Abstract
Purpose
To examine the association between the social determinants of health (SDOH) and hypertension, diabetes, heart disease, and anxiety and/or depression among adult US women.
Design
Cross-sectional survey.
Setting
2022 Health Information National Trends Survey (HINTS).
Sample
Women aged ≥18 years (N = 3535) participated from the U.S.
Measure
Outcome variable was diagnosis of diabetes, hypertension, heart disease, and mental illnesses. Covariates included sociodemographic characteristics along with food, housing, and transportation insecurity.
Analysis
Separate weighted bivariate and multivariate logistic regression models were used to examine the unadjusted and adjusted odds ratios (AORs) associations between insecurities and chronic conditions, controlling for sociodemographic characteristics.
Results
Hypertension (35.4%) and anxiety/depression (33.4%) were the most reported chronic conditions. Approximately 27% of the sample experienced all three forms of insecurity concurrently. Women with anxiety or depression had elevated levels of food, housing, and transportation insecurity (11.3%, 7.4%, 7.5%) than those with other chronic conditions. Adjusted models indicated that all three types of insecurity were significantly associated with chronic conditions. Food, housing, transportation, and any insecurity nearly doubled the odds of reporting any chronic condition (AOR = 2.15, 2.44, 1.70, and 2.20, respectively).
Conclusion
Findings highlight a strong association between SDOH and chronic conditions among women, necessitating the implementation of targeted policies and interventions to address sex-related health inequities to improve women’s health.
Keywords
Purpose
Sex is a biological variable that contributes to stark differences in chronic disease prognosis, diagnosis, manifestation, and treatment between men and women. 1 Compared to men, women experience a higher overall prevalence of chronic diseases2,3 (28.4% vs 25.9%) with cardiovascular disease being the leading cause of mortality, accounting for nearly 30% of female deaths in the US in 2021. 4 In addition, women show unprecedentedly increased rates of other chronic disease-related disability and disease burden, such as heart disease, diabetes, obesity, hypertension, and mental health conditions, well into later life compared to their male counterparts. 1 The intersection of longer female life expectancy with higher chronic disease prevalence results in a paradox, in which women experience a disproportionate burden of disease-related disability and healthcare utilization needs throughout their lifespan. While research establishing the connection between biological and genetic predisposition factors with chronic disease patterns abounds, emerging literature suggests that social and structural factors may play an equally critical role in shaping women’s health. Thus, sex-based disparities in chronic disease burden cannot be solely attributed to biological factors. To understand how social determinants of health (SDOH), particularly housing, food, and transportation, affect women, it is important to consider that women’s social roles, economic conditions, and life experiences often systematically differ from men, which may increase their health risk.
SDOH influence health outcomes and comprise the places where people are born, grow, live, work, and age. 5 Adverse SDOH, such as housing, food, and transportation insecurities, have been linked to poor health outcomes across the life course in the US and worldwide. For example, maintaining a healthy lifestyle requires resources to sustain healthy behaviors. Without adequate and safe housing, transportation, nutritious meals, or residing in unsafe neighborhoods, individuals have lower chances of engaging in behavioral risk reduction to promote positive health outcomes. Literature suggests that individuals with diabetes and food insecurity combined have worse glycemic control and affect adherence to dietary and preventive health behaviors, such as blood glucose monitoring. 6 An earlier study of 27,172 adults, social risk factors, including poverty, educational level, food insecurity, and home ownership, significantly contributed to disparities in cardiovascular health between rural and urban dwellers. 7 Furthermore, housing and transportation insecurity are associated with inequalities in healthcare access and utilization, e.g., mammography and other preventive screenings, attending prenatal visits, or adhering to medical interventions. 8 Inequities in maternal morbidity and mortality are also largely due to an uneven distribution of food, housing, and transportation insecurities across population subgroups, area of residence, and socioeconomic factors.9,10 Moreover, beyond the impact of housing, food, and transportation insecurities on maternal and reproductive health, longstanding gender-based barriers to women’s health care, including a lack of comprehensive insurance, provider bias, economic vulnerability, such as wage gaps, caregiving responsibilities, chronic stress, sociocultural roles, norms, and responsibilities, amplify adverse SDOH on women’s health across the lifespan.5,11-14 These issues limit the ability to manage or treat chronic conditions, thereby exacerbating women’s health issues with dire health consequences. 1
Considering that women’s health continues to be heavily impacted by multifaceted sociocultural and sociopolitical factors, combined with the fact that chronic conditions often present differently in women compared to men, leading to devastating health outcomes for women across the lifespan, this study provides a strong empirical impetus to understand the relationship between food, housing, and transportation insecurities and chronic conditions among women to fill the knowledge gap.1,5,15 Previous studies have focused on aggregated data or failed to disaggregate findings by sex and do not provide the true epidemiological patterns of social insecurities and chronic conditions among women. 16 Even when disaggregated, studies have largely focused within the scope of maternal and reproductive health, which may limit understanding of how social insecurities impact all women regardless of their reproductive status.13,17 Furthermore, earlier studies have examined multiple SDOH in one model, although these social factors often co-occur and may have cumulative health effects. 15 The current study addresses these research gaps by examining the independent and combined effects of food, housing, and transportation insecurities on chronic conditions, particularly diabetes, high blood pressure, heart conditions, and mental health issues. This knowledge can guide the formation and development of tailored interventions meeting women’s unique needs across the life course.
To this end, this study answers the question: What is the correlation between SDOH—specifically food, housing, and transportation insecurity—and the prevalence of chronic conditions among women? This study aims to investigate the relationship between food, housing, and transportation insecurities and chronic conditions, particularly diabetes, high blood pressure, heart conditions, and depression, in adult US women using national data. Findings from this study have serious policy and public health implications, highlighting the importance of closing gaps leading to social factors and educating women to learn about their risk factors and ways to adopt positive behaviors.
Methods
Settings & Design
Data for this cross-sectional study were derived from the Health Information National Trends Survey (HINTS) fielded by the National Cancer Institute between March and November 2022. HINTS is a nationally representative sample of noninstitutionalized US adults 18 years and older. Data on health communication, digital health use, and sociodemographic characteristics are collected.
Sample
The sampling strategy for HINTS 6 comprised a two-stage design. In the first stage, a stratified sample of addresses was selected from a file of residential addresses. In the second stage, one adult was selected within each sampled household. The total number of respondents surveyed was 6252, with a 28.1% response rate. However, this study was restricted to only 3535 female respondents included in the data. Detailed information about the HINTS survey and methodology is reported elsewhere. 18
Measures
Outcome Variables
We selected four binary (no/yes) outcome variables based on current chronic disease trends among women. Respondents were asked: “Has a doctor or other health professional ever told you that you had any of the following medical conditions? “Diabetes or high blood sugar,” “High blood pressure or hypertension”, “heart condition such as heart attack, angina, or congestive heart failure,” and “Depression or anxiety disorder,” We created a binary no/yes for all chronic conditions.
Key Independent Variables
Social factors were examined using four items asking respondents whether “in the past 12 months, how often were the following things true?” 1) Someone in your household cut the size of meals or skipped meals because there wasn’t enough money for food, 2) Someone in your household was not able to afford to eat balanced meals, 3) Someone in your household was worried about being forced to move (for example, because of eviction or foreclosure), and 4) Lack of reliable transportation kept someone in your household from medical appointments, work, or from getting things needed for daily living. Because questions 1 and 2 are used individually or together to measure food insecurity, we merged and coded them as “Food insecurity,” with a Cronbach’s alpha of 0.94. Questions 3 and 4 were coded as housing and transportation insecurity, respectively, bringing together three independent variables analyzed in this study. All items were measured on a 3-point scale (1 = often true, 2 = sometimes true, 3 = never true). Following the literature, we regrouped the scales into binary outcomes as never true = 0 and true/sometimes true = 1. We created a binary never true/sometimes true (No/Yes) variable for all insecurities, coded as “insecurities.”
Covariates
Control variables were included based on theoretical and empirical evidence. Sociodemographic variables comprised: age (18-34, 35-49, 50-64, or ≥65 years), marital status (single, married, divorced/separated), income status (<US $20,000, US $20,000-34,999, US $35,000-49,999, US $50,000-74,999, or ≥US $75,000), race/ethnicity (non-Hispanic White, non-Hispanic Black, Hispanic, non-Hispanic Asian/others), and education (high school degree or below, some college degree, and college degree or above). Health-related variables included health insurance (no/yes) and self-reported health status (fair/poor, good, or excellent). All variables were operationalized based on previous research.19,20
Analysis
All analyses used the recommended analytical strategy by the HINTS analyst and applied 50 replicate jackknife survey weights to account for variance estimation and generalizability.
Initial weighted descriptive statistics were analyzed for all respondents. Chi-square tests were used to compare the key independent variables, food, housing, transportation, and overall insecurities to chronic conditions, and reported in graphs. Next, we performed separate weighted logistic regression models to test the unadjusted association of the study variables and each chronic condition. Third, multivariate logistic regression models were created to explore the adjusted association between the outcome and control variables.
We conducted separate adjusted prediction models based on statistical significance to understand the interactions between age and insecurity (No/Yes) and chronic conditions (No/Yes) and interaction between race and insecurity (No/Yes) and chronic conditions (No/Yes), and reported them in graphs.
Multicollinearity was also examined using the variance inflation factor, and no collinearity was found among the independent variables. Hosmer-Lemeshow goodness-of-fit test was conducted; models with an insignificant chi-square test output demonstrate a good fit. We reported the unadjusted odds ratio (OR), adjusted odds ratio (aOR), and corresponding 95% confidence interval (CI). A 2-sided significance level of α < .05 for statistical significance was applied. Missing or unknown observations were dropped for all analyses. Analyses were performed with Stata statistical software (version 17 SE; StataCorp).
Results
Of the 3,535 women who participated in the HINTS 6 survey, 45.2% (95% CI: 42.2-48.2%) had at least one chronic disease. The majority of the sample had high blood pressure or hypertension 35.4% (95% CI: 33.3-37.6%), 33.4% (95% CI: 30.7-36.2%) had depression or anxiety, 16.8% (95% CI: 15.3-18.4%) had diabetes, and 5.9% (95% CI: 4.8-7.3%) had heart condition. Concerning insecurities, a little over a quarter, 27% (95% CI: 24.4-29.7%) reported having experienced food, transportation, and housing insecurities together. As seen in Figure 1, those who often or sometimes experience food, transportation, and housing insecurities are as follows: 21.2% (95% CI: 18.6 -24.1%), 13.9% (95% CI: 12.1-16%), and 11.9% (95% CI: 10.2-13.8%), respectively. Weighted percentage of food, housing, transportation, and overall insecurities among women in the US, 2022
Figure 2 reports the weighted chi-square test results of reporting “often/sometimes” to insecurities and “yes” to chronic conditions. There was a significant difference between having any chronic condition and food (13.9%, 95% CI: 11.4-16.7%, P < 0.001), housing (8.6%, 95% CI: 7.1-10.3%, P < 0.001), transportation (9.2%, 95% CI: 7.5-11.3%, P < 0.001), and any insecurities (17.2%, 95% CI: 14.8-19.9%, P < 0.001). The same statistically significant relationship was found between food, housing, transportation, and any insecurities with diabetes, high blood pressure or hypertension, heart condition, and depression or anxiety. However, across all insecurity types, other than those with any insecurity, anxiety or depression consistently demonstrated an elevated percentage compared to diabetes, high blood pressure, and heart conditions. Weighted percentage of food, housing, transportation, and overall insecurities by chronic condition status among women in the US, 2022
Study Characteristics of Weighted Population, n = 122,385,407
Unadjusted Odds of Food, Housing, Transportation, and Overall Insecurities Among Women With Chronic Conditions
OR = Odds Ratio, CI = Confidence Interval.
Adjusted Odds of Food, Housing, Transportation, and Overall Insecurities Among Women With Chronic Conditions
AOR = Adjusted Odds Ratio, CI = Confidence Interval. Each model was adjusted for Age, Marital status, Income level, Race/ethnicity, Education status, Health status, and Insurance status.
Prediction models showed a significant difference in the association between having any chronic condition and any insecurities by race and age, as seen in Figure 3. Adjusted predictions of interactions between age/insecurities and race/ethnicity/insecurities
Discussion
Summary
This study examined the association between food, housing, and transportation insecurity and self-reported chronic disease, including diabetes, hypertension, high blood pressure, and depression or anxiety, using a nationally representative sample. Our study found that almost half (45.2%) of the US adult women have at least one chronic condition. Additionally, women who experienced food, housing, and transportation insecurities were statistically more likely to report chronic conditions than those without. These findings support the growing literature showing a strong link between social factors and chronic disease.5,21,22 This calls for a comprehensive approach linking community services and medical care to addressing adverse social determinants of health influencing women’s health and wellbeing.
Access to food, affordable housing, and reliable transportation is crucial to sustaining women’s health. While our analysis did not find a statistically significant relationship between food insecurity and diabetes, we found that food insecurity increased the odds of having high blood pressure, heart condition, depression, or anxiety, or having any insecurity. These results align with the literature, reinforcing the need for strategies to combat food insecurity as an approach to address chronic conditions.23,24 Considering that nutrition and dietary habits play a significant role across the life course, connecting women, particularly those at risk of food insecurity, to social support services across the continuum of care, including within the community level, may help combat the growing rate of chronic conditions. For example, when incorporated into prenatal counselling programs, women who were food insecure at the beginning of pregnancy became food secure by late pregnancy, 25 suggesting that incorporating nutritional counselling and connecting women with social services in the clinical and community settings may reduce food insecurity. 26
This study demonstrated that housing insecurity was correlated with all the chronic conditions analyzed. Safe and reliable housing remains a significant public health problem in the US. About 771,480 people experienced homelessness in 2024, with women representing roughly 39.2% or 302,660 of the homeless population. Women experiencing homelessness are exposed to adverse living conditions, including poverty, mental health problems, or gender-based violence, 17 that exacerbate their vulnerability to chronic conditions and affect their quality of life. They also do not have access to quality health care services, so they likely have limited or lack healthcare coverage, do not have a regular physician, or seek preventive care. While this study did not specifically include homeless populations, although the definition of homelessness is nuanced, our study spotlights the issues that women facing housing insecurity encounter, which expose them to adverse outcomes, including chronic conditions. Moreover, housing insecurity is associated with pregnancy complications and adverse birth and infant outcomes.13,17,27
Furthermore, similar to the literature, transportation insecurity independently predicted heart condition and depression or anxiety. Lack of safe and reliable transportation can lead to non-adherence and general preventive health or health care utilization. Using a national dataset, transportation insecurity was associated with 41% reduced odds of adherence to breast cancer screening. 28 Additionally, the chances of adhering to preventive health screening increase as the distance between the home and the healthcare facility increases. 29 Women make up the largest group of Americans with transportation insecurity (6.1% vs5.3%) which is linked to other adverse social determinants of health, such as poverty, which is prevalent among women than men (8.9% vs11. 8%).14,30 Our study findings highlight the importance of strategies to improve the mechanisms perpetuating these inequities, leading to chronic conditions and poor quality of life.
Results show a positive association between insecurities and the predicted probability of having any chronic conditions across all racial and age groups. Older adults (65 and older) and those in the other racial category with insecurities had significantly higher predicted probabilities of chronic conditions than their counterparts. While it is likely that older adults are at increased risk of chronic conditions than other age groups, our findings deviate slightly from previous studies suggesting that housing insecurity is more prevalent during midlife (<65 vs >65 years). 31 Concerning the result on race and insecurities on chronic conditions, showing that ethnic minorities (non-Hispanic Black, Hispanics, and Asians) with insecurities have a lower predicted probability of chronic conditions, the literature is mixed. 32 While surprising, our study highlights the deeper structural and systemic issues around healthcare access among minority populations. For instance, the literature widely documents significant disparities in the timely screening, diagnosis, management, and treatment of chronic conditions among ethnic minorities, particularly Black and Hispanic populations. 33 These disparities may lead to underestimating the true rates and prevalence of chronic conditions within these groups. Thus, it is likely that our results reflect this reality. We therefore caution against drawing strong conclusions from this observation, particularly in light of our sample distribution, as seen in Table 1. The findings demonstrate a need for future research on insecurities and chronic conditions among women to understand the upstream determinants of health across population subgroups.
Chronic conditions continue to be a significant public health crisis for American women; our study reinforces the need for system-level approaches to addressing the nonbiological factors that impact women’s health and well-being. 5 Women in the US are more likely than men to be socioeconomically disadvantaged, including having higher poverty rates, income inequality, unemployment or lower-paying jobs, and childcare responsibilities, which destabilize their earning power and potential, leading to huge economic and health disparities. 14 Additionally, women who live in under-resourced neighborhoods and built environments, and rural areas may be exposed to environmental toxins and pollutants or limited opportunities for physical activities, which have detrimental effects on their health, particularly during pregnancy and childhood, all leading to increased risk of chronic conditions. 13 Social and gender norms across cultures perpetuate bias and discrimination, leading to gender-based violence and harmful ideologies meant to subjugate women’s right to life, access to care, and freedom. 5 More so, policies and programs are often designed through a male-gendered lens with harmful unintended consequences on women’s health and well-being. 34 These adverse nonbiological factors are linked to women’s health, including chronic conditions, as evident in this study.
Policy and Public Health Implications
Our study has several policies and public health implications. While the riskof chronic diseases is complex, efforts to address structural or environmental factors must be a priority. For example, while Medicaid offers chronic disease management services, issues such as lack of care coordination, the complexity of the Medicaid system, provider reimbursement rates, and differences in the scope of the services provided across states limit beneficiaries from benefiting from these services. Similarly, the 20% cost-sharing or low provider reimbursement rates among Medicare Part B beneficiaries hinder adequate chronic disease management. As a result, policymakers must enact policies to enhance patient engagement and access to care. For example, in 2023, the American Hospital Association endorsed the removal of patient cost-sharing obligations to increase access to chronic disease management. 35 Beyond managing chronic conditions, policymakers must invest in primary chronic disease prevention policies by developing evidence-based direct health policies targeted at the social determinants of health. 36 For example, policies on school nutrition, food assistance and access, food labelling, and the built environment can help prevent chronic disease before it occurs.
Care coordination beyond clinical referrals for chronic conditions must be harnessed to integrate community-based social services into care models. In a time when women’s health is precarious - leading to mistrust in healthcare providers or complete healthcare avoidance behaviors - integrating social services in healthcare delivery has great potential for improving health and achieving health equity.
Additionally, our study highlights the need for more research and tailored public health interventions to understand the link between social factors and chronic conditions across sociodemographic characteristics. Equitable and culturally relevant data surveillance systems, research design, public health programming, and clinical interventions must be considered to ensure representativeness. Additionally, efforts to mitigate social insecurities should account for women’s unique differences and needs across age groups.
Strengths and Limitations
Even though this study significantly contributes to the literature, our results must be interpreted in light of some limitations. We used a cross-sectional survey of a nationally representative cohort of individuals; therefore, we cannot infer causality, and the directions of the associations in the study cannot be indicated. Since the data was self-administered, it is prone to recall bias, and misrepresentation by respondents is likely. Our results only provide a snapshot of how social factors influence chronic conditions based on the confounders included in this study. For example, we would have wanted to see whether having a regular provider moderates our results, since the literature suggests that having a regular provider increases chronic disease management among reproductive-age women However, this question was not included in the 2022 HINTS data. Using clinical vs self-reported data may also alter the results. Future researchers may consider conducting primary quantitative and qualitative research to understand this relationship better.
Despite these limitations, our study updates current knowledge about the association between social factors and chronic conditions among US women.
Conclusions
We analyzed food, housing, and transportation insecurity among women with and without heart diseases, including diabetes, hypertension, high blood pressure, and depression or anxiety. Findings demonstrate that these insecurities are associated with at least one type of chronic condition. Findings indicate the urgent need for policies and programs to close inequities in access to social services, community health services, and non-medical drivers of health. These findings have useful implications for health policy and public health programming, considering that chronic conditions are among the leading causes of death and morbidity among women.
Footnotes
Funding
The authors received no financial support for the research, authorship, and/or publication of this article.
Declaration of conflicting interests
The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
