Cadherins and Integrins in Renal Cell Carcinoma an Immunohistochemical Study

Albelda S.M. : Biology of disease. Role of integrins and other cell adhesion molecules in tumor progression and metastasis. Lab Invest, 68: 4–19, 1993.

Yap A.S. , Brieher W.M. , Gumbiner B.M. : Molecular and functional analysis of cadherin-based adherens junctions. Annu Rev Cell Dev Biol, 13: 119–146, 1997.

Chothia C. , Jones Y.E. : The molecular structure of cell adhesion molecules. Annu Rev Biochem, 66: 823–862, 1997.

Müller G.A. , Müller C.A. , Markovic-Lipkovski J. : Adhesion molecules in renal diseases. Renal Failure, 18: 711–724, 1996.

Breviario F. , Caveda L. , Corada M. , Martin-Padura I. , Navarro P. , Golay J. , Inrtrona M. , Gulino D. , Lampugnani M.G. , Dejana E. : Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin. Arterioscler Thromb Vasc Biol, 15: 1229–1239, 1995.

Rasbridge S.A. , Gillett C.E. , Sampson S.A. , Walsh F.S. , Millis R.R. : Epithelial (E-) and placental (P-) cadherin cell adhesion molecule expression in breast carcinoma. J Pathol, 169: 245–250, 1993.

Schipper J.H. , Frixen U.H. , Behrens J. , Unger A. , Jahnke K. , Birchmeier W. : E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor differentiation and lymph node metastasis. Cancer Res, 51: 6328–6337, 1991.

Washington K. , Chiappori A. , Hamilton K. , Shyr Y. , Blanke C. , Johnson D. , Sawyers J. , Beauchamp D. : Expression of β-catenin, α-catenin, and E-cadherin in Barret's esophagus and esophageal adenocarcinomas. Mod Pathol, 11: 805–813, 1998.

Ruijter E. , van den Kaa C. , Aalders T. , Ruiter D. , Miller G. , De-bruyne F. , Schalken J. : Heterogeneous expression of E-cadherin and p53 in prostate cancer: clinical implications. Mod Pathol, 11: 276–281, 1998.

Hidaka N. , Nagao T. , Asoh A. , Kondo Y. , Nagao K. : Expression of E-cadherin, α-catenin, β-catenin, and γ-catenin in bronchioloalveolar carcinoma and conventional pulmonary adenocarcinoma: an immunohistochemical study. Mod Pathol, 11: 1039–1045, 1998.

Terpe H.J. , Tajrobehkar K. , Günthert U. , Altmannsberger M. : Expression of cell adhesion molecules alpha-2, alpha-5 and alpha-6 integrin, E-cadherin, N-CAM and CD44 in renal cell carcinomas. Virchows Archiv A Pathol Anat, 422: 219–224, 1993.

Shimazui T. , Giroldi L.A. , Briguier P.P. , Oosterwijk E. , Schalken J.A. : Complex cadherin expression in renal cell carcinoma. Cancer Res, 56: 3324–3337, 1996.

Shimazui T. , Oosterwijk E. , Akaza H. , Briguier P.P. , Ruijter E. , van Berkel H. , Oosterwijk Wakka J. , van Bokhoven A. , De-bruyne F.M.J. , Schalken J.A. : Expression of cadherin-6 as a novel diagnostic tool to predict prognosis in patients with E-cadherin-absent renal cell carcinoma. Clin Cancer Res, 4: 2419–2424, 1998.

Tani T. , Laitinen L. , Kangas L. , Lehto V.P. , Virtanen I. : Expression of E- and N-cadherin in renal cell carcinomas, in renal cell carcinoma cell lines in vitro and in their xenografts. Int J Cancer, 64: 407–414, 1995.

Fleming S. : Cell adhesion and epithelial differentiation. J Pathol, 164: 95–100, 1991.

Tomita Y. , Saito T. , Saito K. , Oite T. , Shimizu F. , Sato S. : Possible significance of VLA-4 (α4β1) for hematogenous metastasis of renal-cell cancer. Int J Cancer, 60: 753–758, 1995.

Korhonen M. , Laitinen L. , Ylänne J. , Gould V.E. , Virtanen I. : Integrins in developing, normal and malignant human kidney. Kidney Int, 41: 641–644, 1992.

Korhonen M. , Laitinen L. , Ylänne J. , Koukoulis G.K. , Quaranta V. , Juusela H. , Gould V.E. , Virtanen I. : Integrin distribution in renal cell carcinomas of various grades of malignancy. Am J Pathol, 141: 1161–1171, 1992.

Droz D. , Patey N. , Paraf F. , Chretien Y. , Gogusev J. : Composition of extracellular matrix and distribution of cell adhesion molecules in renal cell tumors. Lab Invest, 71: 710–718, 1994.

Rahilly M.A. , Salter D.M. , Fleming S. : Composition and organization of cell-substratum contacts in normal and neoplastic renal epithelium. J Pathol, 165: 163–171, 1991.

Mostofi F.K. , Davis C.J. (Eds): Histological typing of kidney tumours, 2nd ed., Springer Verlag, Berlin, 1998.

Sobin L.H. , Wittekind C. (Eds): TNM classification of malignant tumours, 5th ed, John Wiley and Sons, New York, 1997.

Taki A. , Nakatani Y. , Misugi K. , Yao M. , Nagashima Y. : Chromophobe renal cell carcinoma: an immunohistochemical study of 21 Japanese cases. Mod Pathol, 12: 310–317, 1999.

Birchmeier W. , Hiilsken J. , Behrens J. E-cadherin as an invasion suppressor. Ciba Found Symp, 189: 124–141, 1995.

Wodarz A. , Nusse R. : Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol, 14: 59–88, 1998.

O'Donnell M. , Fleming S. : Disruption of cell adhesion in renal epithelium without cadherin loss. J Pathol, 175: 45–50, 1995.

Oyama T. , Kanai Y. , Ochiai A. , Akimoto S. , Oda T. , Yanagihara K. , Nagafuchi A. , Tsukita S. , Schibamoto S. , Ito F. , TakeicHi M. , Matsuda H. , Hirohashi S. : A truncated β-catenin disrupts the interaction between E-cadherin and α-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines. Cancer Res, 54: 6282–6287, 1994.

Hirohashi S. : Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol, 153: 333–339, 1998.

Makrigiannakis A. , Coukos G. , Christofidou-Solomidou M. , Gour B.J. , Radice G.L. , Blaschuk O. , Coutifaris C. : N-cadherin-mediated human granulosa cell adhesion prevents apoptosis. A role in follicular atresia and luteolysis? Am J Pathol, 154: 1391–1406, 1999.

Seftor R.E.B. : Role of the β₃ integrin subunit in human primary melanoma progression. Multifunctional activities associated with (α_vβ₃ integrin expression. Am J Pathol, 153: 1347–1351, 1998.

Varner J.A. , Cheresh D.A. : Integrins and cancer. Curr Opin Cell Biol, 8: 724–730, 1996.

Bartolazzi A. , Cerboni C. , Nicotra M.R. , Mottolese M. , Bigotti A. , Natali P.G. : Transformation and tumor progression are frequently associated with expression of the alpha3/betal het-erodimer in solid tumors. Int J Cancer, 58: 488–491, 1994.

Shaw L.M. , Rabinovitz I. , Wang H.H. , Toker A. , Mercurio A.M. : Activation of phosphoinositide 3-OH kinase by the alpha6be-ta4 integrin promotes carcinoma invasion. Cell, 91: 949–960, 1997.

Weaver V.M. , Petersen O.W. , Wang F. , Larabell C.A. , Briand P. , Damsky C. , Bissell M.J. : Reversion of the malignant pheno-type of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol, 137: 231–245, 1997.

Huttenlocher A. , Lakonishok M. , Kinder M. , Wu S. , Truong T. , Knudsen K.A. , Horwitz A.F. : Integrin and cadherin synergy regulates contact inhibition of migration and motile activity. J Cell Biol, 141: 515–526, 1998.