The discipline of affective neuroscience is concerned with the underlying neural substrates of emotion and mood. This review presents an historical overview of the pioneering work in affective neuroscience of James and Lange, Cannon and Bard, and Hess, Papez, and MacLean before summarizing the current state of research on the brain regions identified by these seminal researchers. We also discuss the more recent strides made in the field of affective neuroscience. A final section considers different hypothetical organizations of affective neuroanatomy and highlights future directions for the discipline.
Adolphs, R., Cahill, L., Schul, R., & Babinsky, R. ( 1997). Impaired declarative memory for emotional material following bilateral amygdala damage in humans. Learning & Memory , 4, 291-300.
2.
Adolphs, R., Damasio, H., Tranel, D., & Damasio, A.R. ( 1996). Cortical systems for the recognition of emotion in facial expression. Journal of Neuroscience, 16, 7678-7687.
3.
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. ( 1994). Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala. Nature, 372, 669-672.
4.
Adolphs, R., Tranel, D., Hamann, S., Young, A.W., Calder, A.J., Phelps, E., et al. (1999). Recognition of facial emotion in nine individuals with bilateral amygdala damage. Neuropsychologia, 37, 1111-1117.
5.
Aggleton, J.P. ( 1992). The functional effects of amygdaloid lesions in humans: A comparison with findings from monkeys. In J. P. Aggleton (Ed.), The amygdala (pp. 485-503). New York/Chichester: Wiley-Liss .
6.
Alexander, G.E., DeLong, M.R., & Strick, P.L. ( 1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Reviews of Neuroscience , 9, 357-381.
7.
Alkire, M.T., Gruver, R., Miller, J., McReynolds, J.R., Hahn, E.L., & Cahill, L. ( 2008). Neuroimaging analysis of an anesthetic gas that blocks human emotional memory. Proceedings of the National Academy of Sciences, 105(5), 1722.
Amodio, D.M., & Frith, C.D. ( 2006). Meeting of minds: The medial frontal cortex and social cognition. Nature Reviews Neuroscience, 7(4), 268.
10.
Angrilli, A., Mauri, A., Palomba, D., Flor, H., Birbaumer, N., Sartori, G., et al. (1996). Startle reflex and emotion modulation impairment after right amygdala lesion. Brain, 119, 1991-2000.
11.
Aron, A.R., Behrens, T.E., Smith, S., Frank, M.J., & Poldrack, R.A. (2007). Triangulating a cognitive control network using diffusion-weighted magnetic resonance imaging (MRI) and functional MRI. Journal of Neuroscience, 27(14), 3743.
12.
Aron, A.R., Fletcher, P.C., Bullmore, E.T., Sahakian, B.J., & Robbins, T.W. ( 2003). Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans. Nature Neuroscience, 6(2), 115-116.
13.
Baird, A.A., & Fugelsang, J.A. (2004). The emergence of consequential thought: Evidence from neuroscience. Philosophical Transactions of the Royal Society B: Biological Sciences, 359(1451), 1797-1804.
14.
Baleydier, C., & Mauguiere, F. ( 1980). The duality of the cingulate gyrus in monkey. Brain, 103, 525-554.
15.
Bandler, A., Keay, K.A., Floyd, N., & Price, J. ( 2000). Central circuits mediating patterned autonomic activity during active vs. passive emotional coping. Brain Research Bulletin, 53(1), 95-104.
16.
Bard, P. ( 1928). A diencephalic mechanism for the expression of rage with special reference to the central nervous system. American Journal of Physiology, 84, 490-513.
17.
Bard, P., & Rioch, D.M. ( 1937). A study of four cats deprived of neocortex and additional portions of the forebrain. Johns Hopkins Medical Journal, 60, 73-153.
18.
Barrett, L.F. ( 2006a). Are emotions natural kinds?Perspectives on Psychological Science, 1(1), 28-58.
19.
Barrett, L.F. ( 2006b). Solving the emotion paradox: Categorization and the experience of emotion. Personality and Social Psychology Review , 10(1), 20-46.
20.
Barrett, L.F., Quigley, K.S., Bliss-Moreau, E., & Aronson, K.R. ( 2004). Interoceptive sensitivity and self-reports of emotional experience. Journal of Personality and Social Psychology, 87(5), 684-697.
21.
Baxter, M.G., & Murray, E.A. ( 2002). The amygdala and reward. Nature Reviews Neuroscience, 3, 563-573.
22.
Bechara, A. ( 2005). Decision making, impulse control and loss of will-power to resist drugs: A neurocognitive perspective. Nature Neuroscience , 8, 1458-1463.
23.
Bechara, A., Damasio, H., & Damasio, A.R. ( 2000). Emotion, decision making, and the orbitofrontal cortex . Cerebral Cortex, 10, 295-307.
24.
Bechara, A., Damasio, A.R., Damasio, H., & Anderson, S.W. (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition, 50(1-3), 7-15.
25.
Bechara, A., Tranel, D., Damasio, H., & Adolphs, R. ( 1995). Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science , 269, 1115-1118.
Berridge, K.C., & Kringelbach, M.L. (2008). Affective neuroscience of pleasure: Reward in humans and animals. Psychopharmacology , 199, 457-480.
28.
Berthoz, S., Grèzes, J., Armony, J.L., Passingham, R.E., & Dolan, R.J. ( 2006). Affective response to one’s own moral violations . Neuroimage, 31(2), 945-950.
29.
Blanchard, D.C., & Blanchard, R.J. (1972). Innate and conditioned reactions to threat in rats with amygdaloid lesions. Journal of Comparative and Physiological Psychology, 81, 281-290.
30.
Blanchard, R.J., & Blanchard, D.C. (1990a). Anti-predator defence as models of animal fear and anxiety: Fear and defence. In P. F. Brain, S. Parmigiani , R. J. Blanchard & D. Mainardi (Eds.), Fear and defence (pp. 89-108). London : Harwood Academic Publishers.
31.
Blanchard, R.J., & Blanchard, D.C. (1990b). An ethoexperimental analysis of defence, fear and anxiety. In N. McNaughton & G. Andrews (Eds.), Anxiety (pp. 24-33). Dunedin: Otago University Press.
32.
Breiter, H.C., Etcoff, N.L., Whalen, P.J., Kennedy, W.A., Rauch, S.L., Buckner, R.L., et al. (1996). Response and habituation of the human amygdala during visual processing of facial emotion. Neuron, 17, 875-887.
33.
Broca, P. ( 1878). Anatomie comparée des circonvolutions cérébrales . Revue d’Anthropologie, 1, 385-498.
34.
Brothers, L., Ring, B., & Kling, A. ( 1990). Response of neurons in the macaque amygdala to complex social stimuli. Behavioural Brain Research, 41, 199-213.
35.
Burgdorf, J., & Panksepp, J. ( 2006). The neurobiology of positive emotions. Neuroscience and Biobehavioral Reviews, 30, 173-187.
36.
Bush, G., Luu, P., & Posner, M.I. ( 2000). Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences, 4(6), 215-222.
37.
Cahill, L., Babinsky, R., Markowitsch, H.J., & McGaugh, J.L. ( 1995). The amygdala and emotional memory. Nature , 377, 295-296.
38.
Cahill, L., Haier, R., Fallon, J., Alkire, M., Tang, C., Keator, D., et al. (1996). Amygdala activity at encoding correlated with long-term free recall of emotional information. Proceedings of the National Academy of Sciences, 93, 8016-8021.
39.
Calder, A.J., Keane, J., Lawrence, A.D., & Manes, F. ( 2004). Impaired recognition of anger following damage to the ventral striatum. Brain, 127(9), 1958.
40.
Calder, A.J., Keane, J., Manes, F., Antoun, N., & Young, A.W. ( 2000). Impaired recognition and experience of disgust following brain injury. Nature Neuroscience, 3(11), 1077-1078.
41.
Calder, A.J., Lawrence, A.D., & Young, A.W. ( 2001). Neuropsychology of fear and loathing. Nature Reviews Neuroscience, 2, 352-363.
42.
Calder, A.J., Young, A.W., Rowland, D., Perrett, D.I., Hodges, J.R., & Etcoff, N.L. ( 1996). Facial emotion recognition after bilateral amygdala damage: Differentially severe impairment of fear. Cognitive Neuropsychology , 13(5), 699-745.
43.
Cannon, W.B. ( 1927). The James-Lange theory of emotions: A critical examination and an alternative theory. American Journal of Psychology , 39, 106-124.
44.
Cannon, W.B. ( 1931). Again the James-Lange and the thalamic theories of emotions . Psychological Review, 38, 281-295.
45.
Caria, A., Veit, R., Sitaram, R., Lotze, M., Weiskopf, N., Grodd, W., et al. (2007). Regulation of anterior insular cortex activity using real-time fMRI. Neuroimage, 35(3), 1238-1246.
46.
Carr, L., Iacoboni, M., Dubeau, M.C., Mazziotta, J.C., & Lenzi, G.L. ( 2003). Neural mechanisms of empathy in humans: A relay from neural systems for imitation to limbic areas. Proceedings of the National Academy of Sciences, 100(9), 5497-5502.
47.
Carter, C.S., & van Veen, V. ( 2007). Anterior cingulate cortex and conflict detection: An update of theory and data. Cognitive, Affective, & Behavioural Neuroscience, 7(4), 367-379.
48.
Cloninger, C. ( 1987). A systematic method for clinical description and classification of personality variants. Archives of General Psychiatry, 44, 573-588.
49.
Comoli, E., Ribeiro-Barbosa, E.R., & Canteras, N.S. (2003). Predatory hunting and exposure to live predator induce opposite patterns of Fos immunoreactivity in the PAG . Behavioural Brain Research, 138, 17-28.
50.
Coricelli, G., Critchley, H.D., Joffily, M.O., Doherty, J.P., Sirigu, A., & Dolan, R.J. ( 2005). Regret and its avoidance: A neuroimaging study of choice behavior. Nature Neuroscience, 8(9), 1255.
51.
Craig, A.D. ( 2003). Interoception: The sense of the physiological condition of the body. Current Opinion in Neurobiology, 13(4), 500-505.
52.
Critchley, H.D., Elliot, R., Mathias, C.J., & Dolan, R.J. ( 2000). Neural activity relating to generation and representation of galvanic skin responses: A functional magnetic resonance imaging study . Journal of Neuroscience, 20(8), 3033-3040.
53.
Critchley, H.D., Mathias, C.J., & Dolan, R.J. ( 2001). Neural activity in the human brain relating to uncertainty and arousal during anticipation. Neuron, 29, 537-545.
Dalgleish, T. ( 2004). Cognitive approaches to Post-traumatic Stress Disorder (PTSD): The evolution of multi-representational theorizing. Psychological Bulletin, 130, 228-260.
56.
Dalgleish, T., & Power, M.J. ( 2004). The I of the storm: Relations between self and conscious emotion experience. Psychological Review, 111, 812-819.
57.
Damasio, A.R. ( 1994). Descartes’ error. New York: Putnam.
58.
Damasio, A.R. ( 1996). The somatic marker hypothesis and the possible functions of the prefrontal cortex. Philosophical Transactions of the Royal Society London B, 351, 1413-1420.
59.
Damasio, A.R. ( 1997). Towards a neuropathology of emotion and mood. Nature, 386, 769-770.
60.
Darwin, C. ( 1965). The expression of the emotions in man and animals. Chicago, IL: Chicago University Press. (Original work published 1872)
61.
Davidson, R.J. ( 1984a). Affect, cognition, and hemispheric specialization. In J. Kagan, C. E. Izard & R. B. Zajonc (Eds.), Emotions, cognition, and behavior (pp. 320-365). Cambridge/New York: Cambridge University Press.
62.
Davidson, R.J. ( 1984b). Hemispheric asymmetry and emotion. In K. R. Scherer & P. Ekman (Eds.), Approaches to emotion (pp. 39-58). Hillsdale, NJ: Erlbaum.
63.
Davidson, R.J. ( 1993). The neuropsychology of emotion and affective style. In M. Lewis & J. M. Haviland (Eds.), Handbook of emotions (pp. 143-154). New York/London: Guilford Press .
64.
Davidson, R.J., Ekman, P., Saron, C., Senulis, J., & Friesen, W.V. ( 1990). Approach-withdrawal and cerebral asymmetry: Emotional expression and brain physiologyI. Journal of Personality and Social Psychology, 58, 330-341.
65.
Davidson, R.J., Lewis, D.A., Alloy, L.B., Amaral, D.G., Bush, G., Cohen, J.D., et al. (2002). Neural and behavioral substrates of mood and mood regulation. Biological Psychiatry, 52(6), 478-502.
66.
Davidson, R.J., Putnam, K.M., & Larson, C.L. ( 2000). Dysfunction in the neural circuitry of emotion regulation: A possible prelude to violence. Science, 591-595.
67.
Deakin, J.F.W., & Graeff, F.G. ( 1991). 5-HT and mechanisms of defence. Journal of Psychopharmacology, 5, 305-315.
68.
Dunn, B.D., Dalgleish, T., & Lawrence, A.D. (2006). The somatic marker hypothesis: A critical evaluation. Neuroscience and Biobehavioral Reviews , 30(2), 239-271.
69.
Eisenberger, N.I., Lieberman, M.D., & Williams, K.D. (2003). Does rejection hurt? An fMRI study of social exclusion. Science, 302, 290-292.
70.
Ekman, P., Levenson, R.W., & Friesen, W. ( 1983). Autonomic nervous system activity distinguishes among emotions. Science, 221, 1208-1210.
71.
Fanselow, M.S. ( 1991). The midbrain periaqueductal gray as a coordinator of action in response to fear and anxiety. In A. Depaulis & R. Bandler (Eds.), The midbrain periaqueductal gray matter: Functional, anatomical and immunohistochemical organization (pp. 151-173). New York: Plenum Publishing Corporation.
72.
Fanselow, M.S. ( 1994). Neural organization of the defensive behavior system responsible for fear. Psychonomic Bulletin & Review, 1, 429-438.
73.
Figueiredo, H.F., Bruestle, A., Bodie, B., Dolgas, C.M., & Herman, J.P. ( 2003). The medial prefrontal cortex differentially regulates stress-induced c-fos expression in the forebrain depending on type of stressor . European Journal of Neuroscience, 18(8), 2357-2364.
74.
Fitzgerald, P.B., Brown, T.L., Marston, N.A.U., Daskalakis, Z.J., de Castella, A., & Kulkarni, J. ( 2003). Transcranial magnetic stimulation in the treatment of depression: A double-blind, placebo-controlled trial. Archives of General Psychiatry, 60(10), 1002-1008.
75.
Gallagher, M., Graham, P.W., & Holland, P.C. ( 1990). The amygdala central nucleus and appetitive Pavlovian conditioning: Lesions impair one class of conditioned behavior. Journal of Neuroscience, 10(6), 1906-1911.
76.
Garnefski, N., Teerds, J., Kraaij, V., Legerstee, J., & van den Kommer, T. (2004). Cognitive emotion regulation strategies and depressive symptoms: Differences between males and females . Personality and Individual Differences, 36(2), 267-276.
77.
Glimcher, P.W., & Rustichini, A. (2004). Neuroeconomics: The consilience of brain and decision. Science, 306, 447-452.
78.
Goldstein, D.S., & Kopin, I.J. ( 2007). Evolution of concepts of stress. Stress , 10, 109-120.
79.
Gray, J.A. ( 1982). The neuropsychology of anxiety: An enquiry into the function of the septo-hippocampal system. Oxford: Clarendon Press.
80.
Gray, J.M., Young, A.W., Barker, W.A., Curtis, A., & Gibson, D. ( 1997). Impaired recognition of disgust in Huntington’s disease gene carriers. Brain, 120, 2029-2038.
81.
Gross, J.J. ( 2002). Emotion regulation: Affective, cognitive, and social consequences. Psychophysiology, 39, 281-291.
82.
Gross, J.J., & Levenson, R.W. (1997). Hiding feelings: The acute effects of inhibiting negative and positive emotion. Journal of Abnormal Psychology, 106, 95-103.
83.
Hadjikhani, N., & de Gelder, B. ( 2003). Seeing fearful body expressions activates the fusiform cortex and amygdala. Current Biology, 13(24), 2201-2205.
84.
Hamann, S.B., Ely, T.D., Grafton, S.T., & Kilts, C.D. ( 1999). Amygdala activity related to enhanced memory for pleasant and aversive material. Nature Neuroscience, 2(3), 289-293.
85.
Hariri, A.R., Drabant, E.M., Munoz, K.E., Kolachana, B.S., Mattay, V.S., Egan, M.F., et al. (2005). A susceptibility gene for affective disorders and the response of the human amygdale. Archives of General Psychiatry, 62, 146-152.
86.
Hariri, A.R., Mattay, V.S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., et al. (2002). Serotonin transporter genetic variation and the response of the human amygdale. Science, 297(5580), 400-403.
87.
Harlow, J.M. ( 1993). Recovery of the passage of an iron bar through the head . History of Psychiatry, 4, 271-281. (Original work published 1869)
88.
Harro, J., & Vasar, E. ( 1991). Cholecystokinin-induced anxiety: How is it reflected in studies on exploratory behaviour? Neuroscience and Biobehavioural Reviews, 15, 473-477.
89.
Head, H. ( 1921). Croonian lecture: Release of function in the nervous system. Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character (1905- 1934), 92, 184-209.
90.
Heath, R.G. ( 1972). Pleasure and brain activity in man. Journal of Nervous and Mental Disease, 154, 3-18.
91.
Heims, H.C., Critchley, H.D., Dolan, R.J., Mathias, C.J., & Cipolotti, L. ( 2004). Social and motivational functioning is not critically dependent on feedback of autonomic responses: Neuropsychological evidence from patients with pure autonomic failure. Neuropsychologia , 42, 1979-1988.
92.
Hess, W.R., & Brugger, M. ( 1981). Subcortical center of the affective defence reaction . In K. Akert (Ed.), Biological order and brain organization: Selected works of W. R. Hess (pp. 183-202). Berlin: Springer-Verlag. (Original work published 1943)
93.
Hohmann, G.W. ( 1966). Some effects of spinal cord lesions on experienced emotional feelings. Psychophysiology, 3(2), 143-156.
94.
Izard, C.E. ( 1993). Four systems for emotion activation: Cognitive and noncognitive processes. Psychological Review, 100(1), 68-90.
95.
Jacobson, R. (1986). Disorders of facial recognition, social behaviour and affect after combined bilateral amygdalotomy and subcaudate tractotomy: A clinical and experimental study. Psychological Medicine, 16, 439-450. James, W. (1884). What is an emotion? Mind, 9, 188-205.
96.
James, W. ( 1890). The principles of psychology. New York: Henry Holt.
97.
Kalisch, R. (in press). The functional neuroanatomy of reappraisal: Time matters. Neuroscience and Biobehavioural Reviews (2009). doi:1016/j. neubiorev.2009.06.003
98.
Kluver, H., & Bucy, P.C. ( 1937). "Psychic blindness" and other symptoms following bilateral temporal lobectomy. American Journal of Physiology, 119, 254-284.
99.
Koenigs, M., Young, L., Adolphs, R., Tranel, D., Cushman, F., Hauser, M., et al. (2007). Damage to the prefrontal cortex increases utilitarian moral judgements. Nature, 446(7138), 908.
100.
Lambie, J.A., & Marcel, A.J. ( 2002). Consciousness and the varieties of emotion experience: A theoretical framework. Psychological Review, 109(2), 219-259.
101.
Lane, R.D., Reiman, E.M., Axelrod, B., Yun, L.-S., Holmes, A., & Schwarz, G.E. ( 1998). Neural correlates of levels of emotional awareness: Evidence of an interaction between emotion and attention in the anterior cingulate cortex. Journal of Cognitive Neuroscience, 10, 525-535.
102.
Lang, P.J., Bradley, M.M., & Cuthbert, B.N. (1990). Emotion, attention, and the startle reflex. Psychological Review, 97(3), 377-395.
103.
Lang, P.J., Davis, M., & Ohman, A. ( 2000). Fear and anxiety: Animal models and human cognitive psychophysiology . Journal of Affective Disorders, 61(3), 137-159.
104.
Lange, C. ( 1922). The emotions. In K. Dunlap (Eds.), The emotions (I. A. Haupt, Trans., pp. 33-90). Baltimore, MD: Williams & Wilkins. (Original work published 1885)
105.
LeDoux, J.E. ( 1986). Sensory systems and emotion: A model of affective processing . Integrative Psychiatry, 4, 237-248.
106.
LeDoux, J.E. ( 1987). Emotion. In V. Mountcastle & F. Plum (Eds.), Handbook of physiology: Nervous system. Volume 5, Higher function (pp. 419-459). Washington, DC: American Physiological Society.
107.
LeDoux, J.E. ( 1989). Cognitive-emotional interactions in the brain. Cognition & Emotion, 3, 267-289.
108.
LeDoux, J.E. ( 1993). Emotional networks in the brain. In M. Lewis & J. M. Haviland (Eds.), Handbook of emotions. New York: Guilford Press.
109.
LeDoux, J.E. ( 1995). Emotion: Clues from the brain. Annual Review of Psychology, 46, 209-235.
110.
LeDoux, J.E. ( 1996). The emotional brain: The mysterious underpinning of emotional life. New York: Simon & Schuster .
111.
Leonard, C.M., Rolls, E.T., Wilson, F.A.W., & Baylis, C.G. ( 1985). Neurons in the amygdala of the monkey with responses selective for faces. Behavioural Brain Research, 15, 159-176.
112.
MacLean, P.D. ( 1949). Psychosomatic disease and the "visceral brain": Recent developments bearing on the Papez theory of emotion. Psychosomatic Medicine, 11, 338-353.
113.
MacLean, P.D. ( 1952). Some psychiatric implications of physiological studies on frontotemporal portion of limbic system (visceral brain). Electroencephalography and Clinical Neurophysiology, 4, 407-418.
114.
MacLean, P.D. ( 1970). The triune brain, emotion, and scientific bias. In F. O. Schmidt (Ed.), The neurosciences. Second study program (pp. 336-349). New York: Rockefeller University Press.
115.
Macmillan, M. ( 2002). An odd kind of fame: Stories of Phineas Gage. Boston, MA: MIT Press.
116.
Markowitsch, H. J. (2008). Neuroscience and crime. Neurocase, 14(1), 1-6. Masterman, D. L., & Cummings, J. L. (1997). Frontal-subcortical circuits: The anatomic basis of executive, social and motivated behaviors. Journal of Psychopharmacology, 11(2), 107.
117.
Mayberg, H.S. ( 1997). Limbic-cortical dysregulation: A proposed model of depression . The Journal of Neuropsychiatry and Clinical Neurosciences , 9, 471-481.
118.
Mayberg, H.S., Lozano, A.M., Voon, V., McNeely, H.E., Seminowicz, D., Hamani, C., et al. (2005). Deep brain stimulation for treatment-resistant depression. Neuron, 45, 651-660.
119.
McNaughton, N., & Corr, P.J. ( 2004). A two-dimensional neuropsychology of defence: Fear/anxiety and defensive distance. Neuroscience and Biobehavioral Reviews , 28(3), 285-305.
120.
Meunier, M., Bachevalier, J., Murray, E.A., Malkova, L., & Mishkin, M. ( 1996). Effects of aspiration vs. neurotoxic lesions of the amygdala on emotional reactivity in rhesus monkeys. Society for Neuroscience Abstract, 13, 5418-5432.
121.
Mills, C.K. ( 1912). The cortical representation of emotion, with a discussion of some points in the general nervous system mechanism of expression in its relation to organic nervous disease and insanity. Proceedings of the American Medico-Psychological Association, 19, 297-300.
122.
Mitchell, J.P., Macrae, C.N., & Banaji, M.R. ( 2006). Dissociable medial prefrontal contributions to judgments of similar and dissimilar others. Neuron, 50(4), 655-663.
123.
Mobbs, D., Eckert, M.A., Mills, D., Korenberg, J., Bellugi, U., Galaburda, A.M., et al. (2007). Frontostriatal dysfunction during response inhibition in Williams syndrome. Biological Psychiatry, 62, 256-261.
124.
Mobbs, D., Lau, H.C., Jones, O.D., & Frith, C.D. ( 2007). Law, responsibility, and the brain. PLoS Biology, 5(4), 693-700.
125.
Mobbs, D., Petrovic, P., Marchant, J.L., Hassabis, D., Weiskopf, N., Seymour, B., et al. (2007). When fear is near: Threat imminence elicits prefrontal-periaqueductal gray shifts in humans. Science, 317(5841), 1079.
126.
Montag, C., Buckhlotz, J.W., Hartmann, P., Merz, M., Burk, C., & Hennig, J. ( 2008). COMT genetic variation affects fear processing: Psychophysiological evidence. Behavioural Neuroscience, 4, 901-909.
127.
Montoya, P., & Schandry, R. ( 1994). Emotional experience and heartbeat perception in patients with spinal cord injury and control subjects. Journal of Psychophysiology , 8, 289-296.
128.
Morgane, P. J., & Mokler, D. J. (2006). The limbic brain: Continuing resolution. Neuroscience and Biobehavioral Reviews, 30(2), 119-125. Morris, J., Ohman, A., & Dolan, R. J. (1998). Modulation of human amygdala activity by emotional learning and conscious awareness. Nature, 393, 467-470.
129.
Morris, J., Ohman, A., & Dolan, R.J. ( 1999). A subcortical pathway to the right amygdala mediating unseen fear. Proceedings of the National Academy of Sciences , 96, 1680-1685.
130.
Morris, J.S., DeGelder, B., Weiskrantz, L., & Dolan, R.J. ( 2001). Differential extrageniculostriate and amygdala responses to presentation of emotional faces in a cortically blind field. Brain, 124(6), 1241.
131.
Morris, J.S., Frith, C.D., Perrett, D.I., Rowland, D., Young, A.W., Calder, A.J., et al. (1996). A differential neural response in the human amygdala for fearful and happy facial expressions. Nature , 383, 812-815.
132.
Mowrer, O.H. ( 1960). Learning theory and behavior. New York: Wiley.
133.
Murphy, F.C., Nimmo-Smith, I., & Lawrence, A.D. (2003). Functional neuroanatomy of emotions. Cognitive, Affective, & Behavioural Neuroscience , 3, 207-233.
134.
Murray, E.A., Gaffan, E.A., & Flint, R.W. ( 1996). Anterior rhinal cortex and amygdala: Dissociation of their contributions to memory and food preference in rhesus monkeys. Behavioural Neuroscience, 110, 30-42.
135.
Nauta, W.J.H. ( 1971). The problem of the frontal lobe: A reinterpretation. Journal of Psychiatric Research, 8, 167-187.
136.
Niedenthal, P. M. (2007). Embodying emotion. Science, 316(5827), 1002. Ochsner, K. N., Bunge, S. A., Gross, J. J., & Gabrieli, J. D. E. (2002). Rethinking feelings: An fMRI study of the cognitive regulation of emotion. Journal of Cognitive Neuroscience, 14, 1215-1219.
137.
Ochsner, K.N., & Gross, J.J. ( 2005). The cognitive control of emotion. Trends in Cognitive Sciences, 9(5), 242-249.
138.
Ochsner, K.N., & Lieberman, M.D. (2001). The emergence of social cognitive neuroscience. American Psychologist, 56, 717-734.
139.
Olds, J., & Milner, P. ( 1954). Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. Journal of Comparative and Physiological Psychology, 47, 419-427.
140.
Panksepp, J. ( 1998). Affective neuroscience: The foundations of human and animal emotions. New York: Oxford University Press.
141.
Panksepp, J. ( 2005). Affective consciousness: Core emotional feelings in animals and humans. Consciousness and Cognition, 14, 30-80.
142.
Papez, J.W. ( 1937). A proposed mechanism of emotion. Archives of Neurology and Psychiatry, 38, 725-743.
143.
Pascucci, T., Ventura, R., Latagliata, E.C., Cabib, S., & Puglisi-Allegra, S. (in press). The medial prefrontal cortex determines the accumbens dopamine response to stress through the opposing influences of norepinephrine and dopamine. Cerebral Cortex.
144.
Paulus, M.P., & Stein, M.B. ( 2006). An insular view of anxiety. Biological Psychiatry, 60(4), 383-387.
145.
Penfield, W., & Faulk, M.E. ( 1955). The insula: Further observations of its function. Brain, 78, 445-470.
146.
Perlis, R.H., Holt, D.J., Smoller, J.W., Blood, A.J., Lee, S., Kim, B.W., et al. (2008). Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants . Archives of General Psychiatry, 65, 882-892.
147.
Pessoa, L. ( 2008). On the relationship between emotion and cognition. Nature Reviews Neuroscience, 9(2), 148.
148.
Pessoa, L., McKenna, M., Gutierrez, E., & Ungerleider, L.G. (2002). Neural processing of emotional faces requires attention. Proceedings of the National Academy of Sciences, 99(17), 11458-11463.
149.
Petrides, M. ( 2005). Lateral prefrontal cortex: Architectonic and functional organization. Philosophical Transactions of the Royal Society B: Biological Sciences, 360(1456), 781-795.
150.
Petrovic, P., Kalso, E., Petersson, K.M., & Ingvar, M. ( 2002). Placebo and opioid analgesia: Imaging a shared neuronal network. Science, 295(5560), 1737-1740.
151.
Phan, K.L., Wager, T., Taylor, S.F., & Liberzon, I. ( 2002). Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI. NeuroImage, 16, 331-348.
152.
Phelps, E.A., Delgado, M.R., Nearing, K.I., & LeDoux, J.E. (2004). Extinction learning in humans’ role of the amygdala and vmPFC. Neuron, 43(6), 897-905.
153.
Phillips, M.L., Young, A.W., Senior, C., Brammer, M., Andrew, C., Calder, A.J., et al. (1997). A specific neural substrate for perceiving facial expressions of disgust. Nature, 389, 495-498.
154.
Posse, S., Fitzgerald, D., Gao, K., Habel, U., Rosenberg, D., Moore, G.J., et al. (2003). Real-time fMRI of temporolimbic regions detects amygdala activation during single-trial self-induced sadness. Neuroimage, 18(3), 760-768.
155.
Preuschoff, K., Quartz, S.R., & Bossaerts, P. ( 2008). Human insula activation reflects risk prediction errors as well as risk. Journal of Neuroscience, 28(11), 2745.
156.
Pribram, K.H. ( 1970). Feelings as monitors. In M. B. Arnold (Ed.), Feelings and emotions: The Loyola Symposium (pp. 41-53). New York: Academic Press.
157.
Rolls, E.T. ( 1990). A theory of emotion, and its application to understanding the neural basis of emotion. Cognition & Emotion, 4(3), 161-190.
158.
Rolls, E.T. ( 1996). The orbitofrontal cortex. Philosophical Transactions of the Royal Society of London Series B-Biological Sciences, 351(1346), 1433-1443.
159.
Rolls, E.T. ( 1999). The brain and emotion. Oxford: Oxford University Press.
160.
Rosvold, H.E., Mirsky, A.F., Sarason, I., Bransome, E.D., & Beck, L.H. ( 1956). A continuous performance test of brain damage. Journal of Consulting Psychology, 20, 343-350.
161.
Sackeim, H.A., & Gur, R.C. ( 1978). Lateral asymmetry in intensity of emotional expression . Neuropsychologia, 16, 473-481.
162.
Sackeim, H.A., Gur, R.C., & Saucy, M.C. ( 1978). Emotions are expressed more intensely on the left side of the face. Science, 202, 434-436.
163.
Salomons, T.V., Johnstone, T., Backonja, M.M., & Davidson, R.J. (2004). Perceived controllability modulates the neural response to pain. Journal of Neuroscience , 24, 199-203.
164.
Saver, J.L., & Damasio, A.R. ( 1991). Preserved access and processing of social knowledge in a patient with acquired sociopathy due to ventromedial frontal damage. Neuropsychologia, 29, 1241-1249.
165.
Schachter, S., & Singer, J.E. ( 1962). Cognitive, social, and physiological determinants of emotional state. Psychological Review, 69, 379-399.
166.
Schaefer, S.M., Jackson, D.C., Davidson, R.J., Aguirre, G.K., Kimberg, D.Y., & Thompson-Schill, S.L. (2002). Modulation of amygdalar activity by the conscious regulation of negative emotion. Journal of Cognitive Neuroscience, 14(6), 913-921.
167.
Schmolck, H., & Squire, L.R. ( 2001). Impaired perception of facial emotions following bilateral damage to the anterior temporal lobe. Neuropsychology, 15, 30-38.
168.
Schneirla, T.C. ( 1959). An evolutionary and developmental theory of biphasic processes underlying approach and withdrawal. In M. R. Jones (Ed.), Nebraska Symposium on Motivation (Vol. 7, pp. 1-42). Lincoln: University of Nebraska Press.
Schwartz, G.E., Davidson, R.J., & Maer, F. ( 1975). Right hemisphere lateralization from emotion in the human brain: Interactions with cognition. Science, 190, 286-288.
171.
Scott, S.K., Young, A.W., Calder, A.J., Hellawell, D.J., Aggleton, J.P., & Johnson, M. ( 1997). Impaired auditory recognition of fear and anger following bilateral amygdala lesions. Nature, 385, 254-257.
172.
Simmons, A., Matthews, S.C., Stein, M.B., & Paulus, M.P. ( 2004). Anticipation of emotionally aversive visual stimuli activates right insula. NeuroReport, 15(14), 2261.
173.
Singer, T., Seymour, B., O’Doherty, J., Kaube, H., Dolan, R.J., & Frith, C.D. ( 2004). Empathy for pain involves the affective but not sensory components of pain. Science, 303, 1157-1162.
174.
Smolka, M.N., Bühler, M., Schumann, G., Klein, S., Hu, X.Z., Moayer, M., et al. (2007). Gene-gene effects on central processing of aversive stimuli. Molecular Psychiatry, 12, 307-317.
175.
Smolka, M.N., Schumann, G., Wrase, J., Grusser, S.M., Flor, H., Mann, K., et al. (2005). Catechol-O-Methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. Journal of Neuroscience, 25, 836-842.
176.
Sprengelmeyer, R., Young, A.W., Calder, A.J., Karnat, A., Lange, H., Homberg, V., et al. (1996). Loss of disgust: Perception of faces and emotions in Huntington’s disease. Brain, 119, 1647-1665.
177.
Stein, M.B., Simmons, A.N., Feinstein, J.S., & Paulus, M.P. ( 2007). Increased amygdala and insula activation during emotion processing in anxiety-prone subjects. American Journal of Psychiatry, 164(2), 318.
178.
Stellar, E. ( 1954). The physiology of motivation. Psychological Review, 61, 5-22.
179.
Sukikara, M.H., Mota-Ortiz, S.R., Baldo, M.V., Felicio, L.F., & Canteras, N.S. (2006). A role for the periaqueductal gray in switching adaptive behavioral responses. Journal of Neuroscience, 26(9), 2583-2589.
180.
Summerfield, C., Egner, T., Greene, M., Koechlin, E., Mangels, J., & Hirsch, J. ( 2006). Predictive codes for forthcoming perception in the frontal cortex. Science, 314(5803), 1311-1314.
181.
Teitelbaum, P., & Epstein, A.N. ( 1962). The lateral hypothalamic syndrome: Recovery of feeding and drinking after lateral hypothalamic lesions. Psychological Review, 69, 74-90.
182.
Terzian, H., & Ore, G.D. ( 1955). Syndrome of Kluver-Bucy reproduced in man by bilateral removal of temporal lobes. Neurology, 5, 373-380.
183.
Wager, T.D., Rilling, J.K., Smith, E.E., Sokolik, A., Casey, K.L., Davidson, R.J., et al. (2004). Placebo-induced changes in fMRI in the anticipation and experience of pain. Science, 303, 1162-1167.
184.
Weiskrantz, L. ( 1956). Behavioral changes associated with ablation of the amygdaloid complex in monkeys. Journal of Comparative and Physiological Psychology, 49, 381-391.
185.
Whalen, P.J., Kagan, J., Cook, R.G., Davis, F.C., Kim, H., Polis, S., et al. (2004). Human amygdala responsivity to masked fearful eye whites. Science, 306(5704), 2061.
186.
Whalen, P.J., Rauch, S.L., Etcoff, N.L., McInerney, S.C., Lee, M.B., & Jenike, M.A. ( 1998). Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. The Journal of Neuroscience, 18(1), 411-418.
187.
Young, A.W., Aggleton, J.P., Hellawell, D.J., Johnson, M., Broks, P., & Hanley, J.R. ( 1995). Face processing impairments after amygdalotomy. Brain, 118, 15-24.
188.
Zajonc, R.B. ( 1980). Feeling and thinking: Preferences need no inferences . American Psychologist, 35, 151-175.
