Abstract
Xenia Forsselliana 2018
In memory of the founder of Acta Radiologica – Professor Gösta Forsell – the Xenia Forsselliana Prize has been awarded for the best manuscript from one of the five Nordic countries published in the print version in Acta Radiologica that specific year.
After a formal voting procedure, the section editors of Acta Radiologica decided that the Xenia Forsselliana Prize for 2018 should be awarded to Dr. Lars Ploug Boesen (Fig. 1) from Herlev Gentofte University Hospital in Copenhagen, Denmark for his article “Multiparametric MRI in men with clinical suspicion of prostate cancer undergoing repeat biopsy: a prospective comparison with clinical findings and histopathology” (1).
Dr. Lars Ploug Boesen, winner of the Xenia Forsselliana Prize 2018.
Dr. Lars Ploug Boesen was born in 1979 and was educated at and received his MD from the University of Copenhagen in 2006. During 2011–2014, he was clinical assistant/PhD fellow. The University of Copenhagen approved his PhD thesis “Multiparametric MRI in detection and staging of prostate cancer” in 2015. Since 2014, Dr. Lars Ploug Boesen has undergone specialist training in urology at Roskilde Hospital and Herlev Gentofte University Hospital. Dr. Lars Ploug Boesen has published 12 articles – all as main author.
The purpose of his prize-winning paper was to compare multiparametric magnetic resonance imaging (MRI) score subgroups to systematic transrectal ultrasound-guided biopsies and prostate-specific antigen-based findings for detection of clinically significant prostate cancer in men undergoing repeat biopsies. Prostate cancer was detected in 128/289 patients (44%) with median age, prostate-specific antigen, and prior negative ultrasound-guided biopsy of 64 years, 12.0 ng/mL, and two, respectively. Ultrasound-guided biopsy detected prostate cancer in 108/289 (37%) patients of which 49 (45%) had insignificant cancer. MRI targeted biopsy was performed in 271/289 (94%) patients and detected prostate cancer in 96 (35%) patients, with 78 (81%) having clinically significant prostate cancer. Multiparametric MRI scores showed a high association between suspicion level and biopsy results on both lesion and patient levels. Multiparametric MRI was better than prostate-specific antigen and prostate-specific antigen density in identifying patients with missed clinically significant prostate cancer. In total, 50% of the 128 patients underwent radical prostatectomy; 60/64 had clinically significant prostate cancer. Multiparametric MRI was significantly better in predicting clinically significant prostate cancer on radical prostatectomy compared with ultrasound-guided biopsy.
In conclusion, multiparametric MRI improves the detection of missed clinically significant prostate cancer and suspicion scores correlate well with biopsy and radical prostatectomy results on both patient and lesion level.
The Prize consists of SEK 40,000 and a diploma. The official presentation of the Prize will take place during the Nordic Congress of Radiology in Copenhagen at the Acta Radiologica Award Session on Thursday 23rd May 2019 at 1:30 PM. The manuscript will be presented orally during the Acta Radiologica Award Session.
The Editorial Board congratulates Dr. Lars Ploug Boesen for winning the 2018 Xenia Forsselliana Prize.
International Scientific Prize 2018
In 2016, the Board of the Acta Radiologica Foundation decided that an international prize should be awarded annually for the best scientific manuscript for a non-Nordic country, consisting of a diploma and SEK 40,000.
After a formal voting procedure, the section editors of Acta Radiologica decided that the Acta Radiologica International Prize 2018 should be awarded to Dr. Keith Craig Godley (Fig. 2) from Norfolk and Norwich University Hospitals in the UK for his article “Accuracy of high b-value diffusion-weighted MRI for prostate cancer detection: a meta-analysis” (2).
Dr. Keith Craig Godley, winner of the Acta Radiologica International Scientific Prize 2018.
Dr. Keith Craig Godley was born in 1985 in the UK and got his MD at the University of Edinburgh in 2009. He underwent specialty training in clinical radiology in the Norfolk and Norwich Training Programme during 2012–2018.
Dr. Keith Craig Godley has authored/co-authored nine papers in peer-reviewed journals.
The purpose of the prize-winning paper was to determine the diagnostic performance of high b-value diffusion-weighted imaging (DWI) at detecting prostate cancer and whether quantifying the apparent diffusion coefficient improves accuracy.
A comprehensive literature search of published and unpublished databases was performed. Eligible studies had histopathology proven prostate cancer, DWI sequences using b-values ≥ 1000 s/mm2, > 10 patients, and data for creating a 2 × 2 table. Study quality was assessed with Quality Assessment of Diagnostic Accuracy Studies.
Ten studies met the eligibility criteria with 13 subsets of data available for analysis, including 522 patients. Pooled sensitivity and specificity were 0.59 and 0.92, respectively. The summary receiver operating characteristic curve area under the curve was 0.92. Subgroup analysis showed a statistically significant improvement in accuracy when using tumor visual assessment rather than the apparent diffusion coefficient (ADC).
It was concluded that high b-value DWI gives a good diagnostic performance for prostate cancer detection and visual assessment of tumor diffusion is significantly more accurate than region of interest measurements of the ADC.
The Prize consists of SEK 40,000 and a diploma. The official presentation of the Prize will take place during the Nordic Congress of Radiology in Copenhagen at the Acta Radiologica Award Session on Thursday 23rd May 2019 at 1:30 PM. The manuscript will be presented orally during the Acta Radiologica Award Session.
The Editorial Board congratulates Dr. Keith Craig Godley for winning the 2018 International Scientific Prize.