Special Segment: Soft Tissue Matrices— One Form of Acellular Human Dermis for Use in Tendon and Ligament Repairs in the Foot and Ankle

Abstract

Trauma to tendons and ligaments represents a significant part of orthopaedic and podiatric injuries. To improve the outcome of repair, complex or chronic injuries may require reinforcement of the primary repair with a graft. Biologic grafts currently available provide different handling, strength, and biological responses. One of the currently available grafts, an acellular human dermal membrane with specific properties, has been successfully used in the augmentation of tendon and ligament repairs for more than 6 years.

Keywords

tendon repair ligament repair reinforcement grafts membranes

References

Barber FA , McGarry JE , Herbert MA , Anderson RB A biomechanical study of Achilles tendon repair augmentation using Graft Jacket matrix. Foot Ankle Int. 2008;29(3):329-333.

Snyder SJ , Arnoczky SP , Bond JL , Dopirak R. Histologic evaluation of a biopsy specimen obtained 3 months after rotator cuff augmentation with GraftJacket Matrix. Arthroscopy. 2009;25(3):329-333.

Valentin JE , Badylak JS , McCabe GP , Badylak SF Extracellular matrix bioscaffolds for orthopaedic applications: a comparative histologic study. J Bone Joint Surg Am. 2006 ;88:2673-2686.

Rennekampff HO , Kiessig V. , Griffey S. , Greenleaf G. , Hansbrough J. Acellular human dermis promotes cultured keratinocyte engraftment. Journal Burn Care Rehab. 1997 ;18(6):535-544.

Derwin KA , Baker AR , Spragg RK , Leigh DR , Iannotti JP Commercial extracellular matrix scaffolds for rotator cuff tendon repair: biomechanical, biochemical, and cellular properties. J Bone Joint Surg Am. 2006;88(12):2665-2672.

Blum BE , Hughes K. , Miller LC , Burgess AV Native growth factors in acellularized human dermis. Presented at: Society for Biomaterials, 30th Annual Meeting, Memphis, TN, 2005.

Fini M. , Torricelli P. , Giavaresi G. , Rotini R. , Castagna A. , Giardino R. In vitro study comparing two collagenous membranes in view of their clinical application for rotator cuff tendon regeneration. J Orthop Res. 2007;25:98-107.

Beniker D. , McQuillan D. , Livesey S. , et al. The use of acellular dermal matrix as a scaffold for periosteum replace-ment. Orthopedics. 2003;26(5 suppl):s591-s596.

Turner A. , Blum B. , Burgess AV Effects of acellular human dermal matrix thickness on cellular repopulation capabilities in a submuscular rat model. Presented at: American College of Foot and Ankle Surgery (ACFAS) 66th Annual Scientific Conference; 2008; Long Beach, CA.

10.

Turner TM , Urban RM , Romeo AA , Hall DJ , Inoue N. Repair of a rotator cuff tendon defect using an acellular dermal graft in a large defect model. ORS Transactions, 1528. Presented at: 54th Annual Meeting of the Orthopedic Research Society; 2008; San Francisco, CA.