1 Urinary chlorophenols of the general population of Barcelona, Spain were determined. Pentachlorophenol (PCP: 25.0 ± 3.9 ng/ml; x ± s.e.m., n = 50) and tetrachlorophenol (TCP: 6.2 ± 1.6 ng/ml; x ± s.e.m., n = 25) were found in all samples.
2 Pentachlorophenol and hexachlorobenzene were also determined in serum. Both were present in all samples (PCP: 21.9 ± 1.9 ng/ml; HCB: 11.1 ± 1.1 ng/ml; x ± s.e.m., n = 100). Their concentrations do not show any correlation, suggesting no metabolic relation between them.
References
1.
Kauppinen T. & Lindroos L.Chlorophenol exposure in sawmills. American Industrial Hygiene Association Journal1985; 46: 34-8.
2.
Williams PLPentachlorophenol, an assessment of the occupational hazard. American Industrial Hygiene Association Journal1982; 43: 799-810.
3.
Engst R., Macholz RM & Kujawa M.The metabolism of hexachlorobenzene (HCB) in rats. Bulletin of Environmental Contamination and Toxicology1976; 16: 248-52.
4.
Van Ommen B. , Van Bladeren PJ, Temmik Jhm & Muller F.Formation of pentachlorophenol as the major product of microsomal oxidation of hexachlorobenzene. Biochemical and Biophysical Research Communications1985 ; 126: 25-32.
5.
Cabral Jrp & Shutik P.Carcinogenic activity of hexachlorobenzene in mice and hamsters. First International Symposium on Hexachlorobenzene, Lyon, 1985 (in press).
6.
To-Figueras J., Rodamilans M., Gómez-Catalán J. & Corbella J.Hexachlorobenzene residues in general population of Barcelona (Spain). First International
7.
Symposium on Hexachlorobenzene. Lyon, 1985 (in press). 7 Abbot DC, Goulding R., Holmes DC & Hoodles RAOrganochlorine pesticide residues in human fat in the United Kingdom 1982-1983. Human Toxicology 1985; 4: 435-45.
8.
Shafik TM, Sullivan HC & Enos HRMultiresidue procedure for halo- and nitrophenols. Measure of exposure to biodegradable pesticides yielding these compounds as metabolites. Journal of Agricultural and Food Chemistry1973; 21: 295-8.
9.
Bevenue A., Wilson J., Casarett JJ & Klemmer HWA survey of pentachlorophenol content in human urine. Bulletin of Environmental Contamination and Toxicology1967; 2: 319-33.
10.
Bomhard A., Shaller KH & Triebig G.Capillar-Gas-Chromatographie mit ECD- und MS-detektion zur quantitativen Bestimmung von Pentachlorophenol in menslichen Plasma und Harn. Fresenius Zeitschrift fuer Analytische Chemie1984; 319: 516-9.
11.
Lores EM, Edgerton TR & Moseman RFMethod for the confirmation of chlorophenols in human urine by LC with electrochemical detector. Journal of Chromatographic Science1981; 18: 466-9.
12.
Kalman DADetermination of pentachlorophenol and 2,3,4,6-tetrachlorophenol in human urine by high resolution gas chromatography. Journal of Chromatographic Science1984; 22: 452-5.
13.
Braun WH, Blau GE & Chenoweeth MBThe metabolism/pharmacokinetics of pentachlorophenol in man, and a comparison with the rat and the monkey model. Toxicology and Applied Pharmacology1978; 45: 278-85.
14.
Bristol DW, Crist HL, Howard L., Lewis RG, Macleod KE & Sovocool G.Chemical analysis of human blood for assessment of environmental exposure to semivolatile organochlorine chemical contaminants. Journal of Analytical Toxicology1982; 6: 269-75.
