Platelet dysfunction during cardiopulmonary bypass surgery. With special reference to platelet membrane glycoproteins . ASAIO J 1993; 39: M550-M553 .

17.

Rinder CS , Bohnert J , Rinder HM , Mitchell J , Ault K , Hillman R. Platelet activation and aggregation during cardiopulmonary bypass . Anesthesiology 1991; 75: 388-393 .

18.

Abrams CS , Ellison N , Budzynski AZ , Shattil SJ. Direct detection of activated platelets and platelet-derived microparticles in humans . Blood 1990; 75: 128-138 .

19.

Carteaux JP , Roux S , Kuhn H , Tschopp T , Colombo V , Hadvary P. Ro 44-9883, a new nonpeptide glycoprotein IIb/IIIa antagonist, prevents platelet loss during experimental cardiopulmonary bypass [see comments] . J Thorac Cardiovasc Surg 1993; 106: 834-841 .

20.

Laufer N , Merin G , Grover NB , Pessachowicz B , Borman JB. The influence of cardiopulmonary bypass on the size of human platelets . J Thorac Cardiovasc Surg 1975; 70: 727-731 .

21.

Wahba A , Black G , Koksch M et al. Cardiopulmonary bypass leads to a preferential loss of activated platelets. A flow cytometric assay of platelet surface antigens . Eur J Cardiothorac Surg 1996; 10: 768-773 .

22.

Edmunds LH Jr , Saxena NC , Hillyer P , Wilson TJ. Relationship between platelet count and cardiotomy suction return . Ann Thorac Surg 1978; 25: 306-310 .

23.

Morris KN , Kinross FM , Stirling GR. Haemolysis of blood in the pericardium: the major source of plasma haemoglobin during total body perfusion . J Thorac Cardiovsc Surg 1965; 49: 250-250 .

24.

Addonizio VP , Colman RW. Platelets and extracorporeal circulation . Biomaterials 1982; 3: 9-15 .

25.

Virchow R. Phlogose und thrombose in Gefessystem. Frankfurt-am-main: Meidinger Sohn , 1856.

26.

Gimbrone MA. Vascular endothelium: nature’s blood container. Edinburgh: Churchill Livingstone , 1986.

27.

Weksler BB , Jaffe EA. Prostacyclin and the endothelium. In: Gimbrone MA ed. Vascular endothelium in haemostasis and thrombosis. Edinburgh: Churchill Livingstone , 1986.

28.

Rosenberg RD , Rosenberg JS. Natural anticoagulant mechanisms . J Clin Invest 1984; 74: 1-6 .

29.

Baier RE. Selected methods of investigation for blood-contact surfaces. In: Leonard EF , Turitto VT , Vroman L eds. Blood in contact with natural and artificial surfaces. New York: Academy of Sciences , 1987.

30.

Baier RE. The role of surface energy in thrombogenesis . Bull NY Acad Med 1972; 48: 257-272 .

31.

Dutton RC , Baier RE , Dedrick RL , Bowman RL. Initial thrombus formation on foreign surfaces . Trans Am Soc Artif Organs 1968; 14: 57-62 .

32.

Dutton RC , Weber AJ , Johnson SA , Baier RE. Microstructure of initial thrombus formation on foreign materials . J Biomed Mater Res 1969; 3: 13-23 .

33.

Baier RE , Dutton RC. Initial events in interactions of blood with a foreign surface . J Biomed Mater Res 1969; 3: 191-206 .

34.

Baier RE , Dutton RC , Gott VL. Surface chemical features of blood vessel walls and synthetic materials exhibiting thromboresistance. In Blank M ed. Surface chemistry of biological systems. New York: Plenum , 1970: 235-260.

35.

Ward CA , Ruegsegger B , Stanga D , Zingg W. Reduction in platelet adhesion to biomaterials by removal of gas nuclei . Trans ASAIO 1974; 20A: 77-84 .

36.

Ward CA , Forest TW. On the relation between platelet adhesion and the roughness of a synthetic biomaterial . Ann Biomed Eng 1976; 4: 184-207 .

37.

Ratner BD , Hoffman AS. Synthetic hydrogels for biomedical applications. In: Andrade JD ed. Hydrogels for medical and related applications. Washington, DC: American Chemical Society , 1976.

38.

Silberberg A. The hydrogel-water interface. In: Andrade J ed. Hydrogels for medical and related applications. Washington, DC: American Chemical Society , 1976.

39.

Andrade JD , King RN , Gregonis DE. Probing the hydrogen/water interface. In: Andrade J ed. Hydrogels for medical and related applications. Washington, DC: American Chemical Society , 1976.

40.

Baier RE , Akers CK , Perlmutter S , Dardik H , Dardik I , Wodka M. Processed human umbilical cord veins for vascular reconstructive surgery . Trans ASAIO 1976; 22: 514-524 .

41.

Baier RE , Akers CK , Natiella JR , Meenaghan MA , Wirth J. Physicochemical properties of stabilised umbilical vein . Vasc Surg 1980; 14: 145-157 .

42.

Shapiro RI , Cerra FB , Hoffman JK , Baier RE. Surface chemistry characteristics of human umbilical vein used as chronic canine arteriovenous fistulas . Artif Organs 1978; 2: 301-304 .

43.

Ratner BD , McElroy BJ. Electron spectroscopy for chemical analysis: applications in the biomedical sciences. In: Gendreau RM ed. Spectroscopy in the biomedical sciences. Boca Raton, FL: CRC Press , 1986: 107-107.

44.

Andrade JD. Polymer surface analysis: conclusions and expectations. In: Andrade JD ed. Surface and interfacial aspects of biomedical polymers. Boca Raton, FL: Plenum , 1985: 443-460.

45.

Zisman WA. Relation of the equilibrium contact angle to liquid and solid constitution . Adv Chem Ser 1964; 43: 1-51 .

46.

Baier RE. Key events in blood interactions at non-physiological interfaces - a personal primer . Artif Organs 1978; 2: 422-426 .

47.

Brash JL. Protein’s interactions with artificial surfaces. In: Salzman EW ed. Interactions of the blood with natural and artificial surfaces. New York: Marcel Dekker , 1981: 37-60.

48.

Horbett TA. Adsorption of proteins from plasma to a series of hydrophilic-hydrophobic copolymers: 2. Compositional analysis with the pre-labelled protein technique . J Biomed Mater Res 1981; 15: 673-695 .

49.

Hanson SR , Harker LA , Ratner BD , Hoffman AS. Evaluation of artificial surfaces using baboon arteriovenous shunt model. In: Winter GD , Gibbons DF , Plenk H eds. Biomaterials 1980, advances in biomaterials. Chichester: John Wiley , 1982: 519-530.

50.

Feng L , Andrade JD. Protein adsorption on low-temperature isotropic carbon: I. Protein conformational change probed by differential scanning calorimetry . J Biomed Mater Res 1994; 28: 735-743 .

51.

Chinn JA , Phillips RE , Lew KR , Horbett TA. Tenacious binding of fibrinogen and albumin to pyrolite carbon . J Coll Interface Sci 1996; 184: 11-19 .

52.

Biggs R , Denson K. Inhibitors of blood coagulations. In: Biggs R ed. Human blood coagulation, haemostasis and thrombosis. London: Blackwell Scientific , 1976.

53.

Damus PS , Hicks M , Rosenberg RB. Anticoagulant effect of heparin . Nature 1977; 246: 355-357 .

54.

Aiken J. Prostaglandins . J Cardiovasc Physiol 1984; 6: 5413-5420 .

55.

Whittle B , Moncada S , Vane JR. Comparisons of the effect of PGI1 and PGD2 on platelet aggregation in different species . Prostaglandins 1978; 16: 373-388 .

56.

Packham MA , Evans G , Glynn MF , Mustard JF. The effects of plasma proteins on the interactions of platelets with glass surfaces . J Lab Clin Med 1969; 73: 686-697 .

57.

Zucker MB , Vroman L. Platelet adhesion induced by fibrinogen adsorbed onto glass . Soc Exp Biol Med 1969; 131: 318-320 .

58.

Cross MJ. Effect of fibrinogen on the aggregation of platelets by adenosine diphosphate . Thromb Diath Haemorrh 1964; 12: 524-527 .

59.

Niewiarowski S , Budzynski AZ , Lipinski B. Significance of the intact polypeptide chains of human fibrinogen in ADP-induced platelet aggregation . Blood 1977; 49: 635-644 .

60.

Chinn JA , Horbett TA , Ratner BD. Baboon fibrinogen adsorption and platelet adhesion to polymeric materials . Thromb Haemost 1991; 65: 608-617 .

61.

Chinn JA , Ratner BD , Horbett TA. Adsorption of baboon fibrinogen and the adhesion of platelets to a thin film polymer deposited by radio-frequency glow discharge of allylamine . Biomaterials 1992; 13: 322-332 .

62.

Mustard JF , Packham MA , Kinlough-Rathbone RL , Perry DW , Regoeczi E. Fibrinogen and ADP-induced platelet aggregation . Blood 1978; 52: 453-466 .

63.

Lindon JN , Salzman EW , Merrill EW et al. Catalytic activity and platelet reactivity of heparin covalently bonded to surfaces . J Lab Clin Med 1985; 105: 219-226 .

64.

Roald HE , Barstad RM , Bakken IJ , Roald B , Lyberg T , Sakariassen KS. Initial interactions of platelets and plasma proteins in flowing nonanticoagulated human blood with the artificial surfaces Dacron and PTFE . Blood Coagul Fibrinolysis 1994; 5: 355-363 .

65.

Hanson SR , Kotze HF , Savage B , Harker LA. Platelet interactions with Dacron vascular grafts . Arteriosclerosis 1985; 5: 595-603 .

66.

Yeh YS , Iriyama Y , Matsuzawa Y , Hanson SR , Yasuda H. Blood compatibility of surfaces modified by plasma polymerization . J Biomed Mater Res 1988; 22: 795-818 .

67.

Sheppeck RA , Garrett KO , Bentz ML , Johnson PC. Platelet deposition on polyethylene. Dependence of second layer platelet attachment on von Willebrand’s disease plasma . Trans ASAIO 1991; 37: M260-M261 .

68.

Vroman L , Adams AL , Fischer GC , Munoz PC. Interaction of high molecular weight kininogen, factor XII, and fibrinogen in plasma at interfaces . Blood 1980; 55: 156-159 .

69.

Andrade JD , Hlady V. Vroman effects, techniques, philosophies . J Biomater Sci Polym Edn 1991; 2: 161-172 .

70.

Campbell FW. The contribution of platelet dysfunction to postbypass bleeding . J Cardiothorac Vasc Anesth 1991; 5(suppl 1): 8-12 .

71.

Addonizio VP Jr , Macarak EJ , Niewiarowski S , Colman RW , Edmunds LH Jr. Preservation of human platelets with prostaglandin E1 during in vitro simulation of cardiopulmonary bypass . Circ Res 1979; 44: 350-357 .

72.

Munro MS , Quattrone AJ , Ellsworth SR , Kulkarni P , Eberhart RC. Alkyl substituted polymers with enhanced fibrin affinity . Trans ASAIO 1981; 27: 499-653 .

73.

Lelah MD , Lambrecht LK , Young BR , Cooper SL. Physicochemical characterization and in vivo blood tolerability of cast and extruded biomer . J Biomed Mater Res 1983; 17: 1-22 .

74.

Copeland J. The biomaterial-blood interface in circulatory support devices: a cardiac surgeon’s view. In: Lewis CT , Graham TR eds. Mechanical circulatory support. London: Arnold , 1995.

75.

Holme PA , Orvim U , Hamers MJ et al. Shear-induced platelet activation and platelet microparticle formation at blood flow conditions as in arteries with a severe stenosis . Arterioscler Thromb Vasc Biol 1997; 17: 646-653 .

76.

Plate G , Hollier L , Gloviczki P. Overcoming failure of venous vascular prostheses . Surgery 1984; 96: 503-510 .

77.

Goosen M , Sefton M. Properties of heparinpoly(vinyl-alcohol) hydrogel coating . J Biomed Mater Res 1983; 17: 359-373 .

78.

Nichols J , Owen A , Grossman B. Effect of heparin-bonding on catheter induced fibrin formation and platelet activation . Circulation 1984; 70: 843-850 .

79.

Mori Y , Nagoaka S , Masubuchi Y. The effects of released heparin from heparinised hydrophilic polymer (HRSD) on the process of thrombus formation . Trans ASAIO 1978; 24: 736-745 .

80.

Bennegard K , Curelaru I , Gustausson B. Material thrombogenicity in central venous catheterisation . Acta Anaesthesia Scand 1982; 26: 112-120 .

81.

Lambrecht L , Young B , Mosher D. Transient thrombus deposition in chitosan-heparin coated polyethylene . Trans ASAIO 1981; 27: 380-385 .

82.

Kim SW , Ebert C , Lin J , McRea J. Nonthrombogenic polymers . ASAIO J 1983; 6: 76-87 .

83.

Kim SW , Jacobs H , Lin JY , Nojori C , Okano T. Nonthrombogenic bioactive surfaces. In: Leonard EF ed. Blood in contact with natural and artificial surfaces. New York: Academy of Sciences , 1987.

84.

von Segesser LK , Turina M. Cardiopulmonary bypass without systemic heparinization. Performance of heparin-coated oxygenators in comparison with classic membrane and bubble oxygenators . J Thorac Cardiovasc Surg 1989; 98: 386-396 .

85.

Gravlee GP. Heparin-coated cardiopulmonary bypass circuits . J Cardiothorac Vasc Anesth 1994; 8: 213-222 .

86.

Thelin S , Bagge L , Hultman J , Borowiec J , Nilsson L , Thorelius J. Heparin-coated cardiopulmonary bypass circuits reduce blood cell trauma. Experiments in the pig . Eur J Cardiothorac Surg 1991; 5: 486-491 .

87.

Palatianos GM , Dewanjee MK , Smith W et al. Platelet preservation during cardiopulmonary bypass with iloprost and Duraflo-II heparin-coated surfaces . Trans ASAIO 1991; 37: 620-622 .

88.

Ernofsson M , Thelin S , Siegbahn A. Thrombin generation during cardiopulmonary bypass using heparin-coated or standard circuits . Scand J Thorac Cardiovasc Surg 1995; 29: 157-165 .

89.

Ovrum E , Mollnes TE , Fosse E et al. High and low heparin dose with heparin-coated cardiopulmonary bypass: activation of complement and granulocytes . Ann Thorac Surg 1995; 60: 1755-1761 .

90.

Ovrum E , Holen EA , Tangen G et al. Completely heparinized cardiopulmonary bypass and reduced systemic heparin: clinical and hemostatic effects . Ann Thorac Surg 1995; 60: 365-371 .

91.

Ovrum E , Brosstad F , Am Holen E , Tangen G , Abdelnoor M , Oystese R. Complete heparin-coated (CBAS) cardiopulmonary bypass and reduced systemic heparin dose; effects on coagulation and fibrinolysis . Eur J Cardiothorac Surg 1996; 10: 449-455 .

92.

Ovrum E , Am Holen E , Tangen G , Ringdal MA. Heparinized cardiopulmonary bypass and full heparin dose marginally improve clinical performance . Ann Thorac Surg 1996; 62: 1128-1133 .

93.

Nakajima T , Osawa S , Ogawa M et al. Clinical study of platelet function and coagulation/fibrinolysis with Duraflo II heparin coated cardiopulmonary bypass equipment . ASAIO J 1996; 42: 301-305 .

94.

Gorman RC , Ziats N , Rao AK et al. Surface-bound heparin fails to reduce thrombin formation during clinical cardiopulmonary bypass . J Thorac Cardiovasc Surg 1996; 111: 1-11 ; discussion 11-12.

95.

Kuitunen AH , Heikkila LJ , Salmenpera MT. Cardiopulmonary bypass with heparin-coated circuits and reduced systemic anticoagulation . Ann Thorac Surg 1997; 63: 438-444 .

96.

Weiss BM , von Segesser LK , Turina MI , Seifert B , Pasch T. Perioperative course and recovery after heparin-coated cardiopulmonary bypass: low-dose versus high-dose heparin management . J Cardiothorac Vasc Anesth 1996; 10: 464-470 .

97.

Horimoto H , Kondo K , Asada K , Sasaki S. Heparin-coated cardiopulmonary bypass circuits in coronary bypass surgery . Artificial Organs 1996; 20: 936-940 .

98.

Svenmarker S , Sandstrom E , Karlsson T et al. Clinical effects of the heparin coated surface in cardiopulmonary bypass . Eur J Cardiothorac Surg 1997; 11: 957-964 .

99.

Malpass TW , Hanson SR , Savage B , Hessel EA II , Harker LA. Prevention of acquired transient defect in platelet plug formation by infused prostacyclin . Blood 1981; 57: 736-740 .

100.

Addonizio VP , Macarak EJ , Nicolao KC. Effects of prostacyclin and albumin on platelet loss during in vitro simulation of extracorporeal circulation . Blood 1979; 53: 1033-1042 .

101.

Addonizio VP , Fisher CA , Jenkin BK. Iloprost (ZK36374), a stable analogue of prostacyclin, preserves platelets during simulated extracorporeal circulation . J Thorac Cardiovasc Surg 1985; 89: 926-933 .

102.

Malpass TW , Amory DW , Harker LA. The effect of prostacyclin infusion on platelet haemostatic function in patients undergoing cardiopulmonary bypass . J Thorac Cardiovasc Surg 1984; 87: 550-555 .

103.

Coppe D , Sobel M , Seamans L , Levine F , Salzman E. Preservation of platelet function and number by prostacyclin during cardiopulmonary bypass . J Thorac Cardiovasc Surg 1981; 81: 274-278 .

104.

Peerschke EIB. The platelet fibrinogen receptor . Semin Haematol 1985; 22: 241-259 .

105.

Bennett JS. The platelet-fibrinogen interaction. In: George JN , Nurden AT , Phillips DR eds. Platelet membrane glycoproteins. New York: Plenum , 1985.

106.

Coller BS. Platelet-von Willebrand factor interactions. In: George JN , Nurden AT , Phillips DR eds. Platelet membrane glycoproteins. New York: Plenum , 1985.

107.

Weinstein M , Ware JA , Troll J. Changes in von Willebrand factor during cardiac surgery: effect of desmopressin acetate . Blood 1988; 71: 1648-1655 .

108.

Salmenpera MT , Levy JH , Harker LA. Haemostasis and cardiopulmonary bypass. In: Mora CT ed. Cardiopulmonary bypass. Principles and techniques of extracorporeal circulation. New York: Springer , 1995.

109.

Gorman RR. Analysis of biological activity of azoprostanoids in human platelets . Fed Proc 1981; 40: 1997-1997 .

110.

Reves JG. Adrenergic response to cardiopulmonary bypass . Mt Sinai J Med 1985; 52: 511-515 .

111.

Jaffe EA. Thrombospondin is the endogenous lectin of human platelets . Nature 1982; 295: 246-246 .

112.

Ginsberg MH. Thrombin increases expression of fibronectin antigen on platelet surfaces . Proc Natl Acad Sci USA 1980; 77: 1049-1049 .

113.

Baumgartner HR , Muggli R , Tschopp TB , Turitto V. Platelet adhesion, release and aggregation in flowing blood: effects of surface properties and platelet function . Thromb Haemost 1976; 35: 124-138 .

114.

Packham MA , Mustard JF. Platelet adhesion . Prog Haemost Thromb 1984; 7: 211-288 .

115.

Aster RH. Thrombocytopenia due to sequestration of platelets. In Williams WJ , Beutler E , Erslev AJ eds. Haematology. New York: McGraw-Hill , 1983.

116.

Mazer CD , Hornstein A , Freedman J. Platelet activation in warm and cold heart surgery . Ann Thorac Surg 1995; 59: 1481-1486 .

117.

Nilsson L , Bagge L , Nystrom SO. Blood cell trauma and postoperative bleeding: comparison of bubble and membrane oxygenators and observations on coronary suction . Scand J Thorac Cardiovasc Surg 1990; 24: 65-69 .

118.

Dutton RC , Edmunds LH , Hutchinson JC , Roe BB. Platelet aggregate emboli produced in patients during cardiopulmonary bypass with membrane and bubble oxygenators and blood filters . J Thorac Cardiovasc Surg 1974; 67: 258-265 .

119.

Hope AF , Heyns AD , Lotter MG et al. Kinetics and sites of sequestration of indium 111-labeled human platelets during cardiopulmonary bypass . J Thorac Cardiovasc Surg 1981; 81: 880-886 .

120.

Peterson KA , Dewanjee MK , Kaye MP. Fate of indium 111-labeled platelets during cardiopulmonary bypass performed with membrane and bubble oxygenators . J Thorac Cardiovasc Surg 1982; 84: 39-43 .

121.

van Oeveren W , Kazatchkine MD , Descamps-Latscha B et al. Deleterious effects of cardiopulmonary bypass. A prospective study of bubble versus membrane oxygenation . J Thorac Cardiovasc Surg 1985; 89: 888-899 .

122.

Solis RT , Kennedy PS , Beall AC Jr , Noon GP , DeBakey ME. Cardiopulmonary bypass. Microembolization and platelet aggregation . Circulation 1975; 52: 103-108 .

123.

Trumbull HR , Howe J , Mottl K , Nicoloff DM. A comparison of the effects of membrane and bubble oxygenators on platelet counts and platelet size in elective cardiac operations . Ann Thorac Surg 1980; 30: 52-57 .

124.

Hessel EA II , Johnson DD , Ivey TD , Miller DW Jr. Membrane versus bubble oxygenator for cardiac operations. A prospective randomized study . J Thorac Cardiovasc Surg 1980; 80: 111-122 .

125.

Sade RM , Bartles DM , Dearing JP. A prospective randomised study of membrane versus bubble oxygenators in children . Ann Thorac Surg 1980; 29: 502-511 .

126.

Ruggeri ZM. Mechanisms of shear-induced platelet adhesion and aggregation . Thromb Haemost 1993; 70: 119-123 .

127.

Giorgio TD , Hellums JD. A cone and plate viscometer for the continuous measurement of blood platelet activation . Biorheology 1988; 25: 605-624 .

128.

Giorgio TD , Hellums JD. Inhibition of shear stress-induced platelet activation by commercial luminescence reagents . Thrombos Res 1988; 49: 643-647 .

129.

Jen CJ , McIntire LV. Characteristics of shear-induced aggregation in whole blood . J Lab Clinl Med 1984; 103: 115-124 .

130.

Wright G. Blood cell trauma. In: Taylor KM ed. Cardiopulmonary bypass: principles and management. Cambridge: Cambridge University Press , 1986: 249-265.

131.

Konstantopoulos K , Grotta JC , Sills C , Wu KK , Hellums JD. Shear-induced platelet aggregation in normal subjects and stroke patients . Thromb Haemost 1995; 74: 1329-1334 .

132.

Konstantopoulos K , Wu KK , Udden MM , Banez EI , Shattil SJ , Hellums JD. Flow cytometric studies of platelet responses to shear stress in whole blood . Biorheology 1995; 32: 73-93 .

133.

Ip WF , Sefton MV. Platelet consumption by polyvinyl alcohol coated tubing in canines . J Biomed Mater Res 1991; 25: 875-887 .

134.

George JN , Pickett EB , Saucerman S et al. Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery . J Clin Invest 1986; 78: 340-348 .

135.

Yu SK , Latour JG , Marchandise B , Bois M. Shear stress-induced changes in platelet reactivity . Thromb Haemost 1979; 40: 551-560 .

136.

Wurzinger LJ , Opitz R , Wolf M , Schmid-Schonbein H. ‘Shear induced platelet activation’ - a critical reappraisal . Biorheology 1985; 22: 399-413 .

137.

Reimers RC , Sutera SP , Joist JH. Potentiation by red blood cells of shear-induced platelet aggregation: relative importance of chemical and physical mechanisms . Blood 1984; 64: 1200-1206 .

138.

Chow TW , Hellums JD , Moake JL , Kroll MH. Shear stress-induced von Willebrand factor binding to platelet glycoprotein Ib initiates calcium influx associated with aggregation . Blood 1992; 80: 113-120 .

139.

Goto S , Salomon DR , Ikeda Y , Ruggeri ZM. Characterization of the unique mechanism mediating the shear-dependent binding of soluble von Willebrand factor to platelets . J Biol Chem 1995; 270: 23 352-23 361 .

140.

Ikeda Y , Handa M , Kawano K et al. The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress . J Clin Invest 1991; 87: 1234-1240 .

141.

Peterson DM , Stathopoulos NA , Giorgio TD , Hellums JD , Moake JL. Shear-induced platelet aggregation requires von Willebrand factor and platelet membrane glycoproteins Ib and IIb-IIIa . Blood 1987; 69: 625-628 .

142.

Slack SM , Jennings LK , Turitto VT. Platelet size distribution measurements as indicators of shear stress-induced platelet aggregation . Ann Biomed Engng 1994; 22: 653-659 .

143.

O’Brien JR. Shear-induced platelet aggregation . Lancet 1990; 335: 711-713 .

144.

Hung TC , Hochmuth RM , Joist JH , Sutera SP. Shear-induced aggregation and lysis of platelets . Trans ASAIO 1976; 22: 285-291 .

145.

Belval T , Hellums JD , Solis RT. The kinetics of platelet aggregation induced by fluid-shearing stress . Microvasc Res 1984; 28: 279-288 .

146.

John LC , Rees GM , Kovacs IB. Inhibition of platelet function by heparin. An etiologic factor in postbypass hemorrhage . J Thorac Cardiovasc Surg 1993; 105: 816-822 .

147.

Bell WR , Tomasulo PA , Alving BM. Thrombocytopenia occurring during the administration of heparin . Ann Intern Med 1976; 85: 155-160 .

148.

Khuri SF , Valeri CR , Loscalzo J et al. Heparin causes platelet dysfunction and induces fibrinolysis before cardiopulmonary bypass [see comments] . Ann Thorac Surg 1995; 60: 1008-1014 .

149.

Pixley RA , Schapira M , Colman RW. Effect of heparin on the inactivation rate of human activated factor XII by antithrombin III . Blood 1985; 66: 198-203 .

150.

Mammen EF , Koets MH , Washington BC. Haemostasis changes during cardiopulmonary bypass surgery . Semin Thromb Haemostas 1985; 11: 281-292 .

151.

Lee S. Haematologic disorders following cardiopulmonary bypass. In: Casthely PA , Bregman D eds. Cardiopulmonary bypass: physiology, related complications, and pharmacology. Mount Kisco, NY: Futura , 1991: 191-191.

152.

Porter DM , Silver D. Alterations in fibrinolysis and coagulation associated with cardiopulmonary bypass . J Thorac Cardiovasc Surg 1968; 56: 869-878 .

153.

Wahba A , Black G , Koksch M et al. Aprotinin has no effect on platelet activation and adhesion during cardiopulmonary bypass . Thromb Haemost 1996; 75: 844-848 .

154.

van Oeveren W , Harder MP , Roozendaal KJ , Eijsman L , Wildevuur CR. Aprotinin protects platelets against the initial effect of cardiopulmonary bypass . J Thorac Cardiovasc Surg 1990; 99: 788-796 ; discussion 796-97.

155.

Bidstrup BP , Royston D , Sapsford RN , Taylor KM. Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol) . J Thorac Cardiovasc Surg 1989; 97: 364-372 .

156.

Bidstrup B. Aprotinin for bleeding after cardiopulmonary bypass [letter; comment] . Lancet 1990; 335: 1535-1536 .

157.

Dietrich W , Spannagl M , Jochum M. Influence of high dose aprotinin treatment on blood loss and coagulation patterns in patients undergoing myocardial revescularisation . Anaesthesiology 1990; 73: 1119-1126 .

158.

159.

Tabuchi N , Huet RC , Sturk A , Eijsman L , Wildevuur CR. Aprotinin preserves hemostasis in aspirin-treated patients undergoing cardiopulmonary bypass . Ann Thorac Surg 1994; 58: 1036-1039 .

160.

Tabuchi N , De Haan J , Boonstra PW , Huet RC , van Oeveren W. Aprotinin effect on platelet function and clotting during cardiopulmonary bypass . Eur J Cardiothorac Surg 1994; 8: 87-90 .

161.

Wachtfogel YT , Kucich U , Hack CE et al. Aprotinin inhibits the contact, neutrophil and activation systems during simulated extracorporeal perfusion . J Thorac Cardiovasc Surg 1993; 106: 1-9 .

162.

Mohr R , Goor DA , Lusky A , Lavee J. Aprotinin prevents cardiopulmonary bypass-induced platelet dysfunction. A scanning electron microscope study . Circulation 1992; 86(suppl): II405-II409 .

163.

Lavee J , Savion N , Smolinsky A , Goor DA , Mohr R. Platelet protection by aprotinin in cardiopulmonary bypass: electron microscopic study . Ann Thorac Surg 1992; 53: 477-481 .

164.

Westaby S. Aprotinin in perspective . Ann Thorac Surg 1993; 55: 1033-1041 .

165.

Royston D , Bidstrup BP , Taylor KM , Sapsford RN. Effect of aprotinin on need for blood transfusion after repeat open-heart surgery . Lancet 1987; 2: 1289-1291 .

166.

Gans H , Castenada AR , Subramanian V. Problems in haemostasis during open-heart surgery: IX. Changes observed in the plasmin-plasminogen system and their significance for therapy . Ann Surg 1967; 166: 980-986 .

167.

Mammen EF. Natural proteinase inhibitors in extracorporeal circulation . Ann NY Acad Sci 1968; 146: 754-762 .

168.

169.

Havel M , Teufelsbauer H , Knobl P et al. Effect of intraoperative aprotinin administration on postoperative bleeding in patients undergoing cardiopulmonary bypass operation [see comments] . J Thorac Cardiovasc Surg 1991; 101: 968-972 .

170.

Blauhut B , Gross C , Necek S , Doran JE , Spath P , Lundsgaard-Hansen P. Effects of high-dose aprotinin on blood loss, platelet function, fibrinolysis, complement, and renal function after cardiopulmonary bypass [see comments] . J Thorac Cardiovasc Surg 1991; 101: 958-967 .

171.

Lemmer JH , Stanford W , Bonney SL. Aprotinin for coronary bypass operations: efficacy, safety, and influence on early saphenous vein graft patency. A multicenter, randomised, double-blind, placebo-controlled study . J Thorac Cardiovasc Surg 1994; 107: 543-553 .

172.

Royston D , Bidstrup BP , Taylor KM. Aprotinin (Trasylol) reduces bleeding after open heart surgery in patients taking aspirin and those with renal failure . Anaesthesiology 1989; 71: A6-A6 .

173.

Murkin JM , Lux J , Shannon NA et al. Aprotinin significantly decreases bleeding and transfusion requirements in patients receiving aspirin and undergoing cardiac operations . J Thorac Cardiovasc Surg 1994; 107: 554-561 .

174.

Ray MJ , Marsh NA , Just SJ , Perrin EJ , Hawson GA. Preoperative platelet dysfunction increases the benefit of aprotinin in cardiopulmonary bypass . Ann Thorac Surg 1997; 63: 57-63 .

175.

Cosgrove DM , Heric B , Lytle BW. Aprotinin therapy for preoperative myocardial revascularisation: a placebo controlled study . Ann Thorac Surg 1992; 54: 1031-1038 .

176.

Sundt TM , Kouchoukos NT , Saffitz JE , Murphy SF , Wareing TH , Stahl DJ. Renal dysfunction and intravascular coagulation with aprotinin and hypothermic circulatory arrest [see comments] . Ann Thorac Surg 1993; 55: 1418-1424 .

177.

Royston D. Aprotinin in patients having coronary artery bypass surgery . Curr Opin Cardiol 1995; 10: 591-596 .