Vitamin C and E as Antioxidants in Hemodialysis Patients

Halliwell B. , Gutteridge J.M.C. , Cross C.E. Free radicals, antioxidants, and human disease: where are we now? J Lab Clin Med 1992; 119: 598–620.

Knight J.A. Diseases related to oxygen-derived free radicals. Ann Clin Lab Sci 1995; 25: 111–21.

Roselaar S.E. , Nazhat N.B. , Winyard P.G. , Jones P. , Cunningham J. , Blake D.R. Detection of oxidants in uremic plasma by electron spin resonance spectroscopy. Kidney Int 1995; 48: 199–206.

Westhuyzen J. , Adams C.E. , Fleming S.J. Evidence for oxidative stress during in vitro dialysis. Nephron 1995; 70: 49–54.

Himmelfarb J. , Lazarus J.M. , Hakim R. Reactive oxygen species production by monocytes and polymorphonuclear leukocytes during dialysis. Am J Kidney Dis 1991; 17: 271–6.

Himmelfarb J. , Ault K.A. , Holbrook D. , Leeber D.A. , Hakim R.M. Intradialytic granulocyte reactive oxygen species production: a prospective, crossover trial. J Am Soc Nephrol 1993; 4: 178–86.

Epperlein M.M. , Nourooz-Zadeh J. , Jayasena S.D. , Hothersall J.S. , Noronha-Dutra A. , Neild G.H. Nature and biological significance of free radicals generated during bicarbonate hemodialysis. J Am Soc Nephrol 1998; 9: 457–63.

Richard M.J. , Arnaud J. , Jurkovitz C. Trace elements and lipid peroxidation abnormalities in patients with chronic renal failure. Nephron 1991; 57: 10–5.

Loughrey C.M. , Young I.S. , Lightbody J.H. , McMaster D. , McNamee P.T. , Trimble E.R. Oxidative stress in haemodialysis. Q J Med 1994; 87: 679–83.

Haklar G. , Yegenaga I. , Yalcin A.S. Evaluation of oxidant stress in chronic hemodialysis patients: use of different parameters. Clin Chim Acta 1995; 234: 109–14.

Jackson P. , Loughrey C.M. , Lightbody J.H. , McNamee P.T. , Young I.S. Effect of hemodialysis on total antioxidant capacity and serum antioxidants in patients with chronic renal failure. Clin Chem 1995; 41: 1135–8.

Daschner M. , Lenhartz H. , Bötticher D. Influence of dialysis on plasma lipid peroxidation products and antioxidant levels. Kidney Int 1996; 50: 1268–72.

Antos M. , Jeren-Strujic B. , Raos V. , Romic Z. , Matanovic B. Evidence of antioxidant role of vitamin C in chronic hemodialysis patients. Trace Elem Electrolytes 1997; 14: 159–61.

Koenig J.S. , Fischer M. , Bulant E. , Tiran B. , Elmadfa I. , Druml W. Antioxidant status in patients on chronic hemodialysis therapy: impact of parenteral selenium supplementation. Wien Klin Wochenschr 1997; 109: 13–9.

Giardini O. , Taccone-Gallucci M. , Lubrano R. Effects of alpha-tocopherol administration on red blood cell membrane lipid peroxidation in hemodialysis patients. Clin Nephrol 1984; 21: 174–7.

Giardini O. , Taccone-Gallucci M. , Lubrano R. Evidence of red blood cell membrane lipid peroxidation in haemodialysis patients. Nephron 1984; 36: 235–7.

Nenov D. , Paskalev D. , Yankova T. , Tchankova P. Lipid peroxidation and vitamin E in red blood cells and plasma in hemodialysis patients under rhEPO treatment. Int Artif Organs 1995; 19: 436–9.

Taccone-Gallucci M. , Lubrano R. , Del Principe D. Platelet lipid peroxidation in haemodialysis patients: effects of vitamin E supplementation. Nephrol Dial Transplant 1989; 4: 975–8.

Esterbauer H. , Schaur R.J. , Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991; 11: 81–128.

Gotoh M. , Nagase S. , Aoyagi K. Thiobarbituric acid reactive substances are increased in the subcutaneous fat tissue of patients with end-stage renal disease. Nephrol Dial Transplant 1997; 12: 713–7.

Taccone-Gallucci M. , Lubrano R. , Belli A. Lack of oxidative damage in serum polyunsaturated fatty acids before and after dialysis in chronic uremic patients. Int J Artif Organs 1989; 12: 515–8.

McGrath L.T. , Douglas A.F. , McClean E. , Brown J.H. , Doherty C.C. , Johnston G.D. , Archbold G.P.R. Oxidative stress and erythrocyte membrane fluidity in patients undergoing regular dialysis. Clin Chim Acta 1995; 235: 179–88.

Delmas-Beauvieux M-C , Combe C. , Peuchant E. Evaluation of red blood cell lipoperoxidation in hemodialysed patients during erythropoietin therapy supplemented or not with iron. Nephron 1995; 69: 404–10.

Hultqvist M. , Hegbrant J. , Nilsson-Thorell C. Plasma concentrations of vitamin C, vitamin E and/or malondialdehyde as markers of oxygen free radical production during hemodialysis. Clin Nephrol 1997; 47: 37–46.

Biasioli S. , Schiavon R. , De Fanti E. , Cavalcanti G. , Giavarina D. The role of erythrocytes in the deperoxidative processes in people on hemodialysis. ASAIO J 1996; 42: M890–4.

Witko-Sarsat V. , Friedlander M. , Capeillère-Blandin C. Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int 1996; 49: 1304–13.

Kuroda M. , Asaka S. , Tofuku Y. , Takeda R. Serum antioxidant activity in uremic patients. Nephron 1985; 41: 293–8.

Nagase S. , Aoyagi K. , Hirayama A. Decreased serum antioxidant activity of hemodialysis patients demonstrated by methylguanidine synthesis and microsomal lipid peroxidation. Nephron 1996; 74: 555–60.

Dasgupta A. , Malhotra D. , Levy H. , Marcadis D. , Blackwell W. , Johnston D. Decreased total antioxidant capacity but normal lipid hydroperoxide concentrations in sera of critically ill patients. Life Sci 1997; 60: 335–40.

Nagase S. , Aoyagi K. , Hirayama A. Favorable effect of hemodialysis on decreased serum antioxidant activity in hemodialysis patients demonstrated by electron spin resonance. J Am Soc Nephrol 1997; 8: 1157–63.

Paul J.L. , Sall N.D. , Soni T. Lipid peroxidation abnormalities in hemodialyzed patients. Nephron 1993; 64: 106–9.

Durak I. , Akyol Ö , Basesme E. , Canbolat O. , Kavutcu M. Reduced erythrocyte defense mechanisms against free radical toxicity in patients with chronic renal failure. Nephron 1994; 66: 76–80.

Yoshimura S. , Suemizu H. , Nomoto Y. Plasma glutathione peroxidase deficiency caused by renal dysfunction. Nephron 1996; 73: 207–11.

Zima T. , Stipek S. , Crkovská J. Antioxidant enzymes - superoxide dismutase and glutathione peroxidase - in haemodialyzed patients. Blood Purif 1996; 14: 257–61.

Burton G.W. Vitamin E: molecular and biological function. Proc Nutr Soc 1994; 53: 251–62.

Sauberlich H.E. Pharmacology of vitamin C. Annu Rev Nutr 1994; 14: 371–91.

Jacob R.A. The integrated antioxidant system. Nutr Res 1995; 15: 755–66.

Meydani M. Vitamin E. Lancet 1995; 345: 170–5.

Frei B. , England L. , Ames B.N. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA 1989; 86: 6377–81.

Ono K. Effects of large dose vitamin E supplementation on anemia in hemodialysis patients. Nephron 1985; 40: 440–5.

Pastor M.C. , Sierra C. , Bonal J. , Teixidó J. Serum and erythrocyte tocopherol in uremic patients: effect of hemodialysis versus peritoneal dialysis. Am J Nephrol 1993; 13: 238–43.

Ha T.K.K. , Sattar N. , Talwar D. Abnormal antioxidant vitamin and carotenoid status in chronic renal failure. Q J Med 1996; 89: 765–9.

Zima T. , Janebová M. , Nemecek K. , Bártová V. Retinol and α-tocopherol in hemodialysis patients. Ren Fail 1998; 20: 505–12.

Peuchant E. , Carbonneau M-A , Dubourg L. Lipoperoxidation in plasma and red blood cells of patients undergoing hemodialysis: vitamins A, E, and iron status. Free Radic Biol Med 16; 339–46.

Triolo L. , Lippa S. , Oradei A. , De Sole P. , Mori R. Serum coenzyme Q1O in uremic patients on chronic hemodialysis. Nephron 1994; 66: 153–6.

Panzetta O. , Cominacini L. , Garbin U. Increased susceptibility of LDL to in vitro oxidation in patients on maintenance hemodialysis: effects of fish oil and vitamin E administration. Clin Nephrol 1995; 44: 303–9.

Stein G. , Sperschneider H. , Koppe S. Vitamin levels in chronic renal failure and need for supplementation. Blood Purif 1985; 3: 52–62.

Miyata T. , Wada Y. , Cai Z. Implication of an increased oxidative stress in the formation of advanced glycation end products in patients with end-stage renal failure. Kidney Int 1997; 51: 1170–81.

Sullivan J.F. , Eisenstein A.B. Ascorbic acid depletion in patients undergoing chronic hemodialysis. Am J Clin Nutr 1970; 23: 1339–46.

Sullivan J.F. , Eisenstein A.B. , Mottola O.M. , Mittal A.K. The effect of dialysis on plasma and tissue levels of vitamin C. Trans Am Soc Artif Intern Organs 1972; 18: 277–82.

Washko P.W. , Welch R.W. , Dhariwal K.R. , Wang Y. , Levine M. Ascorbic acid and dehydroascorbic acid analyses in biological samples. Anal Biochem 1992; 204: 1–14.

Rose R.C. Transport of ascorbic acid and other water-soluble vitamins. Biochim Biophys Acta 1988; 947: 335–66.

Hercberg S. , Preziosi P. , Galan P. Vitamin status of a healthy French population: dietary intake and biochemical markers. Int J Vitam Nutr Res 1994; 64: 220–32.

Hallfrisch J. , Muller D.C. , Singh V.N. Vitamin A and E intakes and plasma concentrations of retinol, ß-carotene, and α-tocopherol in men and women of the Baltimore Longitudinal Study of Aging. Am J Clin Nutr 1994; 60: 176–82.

Becker B.N. , Himmelfarb J. , Henrich W.L. , Hakim R.M. Reassessing the cardiac risk profile in chronic hemodialysis patients: a hypothesis on the role of oxidant stress and other non-traditional cardiac risk factors. J Am Soc Nephrol 1997; 8: 476–86.

Galle J. , Wanner C. Oxidative stress and vascular injury - relevant for atherogenesis in uraemic patients? Nephrol Dial Transplant 1997; 12: 2480–3.

Givertz M.M. , Colucci W.S. New targets for heart-failure therapy: endothelin, inflammatory cytokines, and oxidative stress. Lancet 1998; 352(suppl. I): S34–8.

Makoff R. Water-soluble vitamin status in patients with renal disease treated with hemodialysis or peritoneal dialysis. J Ren Nutr 1991; 1: 56–73.

Makoff R. Vitamin supplementation in patients with renal disease. Dial Transplant 1992; 21: 18–24+36.

Descombes E. , Hanck A.B. , Fellay G. Water soluble vitamins in chronic hemodialysis patients and need for supplementation. Kidney Int 1993; 43: 1319–28.

Devine W. Review of nutritional status and diet in dialysis and renal transplant patients. Dial Transplant 1994; 23: 38–41+47–8.

Pru C. , Eaton J. , Kjellstrand C. Vitamin C intoxication and hyperoxalemia in chronic hemodialysis patients. Nephron 1985; 39: 112–6.

Wolfson M. Use of water-soluble vitamins in patients with chronic renal failure. Semin Dial 1988: 1: 28–32.

Ono K. Secondary hyperoxalemia caused by vitamin C supplementation in regular hemodialysis patients. Clin Nephrol 1986; 26: 239–43.

Ono K. The effect of vitamin C supplementation and withdrawal on the mortality and morbidity of regular hemodialysis patients. Clin Nephrol 1989; 31: 31–4.

Maiani G. , Azzini E. , Ferro-Luzzi A. Vitamin C. Int J Vitam Nutr Res 1993; 63: 289–95.

Yalcin A.S. , Yurtkuran M. , Dilek K. , Kilinc A. , Taga Y. , Emerk K. The effect of vitamin E therapy on plasma and erythrocyte lipid peroxidation in chronic hemodialysis patients. Clin Chim Acta 1989; 185: 109–12.

Gilmour E.R. , Hartley G.H. , Goodship T.H.J. Trace elements and vitamins in renal disease. In: Mitch W.E. , Klahr S. , eds. Nutrition and the kidney. 2nd ed. Boston: Little, Brown and Company, 1993; 114–31.

Buoncristiani U. , Galli F. , Rovidati S. , Albertini M.C. , Campus G. , Canestrari F. Oxidative damage during hemodialysis using a vitamin E-modified dialysis membrane: a preliminary characterization. Nephron 1997; 77: 57–61.

Galli F. , Rovidati S. , Chiarantini L. , Campus G. , Canestrari F. , Buoncristiani U. Bioreactivity and biocompatibility of a vitamin E-modified multilayer hemodialysis filter. Kidney Int 1998; 54: 580–9.