This paper reports on birth weight, body length, body mass index, and cranial circumference at birth of infants with cleft lip and/or palate born between 1973 and 1992.
Methods
Data were obtained from two nationwide swedish health registries. Infants with syndromes, twins, and infants with immigrant parentage were excluded from the study. Comparisons were made with all singleton births with the same exclusion criteria (n = 2,031,140).
Results
The body dimensions of infants with isolated cleft lip (n = 865) were found not to differ from those of control subjects, but infants with isolated cleft palate (n = 811) or cleft lip and palate (n = 1139) were found to be lighter and shorter than control subjects. Also, infants with the Pierre Robin sequence (n = 121) had a tendency to be lighter and shorter than control subjects, but these differences did not reach statistical significance despite the large study population.
BossiL.. Fetal effects of anticonvulsants. In: MorselliP.L., PippengerC.E., PenryJ.K., eds. Atiepileptic Drug Therapy in Pediatrics.New York: Raven Press;1983.
2.
BowersE.J., MayroR.F., WithakerL.A., PasquarielloP.S., LaRossaD., RandallP.. General body growth in children with clefts of the lip, palate and craniofacial structure.Scand J Plast Reconstr Surg1987; 21: 7–14.
3.
CnattingiusS., EricssonA., GunnarskogJ., KällénB.. A quality study of a medical birth registry.Scand J Soc Med1990; 18: 143–148.
4.
DrillenC.M., IngramT.T.S., WilkinsonE.M.. The causes and natural history of cleft lip and palate.Baltimore: Williams & Wilkins; 1966.
5.
DuncanP.A., ShapiroL.R., SoleyL., TuretS.E.. Linear growth patterns in patients with cleft lip or palate or both.Am J Dis Child1983; 137: 159–163.
6.
EricssonA., ErikssonM., KällenB., MeirikO.. Birth weight distribution as an indicator of environmental effects on fetal development.Scand J Soc Med1987; 15: 11–17.
7.
Felix-SchollaartB., HoeksmaJ., Phral-AndersenB.. Growth comparison between children with cleft lip and/or palate and controls.Cleft Palate J1992; 29: 475–480.
8.
Fogh-AndersenP.. Inheritance of Harelip and Cleft Palate.Copenhagen: Busck;1942.
9.
HayesC., WellerM.M., WillcettW.C., MitcellA.A.. Case-control study of peri-conceptional folic acid supplementation and oral clefts.Am J Epidemiol1996; 143: 1229–1234.
10.
HunterW.S., DijkmanD.J.. The timing of height and weight deficits in twins discordant for cleft of the lip and/or palate.Cleft Palate J1977; 14: 158–166.
11.
JensenB.L., DahlE., KreiborgS.. Longitudinal study of body height, radius length and skeletal maturity in Danish boys with cleft lip and palate.Scand J Dent Res1983; 91: 473–481.
12.
JensenB.L., KreiborgS., DahlE., Fogh-AderssenP.. Cleft lip and palate in Denmark 1976-1981: epidemiology, variability, and early somatic development.Cleft Palate J1988; 25: 258–269.
13.
JohnstonM.C., BronskyP.T.. Prenatal craniofacial development, new insight on normal and abnormal mechanism.Crit Rev Oral Biol Med1995; 6: 368–422.
14.
KällénB.. Search for teratogenic risks with the aid of malformation registries.Teratology1987; 35: 47–52.
15.
KällénB.. A birth weight for gestional age standard based on data in the Swedish Medical Birth Registry, 1985-1989.Eur J Epidemiol1995; 11: 601–606.
LutzK.R.. A study of the relationship of the occurrence of cleft palate and the presence of associated deformities and other factors.Cleft Palate Bull1959; 9: 47–48.
18.
McWilliamsB.J., MorrisH.L., SheltonR.L.. Cleft Palate Speech.Philadelphia: BC Decker, and St. Louis: CV Mosby;1984.
19.
MantelN., HaenszelW.. Statistical aspects of the analysis of data from retrospective studies of disease.J Natl Cancer Inst1959; 22: 719–748.
20.
MelnickM., BixlerD., ShieldsE.D.. Etiology of cleft lip and palate.Prog Clin Biol Res1980; 46: 529–540.
OkaS.W.. A team approach. In: CooperH.K., HardingR.L., KrogmanW.M., Ma-zaheriM., eds. Cleft Palate and Cleft Lip.Philadelpia: WB Saunders;1979: 108–143.
23.
ProchazkovaJ., VinsovaJ.. Craniofacial morphology as a marker of predisposition to isolated cleft palate.J Craniofac Genet Dev Biol1995; 15: 163–168.
24.
RanalliD.N., MazaheriM.. Height-weight growth of cleft children birth to six years.Cleft Palate J1975; 12: 400–404.
25.
RichmanJ.M., DeggadoJ.L.. Locally released retinoic acid leads to facial clefts in chicken embryo but does not alter the expression of fibroblast growth factor.J Craniofac Genet Dev Biol1995; 15: 190–204.
26.
RintalaA.E., GyllingU.: Birth weight of infants with cleft lip and palate.Scand J Plast Reconstr Surg1967; 1: 109–112.
27.
RobertE., KällénB., HarrisJ.. The epidemiology of orofacial clefts. 1. Some general epidemiological characterstics.J Craniofac Genet Dev Biol1996; 16: 234–241.
28.
RossR.B., JohnstonM.C.. Cleft Lip and Palate.Baltimore: Williams and Wilkins;1972.
29.
RothmanK.J., MooreL.L., SingerM.R., NguyenU.S., ManninoS., MilunskyA.. Teratogenicity of high vitamin A intake.N Engl J Med1995; 333: 1369–1373.
30.
RudmanP., DavisG.T., PriestJ.H.. Prevalence of growth hormone deficiency in children with cleft lip or cleft palate.Pediatrics.1978; 93: 378–382.
31.
SethA.K., McWilliamB.J.. Weight gain in children with cleft palate from birth to two years.Cleft Palate J1988; 25: 146–150.
32.
SharpeP.M., FergussonM.W.. Mesenchymal influence on epithelial differentiation in developing systems.J Cell Sci Suppl1988; 10: 195–230.
33.
ShawG.M., LammerE.J., WassermanC.R., O'MalleyC.D., TolarovaM.M.. Risks of orofacial clefts in children born to women using multivitamins containing folic acid periconceptionally.Lancet1995; 346: 393–396.
34.
ShawG.M., WassermanC.R., BlockG., LammerE.J.. High maternal vitamin A intake and risk of anomalies of structures with a cranial neural crest cell contribution.Lancet1996; 30: 899–900.
35.
WalkerB.E., FraserF.C.. The embryology of cortisone induced cleft palate.J Embryol Exp Morphol1957; 5: 201–209.
