The prevalence of classic autism and autism spectrum disorder (ASD) appears
to be on the rise, and to date, there remains no clear etiology or cure. Out
of desperation, many families are turning to new therapies and interventions
discovered through various media sources and anecdotal reports from other
parents. Unfortunately, many of these newer, well-publicized interventions
have little empirical support. One of the most popular yet currently
scientifically unproven interventions for ASD is the gluten-free, casein-free
(GFCF) diet. Clinicians working with families of individuals with ASD are
often asked for advice and find themselves unable to offer the most up-to-date
and scientifically credible information. This article provides an overview of
ASD and the GFCF diet, a summary and critique of current research findings,
recommendations for future research, and practical advice for families to use
in deciding if a trial of the GFCF diet is in the best interest of their child
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