Induction of Deciduoma in Rabbits Without Uterine Trauma by Treatment with Ethynodiol Diacetate

Summary

Ethynodiol diacetate (E.D.) was administered to immature estrogen-primed rabbits in an attempt to stimulate formation of decidual tissue in the uterus. No uterine trauma was employed in these experiments. DCR were obtained after treatment with 1,2, 4, or 10 mg of E.D. per day for 5 or 6 days. Combination of mestranol, in doses of 0.05 to 0.3 mg per day, with as little as 0.1 mg E.D. resulted in the formation of DCR. When E.D. was administered by itself, doses of 2 mg per day were required to stimulate deciduogenesis and to maintain the response over a 15-day period. The similarity of the responses in humans and rabbits is discussed.

We wish to express our thanks to Mr. and Mrs. James Westney and Mrs. Johanna Roth for their assistance during these studies.