Ultraviolet light modulation of autoantigens,epidermal cytokines and adhesion molecules as contributing factors of the pathogenesis of cutaneous LE

Abstract

Keywords

ultraviolet light Lupus erythematosus cytokines adhesion molecules autoantigens apoptosis

References

Feint H. Light as an exciting agent in lupus erythematosus and other dermatoses. J Med Soc NJ 1996; 24: 226-228.

Naer R. Jarner LC Photobiology of lupus erythematosus. Arch Dermatol 1965; 92: 124-128.

Epstein JH , Tuffanelli D. , Dubois EL Light sensitivity and lupus erythematosus. Arch Dermatol 1965 ; 91: 483-485.

Everett MA , Olson RL Response of cutaneous lupus erythematosus to ultraviolet light. J Invest Dermatol 1965 ; 44: 133-139.

Fronek Z. et al. Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus. Arthritis Rheum 1990; 33: 1542-1553.

Wysenbeek AJ , Block DA , Fries JF Prevalence and expression of photosensitivity in systemic lupus erythematosus. Ann Rheum Dis 1989; 48: 461—463.

Tan EM et al. Criteria for the classification of systemic lupus erythematosus . Arth Rheum 1984; 27: 530-538.

Lehmann P. et al. Experimental reproduction of skin lesions in lupus erythematosus by UVA and UVB radiation. J Am acad Dermatol 1990; 22: 181-187.

Luger TA , Schwarz T. Evidence for an epidermal cytokine network. J Invest Dermatol 1990; 95: 100S-1045.

10.

Schroder JM Cytokine networks in the skin. [review]. J Invest Dermatol 1995; 105: 205-245.

11.

Anderson, RR , Parrish JA The optics of human skin. J Invest Dermatol 1981 ; 77: 13-19.

12.

Cripps DJ , Rankin J. Action spectra of lupus erythematosus and experimental immunofluorescence . Arch Dermatol 1973; 107: 563-567.

13.

Freeman RG , Knox JM Cutaneous lesions of lupus erythematosus induced by monochromatic light. Arch Dermatol 1969; 100: 677-682.

14.

Kochevar I. Action spectrum and mechanism of UV-radiation-induced injury in lupus erythematosus. J Invest Dermatol 1985; 85: 140S-143 S.

15.

Hozle E. Photodermatoses-diagnostic procedures and their interpretation. Photodermatol 1987; 4: 109-114.

16.

Kind P. , Lehmann P. , Plewig G. Phototesting in lupus erythematosus. J Invest Dermatol 1993; 100: 53S-57S.

17.

Mond CB , Peterson MG , Rothfield NF Correlation of anti-Ro antibody with photosensitivity rash in systemic lupus erythematosus patients. Arthritis Rheum 1989 ; 32: 202-204.

18.

Black AK , Fincham N. , Greaves MW , Hensby CN Time course changes in levels of arachidonic acid and prostaglandins D2, E2, F2 alpha in human skin following ultraviolet B irradiation. Br J Clin Pharmacol 1980; 10: 453—457.

19.

Greaves MW , Sondergaard J. Pharmacologic agents released in ultraviolet inflammation studied by continuous skin perfusion. J Invest Dermatol 1970; 54: 365-367.

20.

Hensby CN et al. Time-course of arachidonic acid, prostaglandins E2 and F2 alpha production in human abdominal skin, following irradiation with ultraviolet wavelengths (290-320 nm). Adv Prostaglandin Thromboxane Res 1980; 7: 857-860.

21.

Bennion S. et al. The effect of UVB on 6-Keto-PGFla production by cultured human endothelial cells. J Invest Dermatol 1984; 82: 428a.

22.

Hawk JL et al. Increased concentrations of arachidonic acid, prostaglandins E2, D2, and 6-oxo-Fl alpha, and histamine in human skin following UVA irradiation . J Invest Dermatol 1983; 80: 496-499.

23.

Kupper TS et al. Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation. J Clin Invest 1987; 80: 430-436.

24.

Granstein RD , Sauder DN Whole-body exposure to ultraviolet radiation results in increased serum interleukin-1 activity in humans. Lymphokine Res 1987; 6: 187-193.

25.

Mizutani H. , Black R. , Kupper TS Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) beta. Different strategies of IL-1 production and processing in monocytes and keratinocytes. J Clin Invest 1991; 87: 1066-1071.

26.

Bigler CF , Norris DA , Weston WL , Arend WP Interleukin-1 receptor antagonist production by human keratinocytes. J Invest Dermatol 1992; 98: 38-44.

27.

Kupper TS , Groves RW The interleukin-1 axis and cutaneous inflammation. [review]. J Invest Dermatol 1995; 105: 62S-66S.

28.

Kock A. et al. Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J Exp Med 1990; 172: 1609-1614.

29.

Middleton MH , Norris DA Cytokin-induced icam-1 expression in human keratinocytes is highly variable in keratinocyte strains from different donors . J Invest Dermatol 1995; 104: 489-496.

30.

Kurimoto I. , Streilein JW cis-urocanic acid suppression of contact hypersensitivity induction is mediated via tumor necrosis factor-alpha. J Immunol 1992 ; 148: 3072-3078.

31.

Vinek V. Sunlight induced progression of aids. [review]. Med Hypotheses 1995; 44: 119-123.

32.

Walsh LJ Ultraviolet b irradiation of skin induces mast cell degranulation and release of tumour necrosis factor-alpha. Immunol Cell Biol 1995; 73: 226-233.

33.

Amse; K. et al. Cytokine m odulation of keratinocyte cytokines. J Invest Dermatol 1990; 94: 101S-107S.

34.

Kupper TS Mechanisms of cutaneous inflammation. Arch Dermatol 1989; 125: 1406-1412.

35.

Chouaib S. , Branellec D. , Buurman WA More insights into the complex physiology of TNF. Immunol Today 1991; 12: 141-142.

36.

Jacob CO Studies on the role of tumor necrosis factor in murine and human autoimmunity . J Autoimmun 1992; 5: 133-143.

37.

Kirnbauer R. et al. IFN-beta 2, B cell differentiation factor 2, or hybridoma growth factor (IL-6) is expressed and released by hjuman epidermal cells and epidermoid carcinoma cell lines. J Immunol 1989; 142: 1922-1928.

38.

Urbanski A. et al. Ultraviolet light induces increased circulating interleukin-6 in humans. J Invest Dermatol 1990; 94: 808-811.

39.

Turksen K. et al. Interleukin 6: insights to its function in skin by overexpression in transgenic mice. Proc Natl Acad Sci (USA) 1992; 89: 5068-5072.

40.

Aberer W. et al. Ultraviolet light depletes surface markers of Langerhans cells . J Invest Dermatol 1981; 76: 202-210.

41.

Yoshikawa T. , Kurimoto I. , Streilein JW Tumour necrosis factor-alpha mediates ultraviolet light B-enhanced expression of contact hypersensitivity. Immunol 1992; 76: 264-271.

42.

Beissert S. , Ullrich SE , Hosoi J. , Granstein RD Supernants from uvb radiation-exposed keratinocytes inhibit langerhans cell presentation of tumor-associated antigens via il-10 content. J Leuk Biol 1995; 58: 234-240.

43.

Ullrich SE Mechanism involved in the systemic suppression of antigen-presenting cell function by uv irradiation. Keratinocyte-derived IL-10 modulates antigen-presenting cell function of splenic adherent cells. J Immunol 1994 ; 152: 3410-3416.

44.

Krutmann K. Grewe Involvement of cytokines, dna damage, and reactive oxygen intermediates in ultraviolet radiation-induced modulation of intercellular adhesion molecule-1 expression/ [review]. J Invest Dermatol 1995; 105: 67S-70S.

45.

Grewe K. , Gyufko K. , Krutmann J. Interleukin-10 production by cultured human keratinocytes: regulation by ultraviolet b and ultraviolet al radiation. J Invest Dermatol 1995; 104: 3-6.

46.

el-Ghorr AA , Norval M. A monoclonal antibody to cis-urocanic acid prevents the ultraviolet-induced changes in langerhans cells and delayed hypersensitivity responses in mice, although not preventing dendritic cell accumulation in lymph nodes draining the site of irradiation and contact hypersensitivity responses. J Invest Dermatol 1995; 105: 264-268.

47.

Muller G. et al. IL-12 as mediator and adjuvant for the induction of contact sensitivity in vivo. J Immunol 1995; 155: 4661-4668.

48.

Davis TL , Lyde CB , Davis BM , Sontheimer RD Perturbation of experimental ultraviolet light-induced erythema by passive transfer of serum from subacute cutaneous lupus erythematosus patients. J Invest Dermatol 1989; 92: 573-577.

49.

Norris DA Cytokine modulation of adhesion molecules in the regulation of immunologic cytotoxicity of epidermal targets. J Invest Dermatol 1990; 95: 111S-120S.

50.

Norris DA Immune Mechanisms in Cutaneous Disease. Marcel Dekker, Inc; New York, NY, 1989 pp 123-166.

51.

Dustin ML , Singer KH , Tuck DT , Springer TA Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon-gamma and is mediated by intercellular adhesion molecule-1 (ICAM-1). JExp Med 1988; 167: 1323-1340.

52.

Makgoba MW et al. Functional evidence that intercellular adhesion molecule 1 (ICAM-1) is a ligand for LFA-1 dependent adhesion in T cell-mediated cytotoxicity. Eur J Immunol 1988; 18: 637-640.

53.

Makgoba MW et al. ICAM-1 a ligand for LFA-1 dependent adhesion by B, T and myeloid cells. Nature 1988; 331: 86-91.

54.

Dustin ML et al. A natural adherence molecule (ICAM-1): Induction by IL-1 and interferon gamma, tissue distribution, and function. J Immunol 1986; 137: 245-254.

55.

Kashihara Sawami M. , Norris DA The state of differentiation of cultured human keratinocytes determines the level of intercellular adhesion molecule-1 (ICAM-1) expression induced by gamma interferon. J Invest Dermatol 1992 ; 98: 741-747.

56.

Norris DA et al. Ultraviolet radiation can either suppress or induce expression of intercellular adhesion molecule 1 (ICAM-1) on the surface of cultured human keratinocytes. J Invest Dermatol 1990; 95: 132-138.

57.

Bennion SD et al. In three types of interface dermatitis, different patterns of expression of intercellular adhesion molecule-1 (icam-1) indicate different triggers of disease. J Invest Dermatol 1995 ; 105: 71S-79S.

58.

Barker Jnwn et al. Marked synergism between tumor necrosis factor alpha and interferon-gamma in regulation of keratinocyte-derived chemotactic factors and adhesion molecules. J Clin Invest 1990; 95: 605-608.

59.

Stephansson E. , Ros AM Expression of intercellular adhesion molecule-1 (icam-1) and okm5 in uva- and uvb-induced lesions in patients with lupus erythematosus and polymorphous light eruption. Arch Dermatol Res 1993; 285: 328-333.

60.

Springer TA Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994; 76: 301-314.

61.

Simon SI et al. L-selectin (cd621) cross-linking signals neutrophil adhesive functions via the MAC-1 (CDl lb/CD18) beta 2-integrin. J Immunol 1995; 155: 1502-1514.

62.

Huang AJ et al. Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells. J Cell Biol 1993; 120: 1371-1380.

63.

Beynon HL et al. Combinations of low concentrations of cytokines and acute agonists synergize in increasing the permeability of endothelial monolayers. Clin Exp Immunol 1993; 91: 314-319.

64.

Cornelius LA et al. Selective upregulation of intercellular adhesion molecule (ICAM-1) by ultraviolet b in human dermal microvascular endothelial cells. J Invest Dermatol 1994 ; 103: 23-28.

65.

Norris P. et al. The expression of endothelial leukocyte adhesion molecule-1 (ELAM-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in experimental cutaneous inflammation: a comparison of ultraviolet B erythema and delayed hypersensitivity. J Invest Dermatol 1991; 96: 763-770.

66.

Sauder DN , Wong D. , Laskin C. Epidermal cytokines in murine lupus. J Invest Dermatol 1993; 100: 42S-.46S.

67.

Velthuis PJ , van Weelden H. , vanWichen D. , BaartdelaFaille H. Immunohistopathology of light-induced skin lesions in lupus erythematosus. Acta Derm Venereol (Stockholm) 1990; 70: 93-98.

68.

Sontheimer RD , Bergstresser PR Epidermal Langerhans cell involvement in cutaneous lupus erythematosus. J Invest Dermatol 1982 ; 79: 237-243.

69.

Vole Platzer et al. Accumulation of gamma delta T cells in chronic cutaneous lupus erythematosus. J Invest Dermatol 1993 ; 100: 84S-91S.

70.

Kaufmann She. Heat shock proteins and the immune response . Immunol Today 1990; 11: 129-136.

71.

Norton PM , Isenberg DA , Latchman DS Elevated levels of the 90 kd heat shock protein in a proportion of SLE patients with active disease. J Autoimmun 1989; 2: 187-195.

72.

Norris DA Pathomechanisms of photosensitivie lupus erythematosus. J Invest Dermatol 1993; 100: 58S-68S.

73.

Sontheimer et al. Serologic and HLA associations in subacute cutaneous lupus erythematosus: a clinical subset of lupus erythematosus. Ann Int Med 1982; 97: 664-671.

74.

Weston WL , Harmon C. , Peebles C. A serologic marker for neonatal lupus. Brit J Dermatol 1982; 107: 377-382.

75.

Sontheimer RD Questions pertaining to the true frequencies with which anti-Ro/SS-A autoantibody and the HLA-DR3 phenotype occur in subacute cutaneous lupus erythematosus patients. J Am Acad Dermatol 1987 ; 16: 130-134.

76.

Lee LA , David KM

Cutaneous lupus erythematosus. Curr Probl

Dermatol 1989 ; 1: 161-210.

77.

Buyon JP et al. Acquired congenital heart block. Pattern of maternal antibody response to biochemically defined antigens of the SSA/Ro-SSB/La system in neonatal lupus. J Clin Invest 1989; 84: 627-634.

78.

McCauliffe DP , Sontheimer RD Molecular characterization of the Ro/SS-A autoantigens. J Invest Dermatol 1993; 100: 73S-79S.

79.

Lee LA et al. Autoantibody Markers of Cutaneous Lupus Erythematosus. J Invest Derinatol 1993; 100: 573.

80.

Provost TT , Herrera-Esparaza R. , Diaz LA Nucleoprotein autoantibodies in lupus erythematosus. J Invest Dermatol 1985; 85: 133S-139S.

81.

David Bajar KM et al. Clinical, histologic, and immunofluorescent distinctions between subacute cutaneous lupus erythematosus and discoid lupus erythematosus. J Invest Dermatol 1992; 99: 251-257.

82.

Fabre VC et al. Twenty percent of biopsy specimens from sun-exposed skin of normal young adults demonstrate positive immunofluorescence [see comments] . Arch Dermatol 1991; 127: 1006-1011.

83.

Leibold AM , Bennion S. , David-Bajar K. , Schleve MJ Occurrence of positive immunofluorescence in the dermo-epidermal junction of sun-exposed skin of normal adults. J Cutan Pathol 1994; 21: 200-206.

84.

Jablonska S. , Blaszczyk M. Sclerodermalike diseases/ [review]. Clin Dermatol 1994; 12: 437—448.

85.

Ansel JC et al. Effects of UV radiation on autoimmune strains of mice: increased mortality and accelerated autoimmunity in BXSB male mice. J Invest Dermatol 1985; 85: 181-186.

86.

Natali PG , Tan EM Experimental skin lesions in mice resembling systemic lupus erythematosus . Arthritis Rheum 1973; 16: 579-589.

87.

LeFeber WP et al. Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes. J Clin Invest 1984; 74: 1545-1551.

88.

Furukawa et al. Binding of antibodies to the extractable nuclear antigens SS- A/RO and SS-B/La is induced on the surface of human keratinocytes by ultraviolet light (UVL): implications for the photogenesis of photosensitive cutaneous lupus. 1990; 94: 77-85.

89.

Jones SK The effects of hormonal and other stimuli on cell-surface Ro/SSA antigen expression by human keratinocytes in vitro: their possible role in the induction of cutaneous lupus lesions. Br J Dermatol 1992; 126: 554-560.

90.

Jones SK Ultraviolet radiation (UVR) induces cell-surface Ro/SSA antigen expression by human keratinocytes in vitro: a possible mechanism for the UVR induction of cutaneous lupus lesions. Br J Dermatol 1992; 126: 546-553.

91.

Casciola-Rosen LA , Anhalt G. , Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes [see comments]. J Exp Med 1994; 179: 1317-1330.

92.

Tan EM Autoimmunity and apoptosis [comment]. J Exp Med 1994; 179: 1083-1086.

93.

Golan TD , Elkon KB , Gharavi AE , Krueger JG Enhanced membrane binding of autoantibodies to cultured keratinocytes of systemic lupus erythemtosus patients after ultravioletB/ultraviolet A radiation. J Clin Invest 1992; 90: 1067-1076.

94.

Furukawa F. et al. Estradiol enhances binding to cultured human keratinocytes of antibodies specific for SS-A/RO and SS/B/La. Another possible mechanism for estradiol influence of lupus erythematosus. J Immunol 1988; 141: 1480-1488.

95.

Lee LA et al. Pattern of cutaneous immunoglobulin G deposition in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro (SSA) autoantibodies into human skin-grafted mice. J Clin Invest 1989; 83: 1556-1562.

96.

Nieboer C. , Tak Diamand Z , VanLeeuwen Wallau HE. Dust-like particles: a specific direct immunofluorescence pattern in sub-acute cutaneous lupus erythematosus. Br J Dermatol 1988; 118: 725-729.

97.

Golan TD , Gharavi AE , Elkon KB Penetration of autoantibodies into living epithelial cells. J Invest Dermatol 1993; 100: 316-322.

98.

Norris DA et al. The role of RNP, Sm, and SS-A/Ro-specific antisera from patients with lupus erythematosus in inducing antibody-dependent cellular cytotoxicity (ADCC) of targets coated with nonhistone nuclear antigens. Clin Immunol Immunopathol 1984; 31: 311 320.

99.

Bennion SD et al. IgG subclasses in the serum and skin in subacute cutaneous lupus erythematosus and neonatal lupus erythematosus. J Invest Dermatol 1990; 95: 643-646.

100.

Norris DA et al. Systematic comparison of antibody-mediated mechanisms of keratinocyte lysis MIT ∈. J Immunol 1985; 135: 1073-1079.

101.

Furukawa F. , Kanauchi H. , Imamura S. Susceptibility to uvb light in cultured keratinocytes of cutaneous lupus erythematosus. Dermatology 1994; 189 (Suppl. 1): 18-23.

102.

Norris DA , Lee LA Antibody-dependent cellular cytotoxicity and skin disease. J Invest Dermatol 1985 ; 85: 165S-175S.

103.

Bangert JL , Freeman RG , Sontheimer RD , Gilliam JN Subacute cutaneous lupus erythematosus and discoid lupus erythematosus. Comparative histopathologic findings. Arch Dermatol 1984; 120: 332-337.

104.

Cohen JJ Apoptosis. Immunol Today 1993; 14: 126-130.

105.

Fadok VA et al. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 1992; 148: 2207-2216.

106.

Norris DA Editorial: Differential control of cell death in the skin. Arch Dermatol 1995 ; 131: 945-948.

107.

Wright SC et al. Apoptosis and DNA fragmentation precede TNF-induced cytolysis in U937 cells. J Cell Biochem 1992; 48: 344-355.

108.

Lowin B. , Beermann F. , Schmidt A. , Tschopp J. A null mutation in the perforin gene impairs cytolytic t lymphocyte- and natural killer cell-mediated cytotoxicity. Proc Natl Acad Sci (USA) 1994; 91: 11571-11575.

109.

Lowin B. , Hahne M. , Mattmann C. , Tschopp J. Cytolytic t-cell cytotoxicity is mediated through perforin and fas lytic pathways . Nature 1994; 370: 650-652.

110.

Irmler M. et al. Granzyme a is an interleukin 1 beta-converting enzyme. J Exp Med 1995; 181: 1917-1922.

111.

Stalder T. , Hahn S. , Erb P. Fas antigen is the major target molecule for CD4 + T cell-mediated cytotoxicity . J Immunol 1994; 152: 1127-1133.

112.

Suda T. , Takahashi T. , Golstein P. , Nagata S. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 1993; 75: 1169-1178.

113.

Budtz PE , Spies I. Epidermal tissue homeostasis: apoptosis and cell emigration as mechanisms of controlled cell deletion in the epidermis of the toad, Bufo bufo. Cell Tissue Res 1989; 256: 475-486.

114.

Weedon D. , Strutton G. Apoptosis as the mechanism of the involution of hair follicles in catagen transformation. Acta Derm Venereol (Stockholm ) 1981; 61: 335-3399.

115.

McCall CA , Cohen JJ Progrmamed cell death in terminally differentiating keratinocytes: role of endogenous endonuclease. J Invest Dermatol 1991; 97: 111-114.

116.

Weedon D. Apoptosis in lichen planus. Clin Exp Dermatol 1980; 5: 425-430.