Three-Dimensional Computed Tomography-Guided Salvage Brachytherapy of Recurrent Large Nonresectable Familial Colo-Rectal Cancer in the Pelvis: Case Report
Free accessResearch articleFirst published online February, 2002
Three-Dimensional Computed Tomography-Guided Salvage Brachytherapy of Recurrent Large Nonresectable Familial Colo-Rectal Cancer in the Pelvis: Case Report
Here we present the first reported case of three-dimensional CT-guided salvage brachytherapy of recurring colorectal cancer in the pelvis after failed radiation therapy, total colectomy, and chemotherapy. Initial CEA was 67.0 ng/mL and tumor volume 93 cm3 with no metastasis outside the pelvis. A total of 333 seeds of Iodine-125 were delivered to the entire target, with dosage of 150 to 200 Gy as calculated by post-implant CT dosimetry with Varian MMS software. CEA 12 months after implant decreased to 5.7 ng/mL. Clinical and biochemical results are encouraging; however long-term data in a greater universe of patients are required.
References
1.
Martinez-MongeR, NagS, MartinEW125 Iodine brachytherapy for col orectal adenocarcinoma recurrent in the pelvis and paraortics. Int. J. Radiat. Oncol. Biol. Phys., 42, 545–550 (1998).
2.
KoutrouvelisPG, LailasN, GoldsonA.3-D CT-guided brachytherapy for localized prostate cancer in patients with large volumes: 5-year follow-up. J. Brachytherapy Int., 16, 1–10 (2000).
3.
KoutrouvelisPG, LangE.Stereotactic lumbar microdiscectomy. Neurosurg. Clin. N. Am.7, 49–57 (1996).
4.
KoutrouvelisPGThree-dimensional stereotactic posterior ischiorectal space computerized tomography guided brachytherapy of prostate cancer: A preliminary reportJ. Urol., 159, 142–145 (1998).
5.
KoutrouvelisP, LailasN, HendricksF, Gil-MonteroG, SehnJ.Katz Three-dimensional computed tomography-guided monotherapeutic pararectal brachytherapy of prostate cancer with seminal vesicle invasion. Radiother. Oncol., 60, 31–35 (2001).
