The effects of spermatheca gland extract of snail (Telescopium telescopium) to promote wound healing were studied in an animal model. The spermatheca gland extract of the snail was used as a topical medicament to treat experimentally created full thickness wounds in 12 rabbits (Oryctologous cuniculus). Wound healing was assessed on the basis of physical, histomorphological, and histochemical changes on days 0, 3, 7, and 14. Statistically significant differences were observed between the groups in all measured parameters. These exciting findings suggest that the data should be further tested in animal models to better understand the potential for wound healing in the spermatheca gland extract of the marine snail.
Schulenburg H., Boehnisch C., Michiels NKHow do invertebrates generate a highly specific innate immune response? Mol Immunol . 2007;44:3338-3344.
2.
Ip WK, Lau YLRole of mannose-binding lectin in the innate defense against Candida albicans: enhancement of complement activation, but lack of opsonic function, in phagocytosis by human dendritic cells. J Infect Dis. 2004 ;190:632-640.
3.
Tsikitis VL, Monin NA, Harrington EO, Albina JE, Reichnen JSThe lectin like domain of complement receptor 3 protects endothelial barrier function from activated neutrophils. J Immunol. 2004;173:1284-1291.
4.
Oppeneheim JJ , Dougherty S., Chan SP, Baker J. In: Vyas N, Stites DP, Brecher G , eds. Laboratory Diagnosis of Immunologic Disorders. New York, NY: Grune & Stratton;1975:87-109.
5.
Tripathi KDAntiseptics, disinfectants and ectoparasiticides. In: Tripathi KD, ed. Essentials of Medical Pharmacology . 3rd ed. New Delhi, India: Jaypee Brothers; 1995:785-790.
6.
Plumb DC, ed. Veterinary Drug Handbook. 3rd ed. Ames, IA: Iowa State University Press; 1999.
7.
Biswas T., Auddy B.Bhattacharya N., Bhattacharya S., Mukherjee, B.Wound healing activity of human placental extracts in rats. Acta Pharmacol Sin. 2001;22:1113-1116.
8.
Singh UB, Sulochana S.Handbook of Histological and Histochemical Techniques. 2nd ed. Hyderabad, India: Premier Publishing; 1997:42-43.
9.
Mallory FBPathological Techniques. New York, NY: W. B. Saunders; 1961:154-155.
10.
Gridley MFA modification of the silver impregnation method of staining reticular fibres . Am J Clin Pathol. 1951;21:897-899.
11.
Kundu S., Biswas TK, Das P., Kumar S., De DKTurmeric rhizome (Curcuma longa) paste and honey show similar wound healing potential: a preclinical study in rabbits. Int J Low Extrem Wounds. 2005;4:205-213.
12.
SPSS Inc. SPSS Base 7.5 Applications Guide . Upper Saddle River, NJ: Prentice Hall PTR; 1997.
13.
Probst WC, Bright MRWound healing. In: Slatter DH, ed. Textbook of Small Animal Surgery. Vol. 1. Philadelphia, PA: W. B. Saunders ; 1985:28-36.
14.
Bulet P., Stocklin R., Menin L.Anti-microbial peptides: from invertebrates to vertebrates. Immunol Rev. 2004;198:169-184.
15.
Benhamou N.Ultrastructural study of galacturonic acid distribution in some pathogenic fungi using gold-complexed Aplysia depilans gonad lectin. Can J Microbiol. 1989;35: 349-358.
16.
Vasta GR, Quesenberry M., Ahmed H., Leary NOC-type lectins and galectins mediate innate and adaptive immune functions: their roles in the complement activation pathway. Dev Comp Immunol. 1999;23:401-420.
17.
Leeson TS, Leeson CRConnective tissue proper. In: Histology. 4th ed. Philadelphia, PA: W. B. Saunders ; 1981:106-135.
18.
Luna LGManual of Histologic Staining Methods of the Armed Forces Institute of Pathology . 3rd ed. New York: McGraw-Hill; 1979:38-39.
