BrunoG, DongR, WanderleyHV, et al.Methemoglobin and nitrogen dioxide levels during inhaled nitric oxide therapy at 300 parts per million in healthy volunteers. Respir Care2026: 19433654261427690; doi: 10.1177/19433654261427690
2.
BerraL, KamenshchikovN, TalA, High-Dose Inhaled Nitric Oxide Investigators. et al.Therapeutic potential of high-dose inhaled nitric oxide for antimicrobial effects: Narrative review and future directions. Intensive Care Med Exp2026; 14: 13; doi: 10.1186/s40635-026-00852-1
3.
YuB, Safaee FakhrB, BryL, et al.Inhaled nitric oxide at 300 ppm treats multidrug-resistant Pseudomonas pneumonia in swine and is safe in humans. Sci Transl Med2026; 18: eady2646; doi: 10.1126/scitranslmed.ady2646
4.
GebistorfF, KaramO, WetterslevJ, et al.Inhaled nitric oxide for acute respiratory distress syndrome in children and adults. Cochrane Database Syst Rev2016; 2016: CD002787; doi: 10.1002/14651858.CD002787.pub3
5.
RuanSY, HuangTM, WuHY, et al.Inhaled nitric oxide therapy and risk of renal dysfunction: Systematic review and meta-analysis of randomized trials. Crit Care2015; 19: 137; doi: 10.1186/s13054-015-0880-2
6.
IchinoseF, RobertsJDJr, and ZapolWM. Inhaled nitric oxide: A selective pulmonary vasodilator—Current uses and therapeutic potential. Circulation2004; 109: 3106–3111; doi: 10.1161/01.CIR.0000134595.80170.62
7.
FeinerJR, BicklerPE and MannheimerPD. Accuracy of methemoglobin detection by pulse CO-oximetry during hypoxia. Anesth Analg2010; 111: 143–148; doi: 10.1213/ANE.0b013e3181c91bb6
8.
ZaouterC and ZavorskyGS. Measurement of carboxyhemoglobin and methemoglobin using a noninvasive pulse CO-oximeter. Respir Physiol Neurobiol2012; 182: 88–92; doi: 10.1016/j.resp.2012.05.010
9.
HulseE, ShihanaF and BuckleyNA. Methemoglobin measurements underestimated by Radical-7 co-oximeter: Experience from propanil poisonings. Clin Toxicol (Phila)2016; 54: 826–828; doi: 10.1080/15563650.2016.1217421
10.
GudelunasMK, LipnickM, HendricksonC, et al.Low perfusion and missed diagnosis of hypoxemia by pulse oximetry in darkly pigmented skin. Anesth Analg2024; 138: 552–561; doi: 10.1213/ANE.0000000000006755
11.
BuhlT, CenciS, GianniS, et al.Predictors of methemoglobin formation in high-dose inhaled nitric oxide therapy: Retrospective cohort study. Nitric Oxide2026; 160: 35–43; doi: 10.1016/j.niox.2025.11.006
12.
CooksonMW and KinsellaJP. Inhaled nitric oxide in neonatal pulmonary hypertension. Clin Perinatol2024; 51: 95–111; doi: 10.1016/j.clp.2023.11.001
13.
OkdaM, SpinaS, Safaee FakhrB, et al.Antimicrobial effects of nitric oxide: Narrative review. Nitric Oxide2025; 155: 20–40; doi: 10.1016/j.niox.2025.01.001
14.
WebertKE, VanderzwanJ, DugganM, et al.Effects of inhaled nitric oxide in a rat model of Pseudomonas aeruginosa pneumonia. Crit Care Med2000; 28: 2397–2405; doi: 10.1097/00003246-200007000-00035
15.
Di FenzaR, ShettyNS, GianniS, Nitric Oxide Investigators. et al.High-dose inhaled nitric oxide in acute hypoxemic respiratory failure due to COVID-19: Multicenter phase II trial. Am J Respir Crit Care Med2023; 208: 1293–1304; doi: 10.1164/rccm.202304-0637OC
16.
FriedrichF, CypelM, MichaelsenVS, et al.Inhaled nitric oxide for COVID-19: Open-label randomized controlled trial. ERJ Open Res2025; 11. doi: 10.1183/23120541.00006-2024
17.
ThomsonRM, BurkeAJ, MorganLC, et al.Intermittent inhaled nitric oxide for nontuberculous mycobacterial lung infection: Pilot clinical trial. Ann Am Thorac Soc2025; 22: 1092–1097.