Clinical Outcome of Sacroiliac Rod Fixation for Fragility Fracture of the Pelvis Rommens and Hoffman Classification Type IVb: Case Series

Abstract

Introduction

Fragility fracture of the pelvis (FFP), generally involving Rommens and Hoffman classification type IVb (H-shaped) requires spinopelvic fixation (SPF). We report the clinical outcome of sacroiliac rod fixation (SIRF) for FFP type IVb in a case series.

Materials and Methods

In this retrospective observational study, six patients (mean age, 80.3 years; range, 74-85 years) with FFP type IVb who underwent SIRF since October 2019 and could be followed up for ≥1 year postoperatively were included. All patients were injured in low-energy falls, a patient had a femoral neck fracture, and other had a humeral neck fracture and distal radius fracture.

Results

The mean (range) operative time was 135 (98-200) min, and mean blood loss was 103 (80-130) g. All patients achieved bone union in an average of 4.3 months. No implant failure or surgical site infection requiring reoperation occurred. No patient complained of iliac screw irritation or requested removal. One patient developed a T12 vertebral fracture at 3 weeks postoperatively. The mean final follow-up period was 17.8 months (13-22 months) and mean final modified Majeed Score (maximum 76 points as the items “work” and “sexual intercourse” were omitted for this study) was 71.7 (56-76).

Conclusions

SIRF is a less invasive surgical technique than SPF that uses only an S1 pedicle screw and iliac screw. SIRF using the “within ring” concept showed good clinical outcome in FFP type IVb.

Keywords

fragility fracture of the pelvis sacroiliac rod fixation minimally invasive surgery geriatric trauma osteoporosis

Introduction

Fragility fracture of the pelvis (FFP) reduces activities of daily living (ADL) in the elderly and has a 5-year survival rate similar to that of proximal femoral fracture.¹ Patients with FFP also have more osteoporosis and medical comorbidities than their peers, so systemic complications must be considered during treatment. Conservative therapy is the first choice for FFP without dislocation, but the decline in ADL during the treatment period should be minimized. Additionally, there are many issues to be considered in the surgical treatment of displaced FFP, such as indications, surgical techniques, invasiveness, and fixation in fragile bones.^2,3 FFP causes major problems for the elderly. Recently, based on the Rommens and Hoffman classification,⁴ minimally invasive surgery for early mobilization,⁵ unstable fractures, and failed conservative treatments³ has been reported.

The FFP Rommens and Hoffman classification type IVb (H-shaped) is characterized by a spinopelvic dissociation containing a bilateral vertical fracture through the lateral mass of the sacrum with a horizontal component connecting them. Generally, the FFP type IVb requires spinopelvic fixation (SPF), and clinical outcomes have been reported.⁴ We have experienced several postoperative complications, such as pedicle screw backout of lumbar vertebra, in our SPF surgery cases.

A surgical technique for high-energy pelvic fractures, sacroiliac rod fixation (SIRF), was reported by Futamura et al. in 2018.⁶ In a biomechanical experiment with bone model, it has been reported that SIRF provides fixation equivalent to SPF, assuming an AO classification 61C1.3.⁷ In clinical practice, SIRF for high-energy unstable pelvic ring injuries, including H-type spinopelvic dissociation, has shown good clinical outcomes.⁶

We hypothesized that SIRF would be an effective surgical technique for FFP type IVb and have used it in the surgical treatment of suitable patients. Here we report the clinical outcomes of SIRF for FFP type IVb in a case series.

Materials and Methods

Patients

Six patients (mean age, 80.3; range, 74-85 years old; one male and five females) with FFP type IVb (H-shape, AO/OTA 61C3.3) who underwent SIRF since October 2019 and could be followed up for ≥1 year postoperatively were included in this retrospective study (Table 1). All patients were injured in low-energy falls, one had a femoral neck fracture, and other had a humeral neck fracture and distal radius fracture. The surgical indications were as follows: two patients had difficulty of mobilization due to pain, one patient needed early mobilization due to associated injury (femoral neck fracture), and three patients failed conservative treatment by their previous doctors.

Table 1.

Characteristics.

Patient number	Sex (Male/female)	Age (years)	Associated Injury	Rommens Classification	Comorbidity	CCI	ASA-PS	YAM of the BMD of the vertebral Body	YAM of the BMD of the Femoral Neck	Surgical Indication
1	Male	84	—	IVb (H-shaped)	Diabetes, chronic kidney disease	4	2	92	83	Difficulty of mobilization after 2 weeks of conservative therapy
2	Female	82	Lt. femoral neck fracture	IVb (H-shaped)	Mitral valve regurgitation	1	3	55	56	Need early mobilization due to associated injury (femoral neck fracture)
3	Female	75	—	IVb (H-shaped)	Hypothyroidism	0	2	96	79	Failure of conservative therapy for 1 month
4	Female	82	—	IVb (H-shaped)	Hypertension	0	2	77	68	Failure of conservative therapy for 3 weeks
5	Female	74	Rt. humeral neck fracture, Rt. Distal radius fracture	IVb (H-shaped)	Preoperative deep vein thrombosis, diabetes	2	2	84	79	Failure of conservative therapy for 2 months
6	Female	85	—	IVb (H-shaped)	Aortic stenosis	2	3	70	54	Difficulty of mobilization after 1 weeks of conservative therapy

CCI = Charlson Comorbidity Index. ASA-PS = American Society of Anesthesiologists physical status. YAM = Young Adult Mean. BMD = Bone mineral density.

Operation

All surgeries were performed on the patient under general anesthesia in the prone position using titanium (Ti) alloy-based spinal instrumentation (Expedium^TM Spine System; DePuySynthes Co., Zuchwil, Switzerland). Skin incisions of 6-7 cm were placed medial to both posterior superior iliac spines (PSIS) (Figure 1A). The fascia was peeled away from the surfaces of the PSIS to develop sufficient space for manipulation of the iliac screws (IS) and S1 pedicle screws (S1PS). First, the bilateral S1PS were aimed at the promontorium and inserted via the tricortical orbit (Figure 1B). The entry point of the IS was set 2-3 cm distal to the head of the S1PS, and the longest and largest diameter bilateral IS was inserted from the PSIS to the anterior inferior iliac spine (Figure 1C). To prevent IS irritation, the IS head was inserted to the level of the posterior surface of the sacrum with sufficient PSIS resection. After cracking the base of the S1 spinous process subcutaneously, the IS on both sides were connected with Ti rods passed subcutaneously, and the S1PS and Ti rods were connected with 30-40-mm offset connectors (Figures 1D, E, F). The operation was completed by grafting a local bone taken from the iliac to the fracture site on the posterior surface of the sacrum.

Figure 1.

Overview of sacroiliac rod fixation. A: Skin incisions of 6-7 cm were placed medial to both the posterior superior iliac spines (PSIS). B: Bilateral S1 pedicle screws (S1PS) were inserted by tricortical orbit. C: Both the iliac screws (IS) and offset connectors were connected with a single rod. D: The IS on both sides were connected with a rod, and the S1PS and rod were connected with an offset connector. E, F: A postoperative plain radiograph and 3D computed tomographic image.

In all cases, the dislocation of the fracture was <1 cm, and no intraoperative reduction was performed. As a postoperative treatment, full weight-bearing rehabilitation was allowed immediately after surgery. Additionally, teriparatide was started in all patients after surgery. Subsequently, computed tomography (CT) was used to assess bone union. Bone continuity was determined in at least two planes in multiplanar reconstruction CT images to achieve bone union.

Results

The mean operative time was 135 min (range, 98-200 min), the mean blood loss was 103 g (range, 80-130g) (Table 2). Two patients required postoperative blood transfusion, and one of the patients also had a femoral neck fracture. The mean pain on the Numerical Rating Scale (NRS) improved immediately from 6.3 preoperatively to 2.5 at 1 week postoperatively, and to 0 at the final follow-up. Bone union was achieved in all patients in an average of 4.3 months. No implant failure or surgical site infection (SSI) requiring reoperation was observed. No patient complained of IS irritation or requested implant removal. T12 vertebral fracture at 3 weeks developed in one patient postoperatively.

Table 2.

Clinical outcome.

Patient number	Operation time (min)	Blood loss (g)	Transfusion (g)	Complication	NRS Scores			Duration of bone union (month)	Final Follow-up duration (month)	Final Modified Majeed Score
Patient number	Operation time (min)	Blood loss (g)	Transfusion (g)	Complication	Preoperative	1 week postoperative	Final Follow-up	Duration of bone union (month)	Final Follow-up duration (month)	Final Modified Majeed Score
1	200	110	RCC: 280	—	8	4	0	5.1	15	56
2	139	110	RCC: 560	T12OVF at 3 weeks postoperatively	7	3	0	6.4	14	74
3	139	110	—	—	4	1	0	2.8	13	76
4	124	130	—	—	7	3	0	3.0	12	76
5	107	80	—	—	4	1	0	2.9	13	76
6	98	80	—	—	8	3	0	3.0	13	72

OVF = osteoporotic vertebral fracture. NRS = Numeric Rating Scale. RCC = Red cells concentrates.

The mean final follow-up period was 17.8 months (range, 13-22 months), the mean final modified Majeed Score (maximum 76 points as the items “work” and “sexual intercourse” were omitted for this study) was 71.7 (range, 56-76). Regarding ADL,⁸ at the last follow-up, four patients could walk unassisted and two could walk with a walker.

Illustrative Case No.3

A 75-year-old woman had fallen 1 month earlier and developed buttock’s pain. She was diagnosed with lumbar spinal canal stenosis by her previous doctor and treated with medication, but her symptoms persisted, so she was referred to our hospital for consultation. On the initial examination, a plain radiograph showed a fracture of the left pubic rami (Figure 2A), and CT showed an H-shaped fracture of the sacrum (Figures 2B, C), so FFP type IVb was diagnosed. The NRS at that time was 4, and she had difficulty walking for a long time due to pain. SIRF was performed in response to failed conservative therapy due to delayed diagnosis (Figure 2D, E). The NRS at 1 week postoperatively was 1, which indicated a remarkable improvement. Bone union was achieved 3 months after surgery (Figures 2F, G). The modified Majeed Score at the last follow-up was 76. She is currently being followed up to the assess longer-term outcome.

Figure 2.

Illustrative case. A: A plain radiograph on initial examination: Fracture of the left pubic rami is shown. B, C: An axial and coronal CT image: An H-shaped fracture of the sacrum is shown (arrow), from which FFP type IVb was diagnosed. D, E: A postoperative plain radiograph. F, G: Postoperative computed tomographic image at 3 months: bone union was achieved.

Discussion

The typical posterior surgery for high-energy pelvic fractures is SPF or triangular osteosynthesis.^9,10 Traditionally, high-energy H-shaped fractures of the sacrum have been considered an indication for SPF.

Although SPF is an effective technique, the mobile segment of the lumbosacral spine is included in the fixation, which leads to a constant risk of implant failure.^11,12 However, Futamura et al. reported the use of SIRF with S1PS as an anchor.⁶ Furthermore, in a biomechanical experiment using bone model, it has been reported that SIRF is equivalent to SPF in stiffness, deformation, horizontal resistance, and angular deformity, assuming an AO classification 61C1.3.⁷ In clinical practice, SIRF has been performed for high-energy H-shaped fractures of the sacrum with good results.⁶ The advantages of SIRF are that it is less invasive than SPF, and the “within ring” concept allows fixation to be completed in the pelvis, preserving the mobile segment.⁶

There are few reports of surgery for FFP. Sacroplasty,¹³ percutaneous screw fixation,¹⁴ and trans-sacral positioning bar have been reported as typical techniques.¹⁵ Recently, Maki et al. reported that SPF was performed for FFP type IVb with good clinical outcome.¹⁶ SPF is a good technique for FFP as it provides strong fixation, but the longer operation and lumbosacral fixation is problematic,¹⁵ and one report stated that SPF for FFP may be an overtreatment.¹⁶

FFP is a fragility fracture due to osteoporosis without ligamentous injury,⁴ which is different from high-energy pelvic fractures requiring ligamentous injury in terms of patient background.^2,3,17 Therefore, it is questionable whether FFP and high-energy pelvic fractures should be treated with the same surgical technique, even if both are H-shaped fractures of the sacrum. In the surgery for FFP, since it is performed on elderly patients with osteoporosis, strong fixation is a prerequisite, and measures against SSI, skin ulceration, and screw irritation^9,10 that may cause additional unscheduled surgery as well as fixation that reduces the risk of screw loosening and PS backout are required.^16,18

This report appears to be the first on the application of SIRF to FFP type IVb. Bone union was achieved in all cases without any major complications, including implant failure, and the final score and clinical outcome were satisfactory. In applying SIRF to FFP, we have made several modifications to the original technique (Figure 3). Although our procedure is minimally invasive with only four anchors, the fixation strength should be ensured so that S1PS penetrates the promontorium (Figures 3A, B) and inserts via the tricortical trajectory.¹⁹ The IS with a maximum possible diameter as well as with length >80 mm²⁰ and ≥9-90 mm is inserted in all cases (Figure 3C). In addition, to prevent pain and irritation at the screw insertion site, which is a major problem with use of the IS,²¹ the IS head is inserted to the level of the posterior surface of the sacrum with sufficient PSIS resection (Figure 3D).⁶ In this series, we were fortunate to have no case of SSI and no complaints of irritation of IS. The fixation is smaller than SPF, and it seems to be sufficiently minimally invasive in terms of operative time, blood loss, and 6-7 cm skin incision. The NRS scores at 1 week postoperatively also showed an early pain relief effect. So, far, there have been no implant failures under full weight-bearing immediately after surgery, and the technique seems to be suitable for elderly people who cannot leave their beds due to pain. SIRF for FFP type IVb, which conventionally requires SPF, seems to be a good technique because it provides strong fixation and minimizes the risk of implant failure because of the “within ring” concept.

Figure 3.

Modifications to apply sacroiliac rod fixation to fragility fracture of the pelvis. A, B: S1 pedicle screw penetrates the promontorium (arrow) and inserts by tricortical trajectory. C: The iliac screws (IS) are inserted with diameters as large as possible and longer than 80 mm. This patient received with IS ranging from 10.0-100-mm in diameter. D: To prevent IS irritation, the IS head is inserted to the level of the posterior surface of the sacrum with sufficient the posterior superior iliac spines resection (broken line).

In addition, teriparatide was started in all patients after surgery as a countermeasure for elderly patients with osteoporosis. Teriparatide has been reported to be useful in spinal surgery to prevent screw loosening and in sacral fractures to improve pain early and promote bone union^22-24 In this study, teriparatide was also introduced in all patients to promote bone union and prevent subsequent fractures. In all cases, bone union was achieved in an average of 4.3 months, and there was no screw loosening requiring reoperation. The patient with complications related to bone metabolism (No.1) and the patient with more severe osteoporosis (No.2) required a longer duration of bone union than other patients. Therefore, using teriparatide is important for these patients to achieve bone union, even if it takes a longer duration. Only one patient developed a T12 vertebral body fracture postoperatively, and no subsequent fracture was observed during the follow-up period in the other patients.

There were several limitations in our case series. This was a small retrospective series and patients had small displacement. In patients with large vertical displacement, SPF may be indicated by the results of biomechanical experiments.⁷ Generally, the S2 alar-iliac (SAI) screw is superior to the IS in terms of complications.²¹ However, we used the IS because of the possibility of screw entry through the fracture in our case series. Additional research is needed to determine whether the SAI screw or the IS is superior in SIRF. In addition, since the sacroiliac joint is included in the fixation, there is a possibility that the S1PS or IS may loosen. Long-term follow-up with more cases is necessary.

Conclusion

In conclusion, SIRF using the “within ring” concept showed good clinical outcomes in FFP type IVb, which was previously thought to require SPF. SIRF is a minimally invasive and mobile segment-preserving fixation method suitable for the elderly.

Footnotes

Declaration of Conflicting Interests

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Funding

The author(s) received no financial support for the research, authorship, and/or publication of this article.

Research Ethics

This research has been conducted according to the World Medical Association Declaration of Helsinki. All procedures including review of patient records used in this research were approved by the institutional review board of our institution. Verbal informed consents were obtained from all patients to participate in this study. An IRB approve the study and the procedure outlined for the verbal consent obtainment.

Data Availability

The datasets generated during and analyzed during the current study are available from the corresponding author on reasonable request.

ORCID iD

Hisanori Gamada

References

Hill

Robinson

Keating

. Fractures of the pubic rami. Epidemiology and five-year survival. J Bone Joint Surg Br. 2001;83(8):1141-1144.

Maier

Kolbow

Lazovic

, et al. Risk factors for pelvic insufficiency fractures and outcome after conservative therapy. Arch Gerontol Geriatr. 2016;67:80-85.

Schmitz

Lüdeck

Baumann

Kretschmer

Nerlich

Kerschbaum

. Patient-related quality of life after pelvic ring fractures in elderly. Int Orthop. 2019;43(2):261-267.

Rommens

Hofmann

. Comprehensive classification of fragility fractures of the pelvic ring: recommendations for surgical treatment. Injury. 2013;44(12):1733-1744.

Eckardt

Egger

Hasler

, et al. Good functional outcome in patients suffering fragility fractures of the pelvis treated with percutaneous screw stabilisation: assessment of complications and factors influencing failure. Injury. 2017;48(12):2717-2723.

Futamura

Baba

Mogami

, et al. Within ring”-based sacroiliac rod fixation may overcome the weakness of spinopelvic fixation for unstable pelvic ring injuries: technical notes and clinical outcomes. Int Orthop. 2018;42(6):1405-1411.

Futamura

Baba

Mogami

, et al. A biomechanical study of sacroiliac rod fixation for unstable pelvic ring injuries: verification of the “within ring” concept. Int Orthop. 2018;42(4):909-914.

Majeed

. Grading the outcome of pelvic fractures. J Bone Joint Surg Br. 1989;71(2):304-306.

Bellabarba

Schildhauer

Vaccaro

Chapman

. Complications associated with surgical stabilization of high-grade sacral fracture dislocations with spino-pelvic instability. Spine. 2006;31(11suppl l):S80-S104.

10.

Sagi

Militano

Caron

Lindvall

. A comprehensive analysis with minimum 1-year follow-up of vertically unstable transforaminal sacral fractures treated with triangular osteosynthesis. J Orthop Trauma. 2009;23(5):313-319.

11.

De Iure

Cappuccio

Palmisani

Pascarella

Commessatti

. Lumboiliac fixation in lumbosacral dislocation and associated injuries of the pelvis and lumbosacral junction: a long-term radiological and clinical follow-up. Injury. 2016;47(suppl 4):S44-S48.

12.

Nguyen

Buell

Wang

, et al. Low rates of complications after spinopelvic fixation with iliac screws in 260 adult patients with a minimum 2-year follow-up. J Neurosurg Spine. 2019;30:1-9.

13.

Brook

Mirsky

Bello

. Computerized tomography guided sacroplasty: a practical treatment for sacral insufficiency fracture: case report. Spine. 2005;30(15):E450-E454.

14.

Ruatti

Kerschbaumer

Gay

Milaire

Merloz

Tonetti

. Technique for reduction and percutaneous fixation of U- and H-shaped sacral fractures. Orthop Traumatol Surg Res. 2013;99(5):625-629.

15.

Rommens

Ossendorf

Pairon

Dietz

Wagner

Hofmann

. Clinical pathways for fragility fractures of the pelvic ring: personal experience and review of the literature. J Orthop Sci. 2015;20(1):1-11.

16.

Maki

Nakamura

Yamauchi

, et al. Lumbopelvic fixation for sacral insufficiency fracture presenting with sphincter dysfunction. Case Rep Orthop. 2019;2019:9097876.

17.

Dalal

Burgess

Siegel

, et al. Pelvic fracture in multiple trauma: classification by mechanism is key to pattern of organ injury, resuscitative requirements, and outcome. J Trauma. 1989;29(7):981-1000.

18.

Marie-Hardy

Pascal-Moussellard

Barnaba

Bonaccorsi

Scemama

. Screw loosening in posterior spine fusion: prevalence and risk factors. Global Spine J. 2020;10(5):598-602.

19.

Orita

Ohtori

Eguchi

, et al. Radiographic evaluation of monocortical versus tricortical purchase approaches in lumbosacral fixation with sacral pedicle screws: a prospective study of ninety consecutive patients. Spine. 2010;35(22):E1230-E1237.

20.

Santos

Sembrano

Mueller

Polly

. Optimizing iliac screw fixation: a biomechanical study on screw length, trajectory, and diameter. J Neurosurg Spine. 2011;14(2):219-225.

21.

De la Garza Ramos

Nakhla

Sciubba

Yassari

. Iliac screw versus S2 alar-iliac screw fixation in adults:a meta-analysis. J Neurosurg Spine. 2018;30(2):253-258.

22.

Ohtori

Inoue

Orita

, et al. Comparison of teriparatide and bisphosphonate treatment to reduce pedicle screw loosening after lumbar spinal fusion surgery in postmenopausal women with osteoporosis from a bone quality perspective. Spine. 2013;38(8):E487-E492.

23.

Kasukawa

Miyakoshi

Ebina

, et al. Enhanced bone healing and decreased pain in sacral insufficiency fractures after teriparatide treatment: retrospective clinical-based observational study. Clin Cases Miner Bone Metab. 2017;14(2):140-145.

24.

Zhang

Potty

Vyas

Lane

. The role of recombinant PTH in human fracture healing: a systematic review. J Orthop Trauma. 2014;28(1):57-62.