The neurobiological basis of psychopathology is surveyed with emphasis upon reciprocal balances between opposing ergotropic and trophotropic systems with their central nervous system (CNS), autonomic nervous system (ANS) and neuroendocrine components. The anatomical sites, neurophysiological interconnections, and neurochemical transmitters which subserve functions of arousal, attention, perception, motion, emotion, memory, and learning are outlined. Mechanisms whereby disorders of psychophysiologic, somatopsychic and classically organic type may be triggered through such neurobiological pathways are suggested.
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