Acute Vapour Inhalation Toxicity of Acrolein and its Influence as a Trace Contaminant in 2-Methoxy-3,4-dihydro-2H-pyran

Abstract

1 The LC₅₀ values for acrolein (AC) vapour to Sprague-Dawley rats (combined sexes) were determined to be 26 ppm (1 h) and 8.3 ppm (4 h). Signs of severe irritancy were present, and death was due to lung injury.

2 Exposure of rats to a 2-methoxy-3,4-dihydro-2H-pyran (MDP) saturated vapour atmosphere statically generated from liquid MDP containing 0.037% AC, caused severe irritancy and death from accumulation of AC vapour. Sparging the impure material with nitrogen gas before atmosphere generation significantly reduced or abolished lethal toxicity.

3 Dynamically generated MDP vapour atmosphere produced transient respiratory and occular irritancy, but no mortalities. The intrinsic acute vapour inhalation toxicity of MDP is low.

4 The presence of highly volatile toxic impurities in a material may confer a significant acute inhalation toxicity and hazard under conditions of low air movement. Assessment of potential inhalation hazards from liquid mixtures may require investigation by static and dynamic methods for vapour generation.

References

Sax NI & Lewis RJ Sr. Hawley's Condensed Chemical Dictionary, 11th edn, p.18. New York: Van Nostrand Reinhold Company, 1987.

Izard C. & Libermann C. Acrolein. Mutation Research 1978; 47: 115-38.

Lipari F. & Swarin SJ Determination of formaldehyde and other aldehydes in automobile exhaust with an improved 2,4-dinitrophenyl-hydrazine method. Journal of Chromatography 1982; 247: 297-306.

Dodd DE , Ballantyne B. , Myers RC , Pritts IM & Nachreiner DJ The acute toxicity of methoxydihydropyran. Veterinary and Human Toxicology, in press.

Carpenter CP , Kinkead ER , Geary DL Jr., Sullivan LJ & King JM Petroleum hydrocarbon toxicology studies. I. Methodology. Toxicology and Applied Pharmacology 1975; 32: 246-62.

Thompson WR Use of moving averages and interpolation to estimate medium-effective dose . Bacteriological Review 1947; 11: 115.

Finney DL Probit Analysis, 2nd edn. Cambridge : Cambridge University Press, 1964 .

Catalina P. , Thieblot L. & Champeix J. Lesions respiratories experimentales par inhalation d'acrolein chez le rat . Arch. Mal. Prof. Med. Trav. Secur. Soc. 1966; 27: 857-67.

Skog E. A toxicological investigation of lower aliphatic aldehydes. I. Toxicity of formaldehyde, acetaldehyde, propionaldehyde and butyraldehyde, as well as of acrolein and crotonaldehyde. Acta Pharmacologica et Toxicologica 1950; 6: 299.

10.

Carpenter CP , Smyth HF Jr. & Pozzani U. The assay of acute vapor toxicity, and the grading and interpretation of results on 96 chemical compounds . Journal of Industrial Hygiene and Toxicology 1949; 31: 343-6.

11.

American Conference of Governmental Industrial Hygienists. Threshold Limit Values and Biological Exposure Indices for 1988-1989. Cincinnati, Ohio: ACGIH, 1988.