Abstract
This case report describes the prenatal diagnosis of an intracranial haemorrhage due to allo-immune thrombocytopaenia (AITP) with HPA-1b incompatibility. In this family, a previous child had died neonatally with a presumed diagnosis of schizencephaly. Severe open-lip schizencephaly can be difficult to differentiate from destructive brain lesions due to intracranial haemorrhage, but a correct diagnosis is important due to the high recurrence risk and more severe manifestations in subsequent pregnancies with AITP.