The Specificity of the Regulation of Organ Growth: The Effect of Tissue Extracts on the Incorporation of Tritiated Thymidine in Liver and Kidney

Summary

Experiments with liver and kidneys were undertaken in an attempt to demonstrate organ-specific inhibitory factors analogous to epidermal “chalones.” Extracts and alcohol precipitates of extracts of liver and kidney were tested for inhibitory action on DNA synthesis in the named organs. Whole organ extracts and high concentration alcohol precipitates had marked inhibitory action, as high as 50%, on DNA synthesis in both organs. However, an organ-specific effect could not be demonstrated.