Pantoprazole-Na Release from Poly(acrylamide-co-crotonic acid) and Poly(acrylic acid-co-crotonic acid) Hydrogels

Abstract

Poly(acrylamide-co-crotonic acid) (PAAmCA), poly(acrylic acid-co-crotonic acid) (PAACA), PAA and PAAm hydrogels were prepared by free radical polymerization and ethylene glycol dimethacrylate (EGDMA) as a crosslinker. The variations of swelling values (%) with time, temperature, and pH were determined for four types of hydrogels. The PAACA hydrogel was swollen 2300% at pH = 7.4 and 37°C. The drug release from pantoprazole-Na loaded PAACA and PAAmCA hydrogels was followed at pH = 7.4, 37°C for 30 h. The release from PAACA hydrogel was faster than that from PAAmCA hydrogel; therapeutic levels for both hydrogels are obtained within 1 hour. Non-Fickian diffusion was determined for both hydrogels.

Keywords

hydrogels acrylic acid acrylamide crotonic acid hydrogel swelling pantoprazole non-Fickian diffusion controlled release.

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