The combined oral contraceptive pill has been used by an estimated 300 million women worldwide since it was first developed. In recent years it has been linked with both an increased risk of some forms of cancer and a protective effect against other cancers – leading to considerable confusion for women. In order to provide much-needed clarity, Dr Richard Russell and Mr Charles Kingsland provide an overview of the risks and benefits of the combined oral contraceptive pill.
References
1.
Collaborative Group on Epidemiological Studies of Ovarian Cancer, Beral V, Doll R, Hermon C Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23,257 women with ovarian cancer and 87,303 controls. Lancet2008; 371(9609):303–14.
2.
LurieGWilkensLRThompsonPJCombined oral contraceptive use and epithelial ovarian cancer risk: time-related effects. Epidemiology2008; 19(2):237–43.
3.
TaoMHXuWHZhengWOral contraceptive and IUD use and endometrial cancer: a population-based case-control study in Shanghai, China. Int J Cancer2006; 119(9):2142–7.
4.
HannafordPCSelvarajSElliottAMCancer risk among users of oral contraceptives: cohort data from the Royal College of General Practitioners’ oral contraception study. BMJ2007; 335:651.
5.
NicholsHBTrentham-DietzAEganKMOral contraceptive use and risk of breast carcinoma in situ. Cancer Epidemiol Biomarkers Prev2007; 16(11):2262–8.
6.
LundEBakkenKDumeauxVHormone replacement therapy and breast cancer in former users of oral contraceptives – The Norwegian Women and Cancer study. Int J Cancer2007; 121(3):645–8.
7.
International Collaboration of Epidemiological Studies of Cervical Cancer, Appleby P, Beral V, Berrington de González A Cervical cancer and hormonal contraceptives: collaborative reanalysis of individual data for 16,573 women with cervical cancer and 35,509 women without cervical cancer from 24 epidemiological studies. Lancet2007; 370(9599):1609–21.
8.
WHO Collaborative Study of Neoplasia and Steroid Contraceptives. Invasive squamous-cell carcinoma and combined oral contraceptives: results from a multinational study. Int J Cancer1993; 55:228–36.