Effects of Orally Administered 5-Fluorouracil and Its Derivative 5′-Deoxy-5-fluorouridine on 7,12-Dimethylbenz[β]Anthracene-Induced Breast Carcinomas in Rats
Restricted accessResearch articleFirst published online May, 1991
Effects of Orally Administered 5-Fluorouracil and Its Derivative 5′-Deoxy-5-fluorouridine on 7,12-Dimethylbenz[β]Anthracene-Induced Breast Carcinomas in Rats
Antitumour activity of 20 mg/kg 5-fluorouracil (5-FU) and 100 or 200 mg/kg 5′-deoxy-5-fluorouridine (5′-DFUR) was assessed by tumour regression, light and electron microscopic changes, and immunohistochemical variations in broxuridine labelling in 7,12-dimethylbenz[β]anthracene- (DMBA-) induced breast carcinomas in rats. The relative regression of tumours was significantly (P < 0.05) greater in animals receiving 5-FU or 5′-DFUR than in control animals. Light microscopic changes became apparent after 3 or 4 days' treatment and were more evident after 4–21 days. Electron microscopic degeneration of tumours was observed after 1 day. The broxuridine labelling index decreased significantly (P < 0.05) in rats receiving 5-FU and especially in those receiving 5′-DFUR. Concentrations of 5-FU in DMB A-induced breast carcinomas were significantly (P < 0.05) higher in rats treated with 5′-DFUR than in those treated with 5-FU, and the histological degeneration was significantly (P < 0.05) more advanced in 5′-DFUR-than in 5-FU-treated animals, possibly due to the higher pyrimidine nucleoside phosphorylase activity in the former treatment group.
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