Abstract
Single best answer
A 52-year-old woman with type 2 diabetes mellitus attends for review of abnormal liver function tests identified during routine monitoring. She has no other past medical history. She takes metformin 1 g twice daily and does not drink alcohol. Her body mass index (BMI) is 32 kg/m2 and waist circumference is 102 cm.
Investigations show:
- Alanine aminotransferase (ALT): 45 U/L
- Aspartate aminotransferase (AST): 39 U/L
- Platelet count: 220 × 109/L
- Glycated haemoglobin (HbA1c): 52 mmol/mol
You calculate a FIB-4 score of 1.6, which places her in the intermediate-risk category for liver fibrosis.
A. Abdominal ultrasound
B. Alpha-fetoprotein measurement
C. Liver biopsy
D. Transient elastography (FibroScan®)
E. Viral hepatitis serology
Answer DOI: 10.1177/17557380261446499g