Effect of Friend Virus in Swiss and DBA/1 Mice on Fe 59 Uptake. ∗

Summary

1. These studies demonstrate that Friend Virus produces in HA/ICR Swiss and DBA/1 mice very soon after infection, a marked increase in selective uptake of Fe⁵⁹ by the spleen. This selective uptake is not found in other tissues in Friend Virus Disease. 2. Friend Virus Disease characteristically produces a malignant proliferation of splenic reticulum cells, but is further characterized by a progressive elevation of hematocrit and rbc count which is related to splenic involvement in the disease. 3. The DBA/1 strain is shown to be susceptible to Friend Virus to the same magnitude as HA/ICR Swiss mice.

We wish to acknowledge the assistance of Dr. Paul Trudel, André Bulba, Ruth Deckert, Edward Dywinski, Helen Fox and A. G. Mirand.