Oncocytic meningioma is an uncommon variant of meningioma, characterized histologically by cells rich in mitochondria. This subtype of meningioma needs to be distinguished from other types of meningioma because of its more aggressive behavior. A case of oncocytic meningioma showing rapid clinical progression with diffuse intracranial dissemination after radiosurgery is described. Resistance to radiotherapy has been previously reported in oncocytic tumors of various body sites. This new case is a further example of the greater aggressiveness of oncocytic meningioma, suggesting that radiation therapy might worsen the course of disease.
Roncaroli F, Riccioni L, Cerati M, et al.Oncocytic meningioma. Am J Surg Pathol. 1997;21: 375-382.
2.
Louis DN, Scheithauer BW, Budka H, von Deimling A, Kepes JJ.Meningiomas. In Kleihues P, Cavenee WK (eds): WHO Classification of Tumours of the Nervous System. Lyon, France: IARC Press; 2000:175-196.
3.
Jaaskelainen J.Seemingly complete removal of histologically benign intracranial meningioma: late recurrence rate and factors predicting recurrence in 657 patients. A multivariate analysis. Surg Neurol. 1986;26: 461-469.
4.
Caldarella A, Buccoliero AM, Marini M, Taddei A, Mennonna P, Taddei GL.Oncocytic meningioma: a case report. Pathol Res Pract. 2002;198: 109-113.
5.
Cimmino A, Giangaspero F, Pennella A, et al.Oncocytic meningioma. Case report [in Italian]. Pathologica. 2000; 92: 82-85.
6.
Malik I, Rowe JG, Walton L, Radatz MW, Kemeny AA.The use of stereotactic radiosurgery in the management of meningiomas. Br J Neurosurg. 2005;19: 13-20.
7.
Brell M, Villa S, Teixidor P, et al.Fractionated stereotactic radiotherapy in the treatment of exclusive cavernous sinus meningioma: functional outcome, local control and tolerance. Surg Neurol. 2006;65: 28-33.
8.
Maruyama K, Shin M, Kurita H, Kawahara N, Morita A, Kirino T.Proposed treatment strategy for cavernous sinus meningiomas: a prospective study. Neurosurgery. 2004;55: 1068-1075.
Nishioka H, Ito H, Hirano A, Shibata N, Kobayashi M.Immunocytochemical study of pituitary oncocytic adenomas. Acta Neuropathol. 1997;94: 42-47.
11.
Hirose K, Longo DL, Oppenheim JJ, Matsushima K.Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin-1, tumor necrosis factor, selected anti-cancer drugs and ionizing radiation. FASEB J. 1993;7: 361-368.
12.
Sun J, Chen Y, Li M, Ge Z.Role of antioxidant enzymes on ionizing radiation resistance. Free Radic Biol Med. 1998;24: 586-593.
13.
Ambrosini-Spaltro A, Salvi F, Betts CM, et al.Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy. Virchows Arch. 2006;448: 442-448.
14.
Maximo V, Sobrinho-Simoes M.Hurtle cell tumors of the thyroid. A review with emphasis on mitochondrial abnormalities with clinical relevance. Virchows Arch. 2000;437;107-115.
15.
Sobrinho-Simoes M, Maximo V, Vieira De Castro I, et al.Hurtle (oncocytic) cell tumours of thyroid: etiopathogenesis, diagnosis and clinical significance. Int J Surg Pathol. 2005;13: 29-35.
16.
Qian LW, Mizumoto K, Urashima T, et al.Radiation-induced increase in invasive potential of human pancreatic cancer cells and its blockade by a matrix metalloproteinase inhibitor, CGS27023. Clin Cancer Res. 2002;8: 1223-1227.
17.
Santin AD, Hermonat PL, Ravaggi A, Chiriva-Internati M, Pecorelli S, Parham GP.Radiation-enhanced expression of E6/E7 transforming oncogenes of human papillomavirus-16 in human cervical carcinoma. Cancer. 1998;83: 2346-2352.
