Neurologic complications are common in children with cancer, but the literature dealing with this subject is sparse. Using a symptoms and signs approach, the most common causes for requesting a neurologic evaluation for this population are reviewed. The spectrum of neurologic symptoms in children with cancer differs from adults and requires the consulting neurologist to have a thorough knowledge of childhood cancer and its effects on the nervous system. (J Child Neurol 2000;15:705-716).
References
1.
Posner JB: Neurologic Complications of Cancer. Philadelphia ; FA Davis, 1995.
2.
Antunes NL, DeAngelis LM: Neurological consultations in children with cancer. Pediatr Neurol1999;20:121-124.
3.
Clouston PD, De Angelis LM, Posner JB: The spectrum of neurologic disease in patients with systemic cancer . Ann Neurol1992; 31:268-273.
4.
Antunes NL: Headache in children with cancer, abstract. Neuro- Oncology1999;1:296.
Wee LH, Lam F., Cranston AJ: The incidence of postdural puncture headache in children. Anaesthesia1996;51:1164-1166.
7.
Sharma A.: Most doctors are unaware of features of headache after lumbar puncture, letter . BMJ1998;307:1588A.
8.
Pannullo SC, Reich JB, Krol G., et al: MRI changes in intracranial hypotension. Neurology1993;43:919-926.
9.
Vos PE, de Boer WA, Wurzer JA, Van Gijn J.: Subdural hematoma after lumbar puncture: two case reports and review of the literature. Clin Neurol Neurosurg1991 ;93:127-132.
10.
Geiser CF, Bishop Y., Jaffe N., et al: Adverse effects of intrathecal methotrexate in children with acute leukemia in remission. Blood1975;45:189-195.
Gower DJ, Baker AL, Bell Wo, Ball MR: Contraindication to lumbar puncture as defmed by computed cranial tomography. J Neurol Neurosurg Psychiatr1987;50:1071-1074.
13.
Rennick G., Shann F., de Campo J.: Cerebral herniation during bacterial meningitis in children. BMJ1993;306:953-955.
14.
Sinniah D., Looi LM, Ortega JA, et al: Cerebellar coning and uncal herniation in childhood acute leukaemia . Lancet1982;2:702-704.
15.
van den Berg H., Gerritsen EJ, Haraldsson A., Vossen JM: Changes in cell and protein content of cerebrospinal fluid in children with acute lymphoblastic leukaemia after allogeneic bone marrow transplantation. Bone Marrow Transplant1993;12:615-619.
16.
Flasshove M. , Schutte HJ, Kellner R., et al: Meningeal fluid granulocytosis after cytarabine, letter. Eur J Cancer1992;28:243.
17.
Fennelly M. , Galletly DC, Purdie GI: Is caffeine withdrawal the mechanism of postoperative headache? Anesth Analg1991;72: 449-453.
18.
Arbeit ML, Nicklas TA, Franck GC, et al: Caffeine intakes from a biracial population: the Bogalusa Heart Study. J Am Diet Assoc1988;88:466-471.
19.
Tramer MR, Reynolds DJ, Stoner NS, et al: Efficacy of 5-HT3 receptor antagonists in radiotherapy-induced nausea and vomiting: A quantitative systematic review. Eur J Cancer1998;34: 1836-1844.
20.
Acharya S., Antunes NL, Finlay J., et al: Intracranial metastases in pediatric solid tumors, abstract . Childs Nerv Syst1998;14:521.
21.
Antunes NL, Subramanian H., DeAngelis LM: Brain abscesses in children with cancer. Med Pediatr Oncol1998;31:19-21.
22.
Hagensee ME , Bauwens JE, Kjos B., Bowden RA: Brain abscess following marrow transplantation: Experience at the Fred Hutchinson Cancer Research Center, 1984-92. Clin Infect Dis1994;19: 402-408.
23.
Mampalam TJ , Rosenblum ML: Trends in the management of bacterial brain abscess: A review of 102 cases over 17 years. Neurosurgery1988;23:451-458.
24.
Nielsen H.: Cerebral abscess in children. Neuropediatrics1983;14: 76-80.
25.
Chun CH, Johnson JD, Hofstetter M., Raff MJ: Brain abscess: A study of 45 consecutive cases. Medicine1986;65:415-431.
26.
Yildizhan A. , Pasaoglu A., Kandemir B.: Effect of dexamethasone on various stages of experimental brain abscess. Acta Neurochir ( Wien) 1989;96:141-148.
27.
Choen N., Strauss G., Lew R., et al: Should prophylactic anticonvulsants be administered to patients with newly-diagnosed cerebral metastases? A retrospective analysis. J Clin Oncol1988;6: 1621-1624.
28.
Freifeld AG, Walsh TJ, Pizzo PA: Infectious complications in the pediatric cancer patient, in Pizzo PA, Poplack DG (eds): Principles and Practice of Pediatric Oncology, 3rd ed. Philadelphia , Lippincott-Raven, 1997, 1069-1113.
29.
Hooper DC, Pruitt AA, Rubin RH: Central nervous system infection in the chronically immunosuppressed . Medicine1982;61: 166-185.
30.
Just M., Kramer G., Higer HP, et al: MRI of Lysteria rhombencephalitis. Neuroradiology1987;29:401-402.
31.
Lentz D., Jordan JE, Bruce P., Enzmann DR: MRI in varicella-zoster leukoencephalitis in the immunocompromised host. J Comput Assist Tomogr1993;17:313-316.
Finelli PF: Images in neurology: Mass effect in progressive multifocal leukoencephalopathy . Arch Neurol1998;55:1148.
37.
Jourdan E., Dombret H., Glaisner S., et al: Unexpected high incidence of intracranial subdural haematoma during intensive chemotherapy for acute myeloid leukaemia with a monoblastic component. Br J Haematol1995;89:527-530.
38.
Pitner SE, Warren WJ: Chronic subdural hematoma in childhood acute leukemia. Cancer1973;32:185-190.
39.
Pomeranz S. , Naparstek E., Ashkenazi E., et al: Intracranial haematomas following bone marrow transplantation. J Neurol1994 ;241:252-256.
40.
Staudinger T., Heimberger K., Rabitsch W., et al: Subdural hygromas after bone marrow transplantation: Results of a prospective study. Transplantation1998;65:1340-1344.
41.
Ochs JJ, Bowman WP, Pui CH, et al: Seizures in childhood lymphoblastic leukaemia patients. Lancet1984;2:1422-1424.
42.
Maytal J., Grossman R., Yusuf FH, et al: Prognosis and treatment of seizures in children with acute lymphoblastic leukemia. Epitepsia1995;36:831-836.
43.
Pannullo SC , Posner JB: Seizures after bone marrow transplant, abstract . Ann Neurol1992;32:287.
44.
Norrby SR: Neurotoxicity of carbapenem antibacterials. Drug Saf1996;15:87-90.
Dillard ML, Fink RM, Parkerson R.: Ciprofloxacilin-phenytoin interaction, letter. Ann Pharmacother1992;26:263.
47.
Gillman MA, Sandyk R.: Phenytoin toxicity and co-trimoxazole. Ann Intern Med1985;102:559.
48.
Bartle WR, Walker SE, Shapero T.: Dose-dependent effect of cimetidine on phenytoin kinetics. Clin Pharmacol Ther1983;33:649-655.
49.
Fetell MR, Grossman SA, Fisher JD, et al: Preirradiation paclitaxel in glioblastoma multiforme: Efficacy, pharmacology, and drug interactions. New Approaches to Brain Tumor Therapy Central Nervous System Consortium. J Clin Oncol1997 ; 15: 3121-3128.
50.
Freeman DJ, Laupacis A., Keown PA, et al: Evaluation of cyclosporin-phenytoin interaction with observations on cyclosporin metabolites. Br J Clin Phannacol1984; 18:87-93.
Wamer EG: Gabapentin for seizure control in organ transplant recipients, letter . J Heart Lung Transplant1995;14:1011.
53.
Loiseau P.: Treatment of concomitant illnesses in patients receiving anticonvulsants: Drug interactions of clinical significance. Drug Saf1998;19:495-510.
54.
Hinchey J., Chaves C., Appignani B., et al: A reversible posterior leukoencephalopathy syndrome. N Engl J Med1996;334:494-500.
McDonald JW , Goldberg MP, Gwag BJ, et al: Cyclosporine induces apoptosis and selective oligodendrocyte death in cortical cultures . Ann Neurol1996;40:750-758.
57.
Sheth RD, Bodensteiner JB, Riggs JE, et al: Parietal occipital edema in hypertensive encephalopathy: A pathogenic mechanism. Eur Neurol1996;36:2.5-28.
58.
Schwartz RB, Bravo SM, Klufas RA, et al. Cyclosporine neurotoxicity and its relationship to hypertensive encephalopathy: CT and MRI findings. AJR Am J Roentgenol1995; 165:627-63 1.
59.
Antunes NL, Small TN, George D., et al: Posterior leukoencephalopathy may not be reversible. Pediatr Neurol1999;20: 241-243.
60.
Ay H., Buonanno FS, Schaefer PW, et al: Posterior leukoencephalopathy without severe hypertension: Utility of diffusion-weighted MRI. Neurology1998;51:1369-1376.
61.
Small SL, Fukui MB, Brablett GT, Eidelman BH: Immunosuppression-induced leukoencephalopathy from tacrolimus (FK506) . Ann Neurol1996;40:575-580.
62.
Gleeson JG, duPlessis AJ, Barnes PD, Riviello JJ Jr: Cyclosporin A acute encephalopathy and seizure syndrome in childhood: Clinical features and risk of seizure recurrence. J Child Neurol1998; 13:336-344.
63.
Meloni G., Nasta L., Pinto RM, et al: Clonazepam prophylaxis and busulfan-related myoclonic epilepsy in autografted acute leukemia patients. Haematologica1995;80:532-534.
64.
Hassam M., Oberg G., Bjorkholm M., et al: Incidence of prophylactic anticonvulsant therapy on high-dose busulfan kinetics. Cancer Chemother Pharmacol1993;33:181-186.
65.
Hurwitz RL, Mahoney DH, Armstrong DL, Browder TM: Reversible encephalopathy and seizures as a result of conventional vincristine administration. Med Pediatr Oncol1988; 16:216-219.
66.
Johnson FL, Bernstein ID, Hartmann JR, Chard RLJr: Seizures associated with vincristine sulfate therapy. J Pediatr1973;82: 699-702.
67.
Bhardwaj A. , Badesha PS: Ifosfamide-induced nonconvulsive status epilepticus . Ann Pharmacother1995 ;29:137-139.
68.
Mead GM, Arnold AM, Gren JA, et al: Epileptic seizures associated with cisplatin administration . Cancer Treat Rep1982;66: 1719-1722.
DiMario FJ Jr, Packer RJ: Acute mental status changes in children with systemic cancer. Pediatrics1990;85:353-360.
71.
McCarthy GM , Skillings JR: Jaw and other orofacial pain in patients receiving vincristine for the treatment of cancer. Oral Surg Oral Med Oral Pathol1992;74:299-304.
72.
Haim N., Barron SA, Robinson E.: Muscle cramps associated with vincristine therapy. Acta Oncol1991;30:707-711.
73.
Vial T., Descotes J.: Clinical toxicity of cytokines used as haemopoietic growth factors . Drug Saf1995; 13:371-406.
74.
Steinlin M. , Eich G., Huisman T., Bolthauser E.: Back pain in children: Symptoms which should be taken seriously. Schweiz Med Wochenschr1996;126:1358-1364.
75.
Payne WK III, Ogilvie JW: Back pain in children and adolescents. Pediatr Clin North Am1996;43:899-917.
76.
Cabral DA, Tucker LB: Malignancies in children that initially present with rheumatic complaints . J Pediatr1999;134:53-57.
Sanderson IR , Pritchard J., Marsh HT: Chemotherapy as the initial treatment of spinal cord compression due to disseminated neuroblastoma . J Neurosurg1989;70:688-690.
79.
Plantaz D., Rubie H., Michon J., et al: The treatment of neuroblastoma with intraspinal extension with chemotherapy followed by surgical removal of residual disease. Cancer1996;78:311-319.
80.
Lewis DW, Packer RJ, Raney B., et al: Incidence, presentation and outcome of spinal cord disease in children with systemic cancer. Pediatrics1986;78:438-443.
81.
Hall RC, Popkin MK, Stickney SK, Gardner ER: Presentation of steroid psychoses. J Nerv Ment Dis1979;167:229-236.
82.
Stiefel FC, Breitbart WS, Holland JC: Corticosteroids in cancer: Neuropsychiatric complications. Cancer Invest1989;7:479-491.
83.
Massanari M. , Novitsky J., Reinstein LJ: Paradoxical reactions in children associated with midazolam use during endoscopy. Clin Pediatr1997;36:681-684.
84.
Cantu TG, Korek JS: Central nervous system reactions to histamine-2 receptor blockers . Ann Intern Med1991;114:1027-1034.
85.
Aguglia U., Gambardella A., Zappia M., et al: Negative myoclonus during valproate-related stupor: Neurophysiologic evidence of a cortical non-epileptic origin. Electroencephalogr Clin NeurophysioL1995;94:103-108.
86.
Hickson GB, Altemeier WA, Clayton EW: Should promethazine in liquid form be available without prescription ? Pediatrics1990;86:221-225.
87.
Jones J., Dougherty J., Cannon L.: Diphenhydramine-induced toxic psychosis. Am J Emerg Med1986;4:369-371.
88.
Altes J., Gasco J., de Antonio J., et al: Ciprofloxacin and delirium. Ann Intern Med1989;110:170-171.
89.
Ernst ME, Franey RJ: Acyclovir- and gancyclovir-induced neurotoxicity. Ann Pharmacother1998;32:111-113.
90.
Hurlbut KM: Drug-induced psychoses. Emerg Med Clin North Am1991;9:31-52.
91.
DiMaggio JR , Brown R., Baile WF, Schapira D.: Hallucinations and ifosfamide-induced neurotoxicity . Cancer1994;73:1509-1514.
92.
Kramer ED, Packer RJ, Ginsberg J., et al: Acute neurologic dysfunction associated with high-dose chemotherapy and autologous bone marrow rescue for primary malignant brain tumors. Pediatr Neurosurg1997;27:230-237.
93.
Kupfer A., Aeschlimann C., Cerny T.: Methylene blue and the neurotoxic mechanisms of ifosfamide encephalopathy . Eur J Clin Pharmacol1996;50:249-252.
94.
DiMaggio JR , Brown R., Baile WF, et al: Hallucinations and ifosfamide-induced neurotoxicity. Cancer1994;73:1509-1514.
95.
Bruggers CS , Friedman HS, Tien R., Delong R.: Cerebral atrophy in an infant following treatment with ifosfamide. Med Pediatr Oncol1994;23:380-383.
96.
Balmaceda CM , Walker RW, Castro-Malaspina H., Dalmau J.: Reversal of amphotericin-B-related encephalopathy. Neurology1994;44:1183-1184.
97.
Antonini G. , Morino S., Fiorelli M., et al: Reversal of encephalopathy during treatment with amphotericin-B. J Neurol Sci1996;144:212-213.
Young GB, Bolton CF, Austin TW, et al: The encephalopathy associated with septic illness. Clin Invest Med1990;13:297-304.
100.
Schwarz S. , Schwab S., Fabian CW, et al: Infection impaired consciousness as the initial symptom: Clinical and pathophysiologic aspects of septic encephalopathy . Nervenartz1997 ;68:292-297.
101.
Bleggi-Torres LF, de Medeiros BC, Ogasawara VS, et al: Iatrogenic Wernicke's encephalopathy in allogeneic bone marrow transplantation: A study of eight cases. Bone Marrow Transplant1997;20:391-395.
102.
Pihko H., Saarinen U., Paeteau A.: Wernicke encephalopathy — a preventable cause of death: Report of 2 children with malignant disease. Pediatr Neurol1989;5:237-242.
103.
Ming X., Wang MM, Katz RM, et al: Wernicke's encephalopathy in a child with prolonged vomiting . J Child Neurol1998; 13:178-180.
104.
Mitchell RB , Wagner JE, Karp JE, et al: Syndrome of idiopathic hyperammonemia after high-dose chemotherapy: Review of nine cases . Am J Med1988;85:662-667.
105.
Rosario M. , Werlin SL, Lauer SJ: Hyperammonemic encephalopathy after chemotherapy: Survival after treatment with sodium benzoate and sodium phenylacetate. J Clin Gastroenterol1997;25: 682-684.
106.
Milone J., Napal J., Bordone J., et al: Complete response in severe thrombotic microangiopathy post bone marrow transplant (BMT-TM) after multiple plasmapheresis. Bone Marrow Transplant1998;22:1019-1021.
107.
Moake JL, Byrnes JJ: Thrombotic microangiopathies associated with drugs and bone marrow transplant . Hematol Oncol Clin North Am1996 ;10:485-497.
108.
Walker RW, Allen JC, Rosen G., Caparros B.: Transient cerebral dysfunction secondary to high-dose methotrexate . J Clin Oncol1986;4:1845-1850.
109.
Rubnitz JE , Relling MV, Harrison PL, et al: Transient encephalopathy following high-dose methotrexate treatment in childhood acute lymphoblastic leukemia . Leukemia1998;12:1176-1181.
110.
Packer RJ, Rorke LB, Lange BJ, et al: Cerebrovascular accidents in children with cancer. Pediatrics1985;76:194-201.
111.
Steinherz PG, Miller LP, Ghavimi F., et al: Dural sinus thrombosis in children with acute lymphoblastic leukemia. JAMA1981 ;246: 2837-2839.
Kucuk O., Kwaan HC, Gunnar W., Vazquez RM: Thromboembolic complications associated with L-asparaginase therapy: Etiologic role of low antithrombin III and plasminogen levels and therapeutic correction by fresh frozen plasma. Cancer1985;55:702-706.
114.
Corso A., Castagnola C., Bernasconi C.: Thrombotic events are not exclusive to the remission induction period in patients with acute lymphoblastic leukemia: A report of two cases of cerebral sinus thrombosis. Ann Hematol1997;75:117-119.
Reddingius RE, Patte C., Couanet D., et al: Dural sinus thrombosis in children with cancer. Med Pediatr Oncol1997;29:296-302.
117.
Bushara KO , Rust RS: Reversible MRI lesions due to pegaspargase treatment of non-Hodgkin lymphoma. Pediatr Neurol1997;17: 185-187.
118.
Perkin GD: Cerebral venous thrombosis: Developments in imaging and treatment . J Neurol Neurosurg Psychiatry1995;59:1-3.
119.
Ulmer JL, Elster AD: Physiologic mechanisms underlying the delayed delta sign. AJNR Am J Neuroradiol1991;12:647-650.
120.
Mohamed A. , McLeod JG, Hallinan J.: Superior sagittal sinus thrombosis. Clin Exp Neurol1991;28:23-36.
121.
Cipri S., Gangemi A., Campolo C., et al: High-dose heparin plus warfarin administration in non-traumatic dural sinuses thrombosis: A clinical and neuroradiological study. J Neurosurg Sci1998;42: 23-32.
122.
Gironell A. , Marti-Fabregas J., Bello J., Avila A.: Non-Hodgkin's lymphoma as a new cause of non-thrombotic superior sagittal sinus occlusion . J Neurol Neurosurg Psychiatry1997;63:121-122.
123.
Carter M., Kalwinsky DK, Dahl GV, et al: Childhood acute promyelocytic leukemia: A rare variant of nonlymphoid leukemia with distinctive clinical and biologic features. Leukemia1989;3:298-302.
124.
Chan KW, Steinhertz PG, Miller DR: Acute promyelocytic leukemia in children. Med Pediatr Oncol1981;9:5-15.
125.
Walker RW: Neurologic complications of leukemia. Neurol Clin1991;9:989-999.
126.
Pitner SE, Johnson WW: Chronic subdural hematoma in childhood acute leukemia. Cancer1973;32:185-190.
127.
Jourdan E. , Dombret H., Glaisner S., et al: Unexpected high incidence of intracranial subdural haematoma during intensive chemotherapy for acute myeloid leukaemia with a monoblastic component. Br J Haematol1995;89:527-530.
128.
Graus F., Saiz A., Sierra J., et al: Neurologic complications of autologous and allogeneic bone marrow transplantation in patients with leukemia: A comparative study. Neurology1996;46:1004—1009.
129.
Pomeranz S. , Naparstek E., Ashkenazi E. et al: Intracranial haematomas following bone marrow transplantation. J Neurol1994;241:252-256.
130.
Feldmann E. , Posner JB: Episodic neurologic dysfunction in patients with Hodgkin's disease. Arch Neurol1986;43:1227-1233.
131.
Allen JC, Rosen G.: Transient cerebral dysfunction following chemotherapy for osteogenic sarcoma . Ann Neui-ol1978;3:441-444.
132.
Pectasides D., Alevizakos N., Barbounis V., et al: Transient cerebral dysfunction after treatment with moderately high-dose methotrexate, letter . Ann Oncol1991;2:769.
133.
Berwanger CS, Jeremy JY, Stansby G.: Homocysteine and vascular disease. Br J Surg1995;82:726-731.
134.
Quinn CT, Griener JC, Bottiglieri T., et al: Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer . J Clin Oncol1997;15:2800-2806.
135.
Outinen PA , Sood SK, Liaw PC, et al: Characterization of the stress-inducing effects of homocysteine. Biochem J1998;332: 213-221.
136.
Packer RJ, Grossman RI, Belasco JB: High dose systemic methotrexate-associated acute neurologic dysfunction . Med Pediatr Oncol1983;11:159-161.
137.
Shuper A., Packer RJ, Vezina LG, et al: "Complicated migraine-like episodes" in children following cranial irradiation and chemotherapy. Neurology1995 ;45:1837-1840.
Wolcott GJ , Grunnet ML, Lahey ME: Spinal subdural hematoma in a leukemic child . J Pediatr1970;77:1060-1062.
140.
Zentner J. , Buchbender K., Vahlensieck M.: Spinal epidural lipomatosis as a complication of prolonged corticosteroid therapy. J Neurosurg Sci1995;39:81-85.
141.
Fishman AR: Cerebrospinal Fluid in Diseases of the Nervous System, 2nd ed. Philadelphia, WB Saunders , 1992.
142.
Lukes SA, Posner JB, Nielsen S., Armstrong D.: Bacterial infections of the CNS in neutropenic patients. Neurology1984;34:269-275.
143.
Breuer AC, Tyler HR, Marzewski DJ, Rosenthal DS: Radicular vessels are the most probable source of needle-induced blood in lumbar puncture: Significance for the thrombocytopenic cancer patient. Cancer1982;49:2168-2172.
144.
Scott EW, Cazenave CR, Virapongse C.: Spinal subarachnoid hematoma complicating lumbar puncture: Diagnosis and management . Neurosurgery1989;25:287-292.
145.
Ventureyra EC, Ghanem Q., Ivan LP: Spontaneous spinal epidural haematoma in a youngster. Childs Brain1979;5:103-108.
146.
Robertson WC Jr, Lee YE, Edmonson MB: Spontaneous spinal epidural hematoma in the young. Neurology1979;29:120-122.
147.
Smitt PS, Tsafka A., Teng-van de Zande F., et al: Outcome and complications of epidural analgesia in patients with chronic cancer pain. Cancer1998;83:2015-2022.
148.
Lee HJ , Bach JR, White RE: Spinal epidural abscess complicating vertebral osteomyelitis: An insidious cause of deteriorating spinal cord function . JAm Paraplegia Soc1992; 15:19-21.
149.
Dubbeld P. , van Oostenbrugge RJ, Twinjstra A., Schouten HC: Spinal epidural abscess due to Aspergillus infection of the vertebrae: Report of 3 cases. Neth J Med1996;48:18-23.
Khanna RK, Malik GM, Rock JP, Rosenblum ML: Spinal epidural abscess: Evaluation of factors influencing outcome . Neurosurgery1996;39:958-964.
152.
Arroyo IL, Barron HS, Brewer EJJr: Spinal cord compression by epidural lipomatosis in juvenile rheumatoid arthritis. Arthritis Rheum1988;31:447-451.
153.
Wright MJ, Halton JM, Martin RF, Barr RD: Long-term gross motor performance following treatment for acute lymphoblastic leukemia. Med Pediatr Oncol1998;31:86-90.
154.
Watterson J. , Toogood I., Nieder M., et al: Excessive spinal cord toxicity from intensive central nervous system-directed therapies. Cancer1994;74:3034-3041.
155.
Bates SE, Raphaelson MI, Price RA, et al: Acute myelopathy after chemotherapy for central nervous system acute lymphoblastic leukemia: Correlation with cerebrospinal fluid myelin basic therapy. Med Pediatr Oncol1985;13:4-8.
156.
Dunton SF, Nitscheke R., Spruce WE, et al: Progressive ascending paralysis following administration of intrathecal and intravenous cytosine arabinoside: A Pediatric Oncology Group study. Cancer1986;57:1083-1088.
157.
Ozon A., Topaloglu H., Cila A., et al: Acute ascending myelitis and encephalopathy after intrathecal cytosine arabinoside and methotrexate in an adolescent boy with acute lymphoblastic leukemia. Brain Dev1994;16:246-248.
158.
Koh S. , Nelson MD, Kovanlikaya A., Chen LS: Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment. Pediatr Neurol1999;21:576-578.
159.
Littman P. , Rosenstock JG, Bailey C.: Radiation myelitis following craniospinal irradiation with concurrent actinomycin-D therapy. Med Pediatr Oncol1978;5:145-151.
160.
Ballweg GP , Donnenfeld H., Chusid JG: Subacute radiation myelopathy in a 12-year-old boy. Childs Brain1976;2:195-201.
161.
Adams C., August CS, Maguire H., et al: Neuromuscular complications of bone marrow transplantation. Pediatr Neurol1995;12:58-61.
162.
Amato AA, Barohn RJ, Sahenk Z., et al: Polyneuropathy complicating bone marrow and solid organ transplantation . Neurology1993;43:1513-1518.
163.
Wen PY , Alyea EP, Simon D., et al: Guillain-Barr6 syndrome following allogeneic bone marrow transplantation. Neurology1997; 49:1711-1714.
164.
Sheth RD, Bolton CF: Neuromuscular complications of sepsis in children. J Child Neurol1995;10:346-352.
165.
Edelson R. , Stevens P.: Meralgia paresthetica in children . J Bone Joint Surg Am1994;76:993-999.
166.
Hicken GJ, Ameli FM: Management of subclavian-axillary vein thrombosis: A review. Can J Surg1998;41:13-25.
167.
Williams EC : Catheter-related thrombosis. Clin Cardiol1990;13:V134-V136.
168.
Lossos A., Siegal T.: Electric shock-like sensations in 42 cancer patients: Clinical characteristics and distinct etiologies. J Neurooncol1996 ;29:175-181.
169.
Wen PY , Blanchard KL, Block CC, et al: Development of Lhermitte's sign after bone marrow transplantation. Cancer1992;69:2262-2266.
Lossos A., Siegal T.: Numb chin syndrome in cancer patients: Etiology, response to treatment, and diagnostic significance. Neurology1992 ;42:1181-1184.
172.
Burt RK, Sharfman WH, Karp BI, Wilson WH: Mental neuropathy (numb chin syndrome): A harbinger of tumor progression or relapse. Cancer1992;70:877-881.
173.
Fishman ML , Bean C., Cogan DG: Optic atrophy following prophylactic chemotherapy and cranial radiation for acute lymphoblastic leukemia. Am J Ophthalmol1976;82:571-576.
174.
Margileth DA, Poplack DG, Pizzo PA, Leventhal BG: Blindness during remission in two patients with acute lymphoblastic leukemia — A possible complication of multimodal therapy. Cancer1977;39:58-61.
175.
Dyken ME, Biller J., Yuh WT, et al: Carotid-cavernous sinus thrombosis caused by Aspergillus fumigatus: Magnetic resonance imaging with pathologic correlation — A case report . Angiology1990;41:652-657.
176.
Biousse V. , Guevara RA, Newman NJ: Transient Horner's syndrome after lumbar epidural anesthesia. Neurology1998;51:1473-1475.
177.
Wilhelm H. : Neuro-ophthalmology of pupillary function-practical guidelines. J Neurol1998;245:573-583.
178.
Albert DM: Ocular complications of vincristine therapy. Arch Ophthalmol1967;78:709-713.
179.
Solomon GE , Chutorian AM: Opsoclonus and occult neuroblastoma . N Engl J Med1968;279:475-477.
180.
Wasserstein PH, Honig LS: Parkinsonism during cyclosporine treatment . Bone Marrow Transplant1996; 18:649-650.
181.
Brashear A. , Siemers E.: Focal dystonia after chemotherapy: A case series. J Neurooncol1997;34:163-167.
182.
Pranzatelli MR, Mott SH, Pavlakis SG, et al: Clinical spectrum of secondary parkinsonism in childhood: A reversible disorder. Pediatr Neurol1994;10:131-140.
183.
Mercadante S.: Pathophysiology and treatment of opioid-related myoclonus in cancer patients. Pain1998;74:5-9.
184.
Sporer KA: The serotonin syndrome: Implicated drugs, pathophysiology and management . Drug Saf1995; 13:94-104.
Haider Y., Abbott RJ: Phenytoin-induced choreoathetosis, letter. Postgrad Med J1990;66:1089.
187.
Buetefisch CM, Gutierrez A., Gutmann L.: Choreoathetotic movements: A possible side effect of gabapentin. Neurology1996;46:851-852.
188.
Manley TJ, Chusid MJ, Rand SD, et al: Reversible parkinsonism in a child after bone marrow transplantation and lipid-based amphotericin B therapy. Pediatr Infect Dis J1998;17:433-434.
189.
Kulkantrakorn K., Selhorst JB, Petruska PJ: Cytosine arabinoside and amphotericin B-induced parkinsonism. Ann Neurol1996;39: 413-414.
190.
Mott SH, Packer RJ, Vezina LG, et al: Encephalopathy with parkinsonian features in children following bone marrow transplantations and high-dose amphotericin B. Ann Neurol1995;37:810-814.
191.
Lempert T. : Recognizing syncope: Pitfalls and surprises . J R Soc Med1996;89:372-375.
192.
Hoefnagels WA, Padberg GW, Overweg J., et al: Transient loss of consciousness: The value of the history for distinguishing seizure from syncope. J Neurol1991;238:39-43.
193.
Roca E., Bruera E., Politi PM, et al: Vinca alkaloid-induced cardiovascular autonomic neuropathy. Cancer Treat Rep1985;69: 149-151.
194.
Metheetrairut C., Brown DH: Glossopharyngeal neuralgia and syncope secondary to neck malignancy. J Otolaryngol1993;22: 18-20.
195.
Berard RM, Boersmeester F.: Psychiatric symptomatology in adolescents with cancer. Pediatr Hematol Oncol1998; 15:211-221.
