State of the Art Reviews: Relationship Between Diet/ Physical Activity and Health

Abstract

Obesity and 4 of the leading causes of death—heart disease, cancer, stroke, and type 2 diabetes mellitus—are related to lifestyle. The combination of a healthy weight, prudent diet, and daily physical activity clearly plays a role in primary, secondary, and tertiary prevention of these and other chronic diseases. Because nearly 65% of the adult population is overweight or obese, weight loss and maintenance are central to this review article. Improved lipid profiles, blood pressure, insulin sensitivity, and euglycemia are associated with weight loss or a normal body weight; thus, maintaining a healthy weight is a universal recommendation for health. The methods for improving lifestyle described in the section on obesity include assessing nutritional status and stages of change of the client, setting realistic goals, eating a diet high in fruits and vegetables with low-fat sources of dairy and protein, and achieving appropriate physical activity levels. The importance of physicians discussing weight with clients and vice versa is stressed. The common features of lifestyle-related diseases make them amenable to similar lifestyle interventions.

Keywords

obesity coronary heart disease hypertension type 2 diabetes chronic disease lifestyle diet physical activity

References

National Academy of Sciences, National Research Council, Food and Nutrition Board. Diet and Health: Implications for Reducing Chronic Disease Risk. Washington, DC: National Academy Press; 1989.

US Senate Select Committee on Nutrition and Human Needs. Dietary Goals for the United States. 2nd ed. Washington, DC: Government Printing Office; 1977.

American Heart Association. Available at: http://www.americanheart.org/presenter.jhtml?identifier=3041532. Accessed May 22, 2007.

Third Report of the Expert Panel on: Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). National Institutes of Health; National Heart, Lung, and Blood Institute . Final Report, 2002. Available at: http://www.nhlbi.nih.gov/guidelines/cholesterol/atp3full.pdf. Accessed December 2, 2006.

X Korner J. , Aronne LJ The emerging science of body weight regulation and its impact on obesity treatment . J Clin Invest. 2003;111:565-570.

Chagnon YC , Rankinen T. , Synder EE , Weisnagel SJ , Pérusse L. , Bouchard C. The human obesity gene map: the 2002 update. Obes Res. 2003;11:313-367.

Barsh GS , Farooqi IS , O'Rahilly S. Genetics of body-weight regulation. Nature. 2000;404:644-651.

Segal NL , Allison DB Twins and virtual twins: bases of relative body weight revisited. Int J Obes Relat Metab Disord. 2002;26:437-441.

Rice T. , Tremblay A. , Deriaz O. , Pérusse L. , Rao DC , Bouchard C. A major gene for resting metabolic rate unassociated with body composition: results from the Quebec Family Study. Obes Res. 1996;4:441-449.

10.

Bouchard C. , Pérusse L. , Rice T. , Rao DC The genetics of human obesity. In: Bray GA , Bouchard C , James WPT , eds. Handbook of Obesity. New York: Marcel Dekker; 1998:157-190.

11.

Bouchard C. , Tremblay A. , Despres JP , et al. The response to long-term overfeeding in identical twins. N Engl J Med. 1990;322:1477-1482.

12.

Defining overweight and obesity. Available at: http://www.cdc.gov/nccdphp/dnpa/obesity/defining.htm. Accessed December 3, 2006.

13.

Ogden CL , Carroll MD , Curtin LR , McDowell MA , Tabak CJ , Flegal KM Prevalence of overweight and obesity in the United States, 1999-2004. JAMA. 2006;295:1549-1555.

14.

Hensrud DD , Klein S. Extreme obesity: a new medical crisis in the United States. Mayo Clin Proc. 2006;81:S5-S10.

15.

Overweight and Obesity in Children. Available at: http://www.cdc.gov/nchs/products/pubs/pubd/hestats/overwght99.htm. Accessed December 3, 2006.

16.

World Health Organization Obesity. Available at: http://www.who.int/topics/obesity/en. Accessed December 3, 2006.

17.

Meigs JB Epidemiology of the insulin resistance syndrome. Curr Diab Rep. 2003;3:73-79.

18.

Maggio CA , Pi-Sunyer FX Obesity and type 2 diabetes. Endocrinol Metab Clin North Am. 2003;32:805-822, viii.

19.

Wilson PW , D'Agostino RB , Sullivan L. , Parise H. , Kannel WB Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med. 2002;162:1867-1872.

20.

Poirier P. , Giles TD , Bray GA , et al, and American Heart Association Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2006 ;113:898-918.

21.

Klein S. , Burke LE , Bray GA , et al. Clinical implications of obesity with specific focus on cardiovascular disease a statement for professionals from the American Heart Association. Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2004;110:2952-2967.

22.

Li Z. , Maglione M. , Tu W. , et al. Meta-analysis: pharmacologic treatment of obesity. Ann Intern Med. 2005;142:532-546.

23.

Rexrode KM , Hennekens CH , Willett WC , et al. A prospective study of body mass index, weight change, and risk of stroke in women. JAMA. 1997;277:1539-1545.

24.

Kurth T. , Gaziano JM , Berger K. , et al. Body mass index and the risk of stroke in men. Arch Intern Med. 2002;162:2557-2562.

25.

Calle EE , Rodriguez C. , Walker-Thurmond K. , Thun MJ Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348:1625-1638.

26.

Pottie P. , Presle N. , Terlain B. , Netter P. , Mainard D. , Berenbaum F.

Obesity and osteoarthritis: more complex than predicted!

Ann Rheum Dis. 2006;65:1403-1405.

27.

Cedergren MI Maternal morbid obesity and the risk of adverse pregnancy outcome. Obstet Gynecol. 2004;103:219-224.

28.

Nasraway SA Jr , Albert M. , Donnelly AM , Ruthazer R. , Shikora SA , Saltzman E. Morbid obesity is an independent determinant of death among surgical critically ill patients. Crit Care Med. 2006;34:964-970.

29.

Adams KF , Schatzkin A. , Harris TB , et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med. 2006;355:763-778.

30.

Calle EE , Thun MJ , Petrelli JM , Rodriguez C. , Heath CW Jr. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med. 1999;341:1097-1105.

31.

Welborn TA , Knuiman MW , Vu HT Body mass index and alternative indices of obesity in relation to height, triceps skinfold and subsequent mortality: the Busselton health study. Int J Obes Relat Metab Disord. 2000;24:108-115.

32.

Pi-Sunyer FX Medical hazards of obesity. Ann Intern Med. 1993;119:655-660.

33.

Ford ES , Mokdad AH , Ajani UA Trends in risk factors for cardiovascular disease among children and adolescents in the United States. Pediatrics. 2004;114:1534-1544.

34.

Tauman R. , Gozal D. Obesity and obstructive sleep apnea in children. Paediatr Respir Rev. 2006;7:247-259. Epub 2006 Oct 30.

35.

Sukalich S. , Mingione MJ , Glantz JC Obstetric outcomes in overweight and obese adolescents. Am J Obstet Gynecol. 2006;195:851-855.

36.

Finkelstein EA , Fiebelkorn IC , Wang G. State-level estimates of annual medical expenditures attributable to obesity. Obes Res. 2004;12:18—24.

37.

Sturm R. The effects of obesity, smoking, and problem drinking on chronic medical problems and healthcare costs. Health A fairs. 2002 ;21:245—253.

38.

Sturm R. , Wells KB

Does obesity contribute as much to morbidity as poverty or smoking?

Public Health. 2001;115:229—295.

39.

Lee S. , Kuk JL , Davidson LE , et al. Exercise without weight loss is an effective strategy for obesity reduction in obese individuals with and without type 2 diabetes. J Appl Physiol. 2005;99:1220-1225.

40.

Kushner R. , Foster GD Obesity and quality of life. Nutrition. 2000 ;16:947-952.

41.

Myers A. , Rosen JC Obesity stigmatization and coping: relation to mental health symptoms, body image, and self-esteem. Int J Obes Relat Metab Disord. 1999;23:221-223.

42.

Brown I. Nurses' attitudes towards adult patients who are obese: literature review . J Adv Nurs. 2006;53:221-232.

43.

Kaminsky J. , Gadaleta D. A Surg. 2 study of discrimination within the medical community as viewed by obese patients. Obesity. 2002;12:14-18.

44.

Harvey EL , Hill AJ Health professionals' views of overweight people and smokers. Int J Obes Relat Metab Disord. 2001;25:1253-1261.

45.

Foster GD , Wadden TA , Makris AP , et al. Primary care physicians' attitudes about obesity and treatment . Obes Res. 2003;11:1168-1177.

46.

National Institutes of Health, National Heart, Lung, and Blood Institute. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. Obes Res. 1998;6:51S-209S.

47.

The Surgeon General's call to action to prevent and decrease overweight and obesity. Available at: http://surgeongeneral.gov/topics/obesity . Accessed December 3, 2006.

48.

Sciamanna CN , Tate DF , Lang W. , Wing RR Who reports receiving advice to lose weight? Results from a multistate survey. Arch Intern Med. 2000;160:2334-2339.

49.

Galuska DA , Will JC , Serdula MK , Ford ES

Are health care professionals advising obese patients to lose weight?

JAMA. 1999;282:1576-1578.

50.

Wadden TA , Anderson KA , Foster GD , Bennett A. , Steinberg C. , Sarwer DB Obese women's perceptions of their physician's weight management attitudes and practices. Arch Fam Med. 2000;9:854-860.

51.

Hebl MR , Xu J. Weighing the care: physicians' reactions to the size of a patient. Int J Obes Relat Metab Disord. 2001;25:1246-1252.

52.

Kristeller JL , Hoerr RA Physician attitudes toward managing obesity: differences among six speciality groups. Prev Med. 1997;26:542-549.

53.

Simpkin-Silverman LR , Gleason KA , et al. Predictors of weight control advice in primary care practices: patient health and psychosocial characteristics . Prev Med. 2005;40:71-82.

54.

Bish CL , Blanck HM , Serdula MK , Marcus M. , Kohl HW Iii , Khan LK Diet and physical activity behaviors among Americans trying to lose weight: 2000 Behavioral Risk Factor Surveillance System. Obes Res. 2005;13:596-607.

55.

O'Brien SH , Holubkov R. , Reis EC Identification, evaluation, and management of obesity in an academic primary care center. Pediatrics. 2004;114: e154-e159.

56.

Nader PR , O'Brien M. , Houts R. , et al. Identifying risk for obesity in early childhood. Pediatrics. 2006;118:e594-e601.

57.

Kushner RF Barriers to providing nutrition counseling by physicians: a survey of primary care practitioners. Prev Med. 1995;24:546—552.

58.

Block JP , DeSalvo KB , Fisher WP Are physicians equipped to address the obesity epidemic? Knowledge and attitudes of internal medicine residents. Prev Med. 2003;36:669—675.

59.

Huang J. , Yu H. , Marin E. , Brock S. , Carden D. , Davis T. Physicians' weight loss counseling in two public hospital primary care clinics . Acad Med. 2004;79:156-161.

60.

Billington CJ The challenge of obesity management in primary care. J Am Board Fam Pract. 2000;13:222—223.

61.

Campbell K. , Engel H. , Timperio A. , et al. Obesity management: Australian general practitioners' attitudes and practices. Obes Res. 2000;8:459—466.

62.

Timmerman GM , Reifsnider E. , Allan JD Weight management practices among primary care providers. J Am Acad Nurse Pract. 2000 ;12:113—116.

63.

Epstin L. , Ogden J. A qualitative study of general practitioners' views of treating obesity. Br J Gen Pract. 2005;55:750—754.

64.

Hash RB , Munna RK , Vogel RL , Bason JJ

Does physician weight affect perception of health advice?

Prev Med. 2003;36:41—44.

65.

Anderson DA , Wadden TA Treating the obese patient: suggestions for primary care practice. Arch Fam Med. 1999;8:156—167.

66.

Huang J. , Yu H. , Marin E. , et al. Physicians' weight loss counseling in two public hospital primary care clinics. Acad Med. 2004;79:156—161.

67.

Fox TA , Heimendinger J. , Block G. Telephone surveys as a method for obtaining dietary information: a review . JADA. 1992;92:729-732.

68.

Johnson RK , Driscoll P. , Goran MI Comparison of multiple-pass 24-hour recall estimates of energy intake with total energy expenditure determined by the doubly labeled water method in young children. JADA. 1996;96:1140-1144.

69.

Dodd KW , Guenther PM , Freedman LS , et al. Statistical methods for estimating usual intake of nutrients and foods: a review of the theory. J Am Diet Assoc. 2006;106:1640-1650.

70.

Tooze JA , Midthune D. , Dodd KW , et al. A new statistical method for estimating the usual intake of episodically consumed foods with application to their distribution. J Am Diet Assoc. 2006;106:1575-1587.

71.

Heitmann BL , Lissner L.

Dietary underreporting by obese individuals: is it specific or non-specific?

BMJ. 1995;311:986-989.

72.

Johnson RK , Soultanakis RP , Matthews DE Literacy and body fatness are associated with underreporting of energy intake in US low-income women using the multiple-pass 24-hour recall: a doubly labeled water study. JADA. 1998;98:1136-1140.

73.

Briefel RR , Sempos CT , McDowell MA , Chien S. , Alaimo K. Dietary methods research in the third National Health and Nutrition Examination Survey: underreporting of energy intake. Am J Clin Nutr. 1997;65:1203S-1209S.

74.

Rennie KL , Siervo M. , Jebb SA

Can self-reported dieting and dietary restraint identify underreporters of energy intake in dietary surveys?

J Am Diet Assoc. 2006;106:1667-1672.

75.

St Jeor ST , Brunner RL , Harrington ME , et al. Who are the weight maintainers? Obes Res. 1995;3:249s-259s.

76.

St Jeor ST , Brunner RL , Harrington ME , et al. A classification system to evaluate weight maintainers, gainers, and losers. J Am Diet Assoc. 1997;97:481-488.

77.

Mifflin MD , St Jeor ST, Hill LA, Scott BJ, Daugherty SA, Koh YO. A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr. 1990;51:241-247.

78.

Prochaska JO Strong and weak principles for progressing from precontemplation to action on the basis of twelve problem behaviors. Health Psychol. 1994;13:47—51.

79.

Boudreaux ED , Wood KB , Mehan D. , Scarinci I. , Taylor CL , Brantley PJ Congruence of readiness to change, self-efficacy, and decisional balance for physical activity and dietary fat reduction. Am J Health Promot. 2003;17:329-336.

80.

Wee CC , Davis RB , Phillips RS Stage of readiness to control weight and adopt weight control behaviors in primary care. J Gen Intern Med. 2005;20:410-415.

81.

Logue E. , Sutton K. , Jarjoura D. , Smucker W. , Baughman K. , Capers C. Transtheoretical model-chronic disease care for obesity in primary care: a randomized trial. Obes Res. 2005;13:917-927.

82.

Sutton K. , Logue E. , Jarjoura D. , Baughman K. , Smucker W. , Capers C. Assessing dietary and exercise stage of change to optimize weight loss interventions . Obes Res. 2003;11:641-652.

83.

Rhee KE , De Lago CW , Arscott-Mills T. , Mehta SD , Davis RK Factors associated with parental readiness to make changes for overweight children. Pediatrics. 2005;116:e94-e101.

84.

Weiss EC , Galuska DA , Khan LK , Serdula MK Weight-control practices among U.S. adults, 2001-2002. Am J Prev Med. 2006;31:18-24.

85.

Melchionda N. , Besteghi L. , Di Domizio S. , et al. Cognitive behavioural therapy for obesity: one-year follow-up in a clinical setting. Eat Weight Disord. 2003;8:188-193.

86.

Wilfley DE , Welch RR , Stein RI , et al. A randomized comparison of group cognitive-behavioral therapy and group interpersonal psychotherapy for the treatment of overweight individuals with binge-eating disorder. Arch Gen Psychiatry. 2002;59:713-721.

87.

Wing RR Behavioral weight control. In: Wadden TA , Stunkard AJ , eds. Handbook of Obesity Treatment . New York: Guilford; 2002:301-316.

88.

Brownell KD The LEARN Program for Weight Management 2000: Lifestyle, Exercise, Attitudes, Relationships, Nutrition. Dallas, Tex: American Health Publishing; 2000.

89.

Brownell KD , Stunkard AJ , McKeon PE Weight reduction at the worksite: a promise partially fulfilled. Am J Psychiatry. 1985 ;142:47-52.

90.

Katz DL , O'Connell M. , Yeh MC , et al. Public health strategies for preventing and controlling overweight and obesity in school and worksite settings: a report on recommendations of the Task Force on Community Preventive Services. MMWR Recomm Rep. 2005;54:1-12.

91.

Tate DF , Wing RR , Winett RA Using Internet technology to deliver a behavioral weight loss program. JAMA. 2001;285:1172-1177.

92.

Tate DF , Jackvony EH , Wing RR A randomized trial comparing human e-mail counseling, computer-automated tailored counseling, and no counseling in an Internet weight loss program. Arch Intern Med. 2006;166:1620-1625.

93.

Nothwehr F. , Snetselaar L. , Wu H. Weight management strategies reported by rural men and women in Iowa. J Nutr Educ Behav. 2006;38:249-253.

94.

Wadden TA Treatment of obesity by moderate and severe caloric restriction: results of clinical research trials. Ann Intern Med. 1993;119:688-693.

95.

Ashley JM , St Jeor ST , Perumean-Chaney S. , Schrage J. , Bovee V. Meal replacements in weight intervention. Obes Res. 2001;9:312S-320S.

96.

LeCheminant JD , Jacobsen DJ , Hall MA , Donnelly JE A comparison of meal replacements and medication in weight maintenance after weight loss. J Am Coll Nutr. 2005;24:347-353.

97.

Jeffrey RW , Wing RR , Thornson C. , et al. Strengthening behavioral interventions for weight loss: a randomized trial of food provision and monetary incentives. J Consult Clin Psychol. 1993;61:1038-1045.

98.

Wadden TA , Vogt RA , Andersen RE , et al. Exercise in the treatment of obesity: effects of four interventions on body composition, resting energy expenditure, appetite and mood. J Consult Clin Psychol. 1997;65:269-277.

99.

Wing RR , Jeffery RW , Burton LR , Throson C. , Nissinoff K. , Baxter JE Food provisions vs structured meal plans in the behavioral treatment of obesity . Int J Obes Relat Metab Disord. 1996;20:56-62.

100.

Wing RR Behavioral approaches to the treatment of obesity. In: Bray GA , Bouchard C , eds. Handbook of Obesity: Clinical Applications. 2nd ed. New York: Marcel Dekker; 2004:147-167.

101.

Wadden TA , Butryn ML Behavioral treatment of obesity. Endocrinol Metab Clin North Am. 2003;32:981-1003.

102.

Kirschenbaum DS , Harris ES , Tomarken AJ Effects of parental involvement in behavioral weight loss therapy for preadolescents. Behav Ther. 1984;15:485-500.

103.

Golan M. , Weizman A. , Apter A. , Fainaru M. Parents as the exclusive agents of change in the treatment of childhood obesity . Am J Clin Nutr. 1998;67:1130-1138.

104.

Golan M. , Fainaru M. , Weizman A. Familial approach to the treatment of childhood obesity: a conceptual model . J Nutr Educ. 2001;33:102-106.

105.

Epstein LH , Valoski A. , Wing RR Ten year follow-up of behavioral, family-based treatment for obese children. JAMA. 1990;264:2519-2523.

106.

Freedman MR , King J. , Kennedy E. Popular diets: a scientific review. Obes Res. 2001;9(suppl 1):1S-40S.

107.

Ornish D. , Brown SE , Scherwitz LW , et al. Can lifestyle changes reverse coronary heart disease? Lancet. 1990;336:129-133.

108.

Schlundt DG , Hill JO , Pope-Cordle J. , Arnold D. , Vitrs K. , Katahn M. Randomized evaluation of a low-fat ad libitum carbohydrate diet for weight reduction. Int J Obes Relat Metab Disord. 1993;17:623-629.

109.

Hammer RL , Barrier CA , Roundy ES , Bradford JM , Fisher AG Calorie-restricted low-fat diet and exercise in obese women. Am J Clin Nutr. 1989;49:77-85.

110.

Heilbronn LK , Noakes M. , Clifton PM Effect of energy restriction, weight loss, and diet composition on plasma lipids and glucose in patients with type 2 diabetes. Diabetes Care. 1999;22:889-895.

111.

2005 Dietary Guidelines for Americans. Available at: http://www.health.gov/dietaryguidelines/dga2005/document . Accessed December 4, 2006.

112.

Astrup A.

The role of dietary fat in obesity. Semin

Vasc Med. 2005;5:40-47.

113.

Rolls BJ The role of energy density in the overconsumption of fat. J Nutr. 2000;130:268S-271S.

114.

Kendall A. , Levitsky DA , Strupp BJ , Lissner L. Weight loss on a low-fat diet: consequence of the imprecision of the control of food intake in humans. Am J Clin Nutr. 1991;53:1124-1129.

115.

Schaefer EJ , Lichtenstein AH , Lamon-Fava S. , et al. Body weight and low-density lipoprotein cholesterol changes after consumption of a low-fat ad libitum diet. JAMA. 1995;274:1450-1455.

116.

Erlanson-Albertsson C. , Mei J. The effect of low carbohydrate on energy metabolism . Int J Obes (Lond). 2005;29:S26-S30.

117.

Brehm BJ , Seeley RJ , Daniels SR , D'Allessio DA. A randomized trial comparing a very low carbohydrate diet and a calorie restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrin Metab. 2003 ;88:1617-1623.

118.

Fleming RM The effect of high-, moderate-, and low-fat diets on weight loss and cardiovascular disease risk factors. Prev Cardiol. 2002;5:110-118.

119.

Foster GD , Wyatt HR , Hill JO , et al. A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med. 2003;348:2082-2090.

120.

Stern L. , Iqbal N. , Seshadri P. , et al. The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. Ann Intern Med. 2004;140:778-785.

121.

Glanz K. , Basil M. , Maibach E. , Goldberg J. , Snyder D. Why Americans eat what they do: taste, nutrition, cost, convenience, and weight control concerns as influences on food consumption. J Am Diet Assoc. 1998;98:1118-1126.

122.

Drewnowski A. Intense sweeteners and energy density of foods: implications for weight control. Eur J Clin Nutr. 1999;53:757-763.

123.

Yancy WS Jr , Olsen MK , Guyton JR , Bakst RP , Westman EC A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial. Ann Intern Med. 2004;140:769-777.

124.

St Jeor ST , Howard BV , Prewitt TE , Bovee V. , Bazzarre T. , Eckel RH , and Nutrition Committee of the Council on Nutrition , Physical Activity, and Metabolism of the American Heart Association. Dietary protein and weight reduction: a statement for healthcare professionals from the Nutrition Committee of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association. Circulation. 2001;104:1869-1874.

125.

Shah P. , Isley WL Ketoacidosis during a low-carbohydrate diet. N Engl J Med. 2006;354:97-98.

126.

Brunstrom JM , Davison CJ , Mitchell GL Dietary restraint and cognitive performance in children. Appetite. 2005;45:235-241.

127.

Young LR , Nestle M. The contribution of expanding portion sizes to the US obesity epidemic. Am J Public Health. 2002;92:246-249.

128.

Hannum SM , Carson LA , Evans EM , et al. Use of portion-controlled entrees enhances weight loss in women . Obes Res. 2004;12:538-546.

129.

Wansink B. , Kim J. Bad popcorn in big buckets: portion size can influence intake as much as taste. J Nutr Educ Behav. 2005;37:242-245.

130.

Rolls BJ , Engell D. , Birch LL Serving portion size influences 5-year-old but not 3-year-old child's food intakes. J Am Diet Assoc. 2000;100:232—234.

131.

Diliberti N. , Bordi PL , Conklin MT , Roe LS , Rolls BJ Increased portion size leads to increased energy intake in a restaurant meal. Obes Res. 2004;12:562-568.

132.

Rolls BJ , Roe LS , Meengs JS Larger portion sizes lead to a sustained increase in energy intake over 2 days. J Am Diet Assoc. 2006;106:543-549.

133.

Rolls BJ , Roe LS , Meengs JS Reductions in portion size and energy density of foods are additive and lead to sustained decreases in energy intake. Am J Clin Nutr. 2006;83:11-17.

134.

Young LR , Nestle M. Variation in perceptions of a “medium” food portion: implications for dietary guidance. J Am Diet Assoc. 1998 ;98:458-459.

135.

Hogbin MB , Hess MA Public confusion over food portions and servings. J Am Diet Assoc. 1999;99:1209-1211.

136.

Stewart H. , Blisard N. , Bhuyan S. , Nayga RM Jr. The demand for food away from home full-service or fast food? 2004. ERS Publication No. 829. Available at: http://www.ers.usda.gov/publications/aer829/aer829.pdf. Accessed December 1, 2006.

137.

Food market structures: food service. Available at: http://www.ers.usda.gov/Briefing/FoodMarketStructures/foodservice.htm. Accessed December 1, 2006.

138.

Jakicic JM , Clark K. , Coleman E. , et al. American College of Sports Medicine position stand. Appropriate intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc. 2001;33:2145-2156.

139.

Adult participation in recommended levels of physical activity—United States, 2001 and 2003. MMWR. 2005;54:1208-1212.

140.

Jakicic JM , Otto AD Physical activity considerations for the treatment and prevention of obesity. Am J Clin Nutr. 2005;82:226S-229S.

141.

Jakicic JM , Otto AD

Treatment and prevention of obesity: what is the role of exercise?

Nutr Rev. 2006;64:S57-S61.

142.

Jakicic JM , Otto AD Physical activity recommendations in the treatment of obesity. Psychiatr Clin North Am. 2005;28:141-150.

143.

Hagan RD , Upton SJ , Wong L. , Whittam J. The effects of aerobic conditioning and/or calorie restriction in overweight men and women. Med Sci Sports Exerc. 1986;18:87-94.

144.

Wing RR Physical activity in the treatment of adulthood overweight and obesity: current evidence and research issues. Med Sci Sports Exerc. 1999;31:S547.

145.

Miller WC , Koceja DM , Hamilton EJ A meta-analysis of the past 25 years of weight loss research using diet, exercise or diet plus exercise intervention. Int J Obes Relat Metab Disord. 1997;21:941-947.

146.

Ross R. , Dagnone D. , Jones PJ , et al. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men: a randomized, controlled trial. Ann Intern Med. 2000;133:92-103.

147.

Ross R. , Janssen I. , Dawson J. , et al. Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial. Obes Res. 2004;12:789-798.

148.

Wood PD , Stefanick ML , Williams PT , Haskell WL The effects on plasma lipoproteins of a prudent weight reducing diet, with or without exercise, in overweight men and women. N Engl J Med. 1991;325:461—466.

149.

Bouchard C. , Tremblay A. , Despres J-P. , et al. The response to exercise with constant energy intake in identical twins. Obes Res. 1994;5:400—410.

150.

Duncan JJ , Gordon NF , Scott CB

Women walking for health and fitness: how much is enough?

JAMA. 1991;266:3295-3299.

151.

Curioni CC , Lourenco PM Long-term weight loss after diet and exercise: a systematic review. Int J Obes (Lond ). 2005;29:1168-1174.

152.

Lee ES , Kim YH , Beck SH , Lee S. , Oh SW Depressive mood and abdominal fat distribution in overweight premenopausal women. Obes Res. 2005;13:320-325.

153.

Kirkcaldy BD , Shephard RJ , Siefen RG The relationship between physical activity and self-image and problem behaviour among adolescents. Soc Psychiatry Psychiatr Epidemiol. 2002;37:544-550.

154.

Burdette HL , Wadden TA , Whitaker RC Neighborhood safety, collective efficacy, and obesity in women with young children. Obesity (Silver Spring). 2006;14:518-525.

155.

Douglas F. , Torrance N. , van Teijlingen E. , Meloni S. , Kerr A. Primary care staff's views and experiences related to routinely advising patients about physical activity: a questionnaire survey. BMC Public Health. 2006;6:138.

156.

Ashenden R. , Silagy C. , Weller D. A systematic review of the effectiveness of promoting lifestyle change in general practice. Fam Prac. 1997;14:160-176.

157.

Elley CR , Kerse N. , Arroll B. , Robinson E. Effectiveness of counselling patients on physical activity in general practice: cluster randomised controlled trial. BMJ. 2003;32:7936.

158.

Walsh JE , Swangard DM , Davis T. , McPhee SJ Exercise counselling in the era of managed care. Am J Prev Med. 1999;16:307-313.

159.

Lawlor DA , Keen S. , Neal RD Increasing population levels of physical activity through primary care: GP's knowledge, attitudes and self reported practice. Fam Prac. 1999;16:250-254.

160.

Glazer G. Long-term pharmacotherapy of obesity 2000: a review of efficacy and safety . Arch Intern Med. 2001;161:1814-1824.

161.

Bray GA , Blackburn GL , Ferguson JM , et al. Silbutramine produces dose-related weight loss. Obes Res. 1999;7:189-198.

162.

Wadden TA , Berkowitz RI , Womble LG , et al. Randomized trial of lifestyle modification and pharmacotherapy for obesity. N Engl J Med. 2005;353:2111-2120.

163.

James WP , Astrup A. , Finer N. , et al. Effect of sibutramine on weight maintenance after weight loss: a randomised trial. STORM Study Group. Sibutramine Trial of Obesity Reduction and Maintenance. Lancet. 2000;356:2119—2125.

164.

Hauner H. , Meier M. , Jockel KH , Frey UH , Siffert W. Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein beta3 subunit gene (GNB3) C825T polymorphism. Pharmacogenetics. 2003;13:453-459.

165.

Spraggs CF , Pillai SG , Dow D. , et al. Pharmacogenetics and obesity: common gene variants influence weight loss response of the norepinephrine/dopamine transporter inhibitor GW320659 in obese subjects. Pharmacogenet Genomics. 2005;15:883-889.

166.

Institute of Medicine. Weighing the Options: Criteria for Evaluating Weight Management Programs. Washington, DC: National Academy Press; 1995.

167.

Brown CD , Higgins M. , Donato KA , et al. Body mass index and the prevalence of hypertension and dyslipidemia . Obes Res. 2000;9:605-619.

168.

Stevens VJ , Obarzanek E. , Cook NR , et al. Long-term weight loss and changes in blood pressure: results of the Trials of Hypertension Prevention, phase II. Ann Intern Med. 2001;134:1-11.

169.

Blissmer B. , Rieber D. , Dye G. , Ruggiero L. , Greene G. , Caldwell M. Health-related quality of life following a clinical weight loss intervention among overweight and obese adults: intervention and 24 month follow-up effects. Health Qual Life Outcomes . 2006;4:43.

170.

Knowler WC , Barrett-Connor E. , Fowler SE , et al, for the Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002 ;346:393-403.

171.

Tuomilehto J. , Lindstrom J. , Eriksson JG , et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344:1343-1350.

172.

Wadden TA , Sternberg JA , Ketizia KA , Stunkard AJ , Foster GD Treatment of obesity by very-low-calorie diet, behavior therapy, and their combination: a five-year perspective. Int J Obes. 1989;51:167-172.

173.

Wadden TA , Foster GA , Letizia KA , Mullen JL Long-term effects of dieting on resting metabolic rate in obese outpatients . JAMA. 1990;264:707-711.

174.

Rosenbaum M. , Murphy EM , Heymsfield SB , Matthews DE , Leibel RL Low does leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab. 2002;87:2391-2394.

175.

Cummings DE , Weigle DS , Frayo RS , et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med. 2002;346:1623-1630.

176.

Rolls BJ , Roe LS , Beach AM , Kris-Etherton PM Provision of foods differing in energy density affects long-term weight loss . Obes Res. 2005;13:1052-1060.

177.

Perri MG , Nezu AM , Patti ET , McCann KL Effect of length of treatment on weight loss. J Consult Clin Psychol. 1989;57:450-452.

178.

Latner JD , Stunkard AJ , Wilson GT , Jackson ML , Zelitch DS , Labouvie E. Effective long-term treatment of obesity: a continuing care model. Int J Obes Relat Metab Disord. 2000;24:893-898.

179.

Klem ML , Wing RR , McGuire MT , Seagle HM , Hill JO A descriptive study of individuals successful at long-term maintenance of substantial weight loss. Am J Clin Nutr. 1997 ;66:239-246.

180.

Raynor HA , Jeffery RW , Phelan S. , Hill JO , Wing RR Amount of food group variety consumed in the diet and long-term weight loss maintenance. Obes Res. 2005;13:883-890.

181.

McCrory M. , Fuss P. , McCallum J. Dietary variety within food groups: association with energy intake and body fatness in men and women. Am J Clin Nutr. 1999;69:440-447.

182.

Darmon N. , Ferguson E. , Briend A. A cost constraint alone has adverse effects on food selection and nutrient density: an analysis of human diets by linear programming. J Nutr. 2002;132:3764-3767.

183.

Wing RR , Tate DF , Gorin AA , Raynor HA , Fava JL A self-regulation program for maintenance of weight loss. N Engl J Med. 2006;355:1563-1571.

184.

Linde JA , Jeffery RW , French SA , Pronk NP , Boyle RG Self-weighing in weight gain prevention and weight loss trials. Ann Behav Med. 2005;30: 210-216.

185.

Shick SM , Wing RR , Klem ML , McGuire MT , Hill JO , Seagle H. Persons successful at long-term weight loss and maintenance continue to consume a low-energy, low-fat diet. J Am Diet Assoc. 1998;98:408-413.

186.

Wyatt HR , Grunwald GK , Mosca CL , Klem M. , Wing RR , Hill JO Long-term weight loss and breakfast in subjects in the National Weight Control Registry. Obes Res. 2002;10:78-82.

187.

Wing RR , Phelan S. Long-term weight loss maintenance. Am J Clin Nutr. 2005;82:222S-225S.

188.

Heart disease and stroke statistics—2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2006;113:85-151.

189.

Oparil S.

Women and hypertension: what did we learn from the Women's Health Initiative?

Cardiol Rev. 2006;14:267-275.

190.

Psaty BM , Furberg CD , Kuller LH , et al. Associations between blood pressure level and the risk of myocardial infarction, strokes, and total mortality. Arch Intern Med. 2001;161:1181-1192.

191.

Perry HM , Miller JP , Fornoff JR , et al. Early predictors of 15-year end stage renal disease in hypertensive patients. Hypertension. 1995;25:587-594.

192.

Dickinson HO , Mason JM , Nicolson DJ , et al. Lifestyle interventions to reduce raised blood pressure: a systematic review of randomized controlled trials . J Hypertens. 2006;24:215-233.

193.

Chobanian AV , Bakris GL , Black HR , et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42:1206-1252.

194.

Whelton PK , He J. , Appel LJ , et al. Primary prevention of hypertension: clinical and public health advisory from the National High Blood Pressure Education Program. JAMA. 2002;288:1882-1828.

195.

Kannel WB , Zhang T. , Garrison RJ Is obesity-related hypertension less of a cardiovascular risk? The Framingham Study. Am Heart J. 1990;120:1195-1201.

196.

Garrison RJ , Kannel WB , Stokes J. III , Castelli WP Incidence and precursors of hypertension in young adults: the Framingham Offspring Study. Prev Med. 1987;16:235-251.

197.

Davis BR , Blaufox MD , Oberman A. , et al. Reduction in long-term antihypertensive medication requirements: effects of weight reduction by dietary intervention in over weight persons with mild hypertension. Arch Intern Med. 1993 ;153:1773-1782.

198.

The Trials of Hypertension Prevention Collaborative Research Group. Effects of weight loss and sodium reduction intervention on blood pressure and hypertension incidence in overweight people with high-normal blood pressure. The Trials of Hypertension Prevention, phase II. Arch Intern Med. 1997;157:657-667.

199.

He J. , Whelton PK , Appel LJ , Charleston J. , Klag MJ Long-term effects of weight loss and dietary sodium reduction on incidence of hypertension. Hypertension. 2000;35:544-549.

200.

Aucott L. , Poobalan A. , Smith WC , Avenell A. , Jung R. , Broom J. Effects of weight loss in overweight/obese individuals and long-term hypertension outcomes: a systematic review. Hypertension. 2005;45:1035-1041.

201.

Douketis JD , Sharma AM

The management of hypertension in the overweight and obese patient: is weight reduction sufficient?

Drugs. 2004;64:795-803.

202.

Sharma AM , Golay A. Effect of orlistatinduced weight loss on blood pressure and heart rate in obese patients with hypertension. Hypertension. 2002;20:1873-1878.

203.

Sacks FM , Appel LJ , Moore TJ , et al. A dietary approach to prevent hypertension: a review of the Dietary Approaches to Stop Hypertension (DASH) study. Clin Cardiol. 1999;22:6-10.

204.

Svetkey LP , Simons-Morton D. , Vollmer WM , et al. Effects of dietary patterns on blood pressure: subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial. Arch Intern Med. 1999;159:285-293.

205.

Sacks FM , Svetkey LP , Vollmer WM , et al. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group. N Engl J Med. 2001;344:3-10.

206.

Appel LJ , Moore TJ , Obarzanek E. , et al. A clinical trial of the effects of dietary patterns on blood pressure. N Engl J Med. 1997;336:1117-1124.

207.

John JH , Ziebland S. , Yudkin P. , Roe LS , Neil HA Effects of fruit and vegetable consumption on plasma anti-oxidant concentrations and blood pressure: a randomized controlled trial. Lancet . 2002;359:1969 -1974.

208.

Appel LJ , Champagne CM , Harsha DW , et al. Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial. JAMA. 2003;289:2083-2093.

209.

Obarzanek E. , Sacks FM , Vollmer WM , et al. Effects on blood lipids of a blood pressure lowering diet: the Dietary Approaches to Stop Hypertension (DASH) trial. Am J Clin Nutr. 2001;74:80—89.

210.

Tillotson JL , Grandits GA , Bartsch GE , Stamler J. Relation of dietary fiber to blood lipids in the special intervention and usual care groups in the Multiple Risk Factor Intervention Trial. Am J Clin Nutr. 1997;65:327S—37S.

211.

Rimm EB , Ascherio A. , Giovannucci E. , Spiegelman D. , Stampfer MJ , Willett WC Vegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men. JAMA. 1996;275:447—451.

212.

Shintani TT , Hughes CK Traditional diets of the Pacific and coronary heart disease. J Cardiovasc Risk. 1994;1:16—20.

213.

Harsha DW , Sacks FM , Obarzanek E. , et al. Effect of dietary sodium intake on blood lipids: results from the DASH-sodium trial. Hypertension. 2004;43:393-398.

214.

Azadbakht L. , Mirmiran P. , Esmaillzadeh A. , Azizi T. , Azizi F. Beneficial effects of a Dietary Approaches to Stop Hypertension eating plan on features of the metabolic syndrome. Diabetes Care. 2005;28:2823-2831.

215.

Doyle L. , Cashman KD The DASH diet may have beneficial effects on bone health. Nutr Rev. 2004;62:215-220.

216.

New SA Intake of fruit and vegetables: implications for bone health. Proc Nutr Soc. 2003;62:889-899.

217.

Franco V. , Oparil S. Salt sensitivity, a determinant of blood pressure, cardiovascular disease and survival. J Am Coll Nutr. 2006;25:247S-255S.

218.

Midgley JP , Matthew AG , Greenwood Cmt , Logan AG Effect of reduced dietary sodium on blood pressure: a meta-analysis of randomized controlled trials. JAMA. 1996;275:1590—1597.

219.

Cutler JA , Follmann D. , Allender PS Randomized trials of sodium reduction: an overview. Hypertension . 1997;65:S643—S6451.

220.

Graudal NA , Galloe AM , Garred P. Effects of sodium restriction on blood pressure, renin, aldosterone, catecholamines, cholesterols, and triglycerides. JAMA. 1988;279:1383—1391.

221.

Hooper L. , Bartlett C. , Smith GD , Ebrahim S. Advice to reduce dietary salt for prevention of cardiovascular disease. Cochrane Database Syst Rev. 2004;1:CD003656.

222.

Hooper L. , Bartlett C. , Smith GD , Ebrahim S. Systematic review of long term effects of advice to reduce dietary salt in adults. BMJ. 2002;325:628—636.

223.

Intersalt Cooperative Research Group. Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. BMJ. 1988;297:319—328.

224.

Xin X. , He J. , Frontini MG , Ogden LG , Motasmi OI , Whelton PK Effects of alcohol restriction on blood pressure: a meta-analysis of randomized controlled trials. Hypertension. 2001;38:1112-1127.

225.

Weinberger MH Cardiovascular and humoral response to extremes of sodium intake in normal black and white men. Circulation . 1979;60:697-706.

226.

Hurwitz S. , Fisher NL , Ferri C. , Hopkins PN , Williams GH , Hollenberg NK Controlled analysis of blood pressure sensitivity to sodium intake: interactions with hypertension type. J Hypertens. 2003;21:951-959.

227.

Weinberger MH , Miller JZ , Luft FC , Grim CE , Fineberg NS Definitions and characteristics of sodium sensitivity and blood pressure resistance. Hypertension. 1996;8:127-134.

228.

Katori M. , Majima M. A missing link between a high salt intake and blood pressure increase. J Pharmacol Sci. 2006;100:370-390.

229.

Klatsky AL Alcohol and cardiovascular disease—more than one paradox to consider. Alcohol and hypertension: does it matter? Yes. J Cardiovasc Risk. 2003;10:21-24.

230.

Klatsky AL Alcohol and hypertension. Clin Chim Acta. 1996;246:91-105.

231.

Mukamal KJ , Ascherio A. , Mittleman MA , et al. Alcohol and risk for ischemic stroke in men: the role of drinking patterns and usual beverage. Ann Intern Med. 2005;142:11-19.

232.

Pescatello LS , Barry A. , Franklin BA , et al. American College of Sports Medicine position stand: exercise and hypertension: medicine and science in sports and exercise. Available at: http://www.acsm-msse.org/pt/pt-core/template-journal/msse/media/0304.pdf. Accessed December 3, 2006.

233.

Mazzeo RS , Cavanagh P. , Evans WJ , et al. American College of Sports Medicine position stand: exercise and physical activity for older adults. 1998. Available at: 30: http://www.acsm-msse.org/pt/pt-core/template-journal/msse/media/0698b.htm . Accessed December 3, 2006.

234.

Menotti A. , Keys A. , Kromhout D. , et al. Inter-cohort differences in coronary heart disease mortality in the 25-year follow-up of the seven countries study . Eur J Epidemiol. 1993;9:527-536.

235.

Marmot MG , Syme SL , Kagan A. , Kato H. , Cohen JB , Belsky J. Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: prevalence of coronary and hypertensive heart disease and associated risk factors. Am J Epidemiol. 1975;102:514-525.

236.

National Cholesterol Education Program. Report of the Expert Panel on Population Strategies for Blood Cholesterol Reduction. NIH Pub. No. 90-3046. Bethesda, Md : National Heart, Lung, and Blood Institute; 1990.

237.

Report of the Expert Panel on Population Strategies for Blood Cholesterol Reduction: a statement from the National Cholesterol Education Program, National Heart, Lung, and Blood Institute, National Institutes of Health. Circulation. 1991;83:2154-2232.

238.

Wilson Pwf , D'Agostino RB , Levy D. , Belanger AM , Silbershatz H. , Kannel WB Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97:1837-1847.

239.

Stamler J. , Wentworth D. , Neaton JD , for the MRFIT Research Group. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356 222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT). JAMA. 1986;256:2823-2838.

240.

Brown MS , Goldstein JL A receptor-mediated pathway for cholesterol homeostasis. Science. 1986;232:34-47.

241.

Lipid Research Clinics Program. The Lipid Research Clinics Coronary Primary Prevention Trial results. II: The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA. 1984;251:365-374.

242.

Lipid Research Clinics Program. The Lipid Research Clinics Coronary Primary Prevention Trial results. I: Reduction in the incidence of coronary heart disease. JAMA. 1984;251:351-364.

243.

Pekkanen J. , Linn S. , Heiss G. , Suchindran CM , Leon A. , Rifkind BM , Tyroler HA Ten-year mortality from cardiovascular disease in relation to cholesterol level among men with and without preexisting cardiovascular disease. N Engl J Med. 1990;322:1700-1707.

244.

Wong ND , Wilson Pwf , Kannel WB Serum cholesterol as a prognostic factor after myocardial infarction: the Framingham Study. Ann Intern Med. 1991;115:687-693.

245.

Grundy SM , Cleeman JI , Merz CN , et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation . 2004;110:227-239.

246.

Heart Protection Study Collaborative Group. MRC/BHF Heart Protection: study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 2002;360:7—22.

247.

Shepherd J. , Blauw GJ , Murphy MB , et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. PROspective Study of Pravastatin in the Elderly at Risk. Lancet. 2002;360:1623—1630.

248.

Sever PS , Dahlof B. , Poulter NR , et al, and ASCOT Investigators. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet. 2003;361:1149-1158.

249.

Cannon CP , Braunwald E. , McCabe CH , et al. Pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22 investigators: intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med. 2004;350:1495-1504.

250.

Clarke R. , Frost C. , Collins R. , Appleby P. , Peto R. Dietary lipids and blood cholesterol: 1uantitative meta-analysis of metabolic ward studies. BMJ. 1997;314:112-117.

251.

Hegsted DM , Ausman LM , Johnson JA , Dallal GE Dietary fat and serum lipids: an evaluation of the experimental data. Am J Clin Nutr. 1993;57:875-883.

252.

Mensink RP , Katan MB Effect of dietary fatty acids on serum lipids and lipoproteins: a meta-analysis of 27 trials. Arterioscler Thromb. 1992;12:911-919.

253.

Judd JT , Baer DJ , Clevidence BA , Kris-Etherton PM , Muesing RA , Iwane M. Dietary cis and trans monounsaturated and saturated FA and plasma lipids and lipoproteins in men. Lipids. 2002;37:123-131.

254.

Lovejoy JC , Smith SR , Champagne CM , et al. Effects of diets enriched in saturated (palmitic), monounsaturated (oleic), or trans (elaidic) fatty acids on insulin sensitivity and substrate oxidation in healthy adults. Diabetes Care. 2002;25:1283-1288.

255.

Jenkins DJ , Kendall CW , Marchie A. , et al. Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein . JAMA. 2003;290:502-510.

256.

Tang JL , Armitage JM , Lancaster T. , Silagy CA , Fowler GH , Neil HA Systematic review of dietary in free-living subjects. BMJ. 1998;316:1213-1220.

257.

Brunner E. , White I. , Thorogood M. , Bristow A. , Curle D. , Marmot M. Can dietary interventions change diet and cardiovascular risk factors? A meta-analysis of randomized controlled trials. Am J Public Health. 1997;87:1415-1422.

258.

Denke MA Cholesterol-lowering diets: a review of the evidence. Arch Intern Med. 1995;155:17-26.

259.

de Lorgeril M. , Salen P. , Martin J-L. , et al. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction. Final report of the Lyon Diet Heart Study. Circulation. 1999;99:779-785.

260.

Ornish D. , Scherwitz LW , Billings JH , et al. Intensive lifestyle changes for reversal of coronary heart disease . JAMA. 1998;280:2001 -2007.

261.

Singh RB , Dubnov G. , Niaz MA , et al. Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial. Lancet. 2002 ;360:1455-1461.

262.

Watts GF , Lewis B. , Brunt JN , et al. Effects on coronary artery disease of lipid-lowering diet, or diet plus cholestyramine, in the St Thomas' Atherosclerosis Regression Study (STARS). Lancet. 1992;339:563—569.

263.

Castro Cabezas M , de Vries JH , Van Oostrom AJ , Iestra J. , van Staveren WA. Effects of a stanol-enriched diet on plasma cholesterol and triglycerides in patients treated with statins. J Am Diet Assoc. 2006 ;106:1564-1569.

264.

Patch CS , Tapsell LC , Williams PG Plant sterol/stanol prescription is an effective treatment strategy for managing hypercholesterolemia in outpatient clinical practice. J Am Diet Assoc. 2005;105:46-52.

265.

Ramsay LE , Yeo WW , Jackson PR Dietary reduction of serum cholesterol concentration: time to think again . BMJ. 1991;303:953-957.

266.

Perez-Jimenez F. , Lopez-Miranda J. , Pinillos MD , et al. A Mediterranean and a high-carbohydrate diet improve glucose metabolism in healthy young persons. Diabetologia. 2001;44:2038-2043.

267.

Vessby B. , Unsitupa M. , Hermansen K. , et al. Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: the KANWU study. Diabetologia. 2001;44:312-319.

268.

Covas MI , Nyyssonen K. , Poulsen HE , et al. The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann Intern Med. 2006;145:333-341.

269.

Covas MI , de la Torre K. , Farre-Albaladejo M. , et al. Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans. Free Radic Biol Med. 2006;40:608-616.

270.

Marrugat J. , Covas MI , Fito M. , et al. Effects of differing phenolic content in dietary olive oils on lipids and LDL oxidation: a randomized controlled trial. Eur J Nutr. 2004;43:140-147.

271.

Esrey KL , Joseph L. , Grover SA Relationship between dietary intake and coronary heart disease mortality: lipid research clinics prevalence follow-up study. J Clin Epidemiol. 1996;49:211-216.

272.

Xu J. , Eilat-Adar S. , Loria C. , et al. Dietary fat intake and risk of coronary heart disease: the Strong Heart Study. Am J Clin Nutr. 2006;84:894-902.

273.

Robinson JG , Stone NJ Antiatherosclerotic and antithrombotic effects of omega-3 fatty acids. Am J Cardiol. 2006 ;98(4A):39i-49i.

274.

Mozaffarian D. Effects of dietary fats versus carbohydrates on coronary heart disease: a review of the evidence. Curr Atheroscler Rep. 2005;7:435-445.

275.

Dauchet L. , Amouyel P. , Hercberg S. , Dallongeville J. Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies. J Nutr. 2006;136:2588-2593.

276.

Dauchet L. , Amouyel P. , Dallongeville J. Fruit and vegetable consumption and risk of stroke: a meta-analysis of cohort studies. Neurology. 2005;65:1193-1197.

277.

Sauvaget C. , Nagano J. , Allen N. , Kodama K. Vegetable and fruit intake and stroke mortality in the Hiroshima/Nagasaki Life Span Study. Stroke. 2003;34:2355-2360.

278.

Joshipura KJ , Hu FB , Manson JE , et al. The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med. 2001;134:1106-1114.

279.

Guenther PM , Dodd KW , Reedy J. , Krebs-Smith SM Most Americans eat much less than recommended amounts of fruits and vegetables. J Am Diet Assoc. 2006;106:1371-1379.

280.

Van Duyn MA , Kristal AR , Dodd K. , et al. Association of awareness, intrapersonal and interpersonal factors, and stage of dietary change with fruit and vegetable consumption: a national survey. Am J Health Promot. 2001;16:69-78.

281.

Trudeau E. , Kristal AR , Li S. , Patterson RE Demographic and psychosocial predictors of fruit and vegetable intakes differ: implications for dietary interventions . J Am Diet Assoc. 1998;98:1412-1417.

282.

Neuhouser ML , Kristal AR , Patterson RE Use of food nutrition labels is associated with lower fat intake. J Am Diet Assoc. 1999 ;99:45-53.

283.

Paeratakul S. , Ferdinand DP , Champagne CM , Ryan DH , Bray GA Fast-food consumption among US adults and children: dietary and nutrient intake profile. J Am Diet Assoc. 2003;103:1332-1338.

284.

Liou D. , Contento IR Usefulness of psychosocial theory variables in explaining fat-related dietary behavior in Chinese Americans: association with degree of acculturation. J Nutr Educ. 2001;33:322-331.

285.

Jenkins DJ , Kendall CW , Faulkner D. , et al. A dietary portfolio approach to cholesterol reduction: combined effects of plant sterols, vegetable proteins, and viscous fibers in hypercholesterolemia. Metabolism. 2002;51:1596-1604.

286.

Jenkins DJ , Kendall CW , Faulkner DA , et al. Assessment of the longer-term effects of a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia . Am J Clin Nutr. 2006;83:582-591.

287.

Jenkins DJ , Kendall CW , Marchie A. , et al. Direct comparison of dietary portfolio vs statin on C-reactive protein. Eur J Clin Nutr. 2005;59:851-860.

288.

Anderson JW , Johnstone BM , Cook-Newell ME Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med. 1995 ;333:276-282.

289.

Law M. Plant sterol and stanol margarines and health. BMJ. 2000;320:861-864.

290.

Olson BH , Anderson SM , Becker MP , et al. Psyllium-enriched cereals lower blood total cholesterol and LDL cholesterol, but not HDL cholesterol, in hypercholesterolemic adults: results of a meta-analysis. J Nutr. 1997;127:1973 -1980.

291.

Hyson DA , Schneeman BO , Davis PA Almonds and almond oil have similar effects on plasma lipids and LDL oxidation in healthy men and women. J Nutr. 2002;132:703-707.

292.

Jacobs DR Jr , Anderson JT , Hannan P. , Keys A. , Blackburn H. Variability in individual serum cholesterol response to change in diet. Arteriosclerosis. 1983;3:349-356.

293.

Katan MB , Grundy SM , Willett WC Should a lowfat, high-carbohydrate diet be recommended for everyone? Beyond low-fat diets. N Engl J Med. 1997;337:563-566.

294.

Katan MB , Beynen AC , De Vries JH , Nobels A. Existence of consistent hypo- and hyperresponders to dietary cholesterol in man. Am J Epidemiol. 1986;123:221-234.

295.

Cox C. , Mann J. , Sutherland W. , Ball M. Individual variation in plasma cholesterol response to dietary saturated fat . BMJ. 1995;311:1260-1264.

296.

Krauss RM Dietary and genetic effects on low-density lipoprotein heterogeneity. Annu Rev Nutr. 2001;21:283-295.

297.

Jacobs B. , De Angelis-Schierbaum G. , Egert S. , Assmann G. , Kratz M. Individual serum triglyceride responses to high-fat and low-fat diets differ in men with modest and severe hypertriglyceridemia. J Nutr. 2004;134:1400-1405.

298.

Hellerstein MK Carbohydrate-induced hypertriglyceridemia: modifying factors and implications for cardiovascular risk. Curr Opin Lipidol. 2002;13:33-40.

299.

Ordovas JM , Mooser V. Nutrigenomics and nutrigenetics. Curr Opin Lipidol. 2004;15:101-108.

300.

Ordovas JM Nutrigenetics, plasma lipids, and cardiovascular risk. J Am Diet Assoc. 2006;106:1074-1081.

301.

Ordovas JM Genetic interactions with diet influence the risk of cardiovascular disease. Am J Clin Nutr. 2006;83:443S-446S.

302.

Velez-Carrasco W. , Lichtenstein AH , Welty FK , et al. Dietary restriction of saturated fat and cholesterol decreases HDL ApoA-I secretion. Arterioscler Thromb Vasc Biol. 1999;19:918-924.

303.

Weggemans RM , Zock PL , Urgert R. , Katan MB Differences between men and women in the response of serum cholesterol to dietary changes. Eur J Clin Invest. 1999;29:827-834.

304.

Stein K. Refusal to follow dietary prescriptions. J Am Diet Assoc. 2005;105:1188-1190.

305.

Reid R. , Fodor G. , LydonHassen K. , et al. Dietary counselling for dyslipidemia in primary care: results of a randomized trial. Can J Diet Pract Res. 2002;63:169-175.

306.

Arcand JA , Brazel S. , Joliffe C. , et al. Education by a dietitian in patients with heart failure results in improved adherence with a sodium-restricted diet: a randomized trial. Am Heart J. 2005;150:716.

307.

Teo KK , Ounpuu S. , Hawken S. , et al. Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study. Lancet. 2006;368:647-658.

308.

Yusuf S. , Hawken S. , Ounpuu S. , et al. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet. 2005;366:1640-1649.

309.

Yusuf S. , Hawken S. , Ounpuu S. , et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364:937—952.

310.

Dengel DR , Galecki AT , Hagberg JM , Pratley RE The independent and combined effects of weight loss and aerobic exercise on blood pressure and oral glucose tolerance in older men. Am J Hypertens. 1998;11:1405-1412.

311.

Perseghin G. , Price TB , Petersen KF , et al. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N Engl J Med. 1996;335:1357-1362.

312.

Hu FB , Stampfer MJ , Solomon C. , et al. Physical activity and risk for cardiovascular events in diabetic women. Ann Intern Med. 2001;134:96-105.

313.

Farrell SW , Kampert JB , Kohl HW Iii , et al. Influences of cardiorespiratory fitness levels and other predictors on cardiovascular disease mortality in men. Med Sci Sports Exerc. 1998;30:899-905.

314.

American College of Sports Medicine position stand: exercise for patients with coronary artery disease. Med Sci. 1994;26. Available at: http://www.acsm-msse.org/pt/pt-core/template-journal/msse/media/0394.pdf . Accessed December 3, 2006.

315.

Wang XL , Raveendran M. , Wang J. Genetic influence on cigarette induced cardiovascular disease. Prog Cardiovasc Dis. 2003;45:361-382.

316.

McCollum M. , Ellis SL , Morrato EH , Sullivan PW Prevalence of multiple cardiac risk factors in US adults with diabetes. Curr Med Res Opin. 2006;22:1031-1034.

317.

Danesh J. , Wheeler JG , Hirschfield GM , et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med. 2004;350:1387-1397.

318.

Mobley LR , Root ED , Finkelstein EA , Khavjou O. , Farris RP , Will JC Environment, obesity, and cardiovascular disease risk in low-income women . Am J Prev Med. 2006;30:327-332.

319.

Nambi V. , Ballantyne CM Combination therapy with statins and omega-3 fatty acids. Am J Cardiol. 2006;98:34-38.

320.

Studer M. , Briel M. , Leimenstoll B. , Glass TR , Bucher HC Effect of different antilipidemic agents and diets on mortality: a systematic review. Arch Intern Med. 2005;165:725-730.

321.

Diabetes stats from 2004. Available at: http://www.cdc.gov/diabetes/statistics/prev/national/index.htm. Accessed December 4, 2006.

322.

Cowie CC , Rust KF , Byrd-Holt DD , et al. Prevalence of diabetes and impaired fasting glucose in adults in the U.S. population: National Health and Nutrition Examination Survey 1999-2002 . Diabetes Care. 2006;29:1263-1268.

323.

Diagnosed diabetes among American Indians and Alaska Natives aged 35 years—United States, 1994-2004. MMWR. 2006;55:1201-1203.

324.

The Diabetes Control and Complications Trial Research Group. The relationship of glycemic exposure (HbA1c) to the risk of development and progression of retinopathy in the Diabetes Control and Complications Trial. Diabetes. 1995;44:968-983.

325.

The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977-986.

326.

UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet. 1998;352:854-865.

327.

UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837-853.

328.

Narayan KM , Boyle JP , Thompson TJ , Sorensen SW , Williamson DF Lifetime risk or diabetes mellitus in the United States. JAMA. 2003;290:1884-1890.

329.

Ettaro L. , Songer TJ , Zhang P. , Engelgau MM Cost-of-illness studies in diabetes mellitus. Pharmacoeconomics . 2004;22:149-164.

330.

Zhang P. , Engelgau MM , Norris SL , Gregg EW , Narayan KM Application of economic analysis to diabetes and diabetes care. Ann Intern Med. 2004;140:972-977.

331.

Geiss LS , Herman WH , Smith PJ Mortality among persons with noninsulin dependent diabetes. In: Harris MI , Cowie CC , Stern MP , Boyko EJ , Reiber GE , Bennett PH , eds. Diabetes in America. 2nd ed. Bethesda, Md: National Institutes of Health; 1995:233-258.

332.

Eriksson K-F. , Lindgärde F. Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise: the 6-year Malmö Feasibility Study. Diabetologia. 1991;34:891-898.

333.

Pan XR , Li GW , Hu YH , et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: the Da Qing IGT and Diabetes Study. Diabetes Care. 1997;20:537—544.

334.

Hernan WH , Brandle M. , Zhang P. , et al. Costs associated with the primary prevention of type 2 diabetes mellitus in the diabetes prevention program. Diabetes Care . 2003;26:36-47.

335.

Herder C. , Peltonen M. , Koenig W. , et al. Systemic immune mediators and lifestyle changes in the prevention of type 2 diabetes: results from the Finnish Diabetes Prevention Study. Diabetes. 2006;55:2340-2346.

336.

Mayer-Davis EJ , D'Antonio AM , Smith SM , et al. Pounds off with empowerment (POWER): a clinical trial of weight management strategies for black and white adults with diabetes who live in medically under-served rural communities. Am J Public Health. 2004;94:1736-1742.

337.

Kim SH , Lee SJ , Kang ES , et al. Effects of lifestyle modification on metabolic parameters and carotid intima-media thickness in patients with type 2 diabetes mellitus. Metabolism. 2006;55:1053-1059.

338.

Collier G. , McLean A. , O'Dea K. Effect of co-ingestion of fat on the metabolic responses to slowly and rapidly absorbed carbohydrates. Diabetologia. 1984;26:50-54.

339.

Nuttall FQ , Mooradian AD , Gannon MC , Billington C. , Krezowski P. Effect of protein ingestion on the glucose and insulin response to a standardized oral glucose load. Diabetes Care. 1984;7:465-470.

340.

Wolever TM , Bolognesi C. Source and amount of carbohydrate affect postprandial glucose and insulin in normal subjects. J Nutr. 1996;126:2798-2806.

341.

Wolever TM , Bolognesi C. Prediction of glucose and insulin responses of normal subjects after consuming mixed meals varying in energy, protein, fat, carbohydrate and glycemic index. J Nutr. 1996;126:2807-2812.

342.

Jenkins DJ , Wolever TM , Taylor RH , et al. Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr. 1981;34:362-366.

343.

Franz MJ The glycemic index: not the most effective nutrition therapy intervention . Diabetes Care. 2003;26:2466-2468.

344.

Jenkins DJ , Kendall CW , Augustin LS , et al. Glycemic index: overview of implications in health and disease . Am J Clin Nutr. 2002;76:266S-273S.

345.

Pi-Sunyer FX Glycemic index and disease. Am J Clin Nutr. 2002;76:290S-298S.

346.

Sheard NF , Clark NG , Brand-Miller JC , et al. Dietary carbohydrate (amount and type) in the prevention and management of diabetes: a statement by the American Diabetes Association. Diabetes Care. 2004;27:2266-2271.

347.

Kannel WB , McGee DL Diabetes and cardiovascular disease. The Framingham Study. JAMA. 1979;241:2035-2038.

348.

Nesto RW Beyond low-density lipoprotein: addressing the atherogenic lipid triad in type 2 diabetes mellitus and the metabolic syndrome. Am J Cardiovasc Drugs. 2005;5:379-387.

349.

Ziegler D. Type 2 diabetes as an inflammatory cardiovascular disorder. Curr Mol Med. 2005;5:309-322.

350.

Lebovitz HE Insulin resistance: a common link between type 2 diabetes and cardiovascular disease. Diabetes Obes Metab . 2006;8:237-249.

351.

Howes LG The effects of lipid-lowering drug therapy on cardiovascular responsiveness in type 2 diabetic patients. Diabetes Obes Metab. 2006;8:8-14.

352.

Shepherd J. , Betteridge J, Van Gaal L, and European Consensus Panel. Nicotinic acid in the management of dyslipidaemia associated with diabetes and metabolic syndrome: a position paper developed by a European Consensus Panel. Curr Med Res Opin. 2005;21:665-682.

353.

Mantzoros CS , Li T. , Manson JE , Meigs JB , Hu FB Circulating adiponectin levels are associated with better glycemic control, more favorable lipid profile, and reduced inflammation in women with type 2 diabetes. J Clin Endocrinol Metab. 2005;90:4542—4548.

354.

Mantzoros CS , Williams CJ , Manson JE , Meigs JB , Hu FB Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women. Am J Clin Nutr. 2006;84:328-335.

355.

Qi L. , Rimm E. , Liu S. , Rifai N. , Hu FB Dietary glycemic index, glycemic load, cereal fiber, and plasma adiponectin concentration in diabetic men. Diabetes Care. 2005;28:1022-1028.

356.

Qi L. , Meigs JB , Liu S. , Manson JE , Mantzoros C. , Hu FB Dietary fibers and glycemic load, obesity, and plasma adiponectin levels in women with type 2 diabetes. Diabetes Care. 2006;29:1501-1505.

357.

Savoca MR , Miller CK , Ludwig DA Food habits are related to glycemic control among people with type 2 diabetes mellitus. J Am Diet Assoc. 2004;104:560-566.

358.

Barclay AW , Brand-Miller JC , Mitchell P. Macronutrient intake, glycaemic index and glycaemic load of older Australian subjects with and without diabetes: baseline data from the Blue Mountains Eye study. Br J Nutr. 2006;96:117-123.

359.

Vijan S. , Stuart NS , Fitzgerald JT , et al. Barriers to following dietary recommendations in type 2 diabetes . Diabetes Med. 2005;22:32-38.

360.

Nagelkerk J. , Reick K. , Meengs L. Perceived barriers and effective strategies to diabetes self-management. J Adv Nurs. 2006 ;54:151-158.

361.

Barrera M. Jr , Toobert DJ , Angell KL , Glasgow RE , Mackinnon DP Social support and social-ecological resources as mediators of lifestyle intervention effects for type 2 diabetes. J Health Psychol. 2006;11:483-495.

362.

Eyre H. , Kahn R. , Robertson RM Preventing cancer, cardiovascular disease, and diabetes: a common agenda for the American Cancer Society, the American Diabetes Association, and the American Heart Association. Diabetes Care. 2004;27:1812-1824.

363.

Skerrett PJ , Manson JE Reduction in risk of coronary heart disease and diabetes. In: Ruderman N , Devlin JT , Schneider SH , Kriska A , eds. Handbook of Exercise in Diabetes. Alexandria, Va: American Diabetes Association; 2002.

364.

Hubinger A. , Franzen A. , Gries A. Hormonal and metabolic response to physical exercise in hyperinsulinemic and nonhyperinsulinemic type 2 diabetics. Diabetes Res. 1987;4:57-61.

365.

Koivisto VA , Defronzo RA Exercise in the treatment of type 2 diabetes . Acta Endocrinol. 1984;262:107-111.

366.

Trovati M. , Carta Q. , Cavalot F. , et al. Influence of physical training on blood glucose control, glucose tolerance, insulin secretion, and insulin action in noninsulin-dependent diabetic patients. Diabetes Care. 1984;7:416-420.

367.

Wagner H. , Degerblad M. , Thorell A. , et al. Combined treatment with exercise training and acarbose improves metabolic control and cardiovascular risk factor profile in subjects with mild type 2 diabetes. Diabetes Care. 2006;29:1471-1477.

368.

Bassuk SS , Manson JE Epidemiological evidence for the role of physical activity in reducing risk of type 2 diabetes and cardiovascular disease. J Appl Physiol. 2005;99:1193-204.

369.

Wing RR Exercise and weight control. In: The Health Professional's Guide to Diabetes and Exercise. Alexandria, Va: American Diabetes Association; 1995:111—114.

370.

Wing RR , Epstein LH , Paternostrobayles M. , Kriska A. , Norwalk MP , Gooding W. Exercise in a behavioural weight control programme for obese patients with type 2 (noninsulin-dependent) diabetes. Diabetologia. 1988;31:902—909.

371.

Ford ES , Giles WH , Mokdad AH Increasing prevalence of the metabolic syndrome among U.S. adults. Diabetes Care. 2004;27:2444-2449.

372.

Tzou WS , Douglas PS , Srinivasan SR , et al. Increased subclinical atherosclerosis in young adults with metabolic syndrome: the Bogalusa Heart Study. J Am Coll Cardiol. 2005;46:457-463.

373.

Bacha F. , Saad R. , Gungor N. , Janosky J. , Arslanian SA Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents: race differential in diabetogenic and atherogenic risk factors . J Clin Endocrinol Metab. 2003;88:2534-2540.

374.

Bergman RN , Van Citters GW , Mittelman SD , et al. Central role of the adipocyte in the metabolic syndrome. J Investig Med. 2001;49:119—126.

375.

Grundy SM Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab. 2004;89:2595—2600.

376.

Park YW , Zhu S. , Palaniappan L. , Heshka S. , Carnethon MR , Heymsfield SB The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988—1994. Arch Intern Med. 2003;163:427—436.

377.

Galassi A. , Reynolds K. , He J. Metabolic syndrome and risk of cardiovascular disease: a meta-analysis. Am J Med. 2006;119:812-819.

378.

Hanley AJ , Karter AJ , Williams K. , et al. Prediction of type 2 diabetes mellitus with alternative definitions of the metabolic syndrome: the Insulin Resistance Atherosclerosis Study. Circulation. 2005;112:3713-3721.

379.

Isomaa B. , Almgren P. , Tuomi T. , et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care. 2001;24:683-689.

380.

Rantala AO , Kauma H. , Lilja M. , Savolainen MJ , Reunanen A. , Kesaniemi YA Prevalence of the metabolic syndrome in drug-treated hypertensive patients and control subjects. J Intern Med. 1999;245:163-174.

381.

Ford ES Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Diabetes Care. 2005;28:1769-1778.

382.

Ford ES Rarer than a blue moon: the use of a diagnostic code for the metabolic syndrome in the U.S. Diabetes Care. 2005;28:1808-1809.

383.

Chew GT , Gan SK , Watts GF

Revisiting the metabolic syndrome

Med J Aust. 2006;185:445-449. ation; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation . 2005;112:2735-2752.