FEATURE AT A GLANCE: To address the increasingly serious problem of runway incursions at airports, we developed a novel design based on inexpensive sensor technology and a hybrid cognitive engineering development plan. Alerting time and monetary costs were critical factors in the creation of a low-cost, scalable, and flexible system that can directly warn pilots and air traffic controllers of impending incursions. This article describes the human-centered design process used to develop an alternative to current runway incursion prevention systems. Because it is cost-effective, the system could be employed at nearly any airport regardless of size or budget.