In neurology, paroxysmal syndromes are well-known, eg, as manifestations of multiple sclerosis. We report a patient with meningeal carcinomatosis, who presented with therapyrefractory nausea and vomiting. The clinical suspicion of a paroxysmal syndrome prompted a trial of carbamazepine, which resulted in complete cessation of the symptoms. In cancer patients with central nervous system (CNS) involvement and therapy-refractory symptoms with sudden onset, carbamazepine treatment should be considered.
References
1.
Love S , Coakham HB . Trigeminal neuralgia: pathology and pathogenesis . Brain2001; 124: 2347–2360 .
2.
Khan OA , Sandoz GM , Olek MJ , Kuta AJ . Visually induced paroxysmal nausea and vomiting as presenting manifestation of multiple sclerosis . J Neurol Neurosurg Psychiatry1995; 59: 342–343 .
3.
Osterman PO , Westerberg CE . Paroxysmal attacks in multiple sclerosis . Brain1975; 98: 189–202 .
4.
Twomey JA , Espir LE . Paroxysmal symptoms as the first manifestations of multiple sclerosis . J Neurol Neurosurg Psychiatry1980; 40: 296–304 .
5.
Shukla GD , Mishra DN . Paroxysmal vomiting: an unusual manifestation of temporal lobe epilepsy . J Ass Phys Ind1981; 29: 669–670 .
