Regional cerebral blood flow was investigated in an 8-year-old boy with adrenoleukodystrophy by single photon emission computed tomography. The use of 99mTc-hexamethylpropylene amine oxime revealed markedly reduced blood flow in the occipital, parietal, and temporal cortical gray matter, in addition to the anticipated reduction in white matter. The area with a decreased blood flow was more extensive than that detected by x-ray computed tomography. (J Child Neurol 1994;9:284-286).
References
1.
Aubourg PR, Sack GH Jr, Meyers DA, et al: Linkage of adrenoleukodystrophy to a polymorphic DNA probe. Ann Neurol1987;21:349-352.
2.
Moser HW, Moser AE, Singh J., O'Neill BP: Adrenoleukodystrophy: Survey of 303 cases: Biochemistry, diagnosis and therapy . Ann Neurol1984;16:628-641.
3.
Chugani HT: Functional brain imaging in pediatrics. Pediatr Clin North Am1992;39:777-799.
4.
Leonard J-P. , Nowotnik DP, Neirinckx RD: Technetium-99m-d,l-HM-PAO: A new radiopharmaceutical for imaging regional brain perfusion using SPECT—A comparison with iodine-123 HIPDM. J Nucl Med1986;27:1819-1823.
5.
Adams C., Hwang PA, Gilday DL, et al: Comparison of SPECT, EEG, CT, MRI and pathology in partial epilepsy . Pediatr Neurol1992;8:97-103.
6.
Park CH, Spitzer AR, Desai HJ, et al: Brain SPECT in neonates following extracorporeal membrane oxygenation: Evaluation of technique and preliminary results. J Nucl Med1992;33: 1943-1948.
7.
Aminian A., Strashun A., Rose A.: Alternating hemiplegia of childhood: Studies of regional cerebral blood flow using 99mTc-hexa-methylpropylene amine oxime single-photon emission computed tomography. Ann Neurol1993 ;33:43-47.
8.
Aubourg P., Blanche S., Jambaque I., et al: Reversal of early neurologic and neuroradiologic manifestations of X-linked adrenoleukodystrophy by bone marrow transplantation. N Engl J Med1990;322:1860-1866.
9.
Chang LT: A method for attenuation correction in radionuclide computed tomography . IEEE Trans Nucl Sci1978;25:638-643.
10.
Yoshikawa H. , Fueki N., Sugai K., et al: Decreased blood flow and oxygen metabolism in the cerebellum, brain stem and thalamus in a case with Menkes kinky hair disease. Brain Dev1989;11:426-429.
11.
Botez MI, Leveille J., Lambert R., Botez T.: Single photon emission computed tomography (SPECT) in cerebellar disease: Cerebello-cerebral diaschisis. Eur Neurol1991;31:405-12.
12.
Satoh M., Ishikawa N., Yoshizawa T., et al: N-isopropyl-p-[123I] iodoamphetamine SPECT in MELAS syndrome: Comparison with CT and MR imaging. J Comput Assist Tomogr1991;15: 77-82.
