Increased Resistance to Herpes Simplex Virus of Hamster and Human Cells Transformed by SV 40 . ∗

Summary

Lines of cells derived originally from various hamster and human tissues and transformed in vitro by SV₄₀ consistently exhibited increased resistance to infection with herpes simplex virus, as compared with control cells not exposed to SV₄₀. Increased resistance did not appear to depend upon differences in cellular capacity to adsorb HSV or to allow penetration into the cell; nor could it be related to enhanced production of interferon. It is suggested that the SV₄₀ genome in the nucleus of transformed cells interferes in a manner as yet undefined with the synthesis of HSV which occurs at the same site.