Studies on Uracils: Synthesis of Tetrazolo[4’,5':1,6]pyrido[2,3- d ]pyrimidines by the Action of Cyano Stabilised Carbanions on 6-Azido-5-formyluracils †

(a) Lunt E. , Comprehensive Organic Chemistry, ed. Barton D. , and Ollis W. D. , Pergamon Press, Oxford, 1974, vol. 4, p. 493; (b) J. D. Brown, Comprehensive Heterocyclic Chemistry, ed. Katritzky A. R. , and Rees C. W. , Pergamon Press, Oxford, 1984, vol. 3, p. 57; (c) T. Sasaki, K. Minamoto, T. Suzuki and S. Yamashita, Tetrahedron, 1980, 36, 865; (d) T. K. Bradshaw and D. W. Hutchison, Chem. Soc. Rev., 1977, 6, 43; (e) P. J. Bhuyan, R. C. Boruah and J. S. Sandhu, J. Org. Chem., 1990, 55, 568; (f) P. J. Bhuyan, J. S. Sandhu and A. C. Ghosh, Tetrahedron Lett., 1996, 37, 1853 and references therein.

(a) Marumoto R. , and Furukawa Y. , Chem. Pharm. Bull., 1977, 25, 2974; (b) C. C. Cheng and B. Roth, Prog. Med. Chem., 1971, 8, 61; (c) E. D. Clercq and R. Bernaerts, J. Biol. Chem., 1987, 262, 14905; (d) A. S. Jones, J. R. Swgers, R. T, Walker and E. D. Clercq, J. Med. Chem., 1988, 31, 268.

(a) Baba M. , Pauwels R. , Herdwig P. , Clercq E. D. , Desmyster J. , and Vandepulfe M. , Biochem. Res. Commun., 1957, 142, 128; (b) E. D. Clercq, J. Med. Chem., 1986, 29, 1561.

(a) Clercq E. D. , Anticancer Res., 1986, 6, 549; (b) A. S. Jones, G. Verhalst and R. T. Walker, Tetrahedron Lett., 1974, 4415.

(a) Tennant G. , J. Chem. Soc. C, 1966, 2290; (b) D. R. Sutherland and G. Tennant, J. Chem. Soc., Perkin Trans. 1, 1974, 534; (c) C. Westerlund, J. Heterocycl. Chem., 1980, 17, 1765; (d) R. K. Smalley and M. Teguiche, Synthesis, 1990, 654.

Porter T. C. , Smalley R. K. , Teguiche M. , and Purwono B. , Synthesis, 1997, 773.

Prajapati D. , Bhuyan P. J. , and Sandhu J. S. , J. Chem. Soc., Perkin Trans. 1, 1988, 607.

Hirota K. , Maruhashi K. , Asao T. , Kitamura N. , Maki Y. , and Senda S. , Chem. Pharm. Bull., 1983, 31, 3959.