Effects of Exercise and Diet on Intervention Lipid Reduction and Serum Irisin in Adolescent Obese Rats
Yuanyuan Dai, Heshuang Ye*, Zhenhong Zhao
Physical Education Institute, University of the Chizhou, Chizhou, Anhui 247100, China
Objective: To investigate the effects of exercise and diet intervention on lipid reduction and serum Irisin expression in adolescent obese rats.
Subjects and Methods: 50 adolescent obese rats were selected and randomly divided into 5 groups with 10 rats in each group, namely obesity group (OB), diet control group (DI), exercise group (EI), medicine (conjugated linoleic acid group, CLA) and exercise + diet + medicine combined intervention group (DI+EI+CLA). Moderate exercise intensity was adopted in EI group, 4-5 times/week, intervention for 8 weeks. After 8 weeks, the rats were injected with abdominal anesthesia, and the blood and visceral adipose tissue were collected after anesthesia, and the serum Irisin concentration was measured by ELISA.
Results: (1) Compared with OB group, the body weight, visceral adipose tissue and body fat percentage in DI group, EI group, DI+EI+CLA combined intervention group were decreased in a step way (P < 0.05, P < 0.01, P < 0.01); The effect of fat reduction in EI group was significantly higher than that in DI group (P < 0.05). There were significant differences between DI group, EI group, DI+EI+CLA combined intervention group and CLA group (P < 0.05, P < 0.01, P < 0.01). (2) Compared with OB group, the serum Irisin level in DI group, EI group and DI+EI+CLA combined intervention group showed an increasing trend (P < 0.01), and there was a significant difference between EI group and DI group (P < 0.05), and there was a very significant difference between DI+EI+CLA combined intervention group and DI group (P < 0.01).
Conclusions: The 8-week intervention program has a direct effect on fat loss in adolescent obese rats, and the control effect of combined intervention on weight, body fat percentage and visceral fat is due to a single intervention strategy. Low fat, exercise and combined intervention can achieve the effect of fat reduction, and the combined intervention has the best effect. Low fat, exercise and combined intervention can increase serum Irisin level, and the increased serum Irisin is correlated with obesity index, suggesting that serum Irisin has a certain regulatory role in energy metabolism and fat.
Acknowledgements: This work was supported by 2 project grants from Key research project of natural science in colleges and universities of Anhui Provincial Department of Education (Grant No. KJ2021A1135); Funding project for visiting and studying of young backbone teachers in China (Grant No. JNFX2023071).
Corresponding Author: Heshuang Ye, Physical Education Institute, University of the Chizhou, Chizhou, Anhui 247100, China.
Application of Acupoint Laser Therapy in Postoperative Rehabilitation of Anterior Cruciate Ligament Injury Reconstruction of The Knee Joint
Shuyi Cui1,2, Jiayan Liang3, Guangtian Liu4, Liuxia Guo1,2, Wen Yan1,2,*
1The Fifth People's Hospital of Foshan, Foshan, 528200, China; 2Foshan Rehabilitation Hospital, Foshan, 528200, China; 3Dongguan Rehabilitation Hospital, Dongguan, 523000, China; 4Shishan Town Community Health Service Center, Foshan, 528200, China
Objectives: To explore the clinical effect of acupoint laser therapy in the postoperative rehabilitation process of anterior cruciate ligament injury reconstruction of the knee joint.
Methods: 40 postoperative rehabilitation patients with anterior cruciate ligament injury of the knee joint were randomly selected and they were divided into two groups. The routine orthopedic rehabilitation for the control group patients includes: (1) Providing a comfortable rest environment, maintaining the ward clean, quiet, and comfortable. (2) Guiding reasonable diet. (3) Conducting relevant knowledge education, guiding self finger examination, providing guidance on correct rehabilitation training, and informing patients of the precautions and objectives of rehabilitation treatment. (4) Playing light music, guide relaxation techniques, position appropriately, and raise the affected limb appropriately. (5) Local massage, (6) Psychological care. After undergoing routine orthopedic rehabilitation treatment, patients in the treatment group received acupoint laser therapy. The inner and outer knee-eyes on the affected side as the treatment acupoints were selected, and the laser to irradiate each acupoint was used. During treatment, the laser power was set to 3-4W, the irradiation time for each acupoint was 5 minutes, the size of the spot was controlled at 3cm x 3cm, and the energy density was ensured to reach 150J/cm2. This treatment would be performed once a day for 30 minutes each time and will last for 4 weeks. After treatment, the clinical treatment effects, daily living abilities, and muscle strength performance of the knee joint flexor extensor muscles between the two groups were compared.
Results: There was no significant difference in various indicators between the two groups of patients before treatment (P>0.05). After treatment, the effective rates of both groups was improved (P<0.05), but the effective rate of the treatment group reached 95.0%, significantly higher than the control group’s 85.00%, and this difference was statistically significant (P<0.05). In addition, the daily living ability score (ADL) and knee flexion and extensor muscle strength (PT) of both groups were also improved (P<0.05), but the performance of the treatment group was still better than that of the control group, and the difference was also statistically significant (P<0.05).
Conclusions: Laser acupoint therapy, guided by the theory of traditional Chinese medicine meridians, replace traditional acupuncture with laser and uses low-power laser to irradiate specific acupoints, achieving effective treatment of diseases. The principle of laser acupuncture point selection is consistent with that of traditional acupuncture and moxibustion, which is regarded as the development and improvement of acupuncture tools. Scientific research and practical verification have shown that this therapy has significant effects in the treatment of anterior cruciate ligament injury of the knee joint, reducing complications, promoting functional recovery, improving patient mobility, alleviating neurological deficits, improving quality of life, and reducing disability rates.
Acknowledgements: This work was supported by a project grant from The Foshan 14th Five-Year Key Specialized Traditional Chinese Medicine Construction Project (Grant No. ZDZKJS18).
Corresponding Author: Wen Yan, The Fifth People's Hospital of Foshan, Foshan 528200, China; Foshan Rehabilitation Hospital, Foshan 528200, China.
To Investigate the Effects of Denervated Sympathetic Nerve on the Activities of Systemic Norepinephrine and RAAS, and Myocardial Fibrosis in Diabetes Rats
Dabin Pan1,#,*, Dayong Zha2,#, Lintao Zha1, Zeyang Shan3,Yang Ling1, Mengxiang Ren1
1Department of Cardiology, Yijishan Hospital Affiliated Wannan Medical College, Wuhu, Anhui 241001, China; 2Department of Cardiology, Wuhu Guangji Hospital, Wuhu, Anhui 241001, China; 3Department of Cardiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, 233000, China;
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These author contributed equally to this work.
Objective: Herein, we explored the influences of Benazepril or Renal sympathetic denervation (RDN) on the expression of norepinephrine and RAAS in serum, and the expression of Tyrosine Hydroxylase (TH), and on TGF-β1 mRNA expression and collagen I and III expression in cardiac myocytes of diabetic rats.
Subjects and Methods: 8-week-old male Sprague Dawley rats, with body weight about 210g (SPF grade) were separated into four cohorts: Sham (n = 10), diabetic control (DCM group, n = 10), benazepril (DCM + Drug, n = 10), and denervation (DCM + RDN, n = 10). We measured norepinephrine, RAAS contents, TH, collagen I and III, and TGF-β1 mRNA. The effect of RDN was monitored and confirmed by ECG lead II before closing the abdominal cavity of rats. The arrangement of cardiomyocytes in diabetic rats was shown by HE staining.
Results: ELISA results showed that the norepinephrine and RAAS contents among benazepril and RDN cohorts were substantially diminished, relative to the diabetes cohort (p<0.01), but still elevated relative to the sham cohort (p<0.05). However, HE staining showed that the arrangement of cardiomyocytes in diabetic rats was as disordered as that in diabetic rats with benazepril or RDN; Western blot showed that RDN had no effect on the high expression of TH, collagen I and III in diabetes mellitus. RT-PCR results showed that RDN could not reverse TGF-β1 mRNA in myocardial cells of diabetic rats. Benazepril could partially reverse the high expression of TH, collagen I and III, TGF-β1 mRNA in diabetes mellitus (all p < 0.05).
Conclusion: Although RDN could partly reverse the hypersecretion of norepinephrine and RAAS, it did not influence TH content in myocardial cells and myocardial fibrosis in diabetic rats.
Acknowledgements: This work was supported by Universities Scientific Research project of Anhui Province (KJ2011B192) and Dr. Dabin Pan's scientific research fund project of Yijishan Hospital affiliated Wannan Medical College (KY20580460).
Corresponding Author: Dabin Pan, Department of Cardiology, Yijishan Hospital affiliated Wannan Medical College, Wuhu, Anhui 241001, China
Study on the Impact and Mechanisms of Novel Chrysin Derivatives Conpounds on the Prolifevation and Apoptosis of Breast Cancer Cells
Hongxia Li*, Haichao Wang, Qing Wang*, Min Li, Wei Xu
College of Biological and Food Engineering, Suzhou University, Education Park Campus, Suzhou, Anhui 234000, China
Background: Chrysin has a wide range of pharmacological properties, such as antioxidant, antibacterial, anti-cancer, anti-viral, anti-diabetic activity, anti-anxiety, anti-inflammatory properties and other biological activities, However, Chrysin has some disadvantages, such as poor water solubility, low bioavailability and easy to be inactivated by glycosylation metabolism in vivo. In order to improve the water solubility and metabolic stability of chrysin, People have done a lot of modifications to its structure, many chrysin derivatives with potential pharmacological activity were obtained.
Breast cancer is the most common malignant tumor in women worldwide, with highly heterogeneous characteristics, and is the leading cause of cancer death in women, Therefore, it is very important to explore the mechanism of breast cancer cells for targeted therapy of breast cancer. At present, there is a lack of effective and less toxic drugs for the treatment of breast cancer, and chemotherapy drugs often cause adverse reactions.
Subjects and Methods: In vitro antiproliferative activity of cells was detected by MTT Laser confocal microscope was used to detect reactive oxygen species content and mitochondrial membrane potential of cells, apoptosis of cells was measured by flow cytometry, The apoptotic bands were observed by DNA gel electrophoresis, the protein expression of levels of Caspase-3, Bcl-2, Bax by Western blotting method.
Results: Genistein derivatives can inhibit the proliferation of liver cancer cells, IC50 is (27.043±1.62) μ mol/L, the inhibitory effect of NCD on MCF-7 cells was slightly higher than that of positive control, it shows that NCD has good anti-increment ability. The mitochondrial membrane potential and the relative fluorescence intensity of red/green were significantly lower than those of the control group (p < 0.01), The level of intracellular reactive oxygen species increased with the increase of drug concentration. When the drug concentration was 64μmol/L, the early and late apoptosis reached a significant difference compared with the previous two concentrations, and the degree of apoptosis increased rapidly. The apoptosis rate was increased and the apoptotic band was obvious, compared with the control group, the expression levels of Bax and Caspase-3 were significantly increased (P <0.01). The expression of anti-apoptotic protein BCL-2 was significantly decreased (P < 0.01).
Conclusion: Genistein derivative can inhibit proliferation and promote apoptosis of MCF-7 cells, and its mechanism may be up regulate the protein expression of Bax and Caspase-3 and decreased the protein expression of Bcl-2.
Acknowledgements: Natural Science Research Project in Anhui Province (KJ2021A1109, 2023AH052249), Suzhou University platform project: Anthocyanin of Blueberry extract and anticancer study (No. 2024yzd01). Suzhou, Anhui College provides funding support to 2024 national undergraduate innovation and entrepreneurship training programs (Synthesis and application of novel thiazole fluorescent probes, S202410379085), Fund for the development of biotechnology (horizontal, 07019)
Corresponding Author: Hongxia Li, College of Biological and Food Engineering, Suzhou University, Education Park Campus, Suzhou, Anhui 234000, China; Qing Wang, College of Biological and Food Engineering, Suzhou University, Education Park Campus, Suzhou, Anhui 234000, China
Utilizing Pretrained Convolutional Neural Networks for Classification of Lorenz Plots of RR Intervals
Qingqing Song*, Shaoliang Xia, Zhen Wu
Faculty of Applied Mathematics and Computer Science, Belarusian State University, Minsk, 220030, Belarus
Objectives: Heart rate variability (HRV) and the Lorenz plots of RR intervals are the key indicators for evaluating heart health. The Lorenz plots can effectively describe the dynamic changes of heart rate, but their classification is challenging. At present, mathematical calculation is the main classification method, but there are some problems, such as the difficulty of regional division, complex modes and so on. Convolutional neural network model has been proved to be effective in many problems, but its application in the classification of Lorenz plots is relatively limited.
Methods: The purpose of this study is to propose an advanced method for classifying the Lorenz Plots of RR Intervals using the pretrained convolutional neural network model, and to classify them according to the morphological characteristics of Lorenz plots. This method aims to improve the diagnostic accuracy and efficiency of cardiac diseases such as arrhythmia and heart failure. It is applied to the analysis and interpretation of ECGs in various clinical diagnostic environments. In this study, the convolutional neural network model based on the AlexNet structure and the hyperparameters optimization algorithm are used to process the pre-processing and enhanced Lorenz plots dataset for 7-class classification and 19-class classification tasks. Specifically, in the preprocessing stage, this study preprocesses and enhances the original image, including removing the text, reference lines and borders in the image, and modifying the image to black-and-white mode. In the enhancement phase, this study only uses small amplitude rotation, Gaussian blur, smoothing and other methods to enhance the dataset at a 1:11 ratio. In the pre-training stage, we adjust the input of the model to 128*128*1. In the hyperparameters optimization stage, the grid search enhanced with coordinate ascent method is used to adjust the three hyperparameters of batch size, learning rate and epochs to obtain the optimal hyperparameters combination for the model.
Results: In this study, for the 7-class classification task, when the values of learning rate, batch size and epoch times are 1e-4, 5 and 10 respectively, the accuracy of the model on the validation set reaches 99.45%. For the 19-class classification task, when the values of the three hyperparameters are 1e-5, 5 and 13 respectively, the accuracy of the model on the validation set reaches 97.77%. The method used in this study is superior to the current five classification methods, and shows significant advantages in complex multi-classification tasks, which proves the effectiveness of the method.
Conclusions: The proposed method proves the effectiveness of the pretrained convolutional neural network, especially the AlexNet structure convolutional neural network, in the Lorenz plots classification task. Expanding the sample size of dataset and exploring more complex CNN model structure are helpful for further research. This study is helpful to develop accurate and effective diagnostic tools to meet the urgent challenges of heart health.
Corresponding Author: Qingqing Song, Faculty of Applied Mathematics and Computer Science, Belarusian State University, Minsk, 220030, Belarus.
The Construction and Application of a Tiered Management Model Combining Treatment and Prevention for Hypertension Patients in Township Hospitals under County-Level Medical Institutions
Yu Pang1,*, Li Gu2, Tengyue Zhang3, Jiao Cheng4
1Department of Cardiovascular Medicine, Mianzhu People's Hospital, 618200, Deyang, China; 2Department of Internal Medicine, Xiaode Township Hospital, 618206, Deyang, China; 3Department of General Practice, Xiaode Township Hospital, 618000, Deyang, China; 4Department of Nursing Science, Xinshi Township Hospital, 618209, Deyang, China
Objectives: Hypertension is a common disease, and with numerous medical institutions available, patients have many choices for seeking treatment. To reduce the waste of medical resources while improving patient satisfaction, it is essential to study the blood pressure control of hypertension patients under different treatment and prevention management models. This approach aims to ensure patient satisfaction within a tiered management system, reduce the waste of medical and human resources, and boost the motivation and confidence of grassroots medical staff.
Methods: To explore the construction and application of a tiered management model that combines treatment and prevention for hypertension patients in township hospitals under county-level medical institutions. A prospective randomized controlled study was conducted, selecting 100 hypertension patients from Mianzhu People's Hospital and Xiaode Township Hospital,and Xinshi Township Hospital from May 2022 to May 2024. Using a random number table, patients were divided into a combined group (50 cases) and a control group (50 cases). The control group was managed under a tiered management model, while the combined group was managed under a tiered management model within a medical alliance. Both groups were managed continuously for six months. Systolic and diastolic blood pressure values were compared before management and at 3 and 6 months of management. The Health-Promoting Lifestyle Profile-II Chinese Revised Version (HPLP-II) and the Morisky Medication Adherence Scale were used to assess patients' health behaviors and medication adherence levels before management and at six months of management.
Results: During the study, there were no dropouts in either the control group or the combined group. At 3 and 6 months after implementing the tiered management model, both groups had lower systolic and diastolic blood pressure compared to before management. The blood pressure values at six months were lower than those at three months, and the combined group had lower values than the control group (P<0.05). Six months after implementing the tiered management model, both groups had higher HPLP-IIR scores compared to before management, with the combined group scoring higher than the control group (P<0.05). Medication adherence was better in both groups after six months of tiered management compared to before management, and the combined group showed better adherence than the control group (P<0.05).
Conclusions: The tiered management model combining treatment and prevention under county-level medical institutions is effective for hypertension patients in township hospitals. It can effectively control blood pressure, improve medication adherence, and enhance health behavior levels. This medical model is more conducive to increasing hypertension patients' trust in grassroots medical institutions and boosting the confidence of medical workers.
Corresponding Author: Yu Pang, Department of Cardiovascular Medicine, Mianzhu People's Hospital, 618200, De Yang, China.
Research on the Application of Artificial Intelligence Technology in Mental Health Education
Wei Han*, Jinzi Zhao
Jiaxing Nanhu University, Jiaxing, Zhejiang, China
Objectives: In the 21st century, various complex sciences such as artificial intelligence have triggered changes in the natural science community, increasingly permeating philosophy, humanities, and social sciences, profoundly changing our way of life and work patterns. With the popularization of the Internet and mobile devices, the application of artificial intelligence technology in the field of mental health education has become more and more extensive. With the arrival of the new era of artificial intelligence, the complexity of mental health work in universities has become increasingly prominent, with complex characteristics such as openness, dynamism, nonlinearity, and emergence. Through the application of artificial intelligence technology, improving the efficiency and effectiveness of mental health education, strengthening and improving mental health education in universities has become an important trend in the development of modern education, and directly affects the harmony and stability of the entire society.
Subjects and Methods: This article combines artificial intelligence technology to explore the assistance of psychological health education in universities. Through four dimensions: the urgent need to enhance the competence of psychological health teachers, the urgent need to improve the effectiveness of the overall ideological and political pattern, the urgent need to meet the personalized needs of students, and the urgent need to enhance the effectiveness of psychological health education, this article analyzes the urgency of applying artificial intelligence technology to psychological health education in universities. It clearly proposes the method of constructing a multimodal learning structure for psychological health education in universities based on the construction of a big artificial intelligence database, with a focus on building a knowledge graph, and realizing the method of adaptive feedback of psychological health education content in universities. With the help of improving the application ability of teachers' artificial intelligence, it realizes the method of human-machine cooperation in psychological health education, and promotes the guarantee system for the application of artificial intelligence technology, To achieve innovative development in the pattern of mental health education, artificial intelligence technology will be used as an important tool and practical path to enhance the high-quality and high-level development of mental health services in universities.
Results: Artificial intelligence provides new perspectives and tools for mental health education in universities, improves the effectiveness of mental health education, helps college students better cope with mental health problems, and achieves comprehensive development.
Conclusions: The application of artificial intelligence technology to assist mental health education in universities can provide useful reference and inspiration for mental health education in universities, promote the work of mental health education in universities to a new level, and comprehensively promote the leapfrog development of mental health education in universities in the new era.
Corresponding Author: Wei Han, Jiaxing Nanhu University, Jiaxing, Zhejiang, China.
Observational Study on the Efficacy of Innovative Electroacupuncture Combined with Neostigmine for Postoperative Gastrointestinal Dysmotility in Severe Pancreatitis
Ranran Tang1,*, Li Zhang2, Wenjing Yang1, Rong Ma1
1
Department of Intensive Care Medicine, Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine, Qinhuangdao, China;
2
Department of Clinical Functional Examination Center, Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine, Qinhuangdao, China
Objective: This randomized controlled study investigates the efficacy of electroacupuncture combined with neostigmine in improving postoperative gastrointestinal motility disorders in patients with severe pancreatitis.
Methods: This randomized controlled trial enrolled 98 patients from Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine, dividing them into two groups. The neostigmine control group (NC) received 1 mg of neostigmine intramuscularly every 12 h. The electroacupuncture group (EG) was treated with the same neostigmine regimen supplemented by electroacupuncture sessions twice daily. Electroacupuncture was performed at acupoints ST-36 (Zusanli), ST-25 (Tianshu), SP-6 (Sanyinjiao), and ST-37 (Shangjuxu), using a continuous 10 Hz wave adjusted to each patient's comfort level to achieve muscle twitch responses. Primary measures included the time to first flatus and bowel movement, while secondary outcomes assessed abdominal bloating, nausea, vomiting, and hospital stay length. Additionally, inflammatory markers such as interleukin-6 (IL-6), interleukin-10 (IL-10), and C-reactive protein (CRP) were evaluated on days 3 and 7 post-treatment. Both groups received standardized care, including gastrointestinal decompression and motility aids.
Results: The EG group exhibited significantly accelerated gastrointestinal recovery compared to the NC group. The times to first flatus and first defecation were reduced by more than 6 h (P < 0.001), and similar significant reductions were noted in the times to intestinal sound recovery and initiation of a liquid diet (P < 0.001). The EG group also showed a significantly lower incidence of abdominal distension (18.4% vs. 44.9%, P = 0.0091) and a reduced duration of hospital stay (18.3 days vs. 25.6 days, P < 0.001). Furthermore, time to ambulation was significantly quicker in the EG group (25.1 h vs. 33.4 h, P < 0.001). Inflammatory markers IL-6, IL-10, and CRP significantly decreased in the EG group on days 3 and 7 post-treatment (P < 0.001). Postoperative nausea and vomiting were significantly reduced within the first 24 h, though no significant differences were found in movement-related pain, nausea, or vomiting from 48 to 72 h post-surgery. Pain during movement was initially higher in the EG group in the first 48 h, but resting pain significantly decreased after 72 h (P < 0.001). Additionally, no significant differences were observed in resting and movement-related pain VAS scores between the groups after 24 h.
Conclusions: Electroacupuncture combined with neostigmine significantly enhances the recovery of gastrointestinal function in postoperative severe pancreatitis patients compared to neostigmine alone. This combination therapy also contributes to reduced inflammatory responses and shorter hospital stays, suggesting it may be a valuable adjunct to standard postoperative care protocols.
Acknowledgements: This study was supported by the 2024 Port Group scientific research project (Project No. KY202403020036): “Management and evaluation of early gastrointestinal function in severe patients with artificial intelligence combined with traditional Chinese and Western medicine”.
Corresponding Author: Ranran Tang, Department of Intensive Care Medicine, Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine, Qinhuangdao, China.
Research on Emergency Wheelchair for the Elderly Based on Medical Nursing and Rehabilitation
Wu Guo1,#, Yadi Chen2, Lulu Yan1,#, Shigeng Li3,4, Shuzhu Tian1, Huifang Chen1,5,6,7,*and Lihong Zhang1,*
1Guangdong Lingnan Institute of Technology, Guangzhou, 510663, China; 2Yunda Energy Technology Group Co., Ltd, Hangzhou, 310012, China; 3Guangzhou City Construction College, Guangzhou, 510925, China; 4XIAO Education Group, Guangzhou, 510635, China; 5Guangxi Normal University, 541001, Guilin, China; 6Jinan University, Guangzhou, 510632, China; 7Guangzhou Pearl-River Vocational College of Technology, Guangzhou, 511300, China;
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These authors contributed equally to this work.
Objective: With the aging trend of China's population becoming more and more serious, as well as the growth of medical demand and the development of its service system, the nursing and rehabilitation health care work of the elderly has become increasingly important. In order to meet the needs of the elderly with chronic diseases for activities and rehabilitation, everyone is researching, designing and manufacturing suitable wheelchairs for people who cannot walk easily. Although there are various types of wheelchairs on the market, most of them have disadvantages such as single functionality and inconvenient use. So it is urgent to make a series of optimizations in the design and manufacturing of emergency wheelchairs for the elderly to fully meet their needs.
Subjects and Methods: Firstly, this paper takes the current situation and development of the research on emergency wheelchairs for the elderly based on medical care and rehabilitation as the research background of this article. Firstly, the article combs the relevant theoretical research from the aspect of evidence-based medicine. On this basis, the paper puts forward the research questions and hypotheses, mainly focusing on the overall design, functional design, convenient use and other details of emergency wheelchairs for the elderly in China.
Results: The researchers have scientifically and reasonably designed the overall planning and internal functions of the wheelchair, allowing patients to travel smoothly and conveniently with the wheelchair, facilitating their own mobility. At the same time, qualitative observations and statistical analysis were conducted on the use of wheelchairs by patients and their families. Based on a people-oriented approach, an in-depth analysis was conducted to summarize the needs of patients and their families for wheelchairs in the current medical situation. A wheelchair that basically meets the needs of the elderly was designed. The innovative wheelchair designed by the researchers participated in the Guangdong Provincial College Students' Industrial Design Competition and received praise from the judges, winning the first prize.
Conclusion: The first-aid wheelchair described in this paper is cost-effective and easy to use. The elderly with this wheelchair will make the life and travel of the elderly more convenient, and make the daily exercise and rehabilitation health care of the elderly more relaxed and free. It is a multi-functional Wheelchair Based on the purpose of nursing and health care and rehabilitation, which is deeply loved by the elderly and is conducive to better and faster recovery of health of the elderly. It is very worthy of promotion and use.
Acknowledgements: This paper was supported by the 2023 Guangdong University Students' industrial design competition project fund, and won the first and second place in innovation and entrepreneurship competitions at all levels, especially the wheelchair design won the first prize of the 2023 Guangdong University Students' industrial design competition.
This paper was supported by the 2024 annual planning project of China Association of private education (School Development) - Research on mold applied talent mode of private colleges and Universities under new quality productivity (canfzg24134). This paper also received funding support from the 2024 Guangdong Provincial Department of Education Education Reform Project - Research on the New Mold Application Talent Training Model (No.2024GXJK1070).
Corresponding Author: Huifang Chen, Guangdong Lingnan Institute of Technology, Guangzhou, 510663, China; Guangxi Normal University, 541001, Guilin, China; Jinan University, Guangzhou, 510632, China; Guangzhou Pearl-River Vocational College of Technology, Guangzhou, 511300, China; Lihong Zhang, Guangdong Lingnan Institute of Technology, Guangzhou, 510663, China.
Risk Factors for Progression of Interstitial Lung Disease and Construction of Risk Prediction Model
Yuan Li1,#, Hao Chen1, Jianhua Yi2,#, Huifang Chen3,4,5,6,*, Shuangshi Li1,*
1Benxi Central Hospital of China Medical University, Benxi, 117000, China; 2East Hospital of the First Affiliated Hospital of Sun Yat sen University, Guangzhou, 510700, China; 3Guangxi Normal University, 541001, Guilin, China; 4Guangdong Lingnan Institute of Technology, Guangzhou, 510663, China; 5Guangzhou Pearl-River Vocational College of Technology, Guangzhou, 511300, China; 6Jinan University, Guangzhou, 510632, China
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These authors contributed equally to this work.
Objective: To explore the diagnostic traits and risk factors of interstitial lung disease (ILD) patients presenting with progressive pulmonary fibrosis, and to construct its prognostic nomogram for clinical use.
Methods: A retrospective study was conducted on 110 patients diagnosed with interstitial lung disease (ILD) from January 2021 to December 2023. Patients were divided into stable and progressive pulmonary fibrosis groups according to disease diagnosis and disease progression. The clinical data of 110 patients were collected, univariate and multifactorial logistic regression were used to analyze the influencing factors, a risk prediction model for the disease progression was developed using a nomogram, and the model’s accuracy was assessed using the C-index and calibration curve. The internal validation was performed by using the Bootstrap method for 1,000 times of repetitive sampling.
Results The incidence of progressive pulmonary fibrosis in ILD patients was 34.5%. The neuroendocrine-specific enzyme (NSE), red blood cell width coefficient of variation (RDW-CV) and HRCT score were independent risk factors for the development of progressive pulmonary fibrosis in ILD patients (P < 0.05). The consistency index of the nomogram model was 0.815 (95% CI: 0.708, 0.922). The results of the Hosmer-Lemeshow goodness-of-fit test showed that the nomogram model was well-fitted (X2 = 9.6678, P = 0.289). ROC curve analysis showed an area under the curve (AUC) of 0.871 (95% CI: 0.789, 0.953). The calibration curve analysis results showed that the nomogram's predicted incidence of disease progression was in general agreement with the actual incidence.
Conclusion: NSE, RDW-CV and elevated HRCT imaging scores are independent risk factors for PPF, and the nomogram has a good predictive effect.
Acknowledgements: This paper was supported by the 2023 key R & D program of Benxi City, Liaoning Province, China-the construction of personalized physical examination mode based on precision medicine (No. 2023zdjh006).
Corresponding Author: Huifang Chen, Guangxi Normal University, 541001, Guilin, China; Guangdong Lingnan Institute of Technology, Guangzhou, 510663, China; Guangzhou Pearl-River Vocational College of Technology, Guangzhou, 511300, China; Jinan University, Guangzhou, 510632, China; Shuangshi Li, Benxi Central Hospital of China Medical University, Benxi, 117000, China.
Research on the Integration of Traditional Chinese Medicine Industry Chain and the Development Strategy of Village Collective Economy with the Purpose of Promoting Physical and Mental Health from the Perspective of New Quality Productivity
Zhe Mao1,#, Yumei Zhao1,#, Tong Zhou1, Huifang Chen2,3,4,5,*, Xiaoju Zhang4,*
1Tianjin Public Security Hospital, Tianjin, 300040, China; 2Guangxi Normal University, Guilin, 541004, China; 3Jinan University, Guangzhou, 510632, China; 4Guangdong Lingnan Institute of Technology, Guangzhou 510663, China; 5Guangzhou Pearl-River Vocational College of Technology, Guangzhou, 511300, China;
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These authors contributed equally to this work.
Background: With the increasing global demand for traditional Chinese medicine to promote health, there is an urgent need to optimize the industry chain to ensure sustainability and stimulate rural economies.
Subjects and Methods: This study explores the integration of the traditional Chinese medicine industry chain to promote physical and mental health and the strategic development of village collective economy from the perspective of new quality productivity. This study adopts a mixed method to analyze how traditional Chinese medicine enterprises, based on promoting health, utilize the concept of quality productivity to strengthen the value chain from cultivation to market. Data collected from several traditional Chinese medicine villages shows significant differences in economic outcomes based on the degree of industry chain integration. The case study elucidates the strategy of successfully coordinating traditional technology with modern management, thereby improving production efficiency and product quality.
Results: The basis of this study is the role of innovative governance structures in promoting resource sharing, knowledge transfer, and collective brand building. In addition, this article proposes a framework for a village collective to enhance bargaining power and develop a self-sustaining economic model by effectively integrating it into the traditional Chinese medicine industry chain. The policy implications indicate that government support in the form of subsidies, training programs, and infrastructure investments is crucial for promoting scalable integration models that can revitalize rural economies. The impact on future research includes exploring cross regional scalability and long-term socio-economic effects on rural communities, and which is to develop a self-sustaining model for the healthy development of the traditional Chinese medicine industry chain with the goal of promoting public health.
Conclusions: The research results of this article emphasize the potential of the traditional Chinese medicine industry, which aims to promote the physical and mental health of the whole nation and public health, as a catalyst for the healthy development of rural revitalization on the basis of promoting public health.
Acknowledgements: This study is supported by funding for the following topics: Topic 1: Research Project of Guangdong Health Economics Society in 2024- “Research on the Integration of Traditional Chinese Medicine Industry Chain and the Development Strategy of Village level Collective Economy from the Perspective of New Quality Productivity” (Project Number: 2024-WJMF-153); Topic 2: Application for the Philosophy and Social Sciences Planning Project of Qingyuan City in 2024: “Research on the Multi-dimensional High quality Development Path of Qingyuan Tea Industry Driven by New Quality Productivity” (Project No.: QYSK2024047).
Corresponding Author: Huifang Chen, Guangxi Normal University, Guilin, 541004, China; Jinan University, Guangzhou, 510632, China; Guangdong Lingnan Institute of Technology, Guangzhou 510663, China; Guangzhou Pearl-River Vocational College of Technology, Guangzhou, 511300, China; Xiaoju Zhang, Guangdong Lingnan Institute of Technology, Guangzhou 510663, China.
Comparison of Two Reduction Methods for the Reverse Oblique Supracondylar Humerus Fractures
Youting Dang1, Xuehai Ou2, Deliang Cheng2, Honghao Duan2, Xiaolong Du2, Fei Xie2,*
1Department of Pediatric Orthopedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, Shaanxi, 710054, China; 2Department of Hand Surgery, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, Shaanxi, 710054, China
Background: This study aims to analyze and compare the clinical efficacy of the improved Skaggs reduction method and the Kirschner wire prying assisted method in the treatment of retroverted supracondylar fractures of the humerus.
Subjects and Methods: A retrospective analysis was conducted on 52 cases of Gartland III and IV retroverted supracondylar fractures of the humerus admitted to our hospital from March 2020 to April 2023, including 29 males and 23 females, aged 3 to 11 years, with an average age of (6.79 ± 2.05) years. All cases underwent closed reduction and fixation with Pic's needles, including 26 cases in the modified Skaggs method reduction group (modified group) and 26 cases in the Kirschner wire assisted reduction group (levering group). Compare the differences between two groups of patients in terms of surgical duration, intraoperative fluoroscopy frequency, Baumann angle, traction angle, postoperative elbow joint function, clinical healing time of fractures, and surgical complications.
Results: Follow up for 10-24 months, with an average of (13.8 ± 2.5) months, and clinical healing was achieved 4-6 weeks after surgery. There were no statistically significant differences in gender, age, fracture type, and elbow bruising between the two groups of patients (P>0.05). There were no statistically significant differences in the incidence of complications and fracture healing time between the two groups (P>0.05); The operation time and intraoperative fluoroscopy frequency of the levering group were lower than those of the modified group, and the difference was statistically significant (P<0.05). There was no statistically significant difference (P>0.05) in the excellent and good rates of Baumann angle, traction angle, and postoperative elbow joint function between the two groups during the last follow-up. Both groups of patients did not experience nonunion, elbow impingement, eversion, infection, myositis ossificans, or iatrogenic nerve injury.
Conclusions: The modified Skaggs method or Kirschner wire assisted reduction can achieve satisfactory reduction for the reduction of retroverted humeral condyle fractures. The use of levering and repositioning method can shorten the surgical time and reduce the frequency of fluoroscopy. It is an effective supplementary method based on the failure of manual repositioning and is worth promoting
Corresponding Author: Fei Xie, Department of Hand Surgery, Honghui Hospital, Xi'an Jiao Tong University, 555 East Friendship Road, Xi'an Shaanxi, 710054, China.
Application Evaluation of BOPPPS Teaching Model in Rheumatology and Immunology Teaching
Lei Wan1,*, Haoxiang Fang2, Xiaojun Zhang3
1
The First Clinical School of Medicine, Anhui University of Chinese Medicine, Hefei 230022, China;
2
College of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230031, China;
3
Office of Academic Affairs, Anhui University of Chinese Medicine, Hefei 230028, China
Objectives: The theoretical knowledge related to rheumatic immune diseases is extensive and abstruse, and these theories are frequently hard for novices to comprehend. The traditional teaching of rheumatic immunology often focuses on the teaching of theoretical knowledge and lacks the combination with the clinical practice of rheumatism. This type of education makes it difficult for students to apply theoretical knowledge to practical clinical situations in the learning process. In order to help students better understand and master this knowledge, we adopt the BOPPPS teaching model. The application of BOPPPS teaching model can stimulate students' learning interest and motivation, improve their clinical thinking ability, and promote students' in-depth understanding and application of rheumatism knowledge.
Methods: Rheumatic immune disease teaching, so that students feel the actual impact of rheumatism. This project explores the effectiveness of BOPPPS teaching mode in the teaching of rheumatic immune diseases. BOPPPS teaching was carried out in the teaching process of rheumatic immune diseases. To investigate the learning effect of students on rheumatic immune diseases after the implementation of teaching. 120 interns in the Department of Rheumatology from January 2021 to December 2023 were studied. The 120 interns were randomly divided into 2 groups according to the random comparison table. There were 60 patients in BOPPPS group and control group, respectively. The control group was given routine teaching, and the professor lectured interns mainly on the teaching content and advanced knowledge according to the teaching materials and syllabus, and then summarized and practiced. The BOPPPS group adopts the BOPPPS teaching model, which includes introduction (B), goal (O), pre-test (P), participation in learning (P), discussion (P) and summary (S). After the implementation of the teaching, the evaluation results, classroom effectiveness, critical thinking ability, mini-clinical practice (Mini-CEX), clinical practice thinking survey and class activity of the two groups of interns were evaluated.
Results: In the teaching of rheumatic immune diseases, BOPPPS inspires students' interest and motivation. After teaching, the test scores of practical skills and basic knowledge in BOPPPS group were significantly higher than those in control group (P < 0.01). The BOPPPS group had a higher proportion than the control group in improving comprehensive analysis skills, having enough learning time in class, focusing on learning content and subjective initiative. After teaching, it was found that the BOPPPS group was better than the control group in the dimensions of truth seeking, analytical ability, systematic ability and intellectual curiosity (P < 0.05 or P < 0.01). The scores of medical interview/history collection, rheumatic disease diagnosis and treatment, tissue efficacy and overall performance in BOPPPS group were significantly higher than those in control group (P < 0.05 or P < 0.01). Through post-teaching observation, it was found that the proportion of interns in BOPPPS group was higher than that in the control group in terms of deepening the understanding of theoretical knowledge, improving the overall clinical thinking and improving the dimension of solving clinical practical problems. The scores of problem-analysis ability, problem-solving ability and knowledge mastery in BOPPPS group were significantly higher than those in control group (P < 0.05 or P < 0.01).
Conclusions: The application of BOPPPS teaching model in the teaching of rheumatic immune diseases can stimulate students' learning interest and motivation, and promote students' in-depth understanding and application of rheumatic knowledge. BOPPPS model has achieved remarkable results in the teaching of rheumatoid immune diseases, which can improve the ability of interns to comprehensively analyze rheumatoid immune diseases, and is conducive to the development of clinical teaching of rheumatoid diseases. BOPPPS teaching mode also pays attention to the evaluation and feedback of teaching effect to help teachers adjust teaching strategies in time and improve teaching effect.
Acknowledgements: This work was supported by Anhui University Quality Engineering Project Provincial Education and Teaching Reform Research Project (2022jyxm883); Anhui Province Higher Education Quality Engineering Project (2022jyxm845).
Corresponding Author: Lei Wan, The First Clinical School of Medicine, Anhui University of Chinese Medicine, Hefei 230022, China.
Efficacy and Safety Study of Lysine Acetylsalicylate Injection Given at the Quchi Acupoint in Critically Ill Patients against Postoperative Fever
Li Zhang1, Haiting Wang2, Ranran Tang3,*
1
Clinical Functional Testing Center, Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine, Qinhuangdao, 066000, China;
2
Intensive Care Unit, Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine, Qinhuangdao, 066000, China;
3
Department of Intensive Care Medicine, Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine, Qinhuangdao, 066000, China
Objectives: This study aims to evaluate the effectiveness and safety of administering lysine acetylsalicylate (LAS) at the Quchi (LI11) acupoint for managing postoperative fever in critically ill patients. The focus is on whether this targeted approach can provide rapid fever control, minimize the need for additional antipyretic medications, and reduce systemic side effects.
Methods: This retrospective study has been done at Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine spanned from July 2022 to July 2024, including 124 critically ill postoperative patients. Participants were randomized into two groups: Group A received 0.9 g of lysine acetylsalicylate (LAS) intravenously in 100 mL saline, while Group B received the same dose administered directly at the Quchi (LI11) acupoint. Outcomes assessed included temperature regulation, monitored at baseline, 30, 60, and 120 min, then hourly for up to six hours; inflammatory markers such as CRP, IL-6, and TNF-α; adverse reactions; and quality of life via the SF-36 scale.
Results: In this study of 124 critically ill patients, Group B, treated with LAS at the LI11 acupoint, showed a faster onset of antipyretic effect (1.75 ± 0.62 min) compared to Group A's intravenous administration (1.41 ± 0.34 min, P = 0.0055). Group B also demonstrated more effective fever reduction at 60 and 120 min (P < 0.0001, P = 0.0023). Temperature management was notably better in Group B, with a decrease from 39.8°C to 36.5°C at 120 min, versus Group A's reduction from 39.5°C to 37.3°C. The administration of lysine acetylsalicylate at the LI11 acupoint significantly reduced inflammatory markers CRP, IL-6, and TNF-α compared to intravenous administration, demonstrating enhanced control of systemic inflammation and improved recovery outcomes in post-surgery critically ill patients (all P < 0.001). Adverse reactions were minimal and similar across groups, with no significant differences in frequency or type (P > 0.05). Quality of Life assessments showed substantial improvements in all domains for Group B, indicating enhanced overall well-being post-treatment (P < 0.001).
Conclusions: Targeted administration of LAS at the LI11 acupoint is a viable and effective method for fever management in critically ill postoperative patients. It offers significant advantages in terms of faster fever resolution and reduced pharmacological intervention, with minimal adverse effects. Further research is recommended to validate these findings across a broader patient population.
Acknowledgements: This study was supported by the 2024 Port Group scientific research project (Project No. KY202403020038): “Evaluation of lysine acetylsalicylate injection at the Quchi acupoint for fever in critically ill patients under artificial intelligence”.
Corresponding Author: Ranran Tang, Department of Intensive Care Medicine, Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine, Qinhuangdao, 066000, China.
Effect of Sorafenib Combined with Soy Isoflavones in the Tumor Microenvironment of Hepatocellular Carcinoma
Yan Li1,#, Hao Li1,#, Hongyu Liu2, Zhen Yan3, Xiangjin Meng4, Fangyuan Wang3, Dongmei Wei4, Fei Zhou3, Bingyi Sun3, Heliang Yin3,*
1Department of Clinical Medicine, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157000 China;
2
Pathology Department, the First Hospital of Qiqihar, Qiqihar, Heilongjiang 161005, China;
3
Center of Integrative Research, the First Hospital of Qiqihar, Qiqihar, Heilongjiang 161005, China;
4
Science and Education Department, the First Hospital of Qiqihar, Qiqihar, Heilongjiang 161005, China;
#
These authors contribute equally to this work.
Objectives: Hepatocellular carcinoma is a common malignancy of the digestive system, which is often found in the advanced stage of cancer. Therefore comprehensive treatment has become an important means of treatment for it. In recent years, with the deepening of people's understanding of the tumor microenvironment, the changes in the microenvironment during tumor genesis, development and treatment have become the focus of attention. As the first standard drug for the treatment of hepatocellular carcinoma, the drug resistance problem has been plaguing its therapeutic efficacy. As a plant soybean extract, soybean isoflavones are considered as new drug candidates for the inhibition of malignant tumors alone or in combination due to their multi-target and low toxicity. Therefore, the study of the changes in the tumor microenvironment during their treatment is helpful to solve the problems about the mechanism of drug resistance and propose a new treatment plan. At the same time, due to the similarity between hepatocellular carcinoma and gastrointestinal tumors, such as the phosphatidylinositol-3-kinase/protein kinase B/the mammalian target of rapamycin signaling pathway, this study is also of great significance for gastrointestinal tumors.
Methods: 48 mice were divided into four groups. One group does not receive treatment, and the other three groups receive soy isoflavones, sorafenib, and soy isoflavones combined with sorafenib, respectively. After 21 days of treatment, tumor size and weight were measured, what is more, pathology sections, western blotting and real time reverse transcription polymerase chain reaction will be also observed. Finally, statistics are used to validate the experimental results.
Results: After 21 days, the weight, liver and tumor conditions of the three groups of mice treated were significantly better, and the treatment of sorafenib combined with soy isoflavones was significantly better than that of soy isoflavones alone (p < 0.01). There were more changes of histopathology and lipid contents in control group (p < 0.05).Western blotting showed cleaved caspase3, caspase8 and hypoxia-inducible factors-2α are lower in the control group (p < 0.05).Western blotting also showed hypoxia-inducible factors-1α and Von Hippel-Lindau protein are higher in the control group (p<0.01).Real time reverse transcription polymerase chain reaction showed BCL2-Associated X is lower in the control group (p < 0.01).What’s more, Real time reverse transcription polymerase chain reaction also showed B-cell lymphoma-2,Glucose transporter type 1,the facilitated glucose transporter-1,transforming growth factor-β,transforming growth factor β receptor1 and vascular endothelial growth factor are higher in the control group (p < 0.01).
Conclusions: The results showed soy isoflavones, sorafenib and sorafenib combined with soy isoflavones can significantly change the tumor microenvironment of HCC, which in turn affects the tumor progression. At the same time, soy isoflavones and sorafenib combined with soy isoflavones can also inhibit hepatocellular carcinoma. Furthermore, Soy isoflavones may also be potential drugs for tumors of the digestive tract.
Acknowledgements: This work was supported by the Natural Science Foundation of Heilongjiang Province (grant number: LH2020H136).
Corresponding Author: Heliang Yin, Center of Integrative Research, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161005, China.
The Activity Monitoring of Traditional Chinese Medicines as MβLs Inhibitors in Living NDM-1 E.coli Cells
Yilin Zhang1, Lingyan Kong2, Jie Cao2, Xuejun Wang1, Yong Yan1, Jing Wei1, Chengfang Qiao3,*
1
College of Biology Pharmacy and Food Engineering, Shangluo University, Shangluo 726000, Shaanxi, China;
2
The College of Life Sciences, Northwest University, Xi’an 710069, Shaanxi, China;
3
College of Chemical Engineering and Modern Materials, Shangluo University, Shangluo 726000, Shaanxi, China
Objectives: New Delhi metallo-β-lactamase subclass 1 (NDM-1) is a global public health threat which can produce resistance to a broad spectrum of β-lactam antibiotics. There are currently less effective treatment options for treating NDM-1 “superbug”, and no promising NDM-1 inhibitors were used in clinical practice. The discrepancies of bioactivity in vitro experimental and in living resistance bacteria cell have substantially complicated the process to discover NDM-1 inhibitors.
Methods: In this study, a novel UV-Vis analytical approach was introduced to monitor the hydrolytic decomposition of the carbapenem antibiotic imipenem inside E.coli cells expressing NDM-1. Here it was applied to assess the inhibitory ability of traditional Chinese medicine (TCM) which was regarded as an effective method to solve antibiotic resistance. The TCM extracts and monomer were able to contain the hydrolysis of imipenem by NDM-1 in varying degrees in living E.coli cells, and the obtained result is close to the biological function in physiological environment of target enzyme. The studies demonstrated through the containing process of the hydrolysis of imipenem in vivo by a known NDM-1 inhibitors EDTA and a clinical serine β-lactamases (SβLs) inhibitor clavulanic acid.
Results: The TCM extracts and monomer exhibited inhibitory activity in living NDM-1 E.coli cells in varying extents, inducing significant cellular disruption as evidenced by SEM analysis, including punctate damage, cellular distension, a concave cell membrane surface, and irregular ruptures at the poles of the bacteria. Quercetin can restrain the structural damage of imipenem to the greatest extent with the final concentration of 4.5 μM, and the optimal synergistic inhibitory concentration of rutin was 36 μM. Specifically, the combination of L.chuanxiong and imipenem showed synergistic effect with the FIC value of 0.0078125 and 0.009765625, which reduced the required imipenem concentration to 1/128 MIC and the minimum IC50 value was 158.0 μg/mL.
Conclusions: The UV-Vis method is a straightforward and potent method for examining the inhibitory effects of TCM against NDM-1 in native cellular environment in real time. The UV-Vis technique can be applied in complex biological systems, and the screened TCM provide important information for the lead compound framework and enhance application value of TCM against NDM-1.
Acknowledgments: This work was supported by the National Natural Science Foundation of China [grant numbers 22173056]; the Qin Chuangyuan “scientist+engineer” team construction project of Shaanxi Province [grant numbers 2023KXJ-180]; the Youth Innovation Team of Shaanxi Universities [grant numbers 23JP045]; and the Science and Technology Development Fund of Zhang Shengyong Academician [grant numbers 18YSZX002].
Corresponding Author: Chengfang Qiao, College of Chemical Engineering and Modern Materials, Shangluo University, Shangluo 726000, Shaanxi, China.
Delayed Neurological Improvement after Intravascular Repatency in Acute Posterior Circulation Ischemic Stroke
Licang Zhu1,2#, Xiaofen He3#, Mingyu Hu1, Chao Wang1, Weihua Xu2, Guodong Qian2, Shilong Wang2, Xiaoxu Shen2, Fulei Chen2, Linzhi Dai2, Junqiang Si1,*, Dong Zhao1,2
1Shihezi University, Shihezi, 832000, China; 2The First Affiliated Hospital of the Shihezi University, Shihezi, 832008, China; 3Shihezi Maternal and Child Health Hospital, Shihezi, 832000, China;
#
These authors contributed equally to this work.
Purpose: The objective of this study was to meticulously investigate and comprehensively analyze the prevalence and predictive factors of delayed neurological function improvement (DNI) subsequent to achieving intravascular repatency through endovascular interventional therapy in patients diagnosed with acute posterior circulation ischemic stroke (aPCI).
Method: The patients for this research were sourced from The First Affiliated Hospital of the Medical College of Shihezi University. A total of 127 patients with aPCI who underwent endovascular thrombectomy from January 2022 to December 2023 and met the well-defined inclusion and exclusion criteria were recruited. The degree of vascular repatency was evaluated using the mTICI score, and the prognosis was assessed by the 90-day mRS. The selected patients were classified into two distinct groups: early neurological function improvement (ENI) and no early neurological function improvement (No-ENI). Among the patients without ENI, those who achieved functional independence after 90 days were further divided into DNI and No-DNI subgroups. Basic data of all the patients were meticulously collected, and various clinical biochemical indexes were tested.
Result: The average age of the 127 patients with aPCI was 61.2 ±12.8 years. Out of these, there were 35 females constituting 27.6% of the cohort, and 92 males accounting for 72.4%. Among them, 80 patients (63%) demonstrated ENI, while 47 (37.0%) had No-ENI. After 90 days, within the No-ENI group, 12 patients manifested DNI (25.5%), and 35 patients (74.5%) had No-DNI. In the Univariate Logistic regression analysis, the predictors of DNI, such as the postoperative GCS, preoperative mRS grade, preoperative and postoperative NIHSS, and the postoperative 5-day NIHSS score, exhibited significant disparities between the DNI and No-DNI groups. These factors can undoubtedly serve as reliable predictors of DNI. Moreover, there were notable differences in aspects like sex (male), posterior cerebral artery occlusion, and LAA vascular embolism (P < 0.05) between the DNI and No-DNI groups.
Conclusions: The postoperative GCS score, preoperative mRS grade, preoperative and postoperative NIHSS scores, the NIHSS score and albumin content after 5 days can effectively be utilized as predictive indicators of aPCI. Approximately one-fourth of the patients with aPCI did not experience an improvement in clinical function within the initial 24 hours of achieving complete intravascular repatency. Nevertheless, this circumstance has a pronounced effect on the long-term clinical prognosis, highlighting the significance of continuous monitoring and individualized management for these patients.
Acknowledgements: This study was supported by the Support Programme for Innovation and Development of Key Industries in South Xinjiang (2022DB030).This study was supported by the Natural Science Research Project of Shihezi University (ZZZC201821A).This study was supported by the Key Fund Project of the First Affiliated Hospital of Shihezi University (ZD202002).This study was supported by the Science and Technology Research Project in Key Areas of Shihezi City, Bashi Division (2022SF002).
Corresponding Author: Junqiang Si, Shihezi University, Shihezi, 832000, China
Study on the Prospects of the Application of Chinese Medicine Mouthwash in the Field of Oral Health: A Case Study of Chinese Population
Weihan Huang1, Weichen Huang2, Zhongyan Lin3,*
1The First Clinical Medical College, Southern Medical University, Guangzhou, China; 2School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China; 3International digital Economy College, Minjiang University, Fuzhou, China
Objectives: The objective of this study is to gain an in-depth understanding of the Chinese population's awareness of Chinese medicine mouthwash and to assess its current application status in China. The study explores the prevalence of oral health issues across different age groups and evaluates the potential role of Chinese medicine mouthwash in preventing and improving oral health problems.
Methods: This study employed an online questionnaire survey method, conducting a random sampling of the Chinese population aged 18 and above, collecting a total of 332 valid questionnaires. The questionnaire was designed with reference to “The Fourth Chinese National Oral Health Epidemiological Survey Report” and “World Health Organization Oral Health Surveys: Basic Methods, 5th Edition”, encompassing 14 questions that cover the oral health status of respondents, their self-coping strategies when facing oral problems, and their knowledge and usage experience with Chinese medicine mouthwash. After the collection of data, descriptive statistical analysis and chi-square tests were performed using SPSS 26.0 software to determine the relationships and differences among various variables.
Results: The survey results reveal that oral health issues are prevalent across all age groups in China, yet the use of Chinese medicine mouthwash is not widespread. The majority of respondents indicated that they have never used Chinese medicine mouthwash or have only used health-care mouthwashes. Furthermore, the market recognition of Chinese medicine mouthwash is relatively low, with many respondents having limited understanding of the specific efficacy and usage methods of Chinese medicine mouthwash.
Conclusions: Chinese medicine mouthwash, characterized by its minimal side effects, gentle action, and suitability for long-term use, is considered an effective auxiliary means for oral care. However, enhancing its market position requires strengthening publicity and raising public awareness of Chinese medicine mouthwash. On the technical level, there is a need to address the purification and stability of the active ingredients in Chinese medicine to ensure product quality and efficacy. Further scientific research and market surveys can provide support for the rational positioning and promotion of Chinese medicine mouthwash. It is anticipated that in the future, Chinese medicine mouthwash will play a more significant role in the field of oral care, contributing to the improvement of public oral health levels.
Acknowledgements: This research was supported by Scientific and Technological Major Special Project of Fujian Provincial Health Commission (No.2021ZD01004).
Corresponding Author: Zhongyan Lin, International digital Economy College, Minjiang University, Fuzhou, China.
Research on the Influence of Network Effect on the Health Food Value from the Perspective of Human Health Perception
Yushuang Tang, Feng Luo*, Lin Zhou, Haobo Zhou
School of Economics and Management, Sichuan Tourism University, Chengdu, Sichuan 610100, China
Background: The role of health food in improving and maintaining physical health has received increasing attention. The enhancement of network effects, especially through the influence of social media and online platforms, may change the market performance of health foods and have a real impact on individual health. However, there is still a lack of systematic research on how the network effect affects the health effect by affecting the market value of health food. This paper explores the impact of network effects on the market value of health foods and evaluates the potential impact of these market changes on the health effects of health foods, especially in disease prevention and health management.
Methods: In this study, comprehensive analysis methods such as questionnaire method, field method and data crawler were used to collect and analyze the clinical research data and network evaluation data of health food. Specifically include: systematic review of clinical trials, analysis of health food in cardiovascular health, immune system, bone health and other aspects of the effect; combined with user feedback and product evaluation on the network platform, a statistical model was used to evaluate the impact of network effects on the market performance and health effects of health food.
Results: The study showed that the network effect significantly improved the market awareness of health food and consumers ' willingness to use it. Clinical data show that with the positive increase of network evaluation, the benefits of related health food in cardiovascular health have been improved, and users have made significant progress in lowering cholesterol and improving blood pressure. In addition, the effects of health foods on immune function improvement and bone health support have also been verified, especially in the elderly population.
Conclusion: The network effect improves the health effect of health food in practical application by enhancing consumers ' trust in the health effect of health food. It is suggested that the influence of network effect should be fully considered in the formulation of health management and disease prevention strategies to optimize the application effect of health food.
Acknowledgements: Sichuan Key Laboratory of Philosophy and Social Sciences, Sichuan Provincial Key Laboratory of Artificial Intelligence (CR24Y12). Chengdu Cultural and Economic Research Center (CE202418). Sichuan Provincial Philosophy and Social Science Fund (24GL065).
Corresponding Author: Feng Luo, School of Economics and Management, Sichuan Tourism University, Chengdu, Sichuan 610100, China.
Competitive Interactions of Human Serum Proteins with Chloroquine and Hydroxychloroquine
Yongchun Liu1,*, Jing Luo2, Fei Li3, Yijie He1, Siyuan Wang2, Zixuan Liang2, Huili Qi1, Xiaoxia Wei1, Chunxiao He1, Yingying Li1, Ruixia Lei1, Yunxia Gao1, Fangjun Shi1, Lili Li1
1
College of Petroleum and Chemical Engineering, FLUOBON Pilot Base of Chemical Engineering, Key Laboratory of Efficient Utilization of Oil and Gas Resources in Longdong of Gansu Province, Longdong University, Qingyang 745000, Gansu, China;
2
Qingyang Center for Disease Control and Prevention, Qingyang 745000, Gansu, China;
3
Qingyang Central Blood Station, Qingyang 745000, Gansu, China
Background: There are still no specific drugs for treating SARS-CoV-2 so far. In the face of variant strains, both the protection rate of vaccine and the activity of antibody drugs decrease. There is still an urgent need for antiviral drugs or effective treatment plans that can maintain the activity of various mutant strains in clinical practice.
Subjects and Methods: The binding of serum proteins to drug affects its transport, diffusion, distribution at the lesion site and blood in vivo. The study was to investigate the interaction characteristics and competitive relationship between chloroquine and hydroxychloroquine and major human serum proteins under the physiological conditions of human body in vitro. Fluorescence titration was used to investigate the binding constants, thermodynamic parameters, and further to investigate the binding modes. The BIOVIA Discovery Studio 2019 and Pymol software were used to perform molecular docking, in order to calculate the internal strain energy of the ligand and the receptor-ligand interaction energy and to further determine the binding modes. Centrifugal ultrafiltration and UV-vis spectrometry were used to calculate the molar binding rate (BR%) of serum proteins with drugs in plasma.
Results: The ratio of Ko (IVIg: HSA: Fibrinogen binding to chloroquine) is maintained at 1.0:1.8∼1.1:1.4∼0.56, and the ratio of Ko (IVIg: HSA: Fibrinogen binding to hydroxychloroquine) is maintained at 1.0: 1.6∼0.29:1.6∼0.9, with 1∼4 effective binding sites. If the influence of the other factors on drug binding is ignored and only IgG is considered as a drug-targeted transporter protein, then 1/(37.38∼33.46) of mole fraction of chloroquine or 1/(37.38∼12.28) of mole fraction of hydroxychloroquine can be effectively bound by IgG and targeted for transport to the lesion site, while (14.04∼8.58) /(37.38∼33.46) of mole fraction of chloroquine or (14.48∼2.26)/(37.38∼12.28) of mole fraction of hydroxychloroquine can be effectively bound by HSA and transported to cell surfaces. When the molar ratios of drug to protein change from 1:1 to 6:1, the molar binding rates of chloroquine to proteins in plasma are from 39.64±0.72% to 62.18±0.01%, and the average value is 49.91±1.74%; the molar binding rates of hydroxychloroquine to proteins in plasma are from 36.93±0.52% to 81.22±4.12%, and the average value is 50.87±2.08%. The bindings of chloroquine and hydroxychloroquine to proteins in plasma are not concentration-dependence relationships. The different pH inside and outside the cells has no obvious effect on the bindings of IVIg to drugs, while under low pH conditions (pH ≤ 6.80), the bindings of HSA and Fibrinogen to drugs will be rapidly or completely dissociated, which will facilitate the transportation (pH 7.40) and release to cell surface (pH ≤ 6.80).
Conclusions: There are competitively interactional relationships between chloroquine and hydroxychloroquine with main human serum proteins including IVIg, HSA and Fibrinogen. An emulsion of high dose infusion of 4∼6:1 stoichiometry of drug: IVIg (or HSA) may be recommended and prepared, which may increase the distribution and bioavailability at lesion site, enhance the efficacy of the drug. This study will provide a theoretical basis for the combination and competition of serum proteins with chloroquine and hydroxychloroquine, and help clinicians design new treatments for SARS-CoV-2 and other possible viruses in the future.
Acknowledgments: This study was supported from the Natural Science Foundation of Gansu (No. 21JR7RM187), Science and Technology Commissioner Special Project of Gansu province (No. 22CX8GM138) and Youth Doctoral Project of Gansu province (2023QB-016). We are thankful to Mr. Yanfeng Li and Beijing Zhongke Ruiyun Technology Co., Ltd for providing the Molecular Docking calculations.
Corresponding Author: Yongchun Liu, College of Petroleum and Chemical Engineering, FLUOBON Pilot Base of Chemical Engineering, Key Laboratory of Efficient Utilization of Oil and Gas Resources in Longdong of Gansu Province, Longdong University, Qingyang 745000, Gansu, China.
The Influence of Parent-Child Attachment on Psychological Problems of College Students: The Mediating Role of Resilience and Interpersonal Adaptation
Xiwen Fu1,2, Mei Zhao1,2,*, Junxin Yu1,2, Jing Xu1,2
1CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; 2Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China
Objective: University education plays a crucial role in societal development, and a key criterion for its success is students' campus adjustment. Academic adaptation is integral to this adjustment, significantly influencing students' academic performance and psychological well-being. Recent trends indicate that college students are experiencing heightened psychological issues, such as anxiety and depression. Despite this, many factors influencing academic adaptation remain underexplored, with key variables and their mechanisms not yet fully understood.
Subjects and Methods: A review of existing literature identifies family dynamics, personal traits, and school interpersonal relationships as critical factors impacting the social adaptation and psychological health of college students. Grounded in attachment theory and adaptation theory, this study examines the relationships among family factors (parent-child attachment), personal traits (resilience), and school interpersonal factors (interpersonal adaptation) concerning academic adaptation. A questionnaire survey was conducted with 305 college students using the Adolescent Attachment Scale, Resilience Subscale, Interpersonal Adaptation Subscale for College Students, and Academic Adaptation Subscale for College Students, yielding 275 valid responses. Data analysis was performed using SPSS, with parent-child attachment distinguished into father-child and mother-child components for comparative model construction.
Results: Findings indicate that parent-child attachment, resilience, and interpersonal adaptation positively predict college students' academic adaptation. Resilience and interpersonal adaptation serve as mediators between parent-child attachment and academic adaptation, both independently and in a chain mediation model. Notably, the direct effect of father-child attachment on academic adaptation was found to be insignificant, indicating a complete mediation model, while the effect of mother-child attachment was significant, suggesting a partial mediation model. This underscores the distinct roles of father-child and mother-child attachment in influencing academic adaptation and psychological health.
Conclusion: These findings have both theoretical and practical implications for understanding the factors that affect college students' academic adaptation. They offer insights into potential interventions for enhancing students' academic success and psychological well-being, providing valuable perspectives for school-based support and parental engagement.
Corresponding Author: Mei Zhao, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China
Evaluation of the Efficacy and Readmission Rate of Neiguan Acupoint Device Placement Combined with Vericiguat for the Treatment of Patients with Advanced Heart Failure
Jun Xie1,*, Wei Wang2, Hong Wang2, Baoquan Ren1, Mingjiao Jin1
1
Cardiac Care Unit, Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine, Qinhuangdao, China;
2
Intensive Care Unit, Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine, Qinhuangdao, China
Objectives: This study evaluates the effectiveness of integrating Neiguan acupoint acupuncture with Vericiguat therapy in treating patients with advanced heart failure (HF), focusing on its impact on key cardiac function indicators and rehospitalization rates.
Methods: In a randomized controlled trial at Qinhuangdao Hospital, 94 patients with advanced HF were assigned to two groups: a control group receiving standard care with Vericiguat and an observation group treated with both Vericiguat and Neiguan acupoint acupuncture. Primary outcomes assessed included left ventricular ejection fraction (LVEF), levels of natriuretic peptides (BNP and NT-proBNP), and serological markers like Transforming Growth Factor-beta 1 (TGF-β1) and Connective Tissue Growth Factor (CTGF). Secondary outcomes focused on hospital readmission rates.
Results: Significant improvements were observed in cardiac function indicators and rehospitalization rates following the combined treatment of Neiguan acupoint acupuncture and Vericiguat. The observation group, receiving both Vericiguat and acupuncture, exhibited more pronounced decreases in NT-proBNP and TGF-β1 levels, with reductions achieving statistical significance (P < 0.01). Additionally, left ventricular ejection fraction (LVEF) in the observation group improved significantly, rising from a baseline of 34.19% to 48.68% post-treatment (P < 0.001). Post-treatment measurements showed that the observation group experienced a more significant decrease in plasma fibrinogen and viscosity measures compared to the control group, with the differences achieving statistical significance (P < 0.001 for both groups). Furthermore, rehospitalization rates significantly decreased in the observation group. The heart failure readmission rate dropped to 10.64% from a higher initial rate, compared to the control group's reduction from 25.53% to a less substantial degree (P < 0.01). All-cause readmission rates followed a similar trend, underscoring the effectiveness of the integrated treatment approach.
Conclusions: These results indicate that the addition of Neiguan acupoint acupuncture not only improves cardiac function and reduces the likelihood of hospital readmissions but also positively affects blood rheology, potentially contributing to better overall cardiovascular health and reduced cardiac workload. The addition of Neiguan acupoint acupuncture to standard Vericiguat treatment significantly enhances cardiac function and reduces hospital readmissions in patients with advanced HF. These findings suggest that acupuncture may potentiate the effects of pharmacological treatment in heart failure, offering a viable adjunctive therapy.
Acknowledgements: This study was supported by the 2024 Port Group scientific research project (Project No. KY202403020045): “Clinical study of artificial intelligence combined with traditional Chinese and Western medicine to reduce short-term rehospitalization rate of patients with refractory heart failure”.
Corresponding Author: Jun Xie, Cardiac Care Unit, Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine, Qinhuangdao, China.
Study on the Efficacy and Safety of Shengmai San and Acupuncture in the Treatment of Postoperative Atrial Arrhythmia in Patients with Pulmonary Arterial Hypertension
Jun Xie1,*, Wei Wang2, Hong Wang2, Baoquan Ren1, Mingjiao Jin1
1Cardiac Care Unit, Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine, Qinhuangdao, China;
2
Intensive Care Unit, Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine, Qinhuangdao, China
Objectives: This study aims to evaluate the efficacy and safety of Shengmai san (SMS) combined with acupuncture in the management of postoperative atrial arrhythmias (AAs) in patients diagnosed with pulmonary arterial hypertension (PAH).
Methods: A retrospective analysis was conducted at Qinhuangdao Hospital, encompassing PAH patients who underwent surgery between July 2022 and July 2024. Participants were divided into two groups: the control group received standard postoperative care, including propafenone (100 mg orally, three times daily), while the observation group was additionally treated with SMS and acupuncture. SMS was administered intravenously at a dosage of 2 mL daily for two weeks, followed by oral granules once daily. Acupuncture was performed at the Neiguan (PC-6), Shenmen (HT-7), and Xinshu (BL-15) acupoints using 5-inch needles inserted to a depth of 1 to 1.2 inches, with a twisting frequency of 100 per minute, once daily. Outcomes were assessed based on the incidence and severity of AAs, cardiac structural function, and serum biomarkers, including NT-proBNP and endothelin-1, using enzyme-linked immunosorbent assay (ELISA).
Results: Among the 372 PAH patients assessed, 50 developed AAs, yielding a cumulative incidence of 13.44%. The observation group exhibited significant improvements in pulmonary and cardiac parameters compared to the control group. Specifically, the mean right atrial pressure (RAP) was significantly lower in the observation group (8.05 ± 2.50 mmHg) compared to the control group (12.83 ± 6.25 mmHg, P < 0.001). Mean pulmonary arterial pressure (mPAP) also decreased significantly from 47.33 ± 14.20 mmHg to 25.06 ± 6.34 mmHg in the observation group (P < 0.001). Cardiac structural and functional improvements were observed, with the right ventricular fractional area change (RVFAC) increasing to 32.06 ± 4.06% in the observation group compared to 28.63 ± 4.01% in the control group (P = 0.002). Tricuspid Annular Plane Systolic Excursion (TAPSE) improved significantly, from 18.26 ± 2.20 mm at baseline to 21.37 ± 2.59 mm in the observation group (P < 0.001). Biochemical analyses revealed a significant reduction in NT-proBNP levels and endothelin-1 (ET-1) levels in the observation group (all P < 0.001). The observation group also experienced fewer adverse reactions, with statistically significant reductions in the incidence of nausea/vomiting (10% vs. 20%, P = 0.015) and overall adverse event rates (22% vs. 40%, P = 0.002).
Conclusions: The combination of SMS and acupuncture may offer a beneficial alternative to conventional therapy for managing postoperative AAs in PAH patients, enhancing hemodynamic stability and reducing myocardial stress with minimal adverse effects.
Acknowledgements: This study was supported by the 2024 Port Group scientific research project (Project No. KY202403020044): “Clinical study of artificial intelligence combined with traditional Chinese and Western medicine to treat atrial arrhythmia”.
Corresponding Author: Jun Xie, Cardiac Care Unit, Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine, Qinhuangdao, China.
Wood Foreign Bodies Cause Orbitocranial Penetrating Injury: Diagnosis, Treatment, Prognosis Record
Gang Wei1,2,3,#, Caohang Qiu1,2,3,#, Yuan Yuan1, Xingyu Wang1,2,3, Shunjie Zhong1, Chenshu He1,2,3, Liang Liu1,2,3,4,*
1Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, Luzhou 646600, China; 2Neurosurgery Clinical Medical Research Center of Sichuan Province, Neurological Diseases and Brain Function Laboratory, Luzhou 646600, China; 3Sichuan Clinical Research Center for Neurosurgery, Southwest Medical University, Luzhou 646600, China; 4Academician (Expert) Workstation of Sichuan Province, Southwest Medical University, Luzhou 646600, China;
#
These authors contributed equally to this work.
Objectives: A transorbital injury caused by wood penetration is an uncommon and grave trauma. In general, foreign objects on the surface cannot be identified, and even CT scans may struggle to detect wood fragments due to their similarity to air and adipose tissue. This type of injury can result in the leakage of cerebrospinal fluid. Moreover, given the porous nature of wood and its proximity to soil, it serves as an ideal breeding ground for bacteria, significantly increasing the risk of orbital or intracranial infections. Therefore, timely identification of wooden foreign bodies in the orbital or skull base is of utmost importance. Diagnosing intracranial wooden foreign bodies in patients with traumatic injuries is frequently challenging as such objects tend to be overlooked.
Methods: A 73-year-old male suffered a traumatic incident while cutting a branch in a rural area. During the process, he accidentally fell onto the branch, causing it to pierce his right eye socket. Despite being conscious, he swiftly removed the branch and promptly sought medical attention at our hospital. Upon admission, an examination of the affected eye revealed swelling, an approximately 5mm-diameter pupil with no response to light, increased intraocular pressure, and subsequent blindness. The left eye exhibited no abnormalities. To address the situation, we immediately proceeded with eye surgery. However, post-surgical examination indicated the potential presence of remaining wooden foreign bodies within the skull. As a result, a craniotomy was performed. During the procedure, wood fragments measuring approximately 3 * 0.6 cm were discovered in the orbit, while additional wood fragments measuring approximately 2.5 * 0.6 cm were found within the skull.
Results: The patient made a successful recovery following the surgery and exhibited favorable overall health prior to discharge. During the outpatient follow-up one month later, there were no indications of infection, and the patient resumed an active lifestyle after being discharged. This case highlights the importance of diagnosing intracranial wooden foreign bodies and validates the necessity of surgical intervention.
Conclusions: This case underscores the crucial role of craniotomy exploration in situations where there is a strong suspicion of a wooden foreign body within the skull. Due to the potential for missed diagnoses during examination, a high level of suspicion is necessary. To determine the most effective treatment plan for each patient, diagnostic procedures such as Computed Tomography, Computed Tomography Angiography, and Magnetic Resonance Imaging should be conducted. Additionally, adopting a multi-disciplinary approach to treatment is vital when managing such cases.
Corresponding Author:Liang Liu, Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, Luzhou 646600, China; Neurosurgery Clinical Medical Research Center of Sichuan Province, Neurological Diseases and Brain Function Laboratory, Luzhou 646600, China; Sichuan Clinical Research Center for Neurosurgery, Southwest Medical University, Luzhou 646600, China; Academician (Expert) Workstation of Sichuan Province, Southwest Medical University, Luzhou 646600, China.
Observation on the Curative Effect of Auricular Point Sticking Combined with Chinese Five-tone Therapy on Postoperative Insomnia in Patients with Colorectal Cancer
Lin Feng*, Dan Yuan, Fang Lu
The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550002, Guizhou, China
Objective: To explore the impact of auricular point sticking in conjunction with Chinese five-tone therapy on postoperative insomnia in patients with colorectal cancer.
Methods: From February 2023 to October 2023, a total of 80 patients with insomnia following colorectal cancer surgery admitted to the anorectal department of a Grade-III and Grade-A traditional Chinese medicine hospital in Guizhou Province were divided into a control group and an experimental group by the random number table method, with 40 cases in each group. The control group received conventional drug intervention measures, while the experimental group received auricular point compression combined with traditional Chinese five-tone therapy on the basis of the conventional intervention measures of the control group. The scores of the Pittsburgh Sleep Scale, the quality of life questionnaire, the Self-Rating Anxiety Scale, and the Self-Rating Depression Scale were compared between the two groups before and after treatment. The alterations in the efficacy of traditional Chinese medicine and the incidence of adverse reactions were evaluated and compared between the two groups after two weeks of treatment.
Results: After the intervention, the PQSI scores and total scores, the Self-Rating Anxiety Scale scores, and the Self-Rating Depression Scale scores were significantly lower than before the treatment (P < 0.05), and the scores of the quality of life questionnaire were higher than before the treatment (P < 0.05). After the intervention, the total score of PQSI in the test group was 3 (2, 4), which was lower than that in the control group (6 (5, 7)); The EORTC QLQ-C30 score of the experimental group was 35 (30.5, 43) points, which was higher than that of the control group (27.5 (22, 30.5) points). The Self-Rating Anxiety Scale scores of the test group were 11.5 (6.5, 17.5) points, which was lower than that of the control group (20 (12, 26) points). The scores of the Self-Rating Depression Scale in the test groups were 19 (6.5, 31.5) points, lower than 31 (12.5, 40) points in the control group, and the differences were statistically significant (all P < 0.05).
Conclusion: The effect of auricular point sticking combined with TCM five-tone therapy on postoperative insomnia patients with colorectal cancer is superior to that of simple drug treatment, which can significantly improve the symptoms of TCM and sleep quality.
Corresponding Author: Lin Feng, First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550002, Guizhou, China.
A Study of the Correlation between the Sense of Meaning of Life and Economic Toxicity in Oncology Patients
Ning Chen1, Wenjing Liu1, Ping Shu1, Wenqian Hong1, Xiaoli Tong2, Hengying Che2,*
1
Wannan Medical College, Wuhu 241000, Anhui, China;
2
The First Affiliated Hospital of Wannan Medical College, Wuhu 241000, Anhui, China
Background: This research aims to examine the current state of life meaning and economic distress among tumor patients, identify factors that influence their sense of life meaning, and offer insights to guide targeted intervention strategies.
Subjects and Methods: A total of 304 patients from the Department of Medical Oncology of a tertiary-level hospital in Wuhu City were selected to be investigated by using the General Information Questionnaire, the Sense of Meaning of Life Scale, and the Economic Toxicity Scale, and the data were analyzed by SPSS26.0 statistical software. Pearson correlation analysis was used to explore the relationship between the sense of the meaning of life and economic toxicity in tumor patients. Single factor and multiple linear regression were used to analyze the factors affecting the sense of meaning of life in tumor patients.
Results: Pearson correlation analysis shows that the total score of economic toxicity is significantly positively correlated with the total score of sense of the meaning of life (r=0.211, P<0.05). Multiple linear regression analysis shows that economic toxicity, age, and BMI are independent factors affecting the sense of meaning of life of tumor patients.
Conclusions: The level of sense of the meaning of life and economic toxicity of tumor patients was moderately low, and early assessment, identification, and intervention of economic toxicity in patients by clinical staff were conducive to enhance their sense of the meaning of life. Enhancements in the sense of the meaning of life of tumor patients would help to improve the psychological situation of tumor patients, their confidence in treatment, and their treatment adherence. Clinical staffs should also assess the level of the sense of meaning of life of tumor patients on time, identified the influencing factors, and took targeted measures to improve the level of the sense of meaning of life of tumor patients and promoted the psychological health of tumor patients.
Acknowledgements: This work was supported by a project grant from Anhui Province Quality Project (2023kcszsf150).
Corresponding Author: Hengying Che, the First Affiliated Hospital of Wannan Medical College, Wuhu 241000, Anhui, China.
Clinical Application and Efficacy of Autologous Blood in Breast Abscesses
Haitao Li#, Lihua Xu#, Wanju Wang*
Department of Breast Surgery, Wuhan Children's Hospital, Wuhan Maternal and Child Health Care Hospital, Wuhan 430014, China;
#
These authors contributed equally to this work.
Objectives: Breast abscess is a common disease among lactating women. There are various treatment methods for breast abscess, and autologous blood therapy is one such approach. Autologous blood refers to the patient's own blood. After the abscess is incised and drained, autologous blood is injected into the cavity where the pus has been cleared, serving as a treatment method for breast abscess. The patient's own blood contains inflammatory cells, antibodies, and complement, which play an anti-infective role. Furthermore, the platelets in the blood, after coagulation, can seal the damaged milk ducts, reducing the risk of milk leakage after surgery and promoting faster wound healing. The effectiveness of this treatment warrants further research. The study aims to observe the clinical efficacy of autologous blood therapy for breast abscess and provide a reference for clinical treatment in primary hospitals.
Methods: A total of 162 breast abscess patients who were hospitalized at Wuhan Children's Hospital (Wuhan Women's and Children's Hospital) between July 2020 and July 2024 were selected as the study subjects. Breast ultrasound in 162 patients showed that the size of the abscess cavity was ≥ 5 cm in all cases. They were divided into two groups, an experimental group and a control group, with 81 cases in each group, using a random odd-even number method. The control group received standard incision and drainage surgery, while the experimental group was treated with autologous blood therapy in addition to the standard procedure. The study compared drainage volume, tube removal time, hospital stay duration, treatment costs, and post-operative milk leakage.
Results: The experimental group had less drainage, shorter tube removal time, and shorter hospital stays compared to the control group (P<0.05). The total treatment costs in the experimental group were lower than those in the control group (P<0.05). The rate of post-operative milk leakage was lower, and the continuation of breastfeeding was higher in the experimental group compared to the control group (P<0.05).
Conclusions: For lactating women with breast abscess, the combination of incision drainage and autologous blood therapy can accelerate wound healing, shorten hospital stays, reduce pain, decrease the likelihood of post-operative milk leakage, and reduce abscess recurrence, allowing more patients to continue breastfeeding. The procedure is simple and suitable for application in primary hospitals.
Corresponding Author: Wanju Wang, Department of Breast Surgery, Wuhan Children's Hospital, Wuhan Maternal and Child Health Care Hospital, Wuhan 430014, China.
A Scoping Review of Risk Factors for Adult PICC-Related Bloodstream Infections
Xiaoxia Ma1,#, Yaxian Han2,#, Zhangshuangzi Li1,*
1Affiliated Hospital of Guizhou Medical University, Guiyang, China; 2School of Nursing, Guizhou Medical University, Guiyang, China; #These authors contributed equally to this work.
Objective: To conduct a scoping review of studies related to the risk factors for PICC-related bloodstream infections in adults, evaluate the quality of the included literature, and summarize the risk factors for adult PICC-related bloodstream infections, with the aim of providing clinical healthcare professionals with guidance on reducing infection rates and avoiding susceptible factors for prevention.
Methods: A scoping review methodology framework was adopted, with a systematic search conducted in PubMed, Embase, Web of Science, Cochrane Library, CNKI, Wanfang, VIP, and Chinese Biomedical Literature databases. The search period was from the establishment of the databases to May 16, 2024. After the search was completed, two researchers screened and analyzed the included studies, extracted the basic characteristics of the studies and the risk factors for adult PICC-related bloodstream infections, and used a quality assessment tool to evaluate the methodology of the included studies.
Results: In this study, the risk factors of catheter-related bloodstream infection in adult patients with PICC were analyzed by scope review. A total of 1318 studies were initially retrieved. After excluding duplicates and studies that did not meet the inclusion criteria, 21 studies were included, with 9 in Chinese and 11 in English. The quality assessment by two researchers showed that 8 studies were of high quality, and 13 were of medium quality. The risk factors for adult PICC-related bloodstream infections were categorized into three types: patient factors, iatrogenic factors, and disease factors, with a total of 31 risk factors. The most common type was iatrogenic factors, with 17 factors, followed by disease factors and patient factors. All three types of risk factors negatively impacted the occurrence of catheter-related bloodstream infections (CRBSI) in patients.
Conclusion: By systematically summarizing the 31 risk factors into three categories of susceptible factors, it was found that all three types of risk factors negatively impacted the occurrence of CRBSI in patients with PICC catheters, increasing the infection rate and prolonging recovery time.In the future, more types of studies are needed to further confirm the factors of catheter-related bloodstream infections in adult patients Healthcare providers should develop personalized prevention plans based on different patients and susceptible factors to reduce infections and improve patients' quality of life.
Acknowledgements: This work was supported by the: (1) 2023 Special Scientific Research Project for Intravenous Therapy Nursing from the Chinese Journal of Nursing (ZHHLZZS-202347); (2) 2023 Guizhou Provincial Health Commission Science and Technology Fund Project (gzwkj2023-247); (3) 2024 Guizhou Provincial Health Commission Science and Technology Fund Project (GZWKJ2024-256).
Corresponding Author: Zhangshuangzi Li, Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Influencing Factors of Infarct Size in Acute Stroke Patients with Atrial Fibrillation
Rong Que*
Chengdu Eighth People’s Hospital, Chengdu 610503, China
Objectives: To improve the targeted prevention and management approaches for acute stroke patients, we aim to identify the influencing factors of infarct size in acute stroke patients with atrial fibrillation (AF).
Methods: A total of 58 acute stroke patients with AF admitted to hospital between March 2021 and June 2022 were recruited, including 20 males and 38 females. All patients underwent MRI ex-amination within 24 hours after admission. Clinical data such as age, clinical symptoms, NIHSS score, whether patients are complicated with hypertension or diabetes or coronary heart disease or valvular heart disease, whether they are complicated with smoking or drinking history, and in patients with a history of AF, collect the duration of AF. Laboratory data of D-dimer, fibrinogen, C-reactive protein, hematocrit, platelet count, glycosylated hemoglobin, homocysteine, B-type natriuretic peptide precursor, total cholesterol, total protein. We initially used the Spearman correlation analysis to examine the correlation between infarct size and clinical and laboratory indexes. According to the onset time of AF, patients were included in the first diagnosis group (28 cases) and the non-first diagnosis group (30 cases) respectively. We further used the analysis of variance to investigate the effects of AF type and its complications on infarct size.
Results: The infarct size of acute stroke in AF patients was positively correlated with the duration of AF, NIHSS score and D-dimer expression (All p<0.05), and was negatively associated with the level of HbA1c (p<0.05). The results of variance analysis showed that the main effect of AF group was significant (p=0.03), and the infarct size of non-first diagnosed AF group (Mean±SD, 1075.53±1181.65) was larger than that of the first diagnosed AF group (593.46±512.25). In addition, there was a significant interaction between AF group and AF complications (diabetes) (p=0.03), such that the infarct size of patients without diabetes (1028.07±306.06) was larger than that of patients with diabetes (158.86±210.90) in the group with first diagnosis of AF.
Conclusions: For acute stroke patients with AF, infarct size was closely related to AF duration, NIHSS score, D-dimer expression, and HbA1c level, prolonged AF duration, increased NIHSS score, and elevated D-dimer levels increased infarct size in patients, increased Hba1c levels decreased infarct size in patients. In addition, whereas the diabetes and AF that was diagnosed for the first time could interact with each other to exert impacts on infarct size.
Corresponding Author: Rong Que, Chengdu Eighth People’s Hospital, Chengdu 610503, China.
A Case Report on the Diagnosis and Treatment of a Giant Solitary Fibrous Tumor in the Right Chest
Yi Yang1,2,#, Qiting Liu1,2,#, Na Huang1,2,*, Yingying Cai1,2
1
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, Sichuan, China;
2
Key Laboratory of Geriatic Respiratory Diseases of Sichuan Higher Education Institute, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, Sichuan, China;
#
These authors contributed equally to this work.
Objective: This study aims to investigate a case of solitary fibrous tumor (SFT) located in the right thoracic cavity, providing insights for clinical diagnosis and treatment while enhancing the overall diagnostic and therapeutic approach to this condition.
Methods: A retrospective analysis was performed on the clinical manifestations, imaging findings, pathological data, and multiple follow-up results following complete resection of an SFT within the right thoracic cavity confirmed by surgical pathology. The patient was a middle-aged female who initially presented with recurrent chest tightness and pain. Spiral CT imaging revealed a substantial mass in the right thoracic cavity measuring approximately 15.6cm×14.8cm×20.6cm. Subsequently, a percutaneous lung biopsy was conducted under CT guidance, confirming the diagnosis of “solitary fibrous tumor (giant tumor grade, low-grade malignancy).” Concurrently, surgical intervention involving “right thoracic tumor resection + right total pneumonectomy + pleural adhesion cauterization” was undertaken. Plain and enhanced spiral CT scans were performed at multiple time points before and after surgery.
Results: Regular follow-up has been maintained for over four years post-surgery, demonstrating favorable prognosis without any observed signs of recurrence thus far.
Conclusions: SFTs within the thoracic cavity are rare entities that typically present as small tumors predominantly benign in nature; malignant variants tend to be larger in size. The disease often manifests insidiously with initial symptoms arising only after significant compression occurs. Chest spiral CT remains an invaluable diagnostic tool for this condition as it effectively delineates lesion location and size; enhanced imaging further aids clinicians in assessing resectability of SFTs. Nevertheless, definitive diagnosis relies on histopathological examination coupled with immunohistochemical analysis. Regardless of whether tumors are benign or malignant, complete surgical excision is recognized as the most critical prognostic factor for this disease; therefore, long-term follow-up is recommended for all patients post-complete tumor resection.
Acknowledgements: This paper was supported by the “Research on the Mechanism of Ferroptosis-Induced Lung Adenocarcinoma Development Regulated by Transcription Factor RFX3 in the Elderly” project (Project Number:2024-2301) and the “The Regulatory Effect and Mechanism of Honokiol on Programmed Necrosis of A549” project (Project Number: Q18041)
Corresponding Author: Na Huang, Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, Sichuan, China; Key Laboratory of Geriatic Respiratory Diseases of Sichuan Higher Education Institute, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, Sichuan, China.
Two Approaches to Embodied Cognition Research in Psychotherapeutic Practice
Dongcheng Wang*, Zaiping Guo
Pingxiang University, Pingxiang, China
Objectives: Embodied cognition research can be categorized into two primary paradigms: naturalistic and scientific. This article examines the influence of these paradigms on psychotherapeutic research, providing a comparative analysis of their contributions. Additionally, it summarizes practical applications derived from these approaches, highlighting their implications for therapeutic methodologies.
Methods: Between January 2022 and June 2023, the Psychological Counseling Center at Pingxiang University, Jiangxi Province, provided services to numerous clients. From this pool, two clients diagnosed with anxiety disorders were selected based on data saturation criteria. Each client underwent treatment guided by one of two theoretical orientations within embodied cognition: naturalistic and scientific. The naturalistic approach prioritized the client’s subjective experiences, emphasizing their personal cognition and lived experiences. In contrast, the scientific approach was grounded in empirical methodologies, incorporating neuroscience-based experiments and quantitative assessments. These differing theoretical frameworks informed distinct therapeutic interventions.
Results: The implementation of psychotherapeutic strategies based on the naturalistic approach within embodied cognition theory yielded positive therapeutic outcomes. Clients reported favorable subjective evaluations, highlighting the effectiveness of this approach. The results suggest that naturalistic methods have significant potential to enhance therapeutic processes and outcomes.
Conclusions: The application of naturalistic embodied cognition strategies in psychotherapy demonstrates significant positive effects. Clients report favorable subjective evaluations, highlighting the approach's effectiveness and potential for broader adoption in therapeutic practices.
Acknowledgements: This work was supported by a project grant from Pingxiang University Applied Psychology Center.
Corresponding Author: Dongcheng Wang, Pingxiang University, Pingxiang, China
Research and Exploration of Virtual Simulation Platform in Bone Marrow Cavity Puncture
Yanjun Zhao1, Danfeng Chu2, Haizhen Jiang3,*
1
Dermatology, The 989th Hospital of the People's Liberation Army, Pingdingshan, Henan, China;
2
Department of Dermatology, Changhai Hospital of Naval Medical University, Shanghai, China;
3
Neurosurgery, The 989th Hospital of the People's Liberation Army, Pingdingshan, Henan, China
Background: The main objective of this research is to understand the effect of theory and skill application of virtual simulation platform in bone marrow cavity puncture and infusion, investigate the operator's satisfaction with the application of virtual simulation platform, and provide a reference basis for training and practicing bone marrow cavity puncture for troopers.
Methods: Forty-six hygienists who participated in the first aid training in our hospital in the third quarter of 2023 were selected and randomly divided into two groups according to the order of reporting: the observation group and the control group, with 23 people in each group; in accordance with the training requirements of the training program, both groups underwent 120 minutes of centralized learning, and then the two groups carried out different modes of training, with the observation group adopting the online practice on the virtual simulation platform in combination with the offline simulation of tibial puncture training model practice; and the control group adopting the demonstration video in combination with the offline simulation of tibial puncture training model practice. The observation group used the virtual simulation platform online practice combined with the offline simulation of tibial puncture training model practice; the control group used the demonstration video combined with the offline simulation of tibial puncture training model practice; the training time of the two groups was 2 weeks; after 2 weeks, the two groups of hygienists were evaluated in theory and skills, and their satisfaction with the training mode was scored and surveyed.
Results: The theory and skill scores of the hygienists in the observation group were higher than the theory and skill scores of the hygienists in the control group, with statistically significant differences (P<0.05); the satisfaction scores and satisfaction rates of the hygienists in the observation group are higher than those of the hygienists in the control group, with statistically significant differences (P<0.001).
Conclusion: The use of virtual simulation platform could simulate the complex training environment, the trainer could be repeatedly operated, practiced, which could improve the theoretical level of the trainer and skill operation performance, and enhanced their training satisfaction and enthusiasm. Virtual simulation platform can be further promoted and used in the actual work.
Corresponding Author: Haizhen Jiang, Neurosurgery, The 989th Hospital of the People's Liberation Army, Pingdingshan, Henan, China.
The Application of Time Difference of Arrival (TDOA) Positioning Algorithm in Innovative Medical Care
Baiyu Song1,*, Guiyun Zhao1, Jianyin Lu2
1
Jiangsu Vocational College of Agriculture and Forestry, Jurong 212400, Jiangsu, China;
2
Chao Hu University, Hefei 238000, Anhui, China
Background: The Time Difference of Arrival (TDOA) positioning algorithm has extensive applications in areas such as wireless sensor networks and the Internet of Things (IoT). In recent years, its innovative applications in healthcare have gained increasing attention. Effective real-time tracking of patients, healthcare personnel, and medical devices is crucial for improving operational efficiency in medical environments.
Subjects and Methods: This paper studies the application of the TDOA positioning algorithm in innovative healthcare, focusing on how to enhance positioning accuracy in complex hospital environments through algorithm optimization. With the growing demand for medical services, real-time positioning systems within hospitals have become increasingly important for improving work efficiency and patient safety. Firstly, considering the unique characteristics of the healthcare environment, this paper proposes an optimized TDOA algorithm aimed at effectively addressing challenges such as multipath effects and signal interference commonly found within hospitals. This optimized algorithm integrates advanced signal processing techniques to reduce environmental noise and improve signal quality, thereby enhancing positioning accuracy. Subsequently, this paper conducts in-depth analysis and performance evaluation of the optimized TDOA algorithm through simulation experiments. The experimental results indicate that the optimized TDOA algorithm significantly improves positioning accuracy in medical scenarios, with positioning errors reduced by over 30%.
Results: Through experimentation, the study evaluates the performance of the TDOA algorithm under various conditions. The results demonstrate significant improvements in positioning accuracy due to the proposed optimizations. The algorithm effectively enhances the emergency response speed and resource allocation efficiency in hospitals, particularly in smart ward management and chronic disease care.
Conclusions: The introduction of the TDOA algorithm into the healthcare field represents a significant advancement in real-time positioning technology. The optimizations discussed in this paper successfully address key challenges, improving the algorithm's applicability for precise location tracking in medical settings. This research lays a theoretical foundation for further innovations in smart healthcare systems and telemedicine applications.
Acknowledgements: The research was founded within the project No. X2018zygc029, entitled: “Network engineering excellence engineer education and training program”, supported by funds for a key project from Quality Engineering Project in Colleges and Universities in Anhui Province.
Corresponding Author: Baiyu Song, Jiangsu Vocational College of Agriculture and Forestry, Jurong 212400, Jiangsu, China.
Applied Bioinformatics to Identify Key DNA Methylation Genes in Type 2 Diabetes
Di Xu1,#, Rong Cai2,#, Shangqing Liu1,*
1
Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Nanchong, 637000, Sichuan, China; 2Operation Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, Sichuan, China; # These authors contributed equally to this work.
Objectives: This research aims to identify specific methylation markers that can help in the diagnosis and understanding of T2DM. By analyzing DNA methylation patterns, we hope to gain insights into the disease mechanisms and develop targeted therapies.
Methods: The mRNA data for T2DM (GSE25724 and GSE38642) and DNA methylation (GSE21232) were downloaded from the GEO database. The Limma difference analysis was performed on the T2 DM combined dataset and GSE21232 to determine the DEGs and DMCs of the differential genes. The WGCNA method was used to cluster the differential genes and to analyze the genes of the most strongly correlated blue (MM1) and dark blue (MM2) modules. DEGs, DMCs, MM1 and MM2 finally identified two key DNA methylation genes, CTPS1 and SYNGR3. The ROC curves assessed their diagnostic value for T2DM and performed the final immune infiltration analysis.
Results: There are 1380 differential genes in DEGs, MM1 is the most significant (P=3.4×10-5) with the strongest correlation (R=0.60), 340 genes; DMCs selecte 250 differential genes, MM2 is the most significant (P=3.0×10-10) and the strongest correlation (R=0.51), a total of 851 genes. The Wayne analysis of MM1 and MM2 yielded 21 key genes that are mainly enriched in leukocyte migration, RAS signaling pathway, and fat metabolism. The ROC curve shows that the AUC under the curve of CTPS1 and SYNGR3 is 0.77 and 0.78, respectively; their effects are most related to cytotoxic lymphocytes and T lymphocytes.
Conclusions: CTPS1 and SYNGR3 have the potential to become new signature models for the diagnosis and treatment of type 2 diabetes mellitus (T2DM) in the future. Their identification not only provides a new direction for the diagnosis of T2DM but also shows high value in treatment. At the same time, these two genes provide new ideas for the research on fat metabolism and inflammatory response in T2DM, which is helpful for an in-depth understanding of the pathogenesis of T2DM and lays a foundation for the development of more effective treatment strategies.
Acknowledgements: This work was supported by 2021 Research Project of Famous Old Traditional Chinese Medicine Case Research Center of Nanchong (YAZX21-YB-02), and 2024 Primary Health Development Research Center of Sichuan Province Program (SWFZ24-Y-73)
Corresponding Author: Shangqing Liu, Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Nanchong, 637000, Sichuan, China.
The Effects of Aerobic Exercise on Microcirculation and Chronic Disease Management in the Elderly: A Comprehensive Review
Keqiang Zong1,2,#, Fengling Li3,#, Yan Wang1,*, Xiaohan Zhang1, Shenglei Yang1, Chao Zheng4, Wenbo Zhang2
1
School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing 100010, China;
2
School of physical education, Qiqihar University, Qiqihar 161006, Heilongjiang, China;
3
Beijing Wuzhou Women's and Children's Hospital, Beijing 100010, China;
4
Bengbu University, Bengbu, Anhui 233030, China;
#
These authors contribute equally to this work.
Objective: The objective of this study was to explore the intervention effect of aerobic exercise on the microcirculation function and chronic disease management in middle-aged and elderly individuals. As chronic diseases such as hypertension, diabetes, and cardiovascular diseases are prevalent in this population, improving microcirculation function through aerobic exercise may offer a viable approach to managing these conditions. This study aims to provide a theoretical basis for the use of aerobic exercise in promoting vascular health and preventing further deterioration caused by aging.
Subjects and Methods: This investigation utilized a literature review methodology, analyzing existing studies on microcirculatory function and the effects of aerobic exercise interventions within middle-aged and elderly populations. Key indicators associated with microcirculatory decline—including endothelial dysfunction, vasodilatory capacity, and inflammatory responses—were assessed. The study also explored specific exercise protocols, such as moderate to high-intensity aerobic activities (e.g., 50%-75% VO2max), evaluating their efficacy in enhancing vascular health among individuals with chronic diseases. A range of international and domestic studies were reviewed to compare the role of physical activity in chronic disease management across diverse populations.
Results: The results from various studies indicate that sustained engagement in aerobic exercise significantly enhances microcirculatory function in middle-aged and elderly individuals. Aerobic activity improves endothelial cell functionality, increases capillary density, and augments vasodilatory capacity, thereby diminishing the risk factors associated with chronic diseases like cardiovascular disorders, hypertension, and diabetes mellitus. Moreover, specific training regimens (e.g., maintaining 60% heart rate reserve for 3-6 sessions per week lasting 30-45 minutes each) have proven effective at reversing age-associated declines in vascular health. Additionally, findings underscored the advantages of regular Taijiquan practice in improving transcutaneous oxygen pressure alongside nutrient delivery among older adults.
Conclusions: Aerobic exercise serves as an efficacious intervention for enhancing microcirculatory function while managing chronic diseases within middle-aged and elderly cohorts. Regularly structured exercise programs can alleviate aging's detrimental impacts on vascular health; thus reducing the incidence of chronic conditions while promoting overall well-being. This study underscores the necessity for individualized exercise prescriptions tailored to specific health conditions along with age-related changes; it advocates that future research should concentrate on optimizing these protocols to maximize benefits for elderly patients suffering from chronic illnesses.
Acknowledgements: This paper was supported by (1) Research on the Historical Evolution and Inheritance and Development of Traditional Ice and Snow Sports of Ethnic Minorities in Northeast China, funded by the Humanities and Social Science Planning Foundation of the Ministry of Education in 2021 (21YJA890027); (2) Heilongjiang Province's 2023 Philosophy and Social Science Planning project (23TYC171); (3) 2023 College Students Innovation and Entrepreneurship Project (S202310232053); (4) Open Fund project of Taijiquan Laboratory of Taijiquan Special Committee of China Intangible Cultural Heritage Association (KFJJ20230001); (5) 2022 Heilongjiang Provincial institutions of higher Learning basic scientific research Funds Research project - General project “Heilongjiang Province Folk Sports and Tourism Scientific Integration Development Research” (145109160); (6) Basic Scientific Research Funds Research Project of Heilongjiang Provincial Institutions of Higher Learning in 2021 - General project(145109160); (7) The project was supported by the Hunan Provincial Scientific Achievements Evaluation Committee 2023 (XSP2023JYZ024).
Corresponding Author: Yan Wang, School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing 100010, China.
Effect of Acupoint Opening Method Based on Zi Wu Liu Zhu Theory Combined with Moxibustion on Diarrhea-predominant Irritable Bowel Syndrome
Xujie Xu1, Li Qian1, Yeqi Shou1, Huifen Yu1, Tingnan Huang2, Zheng Wang2,*, Wenli Wang3,*
1Department of Acupuncture and Moxibustion, Second Affiliated Hospital of Jiaxing University, Jiaxing, China; 2School of Medicine, Jiaxing University, Jiaxing, China;
3
Department of Gastroenterology, Jiaxing Traditional Chinese Medicine Hospital, Jiaxing, China
Objectives: This study aims to evaluate the effectiveness of the Zi Wu Liu Zhu point opening method combined with constant temperature moxibustion on improving quality of life and psychological well-being in patients with diarrhea-predominant irritable bowel syndrome (IBS-D). IBS-D, a subtype of irritable bowel syndrome, is characterized by recurring abdominal pain, diarrhea, and disrupted bowel habits, with underlying mechanisms thought to include brain-gut axis dysregulation, visceral hypersensitivity, and inflammation. Given that many IBS-D patients also experience anxiety and depression, which can aggravate gastrointestinal symptoms, this study investigates whether a traditional Chinese medicine (TCM) approach targeting these elements can provide effective relief.
Methods: This single-blind, randomized trial enrolled 60 patients meeting the Rome IV diagnostic criteria for IBS-D and divided them into two groups. The treatment group (n=30) received Zi Wu Liu Zhu point opening combined with constant temperature moxibustion, a TCM approach that activates specific acupoints according to timing and symptoms. The drug group (n=30) received conventional medication, specifically Bacillus licheniformis and Pinaverium Bromide. Both treatments were administered over a 4-week period. Key outcome measures included the SF-36 questionnaire to assess quality of life and the Hamilton Depression (HAMD) and Hamilton Anxiety (HAMA) scales to evaluate psychological state. Baseline and post-treatment scores were compared within and between groups.
Results: Both groups showed significant improvements in quality of life and psychological state following treatment. SF-36 scores increased in both groups, reflecting enhanced quality of life (P=0.000). Similarly, both HAMD and HAMA scores decreased significantly, indicating relief from depressive and anxiety symptoms (P=0.000). However, the treatment group demonstrated more pronounced improvements than the drug group, with greater increases in SF-36 scores and more substantial reductions in HAMD and HAMA scores. These results suggest that the Zi Wu Liu Zhu point opening method combined with moxibustion is more effective than conventional medication in improving both quality of life and mental health in IBS-D patients.
Conclusions: The Zi Wu Liu Zhu point opening method combined with constant temperature moxibustion significantly improves both the psychological well-being and quality of life in IBS-D patients, yielding better outcomes than conventional drug therapy alone. This TCM approach may offer an effective complementary or alternative treatment for IBS-D. Further large-scale, long-term studies are recommended to confirm these findings and to better understand the mechanisms through which this combined therapy benefits IBS-D patients.
Acknowledgements: This work was supported by a project grant from Funding: Research Project of Jiaxing Science and Technology Bureau, (Grant No.2021AD30108); Zhejiang Province College Students' Science and Technology Innovation Activity Plan (New Talent Plan), (Grant No.2024R417A011).
Corresponding Author: Zheng Wang, School of Medicine, Jiaxing University, Jiaxing, China; Wenli Wang, Department of Gastroenterology, Jiaxing Traditional Chinese Medicine Hospital, Jiaxing, China.
Exploring the Mechanism of Digital Chronic Disease Management Enabling Value Co-creation in Primary Public Health
Jianyi Yang, Jinhao Ye, Jingru Zhao, Yuxuan Jian*, Yutong Lin
Department of Public Administration, Sichuan University, Chengdu, Sichuan 610000, China
Background: To analyze the current digital reform mechanism of primary care chronic disease management service in China, so as to provide a reference for China's basic public health career and primary care health management.
Subjects and Methods: This paper takes the Qingquan Town Public Health Center, a pilot project of primary health care reform in Chengdu City, Sichuan as an example and introduces the new analytical perspective of “value co-creation”, adopts the qualitative research method of field research and in-depth interviews to study and analyze the formation and operation mechanism of its digital chronic disease management model. The study was conducted through field research and in-depth interviews to analyze the formation and operation mechanism of its digital chronic disease management model.
Results: The study shows that the formation of the digital chronic disease management model requires organizational, technological, and environmental conditions, in which the grid model, digital platform, and governmental unification play key roles; under the impetus of the digital chronic disease management model, the value relationships of the various subjects involved in primary healthcare have undergone a deepening coupling from triggering, creation, to diffusion, which has pushed the formation of a pattern of co-creation of value between the subjects and realized a virtuous cycle of primary The value co-creation pattern formed by digital chronic disease management is characterized by a closed loop of supply and demand, sustainability, and interaction and cooperation, and responds to the public value demand of grassroots to improve the level of health management.
Conclusions: The digital chronic disease management model in this case is conducive to the implementation of the national strategy to improve national health, enhance the administrative efficiency and standardization of the government, increase the chronic disease management service capacity of hospitals, and strengthen the national awareness of chronic disease management and health management capacity. However, the current digital chronic disease management model still has certain deficiencies, and it is recommended to strengthen the digital skills training of healthcare personnel; pay more attention to the key role of the digital model for the cause of primary healthcare reform, and design a targeted path of technological empowerment; and deepen the study of related research at the governmental and resident levels, to further raise the level of health management of grassroots public health services in China.
Acknowledgements: This work was supported by the National Innovation and Entrepreneurship Training Program for College Students (Health Services for the People, Benefiting the People and Reducing the Burden: Formation Mechanisms, Influencing Factors, and Governance Paths of the Administrative Burden of Basic Public Health Services–Taking the Five Priority Districts and Counties in Sichuan Province as an Example). We thank all the members who participated in the pre-field research, the empirical analysis in the middle period, and wrote the paper in the late period. We thank Jianyi Yang and Yuxuan Jian (corresponding authors) for their efforts and the School of Public Administration of Sichuan University for their support!
Corresponding Author: Yuxuan Jian, Department of Public Administration, Sichuan University, Chengdu, Sichuan 610000, China.
The Mediating Effect of Self-concealment on Stigma, Social Avoidance and Distress in Stroke Patients
Jinwen Bai1,#, Kun Yang1,#, Maria Della Rañeses1,2, Jian Song1,3,*
1
Philippine Women’s University, School of Nursing, Malate, Manila, Philippines;
2
Bicol University, Legazpi City, Albay, Philippines;
3
Jingzhou Institute of Technology, Jingzhou, China;
#
These authors contributed equally to this work.
Objectives: Social avoidance and distress are common and long-standing negative psychology of stroke patients, which is not conducive to the social return of stroke patients. With the continuous development of nursing research, the social status of stroke patients is becoming a concern of clinical nursing. This study intends to examine the mediating effect of self-concealment on stroke patients' stigma, social avoidance and distress.
Methods: From March 2023 to July 2023, about 460 stroke patients as the research object were selected for the present study by convenience sampling. All stroke patients in this study gave informed consent to this study. Utilizing the general information questionnaire, the self-concealment scale, the stroke stigma scale, and the social avoidance and distress scale, researchers gathered information.
Results: This study revealed the self-concealment score of stroke patients was (27.89±6.48), stroke patients' self-concealment was at a moderate to high level. The stigma score was found to be (44.09±8.26), the stigma level is at the upper-middle level. The social avoidance and distress score is (15.51±7.70) respectively, which is relatively high and higher than that of the healthy Chinese population. According to the Pearson test results, the level of stigma in stroke patients is positively correlated with social avoidance and distress (r=0.527, P<0.01). Self-concealment is strongly connected with social avoidance and distress among stroke patients (r=0.591, P<0.01). Self-concealment is strongly connected with stigmatization among stroke patients (r=0.474, P<0.01). The path coefficient of the structural equation model demonstrates that stigma imparts a significant positive effect on self-concealment (β=0.554, P<0.001), stigma has a significant positive effect on the total score of social avoidance and distress (β=0.477, P<0.001), self-concealment has a strong positive effect on the total score of social avoidance and distress (β=0.394, P<0.001), showing that self-concealment mediating effect between stigma, social avoidance, and distress. Using the Bootstrap approach to evaluate the mediation effect of the structural equation model, the findings indicate that none of the 95% confidence interval is 0 and that the mediation effect is true. The direct effect of stigma on social avoidance and discomfort is 0.477, whereas the indirect effect of self-concealment is 0.218.
Conclusions: It was shown that Stroke patients' stigma, self-concealment, social avoidance and distress were all in the upper-middle range. All three factors were connected. Stigma not only directly influenced social avoidance and distress in stroke patients but also indirectly via the mediating effect of self-concealment. The healthcare professionals may provide social support and psychological care to stroke patients based on the relationship between the three variables, to create a good social relationship atmosphere for stroke patients, assist them in resolving their Stigma and self-concealment, and help to reduce their levels of social avoidance and distress, and facilitate their return to society.
Corresponding Author: Jian Song, Philippine Women’s University, School of Nursing, Malate, Manila, Philippines; Jingzhou Vocational and Technical College, Jingzhou, China.
The Application of Music Therapy in the Rehabilitation Education of Children with Cerebral Palsy
Xianwei Lin1,2,3,#, Zefeng Wang1,2,3,4,5,6,#,*, Zihan Zhang1,2, Zhengting Cai1,2, Guangdong Xie1,2, Laurent Peyrodie4,6, Jean-Marie Nianga5,6, Xuecan Yang6, Jian Chu3,7
1College of Information Engineering, Huzhou University, Huzhou, Zhejiang, China; 2Nanjing Tuobu Intelligent Technology Co., Ltd, Nanjing, Jiangsu, China; 3Key Laboratory of Multiomics Research and Clinical Transformation of Digestive Cancer, Huzhou, Zhejiang, China; 4ICL, Junia, Université Catholique de Lille, F-59000 Lille, France; 5Sino-Congolese Foundation for Development, Brazzaville, Republic of the Congo; 6ASIR, Institute - Association of Intelligent Systems and Robotics, Paris, France;
7
Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, Zhejiang, China; #These authors contributed equally to this work.
Background: The application of music therapy spans a wide range of fields, including clinical medicine, psychology, and rehabilitation education, and has gained widespread recognition. In particular, music therapy is regarded as a significant intervention in the rehabilitation education of children with cerebral palsy, attracting attention for its potential effects on improving brain function and enhancing motor skills. In recent years, with the rapid development of artificial intelligence (AI) technology, various industries have been exploring AI solutions to address challenges within their domains. Similarly, music therapy faces certain obstacles in practical application, and the introduction of AI technology offers potential solutions to overcome these challenges.
Subjects and Methods: This study aims to summarize and analyze the current methods of music therapy used in the rehabilitation education of children with cerebral palsy. Through a literature review and integration of existing research data, this study explores the feasibility of combining music therapy with AI technology and analyzes the methods and approaches for practical application. The subjects primarily focus on children with cerebral palsy undergoing rehabilitation education through music therapy. Methods include comparing the effects of existing music therapy, introducing AI technology for optimization, and evaluating its practical effectiveness in rehabilitation education.
Results: Comprehensive analysis of existing literature reveals that music therapy significantly improves brain function and motor skills in children with cerebral palsy. Additionally, studies indicate that the introduction of AI technology can effectively enhance the efficiency and outcomes of music therapy. For instance, AI algorithms can be used to develop more precise and personalized music therapy programs, monitor and adjust the treatment process in real-time, thereby further enhancing the therapeutic effects. Specific methods include utilizing AI technology for music analysis, patient status monitoring, and establishing treatment feedback systems.
Conclusions: In summary, music therapy plays an important role in the rehabilitation education of children with cerebral palsy, and the combination with AI technology offers new possibilities for further improving therapeutic outcomes. Future research should continue to explore the specific methods and applications of integrating music therapy with AI technology, aiming to provide more effective and personalized rehabilitation education programs for children with cerebral palsy. This not only has the potential to improve the quality of life for these children but also provides new research directions and practical approaches for the field of rehabilitation education.
Acknowledgements: This work was supported by the Zhejiang Provincial Philosophy and Social Science Planning Project (No. 22NDJC151YB), titled ‘Research on Innovative Models and Methods of Integrating Education for Children with Cerebral Palsy through AI + Special Education.'
Corresponding Author: Zefeng Wang, College of Information Engineering, Huzhou University, Huzhou, Zhejiang, China; Nanjing Tuobu Intelligent Technology Co., Ltd, Nanjing, Jiangsu, China; Key Laboratory of Multiomics Research and Clinical Transformation of Digestive Cancer, Huzhou, Zhejiang, China; ICL, Junia, Université Catholique de Lille, F-59000 Lille, France; Sino-Congolese Foundation for Development, Brazzaville, Republic of the Congo; ASIR, Institute - Association of Intelligent Systems and Robotics, Paris, France.
Idea of a New Approach to Quantify the Diagnose Effect of Autism
Xianwei Lin1,2,3,#, Zefeng Wang1,2,4,#,*, Jing Chen5, Xia Han1,2, Zhengting Cai1,2, Guangdong Xie1,2, Laurent Peyrodie2,4,6, Jean-Marie Nianga4,6,7, Xuecan Yang6, Jing Zhuang3,8
1College of Information Engineering, Huzhou University, Huzhou, Zhejiang, China;
2
Nanjing Tuobu Intelligent Technology Co., Ltd, Nanjing, Jiangsu, China;
3
Key Laboratory of Multiomics Research and Clinical Transformation of Digestive Cancer, Huzhou, Zhejiang, China;
4
ICL, Junia, Université Catholique de Lille, LITL, F-59000 Lille, France;
5
HuZhou Third Municipal Hospital, Huzhou, Zhejiang, China;
6
ASIR, Institute - Association of Intelligent Systems and Robotics, Paris, France;
7
Sino-Congolese Foundation for Development, Brazzaville, Republic of the Congo;
8
Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, Zhejiang, China;
#
These authors contributed equally to this work.
Objectives: Since it was first reported in 1943, the incidence of autism spectrum disorders has increased, and there have been numerous interventions, but there is no quantitative measure of diagnose effectiveness. Starting with traditional intervention methods for autism, this paper listed common intervention methods and found that the essential needs of different methods are the same: companionship and guidance. This paper aims to investigate the effectiveness of various intervention methods for autism spectrum disorders (ASD) and explore the potential of artificial intelligence (AI) and electroencephalogram (EEG) technology in enhancing these interventions.
Methods: The study complied comprehensive list of common intervention techniques. The research then focused on the role of AI in autism intervention, particularly in enhancing abilities such as eye contact, language, interaction, imitation, emotion recognition, and joint attention. The study also investigated the application of EEG signals in autism intervention, analyzing the differences in EEG patterns between autistic and neurotypical children. Furthermore, the effectiveness of transcranial direct current stimulation (tDCS) in autism intervention was explored. The proposed method involves combining AI robot technology with EEG analysis to create a mapping of behavioral characteristics and brain activities in autistic children.
Results: The findings highlight that AI can significantly aid in autism intervention by providing companionship and guidance, crucial components identified in traditional methods. Additionally, AI's ability to collect behavioral data during interventions was noted as a key advantage. The analysis of EEG signals revealed significant differences between autistic and neurotypical children, suggesting that EEG technology can provide valuable insights into autism intervention. The study also found that tDCS had a notable effect on improving the intervention outcomes for autistic children. Emotional regulation, influenced by external brain electrical stimulation, was found to directly impact the effectiveness of autism interventions.
Conclusions: The research concludes that combining AI and EEG technology offers a promising approach to quantifying the effectiveness of autism interventions. AI's role in enhancing various developmental abilities and collecting behavioral data, coupled with EEG's capability to analyze brain activity, provides a comprehensive method to assess and improve autism interventions. The significant impact of tDCS on emotional regulation further supports the integration of advanced technologies in autism treatment. This combined approach not only addresses the essential needs of companionship and guidance but also introduces a quantitative measure for evaluating intervention outcomes, paving the way for more effective and personalized autism treatments.
Acknowledgements: This research was funded by the Zhejiang Provincial Education Science Planning General Project (No. 2022SCG036), titled ‘Study on New Intervention Education Methods for Children with Autism Based on AI-Guided Games.'
Corresponding Author: Zefeng Wang, College of Information Engineering, Huzhou University, Huzhou, Zhejiang, China; Nanjing Tuobu Intelligent Technology Co., Ltd, Nanjing, Jiangsu, China; ICL, Junia, Université Catholique de Lille, LITL, F-59000 Lille, France.
Exploring the Role of Mandala Painting Art Therapy in Enhancing Mental Health through Psychological Counseling and Consultation for College Students
Shan Li*
Weihai Ocean Vocational College, Weihai, China
Objective: This study aims to explore the use of Mandala painting art therapy in college students' psychological counseling and its therapeutic effects, particularly focusing on its potential to alleviate prevalent psychological issues such as anxiety, depression, and interpersonal conflicts. It is posited that through self-expression and emotional release during the artistic creation process, Mandala painting art therapy offers a non-verbal communication method. This approach aids individuals in gaining a deeper understanding of their inner emotions, thereby facilitating psychological healing.
Subjects and Methodology: This study focused on several representative cases of student psychological issues, with participants commonly experiencing varying degrees of anxiety, depression, and interpersonal communication difficulties. The research deeply explored the theoretical foundation of Mandala art therapy and ingeniously integrated practical methods throughout the process. For example, participants were guided to create personalized Mandala patterns as a means of exploring their inner worlds. During this creative process, students utilized colors and lines to express their deepest emotions, thoughts, and memories. Teachers systematically gathered feedback from participants throughout this process. A comprehensive analysis of these rich and detailed materials revealed effective strategies for helping students alleviate psychological issues and progress towards mental health.
Results: The Mandala painting art therapy significantly reduced participants' psychological stress and enhanced their emotional regulation capacity. Additionally, it fostered personal self-awareness and facilitated emotional expression, thereby aiding in the development of positive interpersonal relationships. Participants consistently reported a heightened sense of relaxation and tranquility throughout the creative process. This positive emotional experience is pivotal in mitigating psychological symptoms. Moreover, this study explored the potential integration of Mandala painting art therapy into university mental health education curricula, offering a comprehensive set of practical implementation strategies.
Conclusions: The innovative psychological intervention of Mandala painting art therapy presents unique benefits in improving the mental health of college students. This study recommends that universities incorporate this form of art therapy into their mental health education and service systems to diversify existing mental health support resources. Future research should investigate the adaptability and long-term effects of Mandala painting art therapy across various cultural contexts, thereby contributing to the innovation and advancement of the mental health field.
Corresponding Author: Shan Li, Weihai Ocean Vocational College, Weihai, China.
Ultrasound-Guided Responsible Nerve Root Block for Acute Herpes Zoster Neuralgia in the Upper Extremity: A Clinical Observational Study
Fengchai Wang1,2, Liping Zhang3, Yanmei Zhuo1, Minyi Lin1, Kaixing Lin1, Shenshen Lin2,*
1Department of Pain Management, The First Hospital of Putian City, Putian, Fujian, China; 2The Graduate School of Fujian Medical University, Fuzhou, 350108, Fujian, China; 3Department of Ultrasound, The First Hospital of Putian City, Putian, Fujian, China
Objectives: How to find a proper nerve root for nerve block in patients with acute herpes zoster neuralgia (HZN) suffering from severe pain after oral medication remains challenging in clinical practice. The traditional method was to identify the involved nerve according to the distribution of the rash and pain, and then block the identified nerve under ultrasound guidance. In recent years, with the rapid development of musculoskeletal ultrasound technology, we have noted a significant increase in the cross-sectional area (CSA) of affected nerve roots in patients with acute HZN. We aim to investigate whether ultrasound-guided nerve block targeting enlarged CSA of affected nerve roots could provide superior pain relief in patients with acute HZN in the upper extremity than traditional methods.
Methods: A retrospective cohort study was conducted for patients who visited Pain Department of the First Hospital of Putian from January 2020 to December 2023. These patients were diagnosed with acute herpes zoster neuralgia (HZN) in the upper extremity. A total of 60 patients were included in this study. Patients were categorized into Traditional Group (T group) and Responsibility Group (R group). The T group identified affected nerve roots based on rash distribution and pain location, while the R group identified responsible nerve roots under ultrasound-guided by comparing cross-sectional areas (CSA) between affected and unaffected sides. Pain Numeric Rating Scale (NRS) scores and pregabalin consumption dose were recorded before and after treatment in both groups. Post-treatment complications such as pain at the puncture site, local hematoma, and puncture site infections were also recorded. Changes in CSA of affected and unaffected side nerve roots in the R group before and after treatment were recorded.
Results: There was no significant difference in gender, age, course of disease, preoperative NRS score and preoperative pregabalin consumption dose between the two groups (P > 0.05). NRS score and pregabalin consumption dose decreased significantly in both groups (P < 0.05). Compared with T group, NRS in R group decreased significantly from 1 week to 12 weeks after treatment (P < 0.05); there was no difference between the two groups after 3 months (P > 0.05). One week after operation, pregabalin was discontinued in 7 patients in R group and 3 patients in T group (P < 0.05). There was no significant difference in complications in both groups (P > 0.05). In R Group, before treatment, the nerve root CSA of the affected side was significantly thicker than that of the unaffected side (P < 0.05).
Conclusions: Ultrasound-guided responsible nerve block can relieve acute HZN rapidly, and the short-term effect is better than the traditional treatment, but the long-term effect is equivalent.
Acknowledgements: The paper was supported by Putian University 2023 Research Project (2023103).
Corresponding Author: Shenshen Lin, The Graduate School of Fujian Medical University, Fuzhou, 350108, Fujian, China.
The Clinical Effect of Natural Product Glycyrrhiza for Lumbar Disc Herniation Patient with Postoperative Stress Ulcer through Down-regulating Inflammatory Cytokines
Congying Chen1,#, Yixuan Tan2,3,#, Xiaolin Li4,#, Qian Zhang5,#, Xiaoming Li6,*, Jian Shi1,*
1
Department of Gastroenterology, NO.905 Hospital of PLA, Naval Medical University, Shanghai, China;
2
Department of Orthopedic Surgery, Shanghai First Hospital, Shanghai Jiao Tong University, Shanghai, China;
3
Department of Orthopedic Surgery, Spine Center, The Second Affiliated Hospital of Naval Medical University, Shanghai, China;
4
Department of Gastroenterology, The Second Affiliated Hospital of Naval Medical University, Shanghai, China;
5
Qindao Special servicemen Recuperation Center of PLA Navy, Qingdao, China;
6
Department of Orthopedic Surgery, The 72nd Army Hospital of the People's Liberation Army, Huzhou, China;
#
These authors contributed equally to this work.
Objectives: This study was aimed to investigate the clinical effect of natural product Glycyrrhiza for lumbar disc herniation patient with postoperative stress ulcer through down-regulating inflammatory cytokines.
Methods: A total of 64 paraplegia patients with single segment of L4-S1 lumbar disc herniation (LDH) were admitted. All patients were selectively treated with L4-L5 or L5-S1 Cage-Fusion. The prone position was taken and general anesthesia was performed. The subcutaneous tissue was cut along the posterior median to fully expose the deep fascia. The sacrospinous muscle was dissected along the lateral margin of laminae and spinous process to expose articular process and laminae. The window of laminae was dissected to remove epidural ligamentum flavum. The nerve root was retracted, the degenerative nucleus pulposus tissue was fully removed. The endplate was removed with a reamer and cancellous bone was implanted in the intervertebral space. The fusion was implanted into the anterior column. All patients were set apart into randomly into 2 groups: 31 patients in oral PPI group and 33 patients in oral PPI+Glycyrrhiza group. 30g Glycyrrhiza was boiled in 600 mL water and removed the dross, then boiled in glauber's glass twice. 50∼60mL Glycyrrhiza was taken orally before meals twice a day. 20mg Omeprazole capsule was taken orally twice a day. Glycyrrhiza and Omeprazole were taken three days before and two weeks after surgery. Within 8 hours after surgery, 80mg methylprednisolone was added into 5% 250ml glucose injection intravenously to relieve neuroedema once a day for 3-5 days. Postoperative hyperbaric oxygen therapy was performed routinely. The American Spinal Cord Injury Association was evaluated for neurological function. The Glasgow Blatchford Score was evaluated for severity of upper gastrointestinal hemorrhage. The interleukin-β, interleukin-6 and tumor necrosis factor α were detected by enzyme-linked immunosorbent assay. All assessments were performed before and 1, 3, 6, 9 days follow-up after surgery.
Results: In the 64 of total patients, The basic information had no significant difference between two groups, as well as intraoperative bleeding loss, operative time and postop drainage. Compared with baseline before operation, The patients in both groups had better ASIA score. Compared with PPI group, The stress ulcer symptom showed better alleviation after surgery, the blood concentration of inflammatory cytokines were significantly reduced, and the GBS score and total effective rate of treatment had remarkable improvement postoperatively in PPI+Glycyrrhiza group.
Conclusions: The treatment for LDH with stress ulcer could effectively alleviated upper gastrointestinal symptom by oral Glycyrrhiza through down-regulating inflammatory cytokines of IL-β, IL-6 and TNF-α.
Corresponding Author: Xiaoming Li, Department of Orthopedic Surgery, The 72nd Army Hospital of the People's Liberation Army, Huzhou, China; Jian Shi, Department of Gastroenterology, NO.905 Hospital of PLA, Naval Medical University, Shanghai, China.
The Clinical Surgical and Health Effects for Traumatic Obsolete Spinal Cord Injury
Yixuan Tan1,2,#, Congying Chen3,#, Shuang Cao1,2,#, Sijia Peng2, Xin Zhou2, Xiaoming Li4,*, Jinnan He1,*, Xuhui Zhou1,2,*
1
Department of Orthopedic Surgery, Shanghai First Hospital, Shanghai Jiao Tong University, Shanghai, China;
2
Department of Orthopedic Surgery, Spine Center, The Second Affiliated Hospital of Naval Medical University, Shanghai, China;
3
Department of Gastroenterology, NO.905 Hospital of PLA, Naval Medical University, Shanghai, China;
4
Department of Orthopedic Surgery, The 72nd Army Hospital of the People's Liberation Army, Huzhou, China;
#
These authors contributed equally to this work.
Objectives: How to promote the regeneration and functional recovery of traumatic obsolete spinal cord injury is always a topic in the medical field. At present, most of the basic research and clinical practice reports on spinal cord injury focus on the acute stage of spinal cord injury, and the literature on surgical intervention for TOSCI is limited. This paper aimed to investigate the clinical effects of surgical treatment and health care for patients with traumatic obsolete spinal cord injury.
Methods: A total of 30 paraplegia patients with traumatic obsolete spinal cord injury (TOSCI) were admitted and divided into three groups according to the area of spinal cord necrosis from December 2018 to June 2022. Retrospective analysis was performed on the clinical data of enrolling patients. The anterior corpectomy or posterior laminectomy was executed selectively. The patients were evaluated by using the MRI, CT, and X-ray findings. Photoshop7.0 was used to measure the intramedullary necrotic area by MRI. The operation time, intraoperative blood loss and postoperative complications were recorded. The American Spinal Cord Injury Association (ASIA) was evaluated for neurological function. The forced expiratory rate in one second (FEV1%) was measured for respiratory function. Modified MacNab was used to evaluate surgical satisfaction at the last follow-up. All assessments were performed before and 1, 6, 12, 24 months follow-up after surgery. All documents, such as electronic medical records and orders, appointment registration, medical imaging documents and medical education information are integrated.
Results: The age distribution, gender ratio and duration of disease had no significant difference among three groups (p>0.05). The injury segment and number of vertebral fractures were not statistically different among three groups (p>0.05). All groups had residual upper extremity root symptoms homoplastically (p>0.05). The choice of anterior and posterior approach had no significant difference in the three groups, as well as intraoperative bleeding loss and operative time (p>0.05). Compared with severe injury group before operation, The patients in mild and moderate injury group had better ASIA sensory and motor score (*p<0.05). Compared with baseline before operation. The patients in mild and moderate injury group showed dramatic improvement of ASIA score and satisfactory rate (*p<0.05), rather than in severe injury group (p>0.05). All these groups showed noticeable improvements of FEV1% by pre- and post-comparisons (#,*p<0.05). No mortality and major complications were observed during follow-up.
Conclusions: The treatment for paralyzed patients with TOSCI could effectively improve somatic and respiratory function reconstruction through anterior corpectomy or posterior laminectomy and pharmacotherapy.
Corresponding Author: Xiaoming Li, Department of Orthopedic Surgery, The 72nd Army Hospital of the People's Liberation Army, Huzhou, China; Jinnan He, Department of Orthopedic Surgery, Shanghai First Hospital, Shanghai Jiao Tong University, Shanghai, China; Xuhui Zhou, Department of Orthopedic Surgery, Shanghai First Hospital, Shanghai Jiao Tong University, Shanghai, China and Department of Orthopedic Surgery, Spine Center, The Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Progress in the Study of Diagnostic Methods for Pneumonia in the Elderly
Mengjie Dai1, Qian Li1, Caibao Hu2,*
1The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China; 2Department of Critical Care Medicine, Zhejiang Hospital, Hangzhou, Zhejiang, China
Objectives: Elderly patients are frail and have more underlying diseases, and lower respiratory tract infections have become the sixth leading cause of disability-adjusted life-years (DALYs) globally affecting people >75 years of age. Pneumonia in the elderly is mainly caused by bacterial, viral, fungal, and other pathogenic infections, and manifests as alveolar capillary congestion, edema, and inflammatory cell infiltration leading to symptoms such as cough, sputum, and dyspnea. We reviewed the diagnostic and mortality rates of pneumonia in the elderly and found that there is a lack of review of diagnostic methods for pneumonia in the elderly. Therefore, this paper reviews the pathogenic diagnosis and clinical diagnostic methods of senile pneumonia, aiming to improve the rate of early diagnosis and accurate diagnosis of senile pneumonia and to reduce the morbidity and mortality rate.
Methods: The research object of this paper is pneumonia in the elderly. This paper adopts a retrospective approach to study the diagnostic methods of pneumonia in the elderly, and comprehensively evaluates the applicability and advantages and disadvantages of each diagnostic technique in terms of pathogen specificity, diagnostic sensitivity, accuracy, area under the ROC curve, and diagnostic advantage ratio of each diagnostic technique.
Results: Traditional pathogenic microorganism detection is low-cost but lagging in the diagnosis, and the molecular nucleic acid amplification technique Demonstrates high sensitivity and accuracy, of which second-generation sequencing has become an important diagnostic modality for senile pneumonia in which the causative organisms cannot be identified at present. Chest imaging techniques, including CT, lung ultrasound, and lung perfusion imaging, provide an important way for early diagnosis of pneumonia in the elderly and, to some extent, allow identification of pathogens through signs such as exudative shadows, solid shadows, and comet's tail signs. In addition, anal swab/fecal specimen testing, ultrasound- or CT-based AI-assisted diagnostic systems have good efficacy in recognizing novel coronavirus infections.
Conclusions: Traditional pathogenicity testing has a low positivity rate and a long incubation time, which do not satisfy the requirements for the early recognition and diagnosis of pneumonia in the elderly. Molecular detection technology has high diagnostic efficacy for all types of pathogens and is suitable for rapid diagnosis. Urine antigen detection has a high diagnostic value for Streptococcus pneumoniae and Legionella serotype 1. Fecal specimen testing, rapid diagnostic antigen testing for respiratory viruses, and AI-assisted diagnostic systems have high diagnostic performance for respiratory viral infections. In addition, chest imaging techniques can make a preliminary diagnosis of the pathogenesis of pneumonia in the elderly through various signs.
Acknowledgements: This work was funded by the Key Research & Development Project of Zhejiang Province (2024C03240).
Corresponding Author: Caibao Hu, Department of Critical Care Medicine, Zhejiang Hospital, Hangzhou, Zhejiang, China.
Analysis of Factors Affecting the Results of Open Double Blepharoplasty
Yunke Li1, Qinggui Zheng2,*, Runlei Zhou2, Zhenrong Lin2, Xiaohan Yan3, Daiwei Cheng3, Chi Zhou4, Huizhong Huang4
1
Zhuhai People's Hospital, Zhuhai, Guangdong, China;
2
Guihang300 Hospital Affiliated to Zunyi Medical University, Guiyang, Guizhou, China;
3
Guizhou Provincial People's Hospital, Guiyang, Guizhou, China;
4
Guiyang Nanming Meimu Clinic, Guiyang, Guizhou, China
Objectives: This paper was to analyze the factors that affect the operation effect of open double blepharoplasty, including HLPF (Horizontal Length of Palpebral Fissure), VHPF (Vertical Height of Palpebral Fissure), the severity of upper eyelid skin laxity, HRES (Height of Removing Eyelid Skin), VROF (Volume of Removing Orbital Fat), the severity of epicanthus, ICD (Inner Canthic Diameter), respectively. In this way, to investigate the law of VHPF, as well as the law of the amount of skin and fat were removed in the patients with different severity of upper eyelid skin laxity. Besides, to investigate SICD (Shorter Inner Canthic Diameter) in epicanthus with different severity, and then to evaluate the result of the modified skin replacement method of inner canthus enlargement. Furthermore, obtaining SICD and VHPF can provide valuable data and ideas for orthopedists anticipating the effect of the operation and for their clinical work.
Methods: 103 patients with open double blepharoplasty from July 2018 to July 2023 were included in this study. Before and 180 days after operation, the eye morphology of the patients was measured and evaluated, and HLPF, VHPF, ICD, the severity of epicanthus, the severity of upper eyelid skin laxity were recorded, respectively. During the operation, the height of double eyelid incision, HERS and VROF were measured and recorded. To evaluate the effect of the operation. For the patients with different severity of upper eyelid skin laxity, to analyze the age difference of each group, besides to analyze VHPF after operation and both HERS and VROF in operation. For the patients with different severity of epicanthus, to analyze the age difference of each group, besides to analyze increscent values of HLPF/ICD and SICD after correcting epicanthus.
Results: 56 patients underwent the modified skin replacement method of inner canthus enlargement in the same period. Among the 103 patients, there were statistically significant differences among the patients without upper eyelid skin laxity group and slight to moderate upper eyelid skin laxity groups, respectively (P<0.01). Among the 103 patients, the inter-group differences of patients with slight to severe upper eyelid skin laxity were statistically significant (P<0.01). Among the 103 patients, HRES in patients without upper eyelid skin laxity group and patients with slight to severe upper eyelid skin laxity groups were 1.64±0.99mm, 3.63±0.43mm, 4.84±0.75mm, 6.55±0.67mm, respectively. The inter-group differences were statistically significant (P<0.01). The VROF in patients without upper eyelid skin laxity group and patients with slight to severe upper eyelid skin laxity groups were 0.09±0.08ml, 0.17±0.13ml, 0.27±0.13ml, 0.36±0.14ml, respectively (P<0.01). Among the 56 patients of correcting epicanthus, the difference values of HLPF/ICD before and after operation in patients with different severity of epicanthus were statistically significant (P<0.01). And HLPF/ICD were closer to 1. And SICD gradually increased in patients with slight to severe epicanthus groups after operation, which were 2.63±0.97mm, 4.20±0.84mm, 6.08±0.81mm, respectively (P<0.01).
Conclusions: The more laxity the skin of upper eyelid were, the more the amount of skin and fat were removed from the upper eyelid, and the more obvious VHPF were increased after open double blepharoplasty.
Acknowledgements: This work was supported by the Science and Technology Foundation of Guizhou Provincial Health Commission, No. gzwjkj2019-1-154
Corresponding Author: Qinggui Zheng, Guihang300 Hospital Affiliated to Zunyi Medical University, Guiyang, Guizhou, China.
Amino Acids and Colorectal Cancer Risk: A Mendelian Randomization Perspective
Fan Zhang1, Wenping Wang2,3*, Mingzhu Li4, Yong Li5
1Liaoning University of Traditional Chinese Medicine, ShenYang, China; 2Department of Phase I Clinical Trail Center, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China; 3Department of Phase I Clinical Trail Center, Liaoning Cancer Hospital, Shenyang, China; 4Department of Integrated Traditional Chinese and Western Medicine Medical Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China; 5Department of Oncology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Affiliated Shenben Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China
Objectives: Colorectal cancer (CRC) is a prevalent and deadly malignancy with complex etiological factors. This study aims to investigate the causal relationships between blood levels of 20 amino acids and CRC risk using Mendelian randomization (MR) analysis.By leveraging MR, we aim to overcome the limitations of observational studies and provide more reliable evidence for the role of amino acids in CRC development.
Methods: We employed a two-sample Mendelian randomization approach, utilizing genome-wide association study (GWAS) data from the IEU GWAS database. Single nucleotide polymorphisms (SNPs) significantly associated with blood levels of 20 amino acids and free from linkage disequilibrium were selected as instrumental variables. We conducted causal inference using five methods: inverse-variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode. To ensure robustness, sensitivity analyses including heterogeneity tests (Cochran’s Q statistic), horizontal pleiotropy tests (MR-Egger intercept analysis), leave-one-out analysis, and MR-PRESSO were performed. Additionally, multivariable Mendelian randomization (MVMR) was carried out to adjust for known cancer risk factors.
Results: The application of IVW MR methodology demonstrated pronounced causal connections linking blood levels of arginine, lysine, and methionine to CRC risk. Higher genetically predicted levels of arginine and methionine were linked to a lower risk of CRC, as evidenced by odds ratios of 0.393 (95% CI 0.155–0.996, P = 0.049) and 0.119 (95% CI 0.020–0.700, P = 0.019), respectively. Conversely, elevated genetically predicted concentrations of lysine were linked to a heightened risk of CRC (IVW OR=4.206, 95%CI 1.007-17.569, P = 0.049). No significant relationship emerged between the levels of the 20 amino acids and CRC risk, as revealed by the reverse MR analysis (P > 0.05). MVMR confirmed the direct effects of arginine, lysine, and methionine on CRC risk without evidence of horizontal pleiotropy.
Conclusions: Our findings suggest that specific blood amino acid levels play a significant role in CRC development, with arginine and methionine potentially offering protective effects while lysine may increase risk. Furthermore, our study's MVMR analysis strengthens the credibility of these associations, providing a foundation for future research into the role of amino acid metabolism in CRC and the development of novel preventive and therapeutic approaches. These results emphasize the role of metabolic pathways in the etiology of CRC. They also highlight potential targets for preventive strategies and therapeutic interventions.
Corresponding Author: Wenping Wang, Department of Phase I Clinical Trail Center, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China; Department of Phase I Clinical Trail Center, Liaoning Cancer Hospital, Shenyang, China.
Visual Analysis of Emergency Governance Research on Public Health Events Using CiteSpace and VOSviewer
Chenyu Wang1,*, Limin Pan2, Lijuan Zhao1, Jing Yuan1, Xiantao Huang1, Yumei Jia1, Tian Tian1
1Department of Medical, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China;
2
Department of Technology, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China
Objectives: This study aims to reveal the research dynamics, collaborative networks, thematic trends and academic influence in the field of global public health emergency (PHE) governance through systematic analysis.
Methods: Literature was retrieved from the Web of Science Core Collection, and the research network was analyzed using CiteSpace and VOSviewer software. Co-citation and co-occurrence networks were used to identify the evolution of the research field.
Results: The research collaboration network shows that the United States, China, the United Kingdom, Australia, and Canada are the main research countries, with institutions such as the Centers for Disease Control and Prevention holding a leading position in this field. Keyword co-occurrence analysis reveals five main research areas: Basic Medicine and Clinical Application, Social Psychology and Health Policy, Infectious Disease and Global Health, Mental Health Status Assessment, and Environmental Science and Public Health. Keyword burst analysis shows that terms related to emerging infectious disease outbreaks, such as "covid 19" and "pneumonia," have become research hotspots, while mental health issues have also received widespread attention. Co-citation analysis indicates that the paper on COVID-19 published in the New England Journal of Medicine in 2020, has been most frequently co-cited, and journals such as The Lancet and the New England Journal of Medicine are highly cited academic resources in this field.
Conclusions: Over the past three decades, there has been a significant increase in research literature in the field of PHE management. The field focuses on basic medicine, clinical application, public health policy, and integrates social psychology, education, and environmental science.
Acknowledgements: This research was supported by 2024 Medical Science Research Project Plan of Health Commission of Hebei Province, NO. 20240224.
Corresponding Author: Chenyu Wang, Department of Medical, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China.
Social Support and Psychological Resilience in Cancer Survivors: Multiple Mediating Effects of Spiritual Health and Illness Uncertainty
Wenjing Liu1, Ning Chen1, Ping Shu1, Wenqian Hong1, Xiaoli Tong2, Hengying Che2,*
1
Graduate School, Wannan Medical College, Wuhu, Anhui 241000, China;
2
Yijishan Hospital, the First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241000, China
Background: At present, with the increasing incidence of cancer year by year, for cancer survivors, maintaining good mental resilience can promote their physical and mental recovery, actively face cancer and cooperate with treatment, and thus improve their quality of life. To explore the relationship between cancer survivors' spiritual health and illness uncertainty in social support and psychological resilience.
Subjects and Methods: Cancer survivors in the Department of Medical Oncology of a tertiary general hospital in Wuhu City from February 2024 to May 2024 were sampled by convenience sampling method, and general information survey, comprehension social support scale, Chinese version of Chronic Disease Therapeutic Functional Assessment-Spiritual Wellness Scale, Illness Uncertainty Scale, and Psychological Resilience Scale were administered. Pearson correlation analysis was used to explore the correlation of spiritual health, disease uncertainty, social support and mental resilience in cancer survivors. Model 6 of the SPSS PROCESS macro was used to analyze the mediating effects of spiritual health and disease uncertainty on social support and mental resilience in cancer survivors.
Results: Cancer survivors' comprehension social support score was (67.20±6.92), spiritual health score (25.11±7.19), illness uncertainty score (67.75±13.06), and psychological resilience score (24.36±6.75). The study proved that the mediating effects of spiritual health and illness uncertainty between social support and psychological resilience were established. The total indirect effect (95%CI=[0.203,0.375]) accounted for 66.82
%
of the total effect (95%CI=[0.303,0.547]), the specific mediating effect of spiritual health and uncertainty of illness accounted for 9.41
%
(95%CI=[0.010,0.083]) and 48.24
%
(95%CI=[0.134,0.289]) of the total effect, respectively, and the chain mediating effect of spiritual health and uncertainty of illness accounted for 9.17
%
(95%CI=[0.014,0.074]) of the total effect.
Conclusion: The overall psychological resilience scores of cancer survivors were at a moderate level. The chain-mediated effects of spiritual health and uncertainty of illness were established between social support and spiritual health of cancer survivors, for which both clinical staff and family caregivers of cancer survivors can improve their level of psychological resilience by reducing their psychological stress through the promotion of social support and the enhancement of spiritual health, as well as the enhancement of the level of awareness of the disease among cancer survivors—individual levels of psychological resilience.
Acknowledgments: This work was supported by a project grant from Provincial Quality Engineering Project "Internal Medicine Nursing" of Anhui Provincial Department of Education in 2023 (Grant No.2023kcszsf150).
Corresponding Author: Hengying Che, Yijishan Hospital, the First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241000, China
Neuroprotective Effects of Respiratory-Circulatory Management in STBI Patients with Multi-Modal Brain Monitoring
Yongyuan Ma, Jianbo Zhang, Zhaoju Li, Bo Xu*
Department of Anesthesiology, Southern Theater General Hospital of PLA, Guangzhou 510010, China
Background: Severe traumatic brain injury (sTBI) is a critical medical condition contributing to high rates of disability and mortality. Prior publications have addressed invasive procedures and postoperative care in sTBI. Still, there is limited data on the possible advantage of non-invasive multi-modal brain monitoring in conjunction with respiratory and circulatory management throughout surgery. This work aims to systematically review and meta-analyze the existing evidence on clinical outcomes of the respiratory-circulatory management approach in patients with sTBI based on non-invasive multi-modal brain monitoring.
Methods: A comprehensive literature search was conducted in multiple databases, including MEDLINE, Embase, and the Cochrane Library. Randomized controlled trials, prospective and retrospective cohorts in which subjects with sTBI underwent non-invasive multi-modal brain monitoring by transcranial Doppler (TCD), optic nerve sheath diameter (ONSD), and regional cerebral oxygen saturation (rScO2) for guidance of respiration and circulation were included. The primary end-points were mortality, Modified Rankin Scale (mRS) and Glasgow Outcome Scale (GOS), and length of hospital and neurointensive care unit (NSICU) stay. Secondary outcomes included cerebral hemodynamic, reoperation, and safety data. A system review of all the treatments was carried out, and a random-effects meta-analysis was used to combine the results of the different studies. Subgroup and sensitivity analyses were also done to identify the sources of heterogeneities.
Results: A total of 42 studies, comprising 18 randomized controlled trials, 15 prospective cohorts, and 9 retrospective analyses, with 3,842 sTBI patients, were included in the meta-analysis. Patients managed with respiratory-circulatory protocols guided by non-invasive multi-modal brain monitoring demonstrated a significantly lower 28-day mortality rate compared to the conventional management group (18.4% vs. 27.6%; odds ratio [OR], 0.68; 95% confidence interval [CI], 0.54-0.85; p<0.001). At 6-month follow-up, the multi-modal monitoring group had a higher proportion of patients achieving favorable functional outcomes (mRS ≤3; 58.2% vs. 44.7%; relative risk [RR], 1.30; 95% CI, 1.15-1.47; p<0.001). The multi-modal monitoring group also had shorter mean NSICU stays (12.4 ± 4.2 days vs. 15.8 ± 5.1 days; p<0.001) and total hospital stays (18.6 ± 6.3 days vs. 22.9 ± 7.2 days; p<0.001). Analysis of cerebral hemodynamic parameters revealed more stable mean cerebral artery flow velocities (Vmean: 55.8 ± 12.4 cm/s vs. 48.3 ± 14.2 cm/s; p<0.001) and lower pulsatility indices (PI: 1.12 ± 0.24 vs. 1.38 ± 0.31; p<0.001) in the multi-modal monitoring group. The rate of monitoring-related complications was significantly lower in the non-invasive monitoring group compared to invasive techniques (0.8% vs. 4.2%; p<0.001).
Conclusions: Combining the current systematic review and meta-analysis of the literature, respiratory-circulatory management indexed by non-invasive multi-modal cerebral monitoring, including TCD, ONSD, and rScO2, appears to afford substantial neuroprotective advantages for severe traumatic brain injury patients. The decreases in mortality, disability, and resource consumption coupled with the relatively low risk and cost profile of non-invasive procedures hint at the possible distinctiveness of this approach as a useful supplementation or at least an alternative to typical management strategies. Studies beyond this work are needed to enhance the advances in combining multi-modal monitoring data and inform the best management practices in different environments.
Corresponding Author: Bo Xu, Department of Anesthesiology, Southern Theater General Hospital of PLA, Guangzhou 510010, China.
Application of Pedestrian Dead Reckoning-Based Multi-Fusion Positioning Algorithm in Smart Healthcare
Guiyun Zhao1, Baiyu Song1,*, Jianyin Lu2
1
Jiangsu Vocational College of Agriculture and Forestry, Jurong, 212400, Jiangsu, China;
2
Chaohu University, Hefei, 238024, Anhui, China
Background: In complex healthcare environments, traditional Global Navigation Satellite System (GNSS) positioning technology faces instability issues due to building obstructions and multipath effects. These problems are especially serious in healthcare settings, where precise patient positioning is critical. Pedestrian Dead Reckoning (PDR) technology, which provides stable positioning information through inertial sensors, can effectively track a user’s location without relying on external signals, making it particularly suitable for indoor environments such as hospitals. Therefore, this study focuses on the application of the PDR positioning algorithm in healthcare settings and conducts a systematic comparative analysis with GNSS positioning performance.
Subjects and Methods: This study used simulation experiments to explore the positioning performance of PDR and GNSS in different complex environments, including scenarios involving irregular track navigation and building obstructions. During the experiments, multiple sets of sensor data were collected, covering data from accelerometers, gyroscopes, position sensors, and magnetometers. Additionally, to verify the stability of the PDR algorithm during long-term use, cumulative error simulation was introduced in the experiments, analyzing the positioning performance under different error ratios.
Results: The experimental results showed that in complex environments such as healthcare settings, the PDR algorithm demonstrated high positioning accuracy and stability, especially in scenarios with building obstructions, where the positioning performance of PDR was significantly better than that of GNSS. Although PDR may accumulate errors over long periods of operation, even in extreme test cases, its positioning error remained lower than that of GNSS. Furthermore, PDR technology also showed advantages in terms of flexibility and privacy protection, effectively adapting to the dynamic changes within hospital environments.
Conclusion: The PDR algorithm, as an effective positioning technology, is particularly well-suited for application in complex indoor environments like healthcare settings, where it can provide stable positioning services when GNSS signals are limited or fail. Based on the results of this study, future research can explore enhancing PDR performance through multi-sensor fusion and algorithm optimization to address more complex environmental challenges and provide more reliable technical support for healthcare services.
Acknowledgements: The research was founded within project No. X2018zygc029, entitled: “Network engineering excellence engineer education and training program”, supported by funds for a key project from Quality Engineering Project in Colleges and Universities in Anhui Province.
Corresponding Author: Baiyu Song, Jiangsu Vocational College of Agriculture and Forestry, Jurong, 212400, Jiangsu, China.
Clinical Observation on the Treatment of Chronic Bacterial Prostatitis with Self-designed Qianlie Qingfu Yin I and II
Heng Lv1,*, Guocai Wang2
1The Fourth Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150070, China; 2Dongfang Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100078, China
Objectives: To observe the clinical efficacy of self-designed Prostate Qingfu Yin Formula I and II in the treatment of chronic bacterial prostatitis.
Methods: A total of 80 patients with chronic bacterial prostatitis admitted to our hospital from March 2022 to March 2024 were selected and randomly divided into control group and treatment group using a random number table method, with 40 cases in each group. The control group was treated with levofloxacin once a day, while the treatment group was treated with self-designed Prostate Qingfu Yin Formula I and II, taken once in the morning and once in the evening, and one dose per day. Both groups of patients were treated continuously for 4 weeks. Compare the clinical efficacy, traditional Chinese medicine symptom score, chronic prostatitis symptom index (NIH-CPSI) score, changes in lecithin corpuscles and white blood cell count and changes in TNF - α, IL-6, and IL-8 levels in prostate fluid.
Results: Compared with the same group before treatment, the control group and the treatment group showed a significant decrease in traditional Chinese medicine syndrome score, NIH-CPSI score, and white blood cell count, TNF-α, IL-6, IL-8 level in prostate fluid, and a significant increase in Lecithin corpuscles score after treatment. The comparison between the two groups was statistically significant (P<0.05). The total effective rate of the treatment group was 92.5%, while the total effective rate of the control group was 80%. The difference between the two groups was statistically significant (P<0.05).
Conclusions: Prostate Qingfu Yin Formula I and II can improve traditional Chinese medicine syndrome scores and clinical symptoms by reducing TNF-α, IL-6, IL-8, and white blood cell count, which improving the scoring of phospholipid bodies in the prostate fluid of patients with chronic bacterial prostatitis, and improving the score of Lecithin corpuscles. The therapeutic effect is significant, and the safety is good, which is worthy of clinical promotion.
Corresponding Author: Heng Lv, The Fourth Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150070, China.
Biomechanical Analysis and Structural Optimization of a Bionic Hand for Medical Prosthetic Applications
Chuanxin Sheng1, Huajun Wang2, Zefeng Wang2,3,4,5*, Lianxin Hu2,5, Jean-Marie Nianga4,5, Xuecan Yang5, Laurent Peyrodie6
1
Art School, Huzhou University, Huzhou, Zhejiang, China;
2
College of Information Engineering, Huzhou University, Huzhou, Zhejiang, China;
3
Nanjing Tuobu Intelligent Technology Co,. Ltd, Nanjing, Jiangsu, China;
4
Sino-Congolese Foundation for Development, Brazzaville, Republic of the Congo;
5
ASIR, Institute - Association of intelligent systems and robotics, Paris, France;
6
ICL, Junia, Université Catholique de Lille, LITL, F-59000 Lille, France
Objectives: The objective of this study is to develop a bionic hand prototype that is optimized for medical prosthetic applications.
Methods: The prototype would be designed to demonstrate structural integrity, functional adaptability and long-term durability. The design incorporated a multi-degree-of-freedom (MDOF) structure and bio-inspired linkage systems, which were intended to mimic the complex motions of a human hand. This was intended to provide the necessary flexibility and stability for diverse daily tasks. The bionic hand employed a strategic material selection to achieve an optimal balance between strength, weight, and user comfort. The joints, which experienced high stress, were constructed from stainless steel, while the lightweight structural support was comprised of aluminum alloy. The palm segment was made from ABS plastic. A Finite Element Analysis (FEA) was conducted under static loading conditions to evaluate the distribution of stress, displacement, and strain in the design's critical components.
Results: The analysis demonstrated an efficient load distribution, with the highest stress observed in the proximal joints and the lowest stress at the fingertips. This distribution of stress is analogous to the natural force patterns observed in human hand mechanics. The displacement analysis confirmed the stability of the design, demonstrating minimal deformation in the key load-bearing areas, which is essential for maintaining precision in motor tasks. The results of the elastic strain analysis demonstrated the durability of the materials under cyclic loading, thereby confirming their suitability for sustained and reliable use. The adaptive grip capability of the hand was also evaluated, demonstrating its ability to securely interact with objects of varying shapes and sizes. This feature enhances the user experience by minimizing grip fatigue and increasing control, thereby meeting the clinical need for versatile and user-friendly prosthetic devices.
Conclusions: This research advances prosthetic hand design by providing a robust, adaptable model that aligns with clinical standards and user requirements, potentially improving the quality of life for individuals requiring upper-limb prostheses.
Acknowledgements: This work is supported by Huzhou Science and Technology Bureau with the plan projects of ‘Huzhou Key Laboratory of Waters Robotics Technology (2022-3)’ and ‘Application Research on Passive Exoskeleton Rehabilitation Assessment Based on Potential Energy Control. (No. 2021G201)’.
Corresponding Author: Zefeng Wang, College of Information Engineering, Huzhou University, Huzhou, Zhejiang, China; Nanjing Tuobu Intelligent Technology Co,. Ltd, Nanjing, Jiangsu, China; Sino-Congolese Foundation for Development, Brazzaville, Republic of the Congo; ASIR, Institute - Association of intelligent systems and robotics, Paris, France.
Ultrasound-guided Pecto-intercostal Fascial Plane Nerve Block Provides Effective Perioperative Pain Relief for Cardiovascular Surgery: A Prospective Study
Lulu Jiang#, Pianpian Yan#, Shengwen Guo*, Yiting Huang, Jiarong Ma, Yanqing Zhou, Liping Wu
Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, Fujian, 361008, China;
#
These authors contribute equally to this work.
Objectives: Cardiovascular surgery patients often suffered significant pain after median sternotomy surgery. Ultrasound-guided pecto-intercostal fascial plane (PIFP) nerve block is a newly developed nerve block technique that provides anterior chest wall with local anesthesia. In this retrospective study, we validated the effect and safety of ultrasound-guided PIFP nerve block on cardiovascular surgery.
Methods: Sixty-four patients underwent cardiovascular surgery were enrolled and were randomly divided into PIFP block group (32 cases) and control group (32 cases). The PIFP block group patients were performed under ultrasound-guided PIFP block by injected with 60 ml of 0.33% ropivacaine and 0.33% lidocaine in four points, while the control group patients injected with 60 ml saline. The mean arterial pressure (MAP) and heart rate (HR) of the two groups after entering the room, before incision, 5 min after incision and before the end of the operation were recorded. The times of patient controlled intravenous analgesia (PCIA) compression, the dosage of sufentanil during surgery and the times of analgesia pump press postoperative within 48 h after the surgery were also detected. The visual analogue scale (VAS) pain score at 4, 16, 24, 48 hours after surgery, the 90° turn-over VAS pain score, and the incidence of postoperative adverse reactions were also observed. The cumulative sufentanil consumption, the days of hospital stay and the hospital expense were examined.
Results: Compared with the control group, the MAP and heart rate at different time were not shown any significant difference. Interestingly, PIFP nerve block show lower can significantly decrease the VAS pain scores at 4, 16, 24 and 48 hours after surgery and the 90° turned-over VAS scores compared to the control group (P<0.001). Moreover, the cumulative sufentanil consumption, PCIA compression, the days of hospital stay and the hospital expense were also significantly reduced than the control group (P<0.05). However, there was no significant difference in the incidence of postoperative adverse reactions between the two groups, and no respiratory depression occurred in either group. There are no serious complications in both groups, including infection, pneumothorax, vascular puncture and hematoma.
Conclusions: This study demonstrated ultrasound-guided pecto-intercostal fascial plane (PIFP) block is a novel pain management strategy for cardiovascular surgery and a safety and effective local anesthesia which can significantly reduce the pain and accelerate recovery in the middle thoracic cardiovascular surgery.
Acknowledgements: This study was supported by the Xiamen Health Guidance Program (3502Z20244ZD1231).
Corresponding Author: Shengwen Guo, Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, Fujian, 361008, China.
Role of PLEKHA7 in Promoting Radioresistance in Esophageal Cancer Cells through Inhibition of Cuproptosis
Guannan Zou1,2,#, Xiang Cao2,#, Fanwei Meng3,#, Yizhi Ge2, Ruozhou Sun2, Jiazhen Chen2, Xin Chen2, Dan Zong2,*, Xia He1,2,4,*
1
Postgraduate College, Xuzhou Medical University, Xuzhou 221000, China;
2
Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Nanjing 210009, China;
3
Suzhou First People's Hospital, Suzhou 234000, China;
4
Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing 210009, China;
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These authors contributed equally to this work.
Background: Esophageal squamous cell carcinoma (ESCC) remains a leading cause of cancer-related deaths worldwide, with radiotherapy (RT) being a primary treatment approach. However, this disease is often characterized by the recurrence of tumors due to radioresistance, which seriously hinders the effectiveness of RT. We have identified one mechanism through which pleckstrin homology domain-containing A7 (PLEKHA7) promotes radioresistance via inhibiting cuproptosis. Clinical data from the TCGA and GEO databases and gene expression analysis of 49 cuproptosis-related genes (CRGs) were employed to identify the potential regulators of cuproptosis in ESCC. Of the identified regulators, the expression of PLEKHA7 was noticed to be significantly lower compared with that in ESCC tissues versus normal tissues, hinting that the gene could play a potential association with the progression of cancer and resistance to treatment.
Methods: Western blotting, qRT-PCR, intracellular copper measurement, colony formation, CCK8, EdU assays, and flow cytometry were performed to explore the role of PLEKHA7 in cuproptosis and radioresistance. Findings revealed that downregulating PLEKHA7 via Elesclomol-CuCl2 (a cuproptosis inducer) led to intracellular copper accumulation and cell death through cuproptosis. Additionally, ionizing radiation (IR) triggered producing ROS and further downregulated the expression of PLEKHA7, contributing to enhanced cuproptosis. Over-expression of PLEKHA7 countered this effect by restoring copper accumulation to lower levels and mitigating IR-induced cell death, suggesting a role for PLEKHA7 in maintaining copper homeostasis.
Results: PLEKHA7 was identified as a key regulator of cuproptosis in ESCC, with reduced expression observed in ESCC tissues compared to normal tissues. PLEKHA7 was decreased by treating Elesclomol-CuCl2, leading to the intracellular accumulation of copper and cell death via cuproptosis. Ionizing radiation (IR) further induced reactive oxygen species (ROS) production, suppressed the expression of PLEKHA7, and increased cuproptosis. Conversely, PLEKHA7 overexpression suppressed the accumulation of copper and reduced IR-induced cell death, proving its role in maintaining copper homeostasis and radioresistance.
Conclusion: The current study proposes PLEKHA7 as a key radioresistance modulator through the inhibition of cuproptosis in ESCC. The findings demonstrate that Elesclomol-CuCl2, a defined inducer of cuproptosis, increases intracellular copper and ROS and improves RT efficacy in PLEKHA7-deficient ESCC cells. This treatment represents a promising therapeutic approach to overcome radioresistance in ESCC for ESCC patients. Using cuproptosis inducers as radiosensitizers will be particularly helpful for patients with low PLEKHA7 expression and may facilitate precision therapy in ESCC.
Corresponding Author: Dan Zong, Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Nanjing 210009, China. Xia He, Postgraduate College, Xuzhou Medical University, Xuzhou 221000, China; Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Nanjing 210009, China; Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing 210009, China.
Author Index and Page Numbers
Baiyu Song, 23, 37
Baoquan Ren, 16, 17
Bingyi Sun, 11
Bo Xu, 36
Caibao Hu, 32
Caohang Qiu, 18
Chao Wang, 12
Chao Zheng, 24
Chengfang Qiao, 12
Chenshu He, 18
Chenyu Wang, 35
Chi Zhou, 33
Chuanxin Sheng, 38
Chunxiao He, 15
Congying Chen, 31, 32
Dabin Pan, 2
Daiwei Cheng, 33
Dan Yuan, 18
Dan Zong, 39
Danfeng Chu, 23
Dayong Zha, 2
Deliang Cheng, 9
Di Xu, 24
Dong Zhao, 13
Dongcheng Wang, 22
Dongmei Wei, 11
Fan Zhang, 34
Fang Lu, 18
Fangjun Shi, 15
Fangyuan Wang, 11
Fanwei Meng, 39
Fei Li, 14
Fei Xie, 9
Fei Zhou, 11
Feng Luo, 14
Fengchai Wang, 30
Fengling Li, 24
Fulei Chen, 13
Gang Wei, 18
Guangdong Xie, 28, 29
Guangtian Liu, 1
Guannan Zou, 39
Guiyun Zhao, 23, 37
Guocai Wang, 37
Guodong Qian, 12
Haichao Wang, 3
Haitao Li, 19
Haiting Wang, 10
Haizhen Jiang, 23
Hao Chen, 7
Hao Li, 11
Haobo Zhou, 14
Haoxiang Fang, 9
Heliang Yin, 11
Heng Lv, 37
Hengying Che, 19, 35
Heshuang Ye, 1
Hong Wang, 16, 17
Honghao Duan, 9
Hongxia Li, 3
Hongyu Liu, 11
Huajun Wang, 38
Huifang Chen, 6, 7, 8
Huifen Yu, 25
Huili Qi, 14
Huizhong Huang, 33
Jean-Marie Nianga, 28, 29, 38
Jian Chu, 28
Jian Shi, 31
Jian Song, 27
Jianbo Zhang, 36
Jianhua Yi, 7
Jianyi Yang, 26
Jianyin Lu, 23, 37
Jiao Cheng, 4
Jiarong Ma, 39
Jiayan Liang, 1
Jiazhen Chen, 39
Jie Cao, 12
Jing Chen, 29
Jing Luo, 14
Jing Wei, 12
Jing Xu, 15
Jing Yuan, 35
Jing Zhuang, 29
Jingru Zhao, 26
Jinhao Ye, 26
Jinnan He, 32
Jinwen Bai, 27
Jinzi Zhao, 5
Jun Xie, 16, 17
Junxin Yu, 15
Kaixing Lin, 30
Keqiang Zong, 24
Kun Yang, 27
Laurent Peyrodie, 28, 29, 38
Lei Wan, 9
Li Gu, 4
Li Qian, 25
Li Zhang, 6, 10
Liang Liu, 18
Lianxin Hu, 38
Licang Zhu, 12
Lihong Zhang, 6
Lihua Xu, 19
Lijuan Zhao, 35
Lili Li, 15
Limin Pan, 35
Lin Feng, 18
Lin Zhou, 14
Lingyan Kong, 12
Lintao Zha, 2
Linzhi Dai, 13
Liping Wu, 39
Liping Zhang, 30
Liuxia Guo, 1
Lulu Jiang, 39
Lulu Yan, 6
Maria Della Rañeses, 27
Mei Zhao, 8, 15
Mengjie Dai, 32
Mengxiang Ren, 2
Min Li, 3
Mingjiao Jin, 16, 17
Mingyu Hu, 12
Mingzhu Li, 34
Minyi Lin, 30
Na Huang, 21
Ning Chen, 19, 35
Pianpian Yan, 39
Ping Shu, 19, 35
Qian Li, 32
Qian Zhang, 31
Qing Wang, 3
Qinggui Zheng, 33
Qingqing Song, 3
Qiting Liu, 21
Ranran Tang, 6, 10
Rong Cai, 24
Rong Ma, 6
Rong Que, 21
Ruixia Lei, 15
Runlei Zhou, 33
Ruozhou Sun, 39
Shan Li, 29
Shangqing Liu, 24
Shaoliang Xia, 3
Shenglei Yang, 24
Shengwen Guo, 39
Shenshen Lin, 30
Shigeng Li, 6
Shilong Wang, 12
Shuang Cao, 32
Shuangshi Li, 7
Shunjie Zhong, 18
Shuyi Cui, 1
Shuzhu Tian, 6
Sijia Peng, 32
Siyuan Wang, 14
Tengyue Zhang, 4
Tian Tian, 35
Tong Zhou, 8
Wanju Wang, 19
Wei Han, 5
Wei Wang, 16, 17
Wei Xu, 3
Weichen Huang, 13
Weihan Huang, 13
Weihua Xu, 12
Wen Yan, 1
Wenbo Zhang, 24
Wenjing Liu, 19, 35
Wenjing Yang, 6
Wenli Wang, 25
Wenping Wang, 34
Wenqian Hong, 19, 35
Wu Guo, 6
Xia Han, 29
Xia He, 39
Xiang Cao, 39
Xiangjin Meng, 13
Xiantao Huang, 35
Xianwei Lin, 28, 29
Xiaofen He, 12
Xiaohan Yan, 33
Xiaohan Zhang, 24
Xiaoju Zhang, 8
Xiaojun Zhang, 9
Xiaoli Tong, 19, 35
Xiaolin Li, 31
Xiaolong Du, 9
Xiaoming Li, 31, 32
Xiaoxia Ma, 20
Xiaoxia Wei, 14
Xiaoxu Shen, 13
Xin Chen, 39
Xin Zhou, 32
Xingyu Wang, 18
Xiwen Fu, 15
Xuecan Yang, 28, 29, 38
Xuehai Ou, 9
Xuejun Wang, 12
Xuhui Zhou, 32
Xujie Xu, 25
Yadi Chen, 6
Yan Li, 11
Yan Wang, 24
Yang Ling, 2
Yanjun Zhao, 23
Yanmei Zhuo, 30
Yanqing Zhou, 39
Yaxian Han, 20
Yeqi Shou, 25
Yi Yang, 21
Yijie He, 14
Yilin Zhang, 12
Yingying Cai, 21
Yingying Li, 15
Yiting Huang, 39
Yixuan Tan, 31, 32
Yizhi Ge, 39
Yong Li, 34
Yong Yan, 12
Yongchun Liu, 14
Yongyuan Ma, 36
Youting Dang, 9
Yu Pang, 4
Yuan Li, 7
Yuan Yuan, 18
Yuanyuan Dai, 1
Yumei Jia, 35
Yumei Zhao, 8
Yunke Li, 33
Yunxia Gao, 15
Yushuang Tang, 14
Yutong Lin, 26
Yuxuan Jian, 26
Zaiping Guo, 22
Zefeng Wang, 28, 29, 38
Zeyang Shan, 2
Zhangshuangzi Li, 20
Zhaoju Li, 36
Zhe Mao, 8
Zhen Wu, 3
Zhen Yan, 11
Zheng Wang, 25
Zhengting Cai, 28, 29
Zhenhong Zhao, 1
Zhenrong Lin, 33
Zhongyan Lin, 13
Zihan Zhang, 28
Zixuan Liang, 14
